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Anti‐obesity effects of long‐chain omega‐3 polyunsaturated fatty acids
Abstract
Summary: Animal studies suggest that increased consumption of the long‐chain omega‐3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, can protect against the development of obesity in animals exposed to an obesogenic diet and reduce body fat when already obese. There is also evidence that increased intakes of these fatty acids can reduce body fat in humans, but human studies are relatively few and have generally been conducted over short time periods with small sample sizes, making it difficult to draw definitive conclusions. Reported reductions in body fat may result from appetite‐suppressing effects, adipocyte apoptosis and changes of gene expression in skeletal muscle, heart, liver, intestine and adipose tissues that suppress fat deposition and increase fat oxidation and energy expenditure. We conclude that increased intakes of long‐chain omega‐3 fatty acids may improve body composition, but longer‐term human studies are needed to confirm efficacy and determine whether increasing omega‐3 intakes might be an effective strategy to combat obesity.
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“The anti-obesity effects of eicosapentaenoic acid and docosahexaenoic acid have been shown in previous studies [89, 90].”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [89]
In the citing paper
“Additionally, ω-3 fatty acids are rich in ALA, which may increase resting energy expenditure by upregulating uncoupling protein 3 mRNA and peroxisomal acyl-CoA oxidase expression.38”
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Self-citation
Metadata
- Authors
- Buckley, J. D., & Howe, P. R. C.
- Affiliations
- University of South Australia (AU)
- Corresponding author
- Buckley, J. D.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2009-10-28
- Volume
- 10
- Issue
- 6
- Pages
- 648-659
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W2018489015
- Cited by
- 213
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 20 · 2020: 19 · 2019: 9 · 2018: 12 · 2017: 16 · 2016: 18 · 2015: 15 · 2014: 25 · 2013: 9 · 2012: 10
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- omega-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, obesity, anti-obesity, obesogenic diet, fat loss, appetite suppression, adipocyte apoptosis, fat oxidation, energy expenditure, gene expression, body composition
- MeSH terms
- Adipose Tissue, Animals, Body Composition, Diet, Reducing, Disease Models, Animal, Energy Metabolism, Humans, Obesity, Fatty Acids, Omega-3, Apoptosis, Evidence-Based Medicine
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