Cited by 214Fatty Acid Research and HealthAquaculture Nutrition and GrowthLipid metabolism and biosynthesis

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Anti‐obesity effects of long‐chain omega‐3 polyunsaturated fatty acids

Buckley, J. D., Howe, P. R. C.·2009·Obesity Reviews

DOI 10.1111/j.1467-789x.2009.00584.x

Open this paper in CoChat — free account

Abstract

Summary: Animal studies suggest that increased consumption of the long‐chain omega‐3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, can protect against the development of obesity in animals exposed to an obesogenic diet and reduce body fat when already obese. There is also evidence that increased intakes of these fatty acids can reduce body fat in humans, but human studies are relatively few and have generally been conducted over short time periods with small sample sizes, making it difficult to draw definitive conclusions. Reported reductions in body fat may result from appetite‐suppressing effects, adipocyte apoptosis and changes of gene expression in skeletal muscle, heart, liver, intestine and adipose tissues that suppress fat deposition and increase fat oxidation and energy expenditure. We conclude that increased intakes of long‐chain omega‐3 fatty acids may improve body composition, but longer‐term human studies are needed to confirm efficacy and determine whether increasing omega‐3 intakes might be an effective strategy to combat obesity.

Integrity signals

Registry

Crossref · 10.1111/j.1467-789x.2009.00584.x

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243
Intake of Fish and Omega-3 Fatty Acids and Risk of Stroke in Women
Iso, H. (2001) · JAMA · doi:10.1001/jama.285.3.304 · Cited by 484
Peroxisomal Lipid Metabolism
Reddy, J. K., & Mannaerts, G. P. (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002015 · Cited by 418
Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce β-oxidation in white fat
Flachs, P., Horakova, O., Brauner, P., Rossmeisl, M., Pecina, P., Franssen-van Hal, N., Ruzickova, J., Sponarova, J., Drahota, Z., Vlcek, C., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1944-7 · Cited by 388
Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults
Couet, C., Delarue, J., Ritz, P., Antoine, J.-M., & Lamisse, F. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800451 · Cited by 344
Fish Consumption and Risk of Stroke in Men
He, K. (2002) · JAMA · doi:10.1001/jama.288.24.3130 · Cited by 340
Omega‐3 PUFA of marine origin limit diet‐induced obesity in mice by reducing cellularity of adipose tissue
Ruzickova, J., Rossmeisl, M., Prazak, T., Flachs, P., Sponarova, J., Vecka, M., TVRZICKÁ, E., Bryhn, M., & Kopecký, J. (2004) · Lipids · doi:10.1007/s11745-004-1345-9 · Cited by 327
Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids
Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318
Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
Mascaró, C., Acosta, E., Ortiz, J. A., Marrero, P. F., Hegardt, F. G., & Haro, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8560 · Cited by 318
Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: A randomized controlled study
Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1670 · Cited by 316

Show all 36 references

Sorted by citations

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
Simopoulos, A. P. (2016) · Nutrients · doi:10.3390/nu8030128 · Cited by 1,673
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591
Marine Bioactive Compounds and Their Health Benefits: A Review
Hamed, I., Özogul, F., Özogul, Y., & Regenstein, J. M. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12136 · Cited by 444
Long-Chain Omega-3 Polyunsaturated Fatty Acids May Be Beneficial for Reducing Obesity—A Review
Buckley, J. D., & Howe, P. R. C. (2010) · Nutrients · doi:10.3390/nu2121212 · Cited by 229
Self-citation
Obesity and metabolic syndrome: Potential benefit from specific nutritional components
Abete, I., Goyenechea, E., Zulet, M. Á., & Martínez, J. A. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.05.001 · Cited by 219
Peripheral Mechanisms in Appetite Regulation
Camilleri, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.09.016 · Cited by 228
Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides
López‐Vicario, C., Alcaraz‐Quiles, J., García‐Alonso, V., Rius, B., Hwang, S. H., Titos, E., Lopategi, A., Hammock, B. D., Arroyo, V., & Clària, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422590112 · Cited by 218
Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice
White, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185
Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials
Akinkuolie, A. O., Ngwa, J. S., Meigs, J. B., & Djoussé, L. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.08.013 · Cited by 167
Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice
Zhuang, P., Li, H., Jia, W. P., Shou, Q., Zhu, Y., Mao, L., Wang, W., Wu, F. L., Chen, X., Wan, X., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01126-6 · Cited by 174
Food Ingredients as Anti-Obesity Agents: A Review
Trigueros, L., Peña, S., Ugidos, A. V., Sayas‐Barberá, E., Pérez‐Álvarez, J. Á., & Sendra, E. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.574215 · Cited by 147
Making Weight in Combat Sports
Langan‐Evans, C., Close, G. L., & Morton, J. P. (2011) · Strength and conditioning journal · doi:10.1519/ssc.0b013e318231bb64 · Cited by 123
Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men
Albert, B. B., Derraik, J. G. B., Brennan, C. M., Biggs, J. B., Smith, G. C., Garg, M. L., Cameron-Smith, D., Hofman, P. L., & Cutfield, W. S. (2014) · Scientific Reports · doi:10.1038/srep06697 · Cited by 105
Role of ω3 Longchain Polyunsaturated Fatty Acids in Reducing Cardio- Metabolic Risk Factors
Abeywardena, M. Y., & Patten, G. S. (2011) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153011796429817 · Cited by 106
An assessment of the techno-functional and sensory properties of yoghurt fortified with a lipid extract from the microalga Pavlova lutheri
Robertson, R. C., Mateo, M. R. G., O’Grady, M. N., Guihéneuf, F., Stengel, D. B., Ross, R. P., Fitzgerald, G. F., Kerry, J. P., & Stanton, C. (2016) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2016.03.017 · Cited by 101
Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials
Zhang, Y. Y., Liu, W., Zhao, T. Y., & Tian, H. M. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-016-0755-5 · Cited by 101
Epigenetic Modification of the Leptin Promoter in Diet-Induced Obese Mice and the Effects of N-3 Polyunsaturated Fatty Acids
Shen, W., Wang, C., Xia, L., Fan, C., Dong, H., Deckelbaum, R., & Qi, K.-M. (2014) · Scientific Reports · doi:10.1038/srep05282 · Cited by 96
Soil health and nutrient density: preliminary comparison of regenerative and conventional farming
Montgomery, D. R., Biklé, A., Archuleta, R., Brown, P., & Jordan, J. (2022) · PeerJ · doi:10.7717/peerj.12848 · Cited by 119
Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism
Caesar, R., Nygrén, H., Orešič, M., & Bäckhed, F. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m065847 · Cited by 94
Eicosapentaenoic and Docosahexaenoic Acids Differentially Alter Gut Microbiome and Reverse High‐Fat Diet–Induced Insulin Resistance
Zhuang, P., Zhang, Y., Shou, Q., Li, H., Zhu, Y., He, L., Chen, J., & Jiao, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900946 · Cited by 94
Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition
DeFina, L. F., Marcoux, L. G., Devers, S. M., Cleaver, J. P., & Willis, B. L. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002741 · Cited by 89
The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function
Todorčević, M., & Hodson, L. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm5010003 · Cited by 93
Does Fish Oil Have an Anti-Obesity Effect in Overweight/Obese Adults? A Meta-Analysis of Randomized Controlled Trials
Du, S., Jin, J., Fang, W., & Su, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142652 · Cited by 87
