The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life
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Although epidemiological data provides evidence that there is an interaction between genetics (nature) and the social and physical environments (nurture) in human development; the main open question remains the mechanism. The pattern of distribution of methyl groups in DNA is different from cell-type to cell type and is conferring cell specific identity on DNA during cellular differentiation and organogenesis. This is an innate and highly programmed process. However, recent data suggests that DNA methylation is not only involved in cellular differentiation but that it is also involved in modulation of genome function in response to signals from the physical, biological and social environments. We propose that modulation of DNA methylation in response to environmental cues early in life serves as a mechanism of life-long genome "adaptation" that molecularly embeds the early experiences of a child ("nurture") in the genome ("nature"). There is an emerging line of data supporting this hypothesis in rodents, non-human primates and humans that will be reviewed here. However, several critical questions remain including the identification of mechanisms that transmit the signals from the social environment to the DNA methylation/demethylation enzymes.
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DNA methylation regulates gene expression, which may induce lasting changes in stress reactivity.
“Through DNA methylation, environmental experiences regulate gene expression, which may induce lasting changes in stress reactivity [91,92].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [92]
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Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700 · see citing works
Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,542 · see citing works
DNA Methylation and Gene Function
Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,076 · see citing works
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · cited 1× · see citing works
“The first evidence that early environmental exposures could alter the phenotype through altering DNA methylation patterns came from the Jirtle lab that demonstrated an effect of maternal diet on the agouti color phenotype in agouti mice which was mediated through methylation of a transposable element.(15) The impact o…”
BackgroundNongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965 · see citing works
Cellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831 · see citing works
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
Okano, M., Xie, S., & Li, E. (1998) · Nature Genetics · doi:10.1038/890 · Cited by 1,643 · see citing works
UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells
Bostick, M. L., Kim, J. K., Estève, P., Clark, A. T., Pradhan, S., & Jacobsen, S. E. (2007) · Science · doi:10.1126/science.1147939 · Cited by 1,459 · see citing works
Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432 · see citing works
Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Guo, J. U., Su, Y., Zhong, C., Ming, G., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,355 · see citing works
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232 · see citing works
Covalent Modification of DNA Regulates Memory Formation
Miller, C. A., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.022 · Cited by 1,180 · see citing works
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2514 · Cited by 1,019 · see citing works
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
Fuks, F., Burgers, W. A., Brehm, A., Hughes‐Davies, L., & Kouzarides, T. (2000) · Nature Genetics · doi:10.1038/71750 · Cited by 988 · see citing works
Active demethylation of the paternal genome in the mouse zygote
Oswald, J., Engemann, S., Lane, N., Mayer, W., Olek, A., Fundele, R. H., Dean, W., Reik, W., & Walter, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00448-6 · Cited by 983 · see citing works
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
Ng, H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument‐Bromage, H., Tempst, P., Reinberg, D., & Bird, A. P. (1999) · Nature Genetics · doi:10.1038/12659 · Cited by 936 · see citing works
Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis
Dengke, K., Jang, M., Guo, J. U., Kitabatake, Y., Chang, M.-L., Pow-anpongkul, N., Flavell, R. A., Lu, B., Ming, G., & Song, H. (2009) · Science · doi:10.1126/science.1166859 · Cited by 929 · see citing works
Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877 · see citing works
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
Popp, C., Dean, W., Feng, S., Cokus, S. J., Andrews, S., Pellegrini, M. A., Jacobsen, S. E., & Reik, W. (2010) · Nature · doi:10.1038/nature08829 · Cited by 860 · see citing works
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
Wade, P. A., Gégonne, A., Jones, P. L., Ballestar, E., Aubry, F., & Wolffe, A. P. (1999) · Nature Genetics · doi:10.1038/12664 · Cited by 811 · see citing works
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800 · see citing works
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
Barreto, G., Schäfer, A., Marhold, J., Stach, D., Swaminathan, S. K., Handa, V., Doederlein, G., Maltry, N., Wu, W., Lyko, F., et al. (2007) · Nature · doi:10.1038/nature05515 · Cited by 758 · see citing works
Transient cyclical methylation of promoter DNA
Kangaspeska, S., Stride, B. D., Métivier, R., Polycarpou-Schwarz, M., Ibberson, D., Carmouche, R. P., Beneš, V., Gannon, F., & Reid, G. (2008) · Nature · doi:10.1038/nature06640 · Cited by 682 · see citing works
DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45
Rai, K., Huggins, I. J., James, S. R., Karpf, A. R., Jones, D. A., & Cairns, B. R. (2008) · Cell · doi:10.1016/j.cell.2008.11.042 · Cited by 657 · see citing works
A mammalian protein with specific demethylase activity for mCpG DNA
Bhattacharya, S. K., Ramchandani, S., Cervoni, N., & Moshe Szyf, A. (1999) · Nature · doi:10.1038/17533 · Cited by 616 · see citing works
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511767200 · Cited by 615 · see citing works
Dnmt3a binds deacetylases and is recruited by a sequence‐specific repressor to silence transcription
Fuks, F., Burgers, W. A., Godin, N., Kasai, M., & Kouzarides, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2536 · Cited by 555 · see citing works
Weaver, I. C. G., D'Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., Szyf, M., & Meaney, M. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4164-06.2007 · Cited by 508 · see citing works
Bruniquel, D., & Schwartz, R. H. (2003) · Nature Immunology · doi:10.1038/ni887 · Cited by 457 · see citing works
Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
McGowan, P. O., Suderman, M., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., & Szyf, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014739 · Cited by 452 · see citing works
Substrate and sequence specificity of a eukaryotic DNA methylase
Gruenbaum, Y., Cedar, H., & Razin, A. (1982) · Nature · doi:10.1038/295620a0 · Cited by 436 · see citing works
The Economics and Psychology of Inequality and Human DEvelopment
Cunha, F., & Heckman, J. J. (2009) · Journal of the European Economic Association · doi:10.1162/jeea.2009.7.2-3.320 · Cited by 407 · see citing works
Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain
McGowan, P. O., Sasaki, A., Huang, T. C. T., Unterberger, A., Suderman, M. J., Ernst, C., Meaney, M. J., Turecki, G., & Moshe Szyf, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002085 · Cited by 372 · see citing works
DNA methylation is a reversible biological signal
Ramchandani, S., Bhattacharya, S. K., Cervoni, N., & Moshe Szyf, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6107 · Cited by 342 · see citing works
Poulter, M. O., Du, L., Weaver, I. C. G., Palkovits, M., Faludi, G., Merali, Z., Szyf, M., & Anisman, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.028 · Cited by 331 · see citing works
DNA methylation patterns Formation and function
Razin, A., & Moshe Szyf, A. (1984) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(84)90043-5 · Cited by 318 · see citing works
Telomere length and early severe social deprivation: linking early adversity and cellular aging
Drury, S. S., Theall, K., Gleason, M. M., Smyke, A. T., De Vivo, I., Wong, J. Y. Y., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.53 · Cited by 316 · see citing works
Methylation of CpG sequences in eukaryotic DNA
Gruenbaum, Y., Stein, R., Cedar, H., & Razin, A. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80055-5 · Cited by 301 · see citing works
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
Dong, E., Nelson, M., Grayson, D. R., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805493105 · Cited by 284 · see citing works
High frequency mutagenesis by a DNA methyltransferase
Shen, J., Rideout, W. M., & Jones, P. A. (1992) · Cell · doi:10.1016/s0092-8674(05)80057-1 · Cited by 262 · see citing works
Hertzman, C., Power, C., Matthews, S., & Manor, O. (2001) · Social Science & Medicine · doi:10.1016/s0277-9536(00)00437-8 · Cited by 249 · see citing works
Ernst, C., Deleva, V., Deng, X., Sequeira, A., Pomarenski, A., Klempan, T., Ernst, N., Quirion, R., Gratton, A., Szyf, M., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archpsyc.66.1.22 · Cited by 235 · see citing works
Linthorst, A., Flachskamm, C., Müller-Preuss, P., Holsboer, F., & Reul, J. M. H. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02920.1995 · Cited by 233 · see citing works
A 10-year perspective of motherless-mother monkey behavior.
Ruppenthal, G. C., & Al, E. (1976) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.85.4.341 · Cited by 218 · see citing works
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated
Mastronardi, F. G., Noor, A., Wood, D. D., Paton, T., & Moscarello, M. A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21329 · Cited by 205 · see citing works
Power, C., Atherton, K., Strachan, D. P., Shepherd, P., Fuller, E., Davis, A. C., Gibb, I., Meena Kumari, B., Lowe, G. D. O., Macfarlane, G. J., et al. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dyl310 · Cited by 196 · see citing works
A 10-year perspective of motherless-mother monkey behavior.
Ruppenthal, G. C., Arling, G. L., Harlow, H. F., et al. (1976) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.85.4.341 · Cited by 193 · see citing works
Variations in DNA methylation during mouse cell differentiation in vivo and in vitro.
Razin, A., Webb, C., Moshe Szyf, A., Yisraeli, J. K., Rosenthal, A., Naveh‐Many, T., Sciaky-Gallili, N., & Cedar, H. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2275 · Cited by 191 · see citing works
The Role of DNA Methylation in the Central Nervous System and Neuropsychiatric Disorders
Feng, J., & Fan, G. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)89004-1 · Cited by 178 · see citing works
Promoter-specific Activation and Demethylation by MBD2/Demethylase
Detich, N., Théberge, J., & Szyf, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200408200 · Cited by 178 · see citing works
Self-citationRazin, A., Moshe Szyf, A., Kafri, T., Roll, M., Giloh, H., Scarpa, S., Carotti, D., & Cantoni, G. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.2827 · Cited by 174 · see citing works
Zhu, B. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4157 · Cited by 172 · see citing works
GADD45A Does Not Promote DNA Demethylation
Jin, S., Guo, C., & Pfeifer, G. P. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000013 · Cited by 161 · see citing works
Jost, J. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4684 · Cited by 158 · see citing works
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase
Li, B.-Z., Huang, Z., Cui, Q., Song, X., Du, L., Jeltsch, A., Chen, P., Li, G., Li, E., & Xu, G. (2011) · Cell Research · doi:10.1038/cr.2011.92 · Cited by 145 · see citing works
Zhu, B., Zheng, Y., Heß, D., Angliker, H., Schwarz, S., Siegmann, M., Thiry, S., & Jost, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100107597 · Cited by 145 · see citing works
Lucarelli, M., Fuso, A., Strom, R., & Scarpa, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008234200 · Cited by 124 · see citing works
EFFECTS OF MATERNAL AND PEER SEPARATIONS ON YOUNG MONKEYS
Suomi, S. J., Collins, M. L., Harlow, H. F., & Ruppenthal, G. C. (1976) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1976.tb00382.x · Cited by 117 · see citing works
Fuso, A., Nicolia, V., Cavallaro, R. A., & Scarpa, S. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.01.010 · Cited by 108 · see citing works
Wilks, A. F., Seldran, M., & Jost, J. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.2.1163 · Cited by 106 · see citing works
Power, C., Hertzman, C., Matthews, S., & Manor, O. (1997) · American Journal of Public Health · doi:10.2105/ajph.87.9.1499 · Cited by 101 · see citing works
Turnbull, J. F., & Adams, R. L. P. (1976) · Nucleic Acids Research · doi:10.1093/nar/3.3.677 · Cited by 97 · see citing works
Angrisano, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj400 · Cited by 80 · see citing works
Epigenetic Programming of the rRNA Promoter by MBD3
Brown, S., & Szyf, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02037-07 · Cited by 72 · see citing works
Self-citationAntithetic Effects of MBD2a on Gene Regulation
Fujita, H., Fujii, R., Aratani, S., Amano, T., Fukamizu, A., & Nakajima, T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2645-2657.2003 · Cited by 62 · see citing works
On the mechanism of demethylation of 5-methylcytosine in DNA
Hamm, S., Just, G., Lacoste, N., Moitessier, N., Moshe Szyf, A., & Mamer, O. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.12.027 · Cited by 61 · see citing works
Moshe Szyf, A., Rouleau, J., Théberge, J., & Bozovic, V. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42351-4 · Cited by 59 · see citing works
Ras Induces a General DNA Demethylation Activity in Mouse Embryonal P19 Cells
Szyf, M., Théberge, J., & Bozovic, V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12690 · Cited by 58 · see citing works
Self-citationEpigenetic Reprogramming of Mouse Germ Cells toward TotipotencyPreprint
Surani, M. A., & Hájková, P. (2010) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2010.75.010 · Cited by 54 · see citing works
Associations of Early Growth and Adult Adiposity with Patterns of Salivary Cortisol in Adulthood
Power, C., Li, L., & Hertzman, C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0625 · Cited by 51 · see citing works
Reading and writing DNA methylation
Jeltsch, A. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1008-1003 · Cited by 33 · see citing works
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI
Zingg, J.-M. A., Shen, J., & Jones, P. A. (1998) · Biochemical Journal · doi:10.1042/bj3320223 · Cited by 27 · see citing works
A dynamic methylome: Implications of non-CG methylation/demethylation
Szyf, M. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13563 · Cited by 14 · see citing works
Self-citationEpigenetic Programming of the rRNA Promoter by MBD3
Brown, S., & Szyf, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01880-06 · Cited by 4 · see citing works
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Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217750110 · Cited by 548 · see citing works
The Consequences of Early‐Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations
Maccari, S., