Cited by 251Gut microbiota and healthClostridium difficile and Clostridium perfringens researchOral microbiology and periodontitis research

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Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis

Scanlan, Pauline D., Shanahan, Fergus, Clune, Yvonne, Collins, John K., O'Sullivan, Gerald C., O'Riordan, Micheal, Holmes, Elaine, Wang, Yulan, Marchesi, Julian R.·2008·Environmental Microbiology

DOI 10.1111/j.1462-2920.2007.01503.x

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Abstract

Summary: A role for the intestinal microbiota is routinely cited as a potential aetiological factor in colorectal cancer initiation and progression. As the majority of bacteria in the gut are refractory to culture we investigated this ecosystem in subjects with colorectal cancer and with adenomatous polyposis who are at high risk of developing colorectal cancer, using culture‐independent methods. Twenty colorectal cancer and 20 polypectomized volunteers were chosen for this analysis. An exploration of the diversity and temporal stability of the dominant bacteria and several bacterial subgroups was undertaken using 16S rRNA gene denaturing gradient gel electrophoresis and ribosomal intergenic spacer analysis (RISA). Metabonomic analysis of the distal gut microbiota's environment was also undertaken. A significantly reduced temporal stability and increased diversity for the microbiota of subjects with colorectal cancer and polyposis was evident. A significantly increased diversity of the Clostridium leptum and C. coccoides subgroups was also noted for both disease groups. A clear division in the metabonome was observed for the colorectal cancer and polypectomized subjects compared with control volunteers. The intestinal microbiota and their metabolites are significantly altered in both colorectal cancer and polypectomized subjects compared with controls.

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Gut Microbes, Diet, and Cancer
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Impact of polydextrose on the faecal microbiota: a double-blind, crossover, placebo-controlled feeding study in healthy human subjects
Costabile, A., Fava, F., Röytiö, H., Forssten, S. D., Olli, K., Klievink, J., Rowland, I. R., Ouwehand, A. C., Rastall, R. A., Gibson, G. R., et al. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511005782 · Cited by 135
“Little information is available on increased microbial diversity; however, the research of Scanlan et al.((44)) associated increased diversity with colonic polyps and cancer formation.”
BackgroundInfluential
LRLSHMDA: Laplacian Regularized Least Squares for Human Microbe–Disease Association prediction
Wang, F., Huang, Z.-A., Chen, X., Zhu, Z., Wen, Z., Zhao, J., & Yan, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-08127-2 · Cited by 126
“The dramatic increase of Clostridium difficile (3th in the prediction list) and C . coccoides (4th in the prediction list) was a potential pathogenic factor for triggering colorectal carcinoma 72 .”
Background
Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer
Candela, M., Guidotti, M., Fabbri, A., Brigidi, P., Franceschi, C., & Fiorentini, C. (2010) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2010.501760 · Cited by 117
“Even if relatively few studies have been carried out, there is an increasing evidence of the potential role of the intestinal microbiota in colorectal carcinogenesis (O’Keefe, 2008; Scanlan et al. 2008; Davis and Milner., 2009; Mai et al. 2009; O’Kneefe et al. 2009; Uronis et al. 2009).”
Background
The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells
Prakash, S., Tomaro-Duchesneau, C., Saha, S., & Cantor, A. (2011) · BioMed Research International · doi:10.1155/2011/981214 · Cited by 117
Diet Effects in Gut Microbiome and Obesity
Chen, J., He, X., & Huang, J. (2014) · Journal of Food Science · doi:10.1111/1750-3841.12397 · Cited by 121
Understanding How Commensal Obligate Anaerobic Bacteria Regulate Immune Functions in the Large Intestine
Maier, E., Anderson, R. C., & Roy, N. C. (2014) · Nutrients · doi:10.3390/nu7010045 · Cited by 123
“The health of humans is impacted by the symbiotic relationship with their microbiota, while a dysbiosis of the resident microbiota is associated with various disorders, such as inflammatory bowel diseases [1–3], colorectal cancer [4,5], coeliac disease [6] and obesity [7].”
Background
Pyrosequencing-Based Analysis of the Mucosal Microbiota in Healthy Individuals Reveals Ubiquitous Bacterial Groups and Micro-Heterogeneity
Hong, P., Croix, J. A., Greenberg, E., Gaskins, H. R., & Mackie, R. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025042 · Cited by 107
“To illustrate, numerous recent studies examined the gut microbiota present in various disease models: obesity [2,3,4,5], and gastrointestinal diseases including ulcerative colitis and colorectal cancer [6,7,8].”
Background
“Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives
Yan, S., Liu, R., Jin, H., Liu, X., Ye, J., Shan, L., & Zhang, W. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)60002-4 · Cited by 115
“Metagenomics studies have also demonstrated an imbalanced microbiota composition in various diseases, such as Crohn's disease ([13]), necrotizing enterocolitis ([14]), polyposis or colorectal cancer ([15]), and type 2 diabetes ([16]).”
Background
Characterization of the intestinal microbiota and its interaction with probiotics and health impacts
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6582-5 · Cited by 102
Is It Time to Use Probiotics to Prevent or Treat Obesity?
Brusaferro, A., Cozzali, R., Orabona, C., Biscarini, A., Farinelli, E., Cavalli, E., Grohmann, U., Principi, N., & Esposito, S. (2018) · Nutrients · doi:10.3390/nu10111613 · Cited by 106
“Dysbiosis has been described in irritable bowel syndrome [6], inflammatory bowel disease [7,8], colorectal cancer [9,10], allergic diseases [11], non-alcoholic steatohepatitis [12,13], arteriosclerotic diseases [14,15], several neurologic diseases [16], and metabolic syndromes [17,18], most notably diabetes and obesit…”
Background
Linking pollution and cancer in aquatic environments: A review
Baines, C., Lerebours, A., Frédéric Thomas, A., Fort, J., Kreitsberg, R., Gentès, S., Meitern, R., Saks, L., Újvári, B., Giraudeau, M., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106391 · Cited by 105
Diet, fecal water, and colon cancer - development of a biomarker
Pearson, J. R., Gill, C. I., & Rowland, I. R. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00224.x · Cited by 103
Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism
Dheer, R., Patterson, J., Dudash, M., Stachler, E. N., Bibby, K. J., Stolz, D. B., Shiva, S., Wang, Z., Hazen, S. L., Barchowsky, A., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.10.020 · Cited by 95
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript (Scanlan et al., 2008; Spencer et al., 2011).”
Background
Human distal gut microbiome
Marchesi, J. R. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02574.x · Cited by 97
“The most common species and 16S rRNA gene sequence isolated from the distal gut come from the Euryarchaeota and in particular the Methanobacteriaceae family (Scanlan et al., 2008a; Dridi et al., 2009) with Methanobrevibacter smithii and Methanosphaera stadtmanae the two predominant Archaea found.”
BackgroundSelf-citation
Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-κB/JNK pathways in colorectal cancer
Zhu, G., Huang, Q., Huang, Y., Zheng, W., Jin, H., Yang, S., Zhuang, J., Wang, J., & Ye, J. (2016) · Oncotarget · doi:10.18632/oncotarget.12449 · Cited by 91
“In colorectal cancer, the intestinal microbiota and their metabolic microenvironment are usually altered and a significantly increased diversity of Gram-negative bacteria subgroups was noted [13, 14].”
Background
Compositional dynamics of the human intestinal microbiota with aging: Implications for health
Lakshminarayanan, B., Stanton, C., O’Toole, P. W., & Ross, R. P. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0549-6 · Cited by 93
“…observed that colon cancer patients exhibit a significantly increased diversity and reduced stability of clostridia compared to healthy individuals (89). interestingly, sobhani et al demonstrated (using qPCr) that all the bacterial species belonging to the Bacteroides/Prevotella group were more…”
Gut microbiome of Moroccan colorectal cancer patients
Allali, I., Boukhatem, N., Bouguenouch, L., Hardi, H., Boudouaya, H. A., Cadenas, M. B., Ouldim, K., Amzazi, S., Azcárate-Peril, M. A., & Ghazal, H. (2018) · Medical Microbiology and Immunology · doi:10.1007/s00430-018-0542-5 · Cited by 90
“Our findings agree with previous studies that showed that Bacteroides were enriched in CRC patients [20, 34, 75].”
Result
Upper gastrointestinal microbiota and digestive diseases
Wang, Z.-K. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i10.1541 · Cited by 90
Unveiling an abundant core microbiota in the human adult colon by a phylogroup-independent searching approach
Sekelja, M., Berget, I., Næs, T., & Rudi, K. (2010) · The ISME Journal · doi:10.1038/ismej.2010.129 · Cited by 93
“Recent research has shown that human intestinal microbiota can be linked to obesity (Ley et al., 2006; Turnbaugh, 2006), allergies, inflammatory bowel disease (Frank et al., 2007) and colon cancer (Scanlan et al., 2008).”
Background
Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome
Lamoureux, E., Grandy, S. A., & Langille, M. G. I. (2017) · mSystems · doi:10.1128/msystems.00006-17 · Cited by 90
Diet, Microbiota, and Colorectal Cancer
Akin, H., & Tozun, N. A. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000252 · Cited by 86
Gut microbial diversity in health and disease: experience of healthy Indian subjects, and colon carcinoma and inflammatory bowel disease patients
Bamola, V. D., Ghosh, A., Kapardar, R. K., Lal, B., Cheema, S., Sarma, P. M., & Chaudhry, R. (2017) · Microbial Ecology in Health and Disease · doi:10.1080/16512235.2017.1322447 · Cited by 77
The gut microbiota and aging: interactions, implications, and interventions
Gyriki, D., Nikolaidis, C. G., Bezirtzoglou, E., Voidarou, C. C., Stavropoulou, E., & Tsigalou, C. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1452917 · Cited by 80
Restoration of cefixime-induced gut microbiota changes by Lactobacillus cocktails and fructooligosaccharides in a mouse model
Shi, Y., Zhai, Q., Li, D., Mao, B., Liu, X., Zhao, J., Zhang, H., & Chen, W. (2017) · Microbiological Research · doi:10.1016/j.micres.2017.04.001 · Cited by 75
Intrauterine Growth Restriction Not Only Modifies the Cecocolonic Microbiota in Neonatal Rats But Also Affects Its Activity in Young Adult Rats
Fança‐Berthon, P., Hoebler, C., Mouzet, E., David-Sochard, A., & Michel, C. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d75d52 · Cited by 74
“On the one hand, this bacterial group has been associated with CRC or polyposis (25); on the other hand, the stimulation of these bacteria is now sometimes advised (21) because they include butyrate producers.”
Background
Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis
Li, Y., Wang, S., Sun, Y., Xu, W., Zheng, H., Wang, Y., Tang, Y., Gao, X., Song, C., Long, Y., et al. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115726 · Cited by 71
Self-citation
Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas
Kang, M. S., Edmundson, P., Araújo-Pérez, F., McCoy, A. N., Galanko, J. A., & Keku, T. O. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-91 · Cited by 69
“More recently, CRC has been linked to changes in the gut microbiota [2-5].”
Background
The Role of the Microbiome in Gastrointestinal Cancer
Wroblewski, L. E., Peek, R. M., & Coburn, L. A. (2016) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.04.010 · Cited by 79
“shown decreased temporal stability, with increased diversity of theClostridium leptum and C coccoides subgroups versus control subjects, although not between patients with CRC versus colonic polyps.(60) Studies assessing mucosa-associated bacteria”
Genomics and metagenomics in medical microbiology
Padmanabhan, R., Mishra, A. K., Raoult, D., & Fournier, P. (2013) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2013.10.006 · Cited by 67
“, 2008) polyposis or colorectal cancer (Scanlan et al., 2008), type II diabetes (Larsen et al.”
Background
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?
Jahankhani, K., Ahangari, F., Adcock, I. M., & Mortaz, E. (2023) · Biochimie · doi:10.1016/j.biochi.2023.05.014 · Cited by 67
Differential susceptibility to colorectal cancer due to naturally occurring gut microbiota
Ericsson, A. C., Akter, S., Hanson, M. M., Busi, S. B., Parker, T. W., Schehr, R., Hankins, M. A., Ahner, C. E., Davis, J. W., Franklin, C. L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5604 · Cited by 62
“In one of the first studies using culture-independent methods to compare the GM of patients diagnosed with CRC and healthy controls, an association was demonstrated between the incidence of CRC and increased overall microbial diversity [7].”
BackgroundResult
The Role of the gut Microbiome in the Pathogenesis and Treatment of Obesity
Okeke, F. C., Roland, B. C., & Mullin, G. E. (2014) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.018 · Cited by 63
Characterization of Bacteria, Clostridia and Bacteroides in Faeces of Vegetarians Using qPCR and PCR-DGGE Fingerprinting
Liszt, K., Zwielehner, J., Handschur, M., Hippe, B., Thaler, R., & Haslberger, A. G. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000229505 · Cited by 61
“The highly diverse microbiota of the human gastrointestinal tract has been associated with colorectal cancer [”
Background
The Effects from DNA Extraction Methods on the Evaluation of Microbial Diversity Associated with Human Colonic Tissue
Cuív, P. Ó., de Cárcer, D. A., Jones, M., Klaassens, E. S., Worthley, D. L., Whitehall, V., Kang, S., McSweeney, C. S., Leggett, B., & Morrison, M. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9771-x · Cited by 60
Notes on the practical utility of OPLS
Tapp, H. S., & Kemsley, E. K. (2009) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2009.08.006 · Cited by 60
Tonsillar microbiota in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome
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The Human Gutome: Nutrigenomics of the Host–Microbiome Interactions
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Altered Tissue Metabolites Correlate with Microbial Dysbiosis in Colorectal Adenomas
Nugent, J. L., McCoy, A. N., Addamo, C. J., Jia, W. P., Sandler, R. S., & Keku, T. O. (2014) · Journal of Proteome Research · doi:10.1021/pr4009783 · Cited by 58
Effects of Diet on Gut Microbiota Profile and the Implications for Health and Disease
Lee, Y. K. (2013) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.32.1 · Cited by 58
Profiling of Root Canal Bacterial Communities Associated with Chronic Apical Periodontitis from Brazilian and Norwegian Subjects
Siqueira, J. F., Jr., Rôças, I. N., Debelian, G., do Carmo, F. L., Paiva, S. S. M., Alves, F. R. F., & Rosado, A. S. (2008) · Journal of Endodontics · doi:10.1016/j.joen.2008.08.037 · Cited by 54

Authors: Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R.
Affiliations: University College Cork (IE)
Imperial College London (GB)
Corresponding author: Marchesi, Julian R.
ORCID: Scanlan, Pauline D.
Shanahan, Fergus
Collins, John K.
Holmes, Elaine
Wang, Yulan
Marchesi, Julian R.
Venue: Environmental Microbiology
Publisher: Wiley
Published: 2008-01-25
Volume: 10
Issue: 3
Pages: 789-798
ISSN: 1462-2912 (ISSN-L)
1462-2920
DOI: 10.1111/j.1462-2920.2007.01503.x
OpenAlex: W2146480823
Cited by: 245
References: 47
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 20 · 2017: 13 · 2016: 17 · 2015: 23 · 2014: 22 · 2013: 26 · 2012: 12
FWCI: 6.96
Type: journal article
Language: en
Update notices: erratum (2008-04-04)
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Environmental Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
Higher Education Authority
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, colorectal cancer, adenomatous polyposis, polypectomy, microbial diversity, temporal stability, Clostridium leptum, Clostridium coccoides, 16S rRNA gene, RISA, metabolomics, cancer etiology
MeSH terms: Clostridium, DNA, Bacterial, Electrophoresis, Polyacrylamide Gel, Female, Humans, Intestines, Male, Adenomatous Polyposis Coli, RNA, Ribosomal, 16S, Colorectal Neoplasms, DNA, Ribosomal Spacer, Gastrointestinal Tract, Biodiversity

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Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis

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