Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
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Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.
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Despite obese insulin resistant subjects presenting similar amounts of intracellular triglycerides as endurance athletes, the degree of lipid peroxidation is 4.2-fold higher in obese insulin resistant individuals than endurance athletes.
“despite obese insulin resistant subject presenting similar amount of intracellular triglycerides as endurance athletes, the degree of lipid peroxidation was 4.2-fold higher in obese insulin resistant individuals than endurance athletes (Russell et al., 2003)”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Russell et al., 2003
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- Authors
- Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P.
- Affiliations
- University of Geneva (CH)
- University Hospital of Geneva (CH)
- Clinique Romande de Réadaptation (CH)
- University of California San Diego (US)
- Corresponding author
- Russell, Aaron P
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-08-27
- Volume
- 551
- Issue
- 1-3
- Pages
- 104-106
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2042613416
- Cited by
- 166
- References
- 13
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 5 · 2012: 11
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Stiftung für die Erforschung der Muskelkrankheiten
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (65431)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- lipid peroxidation, skeletal muscle, obesity, endurance training, insulin resistance, muscle lipids
- MeSH terms
- Adult, Aldehydes, Humans, Lipids, Male, Middle Aged, Obesity, Physical Endurance, Triglycerides, Lipid Peroxidation, Muscle, Skeletal
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