Semi-automated non-target processing in GC × GC–MS metabolomics analysis: applicability for biomedical studies
Koek, M. M., van der Kloet, F. M., Kleemann, R., Kooistra, T., Verheij, E. R., & Hankemeier, T. (2010) · Metabolomics · doi:10.1007/s11306-010-0219-6 · Cited by 86
Fermented mixed feed alters growth performance, carcass traits, meat quality and muscle fatty acid and amino acid profiles in finishing pigs
Liu, S., Du, M., Tu, Y., You, W., Chen, W., Liu, G., Li, J., Wang, Y., Lu, Z., Wang, T., et al. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.09.003 · Cited by 90
Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease
Kim, E., Bae, J.-S., Hahm, K. B., & Cha, J.-Y. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.029 · Cited by 77
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos
Lemas, D. J., Wiener, H. W., O’Brien, D. M., Hopkins, S. E., Stanhope, K. L., Havel, P. J., Allison, D. B., Fernández, J. R., Tiwari, H. K., & Boyer, B. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p018952 · Cited by 75
Omega-3 polyunsaturated fatty acids
Hull, M. A. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.08.001 · Cited by 73
The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta‐analysis of 45 randomized placebo‐controlled trials
Mohammadi‐Sartang, M., Mazloom, Z., Raeisi‐Dehkordi, H., Barati‐Boldaji, R., Bellissimo, N., & de Zepetnek, J. O. T. (2017) · Obesity Reviews · doi:10.1111/obr.12550 · Cited by 73
Dietary supplementation withn-3 PUFA does not promote weight loss when combined with a very-low-energy diet
Munro, I., & Garg, M. L. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511006817 · Cited by 66
ω‐3 Polyunsaturated Fatty Acid Supplementation Does Not Influence Body Composition, Insulin Resistance, and Lipemia in Women With Type 2 Diabetes and Obesity
Crochemore, I. C. C., Souza, A. F. P., de Souza, A. C. F., & Rosado, E. L. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612444535 · Cited by 66
Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology
Khadge, S., Sharp, J. G., Thiele, G. M., McGuire, T. R., Klassen, L. W., Duryee, M. J., Britton, H. C., Dafferner, A. J., Beck, J., Black, P. N., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.09.017 · Cited by 66
Mechanisms of Abnormal Lipid Metabolism in the Pathogenesis of Disease
Xu, L., Yang, Q., & Zhou, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158465 · Cited by 71
A New Insight to Bone Turnover: Role of ω‐3 Polyunsaturated Fatty Acids
Kajarabille, N., Díaz‐Castro, J., Hijano, S., López‐Frías, M., López‐Aliaga, I., & Ochoa, J. J. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/589641 · Cited by 67
Dietary supplementation with long chain omega-3 polyunsaturated fatty acids and weight loss in obese adults
Munro, I., & Garg, M. L. (2011) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2011.11.001 · Cited by 65
Host-microbial interactions in the metabolism of different dietary fats
Chadaideh, K. S., & Carmody, R. N. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.011 · Cited by 63
Plasma stearoyl‐CoA desaturase indices: Association with lifestyle, diet, and body composition
Vinknes, K. J., Elshorbagy, A. K., Nurk, E., Drevon, C. A., Gjesdal, C. G., Tell, G. S., Nygard, O. K., Vollset, S. E., & Refsum, H. (2013) · Obesity · doi:10.1002/oby.20011 · Cited by 64
The microbiome-adipose tissue axis in systemic metabolism
Lundgren, P., & Thaiss, C. A. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2019 · Cited by 62
Effect of n-3 (Omega-3) Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers and Body Weight in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs
Khalili, L., Valdés‐Ramos, R., & Harbige, L. S. (2021) · Metabolites · doi:10.3390/metabo11110742 · Cited by 60
Anti-inflammatory effects of docosahexaenoic acid: Implications for its cancer chemopreventive potential
Yum, H.-W., Na, H., & Surh, Y. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.08.004 · Cited by 58
Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study
Vidakovic, A. J., Jaddoe, V. W. V., Gishti, O., Felix, J. F., Williams, M. A., Albert Hofman, D., Demmelmair, H., Koletzko, B. V., Tiemeier, H. W., & Gaillard, R. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0106-6 · Cited by 54
Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
Khan, S. A., Ali, A., Khan, S. A., Zahran, S. A., Damanhouri, G. A., Azhar, E. I., & Qadri, I. (2014) · Mediators of Inflammation · doi:10.1155/2014/502749 · Cited by 55
Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins
White, P. J., Mitchell, P. L., Schwab, M. G., Trottier, J., Kang, J., Barbier, O., & Marette, A. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.017 · Cited by 55
Fish oil supplementation for two generations increases insulin sensitivity in rats
Hirabara, S. M., Folador, A., Fiamoncini, J., Lambertucci, R. H., Rodrigues, C., Rocha, M. S., Aikawa, J., Yamazaki, R. K., Martins, A. R., Rodrigues, A. C., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.014 · Cited by 51
BPA and its alternatives BPF and BPAF exaggerate hepatic lipid metabolism disorders in male mice fed a high fat diet
Sun, F., Huang, Y., Chen, H., Huang, J., Zhang, L., Wei, S., Liu, F., Chen, D., & Huang, W. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161521 · Cited by 51
The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters
Fan, C., Liu, X., Shen, W., Deckelbaum, R. J., & Qi, K. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-31 · Cited by 48
Food Components with Anti-Obesity Effect
Kim, K., & Park, Y. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133656 · Cited by 47
Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function
Neuman, J. C., Schaid, M. D., Brill, A. L., Fenske, R. J., Kibbe, C. R., Fontaine, D. A., Sdao, S. M., Brar, H. K., Connors, K. M., Wienkes, H. N., et al. (2017) · Diabetes · doi:10.2337/db16-1362 · Cited by 46
Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation
Hsueh, T., Baum, J., & Huang, Y. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00015 · Cited by 50
Increased Serum Dihomo-γ-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes
Tsurutani, Y., Inoue, K., Sugisawa, C., Saito, J., Omura, M., & Nishikawa, T. (2018) · Internal Medicine · doi:10.2169/internalmedicine.0816-18 · Cited by 47
The Effects of Omega 3 and Omega 6 Fatty Acids on Glucose Metabolism: An Updated Review
Egalini, F., Guardamagna, O., Gaggero, G., Varaldo, E., Giannone, B., Beccuti, G., Benso, A. S., & Broglio, F. (2023) · Nutrients · doi:10.3390/nu15122672 · Cited by 51
Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival
Khadge, S., Thiele, G. M., Sharp, J. G., McGuire, T. R., Klassen, L. W., Black, P. N., Dirusso, C., Cook, L. M., & Talmadge, J. E. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9941-7 · Cited by 45
Efficacy of omega-3-rich Camelina sativa on the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, controlled trial
Musazadeh, V., Dehghan, P., & Khoshbaten, M. (2021) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002297 · Cited by 45
COX inhibitors: a patent review (2011 – 2014)
Consalvi, S., Biava, M., & Poce, G. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1090973 · Cited by 44
Application of laboratory methods for understanding fish responses to black soldier fly (Hermetia illucens) based diets
Zarantoniello, M., Randazzo, B., Secci, G., Notarstefano, V., Giorgini, E., Lock, E., Parisi, G., & Olivotto, I. (2021) · Journal of Insects as Food and Feed · doi:10.3920/jiff2020.0135 · Cited by 44
Fish Oil Protects Wild Type and Uncoupling Protein 1‐Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure
Oliveira, T. E., Castro, É., Belchior, T., Andrade, M. L., Chaves‐Filho, A. B., Peixoto, Á. S., Moreno, M. F., Ortiz‐Silva, M., Moreira, R. J., Inague, A., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800813 · Cited by 41
Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women
Harden, C. J., Dible, V. A., Russell, J., Garaiová, I., Plummer, S. F., Barker, M. E., & Corfe, B. M. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.10.004 · Cited by 41
Relationship between Erythrocyte Omega-3 Content and Obesity Is Gender Dependent
Howe, P. R. C., Buckley, J. D., Murphy, K. J., Pettman, T. L., Milte, C. M., & Coates, A. M. (2014) · Nutrients · doi:10.3390/nu6051850 · Cited by 40
Self-citation
Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials
Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00619-3 · Cited by 40
Plasma fatty acid changes following consumption of dietary oils containing n-3, n-6, and n-9 fatty acids at different proportions: preliminary findings of the Canola Oil Multicenter Intervention Trial (COMIT)
Senanayake, V. K., Pu, S., Jenkins, D. A., Lamarche, B., Kris‐Etherton, P. M., West, S. G., Fleming, J. A., Liu, X., McCrea, C. E., & Jones, P. J. H. (2014) · Trials · doi:10.1186/1745-6215-15-136 · Cited by 39
Effects of polyunsaturated fatty acid intake and status during pregnancy, lactation, and early childhood on cardiometabolic health: A systematic review
Voortman, T., van den Hooven, E. H., Braun, K. V. E., van den Broek, M., Bramer, W. M., Chowdhurry, R., & Franco, O. H. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.05.001 · Cited by 40
Greasing the wheels of managing overweight and obesity with omega-3 fatty acids
Golub, N. I., Geba, D.-A., Mousa, S. A., Williams, G. C., & Block, R. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.016 · Cited by 40
Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health
Meyer, B. J., & Kolanu, N. (2011) · Nutrition · doi:10.1016/j.nut.2011.01.004 · Cited by 37
Of 'junk food' and 'brain food': how parental diet influences offspring neurobiology and behaviour
Bodden, C., Hannan, A. J., & Reichelt, A. C. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.04.001 · Cited by 36
Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models
Zheng, H., Tang, H., Liu, M., He, M., Lai, P., Dong, H., Lin, J., Jia, C., Zhong, M., Dai, Y., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0378-t · Cited by 36
Effects of microalgal polyunsaturated fatty acid oil on body weight and lipid accumulation in the liver of C57BL/6 mice fed a high fat diet
Go, R., Hwang, K., Geon-Tae, P., Lee, H.-M., Lee, G.-A., Kim, C., Jeon, S., Seo, J., Hong, W.-K., & Choi, K. (2016) · Journal of Biomedical Research · doi:10.7555/jbr.30.2016k0004 · Cited by 35
Associations of Serum Fatty Acid Proportions with Obesity, Insulin Resistance, Blood Pressure, and Fatty Liver: The Cardiovascular Risk in Young Finns Study
Kaikkonen, J., Jula, A., Viikari, J. S. A., Juonala, M., Hutri‐Kähönen, N., Kähönen, M. A. P., Lehtimäki, T. J., & Raitakari, O. T. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa409 · Cited by 39
Cooked rice prevents hyperlipidemia in hamsters fed a high-fat/cholesterol diet by the regulation of the expression of hepatic genes involved in lipid metabolism
Choi, W. H., Gwon, S. Y., Ahn, J., Jung, C. H., & Ha, T. Y. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.04.006 · Cited by 35
Enhanced M2 macrophage polarization in high n‐3 polyunsaturated fatty acid transgenic mice fed a high‐fat diet
Song, M., Wang, J., Lee, Y., Lee, J. H., Kwon, K.-S., Bae, E. J., & Park, B. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600014 · Cited by 33
Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
Worsch, S., Heikenwalder, M., Hauner, H., & Bader, B. L. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0291-x · Cited by 34
Effects of high EPA and high DHA fish oils on changes in signaling associated with protein metabolism induced by hindlimb suspension in rats
Marzuca-Nassr, G. N., Vitzel, K. F., de Sousa, L. G. O., Murata, G. M., Crisma, A. R., Rodrigues, C., Abreu, P., Torres, R. P., Mancini-Filho, J., Hirabara, S. M., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12958 · Cited by 39
Omega-3 fatty acids and changes in LBM: alone or in synergy for better muscle health?
McDonald, C. J., Bauer, J. D., & Capra, S. M. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0304 · Cited by 34
Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes
Nuernberg, K., Breier, B. H., Jayasinghe, S. N., Bergmann, H., Thompson, N. M., Nuernberg, G., Dannenberger, D., Schneider, F., Renne, U., Langhammer, M., et al. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-56 · Cited by 32
Preoperative 4-Week Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Liver Volume and Facilitates Bariatric Surgery in Morbidly Obese Patients
Iannelli, A., Martini, F., Schneck, A. S., Ghavami, B., Baudin, G., Anty, R., & Gugenheim, J. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0942-y · Cited by 31
Omega-3 fatty acid improves the clinical outcome of hepatectomized patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma
Wu, Z., Jianjie, Q., & Liyong, P. (2012) · Journal of Biomedical Research · doi:10.7555/jbr.26.20120058 · Cited by 30
Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders
Andersen, M. K., Jørsboe, E., Sandholt, C. H., Grarup, N., Jørgensen, M. E., Færgeman, N. J., Bjerregaard, P., Pedersen, O. B., Moltke, I., Hansen, T. F., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006119 · Cited by 30
The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats
Sunagawa, Y., Katayama, A., Funamoto, M., Shimizu, K., Shimizu, S., Sari, N., Katanasaka, Y., Miyazaki, Y., Hosomi, R., Hasegawa, K., et al. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109031 · Cited by 29
Plasma fatty acid patterns during pregnancy and child's growth, body composition, and cardiometabolic health: The Generation R Study
Voortman, T., Tielemans, M. J., Stroobant, W., Schoufour, J. D., Jong, J. C. K., Graaff, J. S., van den Hooven, E. H., Tiemeier, H. W., Jaddoe, V. W. V., & Franco, O. H. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.04.006 · Cited by 31
Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice
Lopez-Dominguez, J. A., Khraiwesh, H. M., González-Reyes, J. A., López‐Lluch, G., Navas, P., Ramsey, J. J., de Cabo, R., Burón, M. I., & Villalba, J. M. (2012) · AGE · doi:10.1007/s11357-012-9492-9 · Cited by 28
Fish Oil and Microalga Omega‐3 as Dietary Supplements: A Comparative Study on Cardiovascular Risk Factors in High‐Fat Fed Rats
Haimeur, A., Mimouni, V., Ulmann, L., Martineau, A., Messaouri, H., Pineau‐Vincent, F., Tremblin, G., & Meskini, N. (2016) · Lipids · doi:10.1007/s11745-016-4177-2 · Cited by 28
Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice
Kumar, S. P. S., Shen, M., Spicer, E. G., Goudjo-Ako, A. J., Stumph, J. D., Zhang, J., & Shi, H. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej13-0455 · Cited by 26
Fish consumption and subsequent change in body weight in European women and men
Jakobsen, M. U., Dethlefsen, C., Due, K. M., May, A. M., Romaguera, D., Vergnaud, A., Norat, T., Sørensen, T. I. A., Halkjær, J., Tjønneland, A. M., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001079 · Cited by 26
N-3 Polyunsaturated Fatty Acids, Body Fat and Inflammation
Lund, A.-S. Q., Hasselbalch, A. L., Gamborg, M., Skogstrand, K., HOUGAARD, D. M., Heitmann, B. L., Kyvik, K. O., Sørensen, T. I. A., & Jess, T. (2013) · Obesity Facts · doi:10.1159/000354663 · Cited by 26
Impact of health and lifestyle food supplements on periodontal tissues and health
Spahr, A., & Divnic‐Resnik, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12455 · Cited by 28
Effect of fish and krill oil supplementation on glucose tolerance in rabbits with experimentally induced obesity
Ivanova, Z., Bjørndal, B., Григорова, Н., Rusenov, A. G., Vachkova, Е., Berge, K., Burri, L., Berge, R. K., Stanilova, S. A., Milanova, A., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0782-0 · Cited by 26
Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease
Lou, D.-J., Zhu, Q.-Q., Si, X.-W., Guan, L.-L., You, Q.-Y., Yu, Z., Zhang, A., & Li, D. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.04.008 · Cited by 24
Microalgal Oil fromSchizochytriumsp. Prevents HFD-Induced Abdominal Fat Accumulation in Mice
Yu, J., Ma, Y., Sun, J. L., Ran, L., Li, Y., Wang, N., Yu, T., Gao, W., Jia, W., Jiang, R., et al. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1302366 · Cited by 25
Anti‐obesity potentiality of Tapra fish ( Opisthopterus tardoore ) oil
Pradhan, S., Panchali, T., Paul, B., Khatun, A., Jarapala, S. R., Mondal, K. C., Ghosh, K., & Chakrabarti, S. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13448 · Cited by 23
The Effects of an Oral Supplement Enriched With Fish Oil, Prebiotics, and Antioxidants on Nutrition Status in Crohn's Disease Patients
Wiese, D. M., Lashner, B. A., Lerner, E., DeMichele, S. J., & Seidner, D. L. (2011) · Nutrition in Clinical Practice · doi:10.1177/0884533611413778 · Cited by 22
Compositional analysis, biological activity, and food protecting ability of ethanolic extract ofQuercus infectoriagall
Başyi̇ğit, B., Sağlam, H., Köroğlu, K., & Karaaslan, M. (2020) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.14692 · Cited by 22
LipiD-QuanT: a novel method to quantify lipid accumulation in live cells
Varinli, H., Osmond-McLeod, M. J., Molloy, P. L., & Vallotton, P. (2015) · Journal of Lipid Research · doi:10.1194/jlr.d059758 · Cited by 21
Seeds from ancient food crops with the potential for antiobesity promotion
Hernández‐Pérez, T., Valverde, M. E., & Paredes‐López, O. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1877107 · Cited by 21
Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells
Song, N., Na, H., Baek, J., & Surh, Y. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.030 · Cited by 20
Fish consumption does not prevent increase in waist circumference in European women and men
Jakobsen, M. U., Due, K. M., Dethlefsen, C., Halkjær, J., Holst, C., Forouhi, N. G., Tjønneland, A. M., Boeing, H., Buijsse, B., Palli, D., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006039 · Cited by 20
Functional foods and obesity
Myrie, S. B., & Jones, P. J. H. (2011) · Elsevier eBooks · doi:10.1533/9780857092557.2.234 · Cited by 19
Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA
Phitak, T., Boonmaleerat, K., Pothacharoen, P., Pruksakorn, D., & Kongtawelert, P. (2017) · Connective Tissue Research · doi:10.1080/03008207.2017.1385605 · Cited by 19
Adipose Tissue Fatty Acid Patterns and Changes in Anthropometry: A Cohort Study
Dahm, C. C., Gorst‐Rasmussen, A., Jakobsen, M. U., Schmidt, E. B., Tjønneland, A. M., Sørensen, T. I. A., & Overvad, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022587 · Cited by 18
Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis
Hastert, T. A., Otto, M. C. D. O., Lê‐Scherban, F., Steffen, B. T., Steffen, L. M., Tsai, M. Y., Jacobs, D. R., & Baylín, A. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.282 · Cited by 18
The effect of omega3 fatty acid supplementation on PPARγ and UCP2 expressions, resting energy expenditure, and appetite in athletes
Moradi, S., Alivand, M., Khajebishak, Y., Jafarabadi, M. A., Alipour, M., Chilibeck, P. D., & Alipour, B. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00266-4 · Cited by 17

Authors: Buckley, J. D., & Howe, P. R. C.
Affiliations: University of South Australia (AU)
Corresponding author: Buckley, J. D.
ORCID: Buckley, J. D.
Howe, P. R. C.
Venue: Obesity Reviews
Publisher: Wiley
Published: 2009-10-28
Volume: 10
Issue: 6
Pages: 648-659
ISSN: 1467-7881 (ISSN-L)
1467-789X
DOI: 10.1111/j.1467-789x.2009.00584.x
OpenAlex: W2018489015
Cited by: 213
References: 36
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 20 · 2020: 19 · 2019: 9 · 2018: 12 · 2017: 16 · 2016: 18 · 2015: 15 · 2014: 25 · 2013: 9 · 2012: 10
FWCI: 1.48
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Obesity Reviews (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: omega-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, obesity, anti-obesity, obesogenic diet, fat loss, appetite suppression, adipocyte apoptosis, fat oxidation, energy expenditure, gene expression, body composition
MeSH terms: Adipose Tissue, Animals, Body Composition, Diet, Reducing, Disease Models, Animal, Energy Metabolism, Humans, Obesity, Fatty Acids, Omega-3, Apoptosis, Evidence-Based Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anti‐obesity effects of long‐chain omega‐3 polyunsaturated fatty acids

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks