Cited by 251Epigenetics and DNA MethylationBirth, Development, and HealthChild Abuse and Trauma

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

DNA Methylation: A Mechanism for Embedding Early Life Experiences in the Genome

Open access

Szyf, Moshe, Bick, Johanna·2013·Child Development

DOI 10.1111/j.1467-8624.2012.01793.xPMC PMC4039199

Open this paper in CoChat — free account

Abstract

Although epidemiological data provide evidence that early life experience plays a critical role in human development, the mechanism of how this works remains in question. Recent data from human and animal literature suggest that epigenetic changes, such as DNA methylation, are involved not only in cellular differentiation but also in the modulation of genome function in response to early life experience affecting gene function and the phenotype. Such modulations may serve as a mechanism for life-long genome adaptation. These changes seem to be widely distributed across the genome and to involve central and peripheral systems. Examining the environmental circumstances associated with the onset and reversal of DNA methylation will be critical for understanding risk and resiliency.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1467-8624.2012.01793.x

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Translating the Histone Code
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
DNA Methylation and Gene Function
Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,076
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · cited 2×
“Although the interaction between genotypes and environmental conditions has been an exciting possibility, there is significant controversy regarding the replicability of these original findings (Risch et al., 2009).”

Show all 60 references

Research works printed but not linked: 3

Suderman, 2012, Epigenetic response to childhood abuse in the human hippocampus
Suderman, Proceedings of the National Academy of Sciences of the United States of America
Weaver, 2012, MBD2 mediates epigenetic programming of the glucocorticoid receptor

Sorted by citations

Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083891 · Cited by 768
Preventing Childhood Toxic Stress: Partnering With Families and Communities to Promote Relational Health
Garner, A., Yogman, M., COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, Lavin, A., Askew, G. L., Baum, R. A., Berger-Jenkins, E., Johnson, T. J., Jutte, D., Nasir, A. A., et al. (2021) · Pediatrics · doi:10.1542/peds.2021-052582 · Cited by 392
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Dunn, E. C., Soare, T. W., Zhu, Y., Simpkin, A. J., Suderman, M. J., Klengel, T., Smith, A. D. A. C., Ressler, K. J., & Relton, C. L. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.023 · Cited by 315
Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes
Ho, S., Johnson, A. D., Tarapore, P., Janakiram, V., Zhang, X., & Leung, Y. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.289 · Cited by 327
Resilience in developing systems: the promise of integrated approaches
Masten, A. S. (2016) · European Journal of Developmental Psychology · doi:10.1080/17405629.2016.1147344 · Cited by 303
Neural substrates of early executive function development
Fiske, A., & Holmboe, K. (2019) · Developmental Review · doi:10.1016/j.dr.2019.100866 · Cited by 307
Resilience in Development: Progress and Transformation
Masten, A. S., & Cicchetti, D. (2016) · Developmental Psychopathology · doi:10.1002/9781119125556.devpsy406 · Cited by 416
Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy
Dadds, M. R., Moul, C., Cauchi, A., Dobson-Stone, C., Hawes, D. J., Brennan, J., & Ebstein, R. E. (2014) · Development and Psychopathology · doi:10.1017/s0954579413000497 · Cited by 230
Children's Parents
Bornstein, M. H. (2015) · Wiley eBooks · doi:10.1002/9781118963418.childpsy403 · Cited by 229
Child maltreatment and the development of substance use and disorder
Cicchetti, D., & Handley, E. D. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100144 · Cited by 210
Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers
D’Agnelli, S., Arendt‐Nielsen, L., Gerra, M. C., Zatorri, K., Boggiani, L., Baciarello, M., & Bignami, E. G. (2018) · Molecular Pain · doi:10.1177/1744806918819944 · Cited by 209
Child Maltreatment and Developmental Psychopathology: A Multilevel Perspective
Cicchetti, D., & Toth, S. L. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy311 · Cited by 193
What's mom got to do with it? Contributions of maternal executive function and caregiving to the development of executive function across early childhood
Cuevas, K., Deater-Deckard, K. D., Kim‐Spoon, J., Watson, A. J., Morasch, K. C., & Bell, M. A. (2014) · Developmental Science · doi:10.1111/desc.12073 · Cited by 184
Analysis of DNA methylation in young people: limited evidence for an association between victimization stress and epigenetic variation in blood
Marzi, S. J., Sugden, K., Arseneault, L., Belsky, D. W., Burrage, J., Corcoran, D. L., Danese, A., Fisher, H. L., Hannon, E., Moffitt, T. E., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17060693 · Cited by 163
Oxytocin receptor genetic and epigenetic variations: Association with child abuse and adult psychiatric symptoms
Smearman, E. L., Almli, L. M., Conneely, K. N., Brody, G. H., Sales, J. M., Bradley, B., Ressler, K. J., & Smith, A. K. (2016) · Child Development · doi:10.1111/cdev.12493 · Cited by 173
Effects of early life stress on amygdala and striatal development
Fareri, D. S., & Tottenham, N. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.04.005 · Cited by 177
Prenatal influences on temperament development: the role of environmental epigenetics
Gartstein, M. A., & Skinner, M. K. (2018) · Development and Psychopathology · doi:10.1017/s0954579417001730 · Cited by 161
The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention
Schiele, M. A., Gottschalk, M. G., & Domschke, K. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101830 · Cited by 156
Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis
Cattaneo, A., Macchi, F., Plazzotta, G., Veronica, B., Bocchio-Chiavetto, L., Riva, M. A., & Pariante, C. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00040 · Cited by 152
Child Maltreatment and Long-Term Physical and Mental Health Outcomes: An Exploration of Biopsychosocial Determinants and Implications for Prevention
Mehta, D., Kelly, A. B., Laurens, K. R., Haslam, D. M., Williams, K. E., Walsh, K., Baker, P., Carter, H. E., Khawaja, N. G., Zelenko, O., et al. (2021) · Child Psychiatry & Human Development · doi:10.1007/s10578-021-01258-8 · Cited by 188
The Biological Underpinnings of Peer Victimization: Understanding Why and How the Effects of Bullying Can Last a Lifetime
Vaillancourt, T., Hymel, S. C., & McDougall, P. (2013) · Theory Into Practice · doi:10.1080/00405841.2013.829726 · Cited by 167
Developmental Psychopathology
Cicchetti, D. (2023) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197542521.003.0006 · Cited by 146
Peer Relations and Developmental Psychopathology
Prinstein, M. J., & Giletta, M. (2016) · Developmental Psychopathology · doi:10.1002/9781119125556.devpsy112 · Cited by 150
Underlying Mechanisms of Gene–Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms
Weeland, J., Overbeek, G., de Castro, B. O., & Matthys, W. (2015) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-015-0196-4 · Cited by 138
Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health
Olvera Alvarez, H. A., Kubzansky, L. D., Campen, M. J., & Slavich, G. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.002 · Cited by 133
“Although the specific mechanisms by which early life stress becomes biologically embedded are not yet fully understood, at least one pathway likely involves early life stress-related programming of a proinflammatory phenotype via changes in the epigenetic regulation of gene expression (Table 3) (Khulan et al., 2014; L…”
Learning from the past and looking to the future: emerging perspectives for improving the treatment of psychiatric disorders
Millan, M. J., Goodwin, G. M., Meyer-Lindenberg, A., & Ove Ögren, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.016 · Cited by 132
Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles
Wankerl, M., Miller, R. E., Kirschbaum, C., Hennig, J., Stalder, T., & Alexander, N. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.37 · Cited by 126
Infant Temperament: Stability by Age, Gender, Birth Order, Term Status, and Socioeconomic Status
Bornstein, M. H., Putnick, D. L., Gartstein, M. A., Hahn, C., Auestad, N., & O’Connor, D. L. (2015) · Child Development · doi:10.1111/cdev.12367 · Cited by 132
Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins
Córdova-Palomera, A., Fatjó-Vilas, M., Gastó, C., Navarro, V, Krebs, M.-O., & Fañanás, L. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.49 · Cited by 117
Epigenetics in eating disorders: a systematic review
Hübel, C., Marzi, S. J., Breen, G., & Bulik, C. M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0254-7 · Cited by 116
Intergenerational transmission of depression: clinical observations and molecular mechanisms
Sawyer, K. M., Zunszain, P. A., Dazzan, P., & Pariante, C. M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0265-4 · Cited by 111
Epigenetics in Personality Disorders: Today's Insights
Gescher, D. M., Kahl, K. G., Hillemacher, T., Frieling, H., Kuhn, J., & Frodl, T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00579 · Cited by 115
Determinants of Parenting
Bornstein, M. H. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy405 · Cited by 111
Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
Gouin, J.-P., Zhou, Q. Q., Booij, L., Boivin, M., Côté, S. M., Hébert, M., Ouellet‐Morin, I., Szyf, M., Tremblay, R. E., Turecki, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07950-x · Cited by 106
Epigenetics for the social sciences: justice, embodiment, and inheritance in the postgenomic age
Meloni, M. (2015) · New Genetics and Society · doi:10.1080/14636778.2015.1034850 · Cited by 105
Overweight and CpG methylation of the Pomc promoter in offspring of high‐fat‐diet‐fed dams are not “reprogrammed” by regular chow diet in rats
Marco, A., Kisliouk, T., Tabachnik, T., Meiri, N., & Weller, A. (2014) · The FASEB Journal · doi:10.1096/fj.14-255620 · Cited by 97
DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle?
Nielsen, C. H., Larsen, A., & Nielsen, A. L. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1426-0 · Cited by 95
Glucocorticoid receptor gene methylation moderates the association of childhood trauma and cortisol stress reactivity
Alexander, N., Kirschbaum, C., Wankerl, M., Stauch, B. J., Stalder, T., Steudte-Schmiedgen, S., Muehlhan, M., & Miller, R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.020 · Cited by 90
Bdnf DNA methylation modifications in the hippocampus and amygdala of male and female rats exposed to different caregiving environments outside the homecage
Roth, T. L., Matt, S. M., Chen, K., & Blaze, J. (2014) · Developmental Psychobiology · doi:10.1002/dev.21218 · Cited by 98
An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk
Cicchetti, D., Hetzel, S., Rogosch, F. A., Handley, E. D., & Toth, S. L. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000869 · Cited by 91
Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 ( NR3C1 ), in maltreated and nonmaltreated children: Associations with behavioral undercontrol, emotional lability/negativity, and externalizing and internalizing symptoms
Cicchetti, D., & Handley, E. D. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001407 · Cited by 93
Epigenetic drug discovery for Alzheimer’s disease
Cacabelos, R., & Torrellas, C. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.930124 · Cited by 88
Diagnostic Challenges and Management of Fibromyalgia
Qureshi, A. G., Jha, S. K., Iskander, J., Avanthika, C., Jhaveri, S., Patel, V. H., Potini, B. R., & Azam, A. T. (2021) · Cureus · doi:10.7759/cureus.18692 · Cited by 90
Eye Gaze in Autism Spectrum Disorder: A Review of Neural Evidence for the Eye Avoidance Hypothesis
Stuart, N., Whitehouse, A., Palermo, R., Bothe, E., & Badcock, N. A. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05443-z · Cited by 97
Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children
King, L., Robins, S., Chen, G., Yerko, V., Zhou, Y., Nagy, C., Feeley, N., Gold, I., Hayton, B. C., Turecki, G., et al. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.006 · Cited by 85
Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood
Ebner, N. C., Lin, T., Muradoglu, M., Weir, D. H., Plasencia, G. M., Lillard, T. S., Pournajafi-Nazarloo, H., Cohen, R. A., Sue Carter, C., & Connelly, J. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.01.008 · Cited by 79
Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior
Phillips, N. L. H., & Roth, T. L. (2019) · Genes · doi:10.3390/genes10010047 · Cited by 77
Epigenetic Alterations and Prenatal Maternal Depression
Nemoda, Z., & Szyf, M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1081 · Cited by 75
Early-life origin of adult insomnia: does prenatal–early-life stress play a role?
Palagini, L., Drake, C. L., Gehrman, P., Meerlo, P., & Riemann, D. W. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.10.013 · Cited by 75
Corticotropin releasing factor in neuroplasticity
Regev, L., & Baram, T. Z. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.001 · Cited by 72
Expression of DNA methyltransferases in adult dorsal root ganglia is cell-type specific and up regulated in a rodent model of neuropathic pain
Pollema‐Mays, S. L., Centeno, M. V., Apkarian, A. V., & Martina, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00217 · Cited by 70
The effects of DNA methylation on human psychology
Kader, F., Ghai, M., & Maharaj, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.004 · Cited by 75
Linking the Aryl Hydrocarbon Receptor with Altered DNA Methylation Patterns and Developmentally Induced Aberrant Antiviral CD8+ T Cell Responses
Winans, B., Nagari, A., Chae, M., Post, C. M., Ko, C.-Y. J., Puga, A., Kraus, W. L., & Lawrence, B. P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402044 · Cited by 68
Translating Developmental Science to Address Childhood Adversity
Garner, A. S., Forkey, H. C., & Szilagyi, M. A. (2015) · Academic Pediatrics · doi:10.1016/j.acap.2015.05.010 · Cited by 67
Sensory processing sensitivity and childhood quality’s effects on neural responses to emotional stimuli.
Acevedo, B. P., Jagiellowicz, J., Aron, E. N., Marhenke, R., & Aron, A. P. (2017) · Cited by 62
Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state
Khulan, B., Manning, J. R., Dunbar, D. R., Seckl, J. R., Raikkonen, K., Eriksson, J. G., & Drake, A. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.94 · Cited by 59
Implementation research for early childhood development programming in humanitarian contexts
Murphy, K. M., Yoshikawa, H., & Wuermli, A. J. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13691 · Cited by 58
Affording autism an early brain development re-definition
Klin, A. J., Micheletti, M., Klaiman, C., Shultz, S., Constantino, J. N., & JONES, W. R. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000802 · Cited by 63
Aportaciones y Limitaciones del DSM-5 desde la Psicología Clínica
Echeburúa, E., Salaberría, K., & Cruz-Sáez, M. (2014) · Terapia psicológica · doi:10.4067/s0718-48082014000100007 · Cited by 61
Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children
Stonawski, V., Frey, S., Golub, Y., Rohleder, N., Kriebel, J., Goecke, T. W., Fasching, P. A., Beckmann, M. W., Kornhuber, J., Kratz, O., et al. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000056 · Cited by 62
Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies
Kraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.016 · Cited by 62
Is serotonin transporter genotype associated with epigenetic susceptibility or vulnerability? Examination of the impact of socioeconomic status risk on African American youth
Beach, S. R. H., Brody, G. H., Lei, M., Kim, S., Cui, J., & Philibert, R. A. (2014) · Development and Psychopathology · doi:10.1017/s0954579413000990 · Cited by 48
Individual Differences in Social Behavior and Cortical Vasopressin Receptor: Genetics, Epigenetics, and Evolution
Phelps, S. M., Okhovat, M., & Berrío, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00537 · Cited by 52
Teeth as Potential New Tools to Measure Early-Life Adversity and Subsequent Mental Health Risk: An Interdisciplinary Review and Conceptual Model
Davis, K. A., Mountain, R. V., Pickett, O. R., Besten, P. K. D., Bidlack, F. B., & Dunn, E. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.030 · Cited by 51
Individual Differences in Childhood Behavior Disorders Associated With Epigenetic Modulation of the Cortisol Receptor Gene
Dadds, M. R., Moul, C., Hawes, D. J., Diaz, A. M., & Brennan, J. (2015) · Child Development · doi:10.1111/cdev.12391 · Cited by 47
Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder
Cicchetti, D., Hetzel, S., Rogosch, F. A., Handley, E. D., & Toth, S. L. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000912 · Cited by 47
Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma
Cui, X., Zhao, Z., Liu, D., Guo, T., Su, L., Hu, J., Liu, C., Yang, L., Cao, Y., Jiang, J., et al. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-33-20 · Cited by 48
Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review
Rinne, G. R., Hartstein, J., Guardino, C. M., & Schetter, C. D. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106115 · Cited by 53
Epigenetic regulation of the DRD4 gene and dimensions of attention-deficit/hyperactivity disorder in children
Dadds, M. R., Schollar‐Root, O., Lenroot, R., Moul, C., & Hawes, D. J. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0828-3 · Cited by 47
Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study
Cecil, C. A. M., Walton, E., Jaffee, S. R., O'Connor, T., Maughan, B., Relton, C. L., Smith, R. G., McArdle, W., Gaunt, T. R., Ouellet-Morin, I., et al. (2018) · Development and Psychopathology · doi:10.1017/s095457941700092x · Cited by 46
Combined effects of genotype and childhood adversity shape variability of DNA methylation across age
Czamara, D., Tissink, E., Tuhkanen, J., Martins, J., Awaloff, Y., Drake, A. J., Khulan, B., Palotie, A. V., Winter, S., Nemeroff, C. B., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01147-z · Cited by 48
Stability of child temperament: Multiple moderation by child and mother characteristics
Bornstein, M. H., Hahn, C., Putnick, D. L., & Pearson, R. M. (2018) · British Journal of Developmental Psychology · doi:10.1111/bjdp.12253 · Cited by 47
DNA methylation associated with healthy aging of elderly twins
Kim, S., Wyckoff, J., Morris, A.-T., Succop, A., Avery, A. R., Duncan, G. E., & Jazwinski, S. M. (2018) · GeroScience · doi:10.1007/s11357-018-0040-0 · Cited by 47
Classification of behaviour and experience in relation to functional psychiatric diagnoses: Time for a paradigm shift
(2013) · DECP Debate · doi:10.53841/bpsdeb.2013.1.149.8 · Cited by 45
Improving Sleep to Improve Stress Resilience
Martire, V. L., Berteotti, C., Zoccoli, G., & Bastianini, S. (2024) · Current Sleep Medicine Reports · doi:10.1007/s40675-024-00274-z · Cited by 52
Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.
Kempke, S., Luyten, P., Coninck, S. D., van Houdenhove, B., Mayes, L., & Claes, S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.027 · Cited by 44
Temporal Dynamics of DNA Methylation Patterns in Response to Rearing Juvenile Steelhead (Oncorhynchus mykiss) in a Hatchery versus Simulated Stream Environment
Gavery, M. R., Nichols, K. M., Berejikian, B. A., Tatara, C. P., Goetz, G., Dickey, J. T., Doornik, D. M. V., & Swanson, P. (2019) · Genes · doi:10.3390/genes10050356 · Cited by 44
Epigenetics and its implications for Psychology
González‐Pardo, H., & Álvarez, M. P. (2013) · Psicothema · doi:10.7334/psicothema2012.327 · Cited by 46
Glucocorticoid receptor gene (NR3C1) methylation during the first thousand days: Environmental exposures and developmental outcomes
Berretta, E., Guida, E., Forni, D., & Provenzi, L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.003 · Cited by 47
Identifying placental epigenetic alterations in an intrauterine growth restriction (IUGR) rat model induced by gestational protein deficiency
Reamon-Buettner, S. M., Buschmann, J., & Lewin, G. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.02.009 · Cited by 41
Methylation of HPA axis related genes in men with hypersexual disorder
Jokinen, J., Boström, A. E. D., Chatzittofis, A., Ciuculete, D. M., Öberg, K. G., Flanagan, J. N., Arver, S., & Schiöth, H. B. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.007 · Cited by 39
The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation
Moncayo, R., & Moncayo, H. (2014) · BBA Clinical · doi:10.1016/j.bbacli.2014.11.002 · Cited by 40
The Pathways between Cortisol-Related Regulation Genes and PTSD Psychotherapy
Castro-Vale, I., & Carvalho, D. M. (2020) · Healthcare · doi:10.3390/healthcare8040376 · Cited by 39
HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes
Chatzittofis, A., Boström, A. D. E., Ciuculete, D. M., Öberg, K. G., Arver, S., Schiöth, H. B., & Jokinen, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-99714-x · Cited by 35
Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes
Childebayeva, A., Goodrich, J. M., Lèon‐Velarde, F., Rivera, M. C., Kiyamu, M., Brutsaert, T. D., Dolinoy, D. C., & Bigham, A. W. (2020) · Genome Biology and Evolution · doi:10.1093/gbe/evaa239 · Cited by 37
Gene x environment interactions in conduct disorder: Implications for future treatments
Holz, N. E., Zohsel, K., Laucht, M., Banaschewski, T., Hohmann, S., & Brandeis, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.017 · Cited by 35
An Evolutionary Outlook on Motivation: Implications for the Clinical Dialogue
Cortina, M., & Liotti, G. (2014) · Psychoanalytic Inquiry · doi:10.1080/07351690.2014.968060 · Cited by 33
Pathways to inflammation in adolescence through early adversity, childhood depressive symptoms, and body mass index: A prospective longitudinal study of Chilean infants
Reid, B. M., Doom, J. R., Argote, R. B., Correa‐Burrows, P., Lozoff, B., Blanco, E., & Gahagan, S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.003 · Cited by 37
Integrative Brain Dynamics in Childhood Bullying Victimization: Cognitive and Emotional Convergence Associated With Stress Psychopathology
Palamarchuk, I. S., & Vaillancourt, T. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.782154 · Cited by 38
Epigenetic marks as the link between environment and development: examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene
Jones‐Mason, K., Allen, I. E., Bush, N. R., & Hamilton, S. (2016) · Brain and Behavior · doi:10.1002/brb3.480 · Cited by 30
Caregiver-Child Relationships in Early Childhood: Interventions to Promote Well-Being and Reduce Risk for Psychopathology
Julian, M. M., Lawler, J. M., & Rosenblum, K. L. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0110-0 · Cited by 32
DNA methylation profiles of elderly individuals subjected to indentured childhood labor and trauma
Marinova, Z., Maercker, A. R. A., Küffer, A., Robinson, M. D., Wojdacz, T. K., Walitza, S., Grünblatt, E., & Burri, A. V. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0370-2 · Cited by 31
Biology, Development, and Human Systems
Lickliter, R. E., & Honeycutt, H. G. (2015) · Wiley eBooks · doi:10.1002/9781118963418.childpsy105 · Cited by 31
Compounding Stress: Childhood Adversity as a Risk Factor for Adulthood Trauma Exposure in the Health and Retirement Study
Bürgin, D., Boonmann, C., Schmeck, K., Schmid, M., Tripp, P., Nishimi, K. M., & O’Donovan, A. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22617 · Cited by 30
Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood
Todd, N., Valleron, A., & Bougneres, P. F. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617911114 · Cited by 31
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children
Cicchetti, D., & Rogosch, F. A. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000984 · Cited by 29
Co- and multimorbidity patterns in an unselected Norwegian population: cross-sectional analysis based on the HUNT Study and theoretical reflections concerning basic medical models
Tómasdóttir, M. Ó., Getz, L., Sigurdsson, J. A., Pétursson, H., Kirkengen, A. L., Krokstad, S., McEwan, B., & Hetlevik, I. (2014) · European Journal for Person Centered Healthcare · doi:10.5750/ejpch.v2i3.734 · Cited by 29
An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome
Ali, O., Cerjak, D., Kent, J. W., James, R. G., Blangero, J., Carless, M. A., & Zhang, Y. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0048-6 · Cited by 32
Are Epigenetic Factors Implicated in Chronic Widespread Pain?
Burri, A. V., Marinova, Z., Robinson, M. D., Kühnel, B., Waldenberger, M., Wahl, S., Kunze, S., Gieger, C., Livshits, G., & Williams, F. M. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165548 · Cited by 31
Brood size influences patterns of DNA methylation in wild Zebra Finches (Taeniopygia guttata)
Sheldon, E. L., Schrey, A. W., Ragsdale, A. K., & Griffith, S. C. (2018) · The Auk · doi:10.1642/auk-18-61.1 · Cited by 28

Authors: Szyf, M., & Bick, J.
Affiliations: McGill University
Yale University (US)
ORCID: Bick, Johanna
Venue: Child Development
Publisher: Oxford University Press (OUP)
Published: 2013-01-01
Volume: 84
Issue: 1
Pages: 49-57
ISSN: 0009-3920 (ISSN-L)
1467-8624
DOI: 10.1111/j.1467-8624.2012.01793.x
PMC: PMC4039199
OpenAlex: W2115460495
Cited by: 251
References: 60
Citations by year: 2026: 6 · 2025: 4 · 2024: 21 · 2023: 11 · 2022: 23 · 2021: 23 · 2020: 19 · 2019: 17 · 2018: 25 · 2017: 23 · 2016: 23 · 2015: 24 · 2014: 25 · 2013: 6
FWCI: 1.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Child Development (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes of Health Research
National Institute of Mental Health (T32MH018268)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: DNA methylation, epigenetics, early life experience, genome adaptation, gene expression regulation, developmental origins of health and disease, resilience, central and peripheral nervous system
MeSH terms: Adaptation, Physiological, Humans, Life Change Events, Phenotype, Stress, Psychological, Signal Transduction, Genome, Human, DNA Methylation, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA Methylation: A Mechanism for Embedding Early Life Experiences in the Genome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks