Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

Couet, C; Delarue, J; Ritz, P; Antoine, J-M; Lamisse, F

doi:10.1038/sj.ijo.0800451

Cited by 344Fatty Acid Research and HealthLipid metabolism and biosynthesisDiet and metabolism studies

Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

Couet, C, Delarue, J, Ritz, P, Antoine, J-M, Lamisse, F·1997·International Journal of Obesity

DOI 10.1038/sj.ijo.0800451

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Abstract

Objective To investigate whether the substitution of fish oil for visible fats in a control diet (52% carbohydrates, 16% protein, 32% fat; P:S 0.2) influences body fat mass and substrate oxidation in healthy adults.Design Six volunteers (5 men; 23 +/- 2 y; BMI: 21.9 +/- 1.6) were fed a control diet (C) ad libitum during a period of three weeks and, 10-12 weeks later, the same diet where 6 g/d of visible fat were replaced by 6 g/d of fish oil (FO) for another three weeks.Results Energy intakes (IKA-calorimeter) were unchanged. Body fat mass (Dual-energy X-ray absorptiometry) decreased with FO (-0.88 +/- 0.16 vs -0.3 +/- 0.34 kg; FO vs C; P < 0.05). When adjusted for lean body mass (Ancova), resting metabolic rate (indirect calorimetry) was unchanged. Basal respiratory quotient decreased with FO (0.815 +/- 0.02 vs 0.834 +/- 0.02; P < 0.05) and basal lipid oxidation increased with FO (1.06 +/- 0.17 vs 0.87 +/- 0.13 mg kg(-1) min(-1); P < 0.05).Conclusion Dietary FO reduces body fat mass and stimulates lipid oxidation in healthy adults.

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OM3FA treatment increases fatty acid oxidation.
“Clinical studies have shown that OM3FA treatment increases fatty acid oxidation, as determined by indirect calorimetry [35, 36].”
From Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review (2017) · cites this paper as [35]
Increased hepatic fatty acid oxidation is likely the mechanism for reduced VLDL production.
“rather, increased hepatic fatty acid oxidation is likely.”
From Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review (2017) · cites this paper as [35]

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Authors: Couet, C., Delarue, J., Ritz, P., Antoine, J.-M., & Lamisse, F.
Affiliations: Université de Tours (FR)
Unité de Nutrition Humaine (FR)
Danone (France) (FR)
ORCID: Delarue, J
Ritz, P
Venue: International Journal of Obesity
Publisher: Springer Science and Business Media LLC
Published: 1997-08
Volume: 21
Issue: 8
Pages: 637-643
ISSN: 0307-0565 (ISSN-L)
1476-5497
DOI: 10.1038/sj.ijo.0800451
OpenAlex: W2048032483
Cited by: 344
References: 0
Citations by year: 2026: 2 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 15 · 2020: 20 · 2019: 16 · 2018: 14 · 2017: 15 · 2016: 24 · 2015: 21 · 2014: 15 · 2013: 16 · 2012: 12
FWCI: 5.67
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: International Journal of Obesity (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords: fish oil, fat replacement, fat mass, lipid oxidation, respiratory quotient, resting metabolic rate, energy intake, healthy adults, weight loss
MeSH terms: Adult, Basal Metabolism, Body Composition, Energy Intake, Calorimetry, Indirect, Densitometry, Female, Fish Oils, Humans, Male, Oxidation-Reduction, Fatty Acids, Omega-3, Linear Models, Lipid Metabolism

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Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

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