Cited by 166Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesMuscle metabolism and nutrition

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

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Russell, Aaron P, Gastaldi, Giacomo, Bobbioni-Harsch, Elisabetta, Arboit, Patrizia, Gobelet, Charles, Dériaz, Olivier, Golay, Alain, Witztum, Joseph L +1 more·2003·FEBS Letters

Abstract

Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.

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  • Despite obese insulin resistant subjects presenting similar amounts of intracellular triglycerides as endurance athletes, the degree of lipid peroxidation is 4.2-fold higher in obese insulin resistant individuals than endurance athletes.

    “despite obese insulin resistant subject presenting similar amount of intracellular triglycerides as endurance athletes, the degree of lipid peroxidation was 4.2-fold higher in obese insulin resistant individuals than endurance athletes (Russell et al., 2003)”

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Authors
Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P.
Affiliations
  • University of Geneva (CH)
  • University Hospital of Geneva (CH)
  • Clinique Romande de Réadaptation (CH)
  • University of California San Diego (US)
Corresponding author
Russell, Aaron P
Venue
FEBS Letters
Publisher
Wiley
Published
2003-08-27
Volume
551
Issue
1-3
Pages
104-106
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2042613416
Cited by
166
References
13
Citations by year
2026: 1 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 5 · 2012: 11
FWCI
6.38
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Science Foundation
  • Stiftung für die Erforschung der Muskelkrankheiten
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (65431)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
lipid peroxidation, skeletal muscle, obesity, endurance training, insulin resistance, muscle lipids
MeSH terms
Adult, Aldehydes, Humans, Lipids, Male, Middle Aged, Obesity, Physical Endurance, Triglycerides, Lipid Peroxidation, Muscle, Skeletal

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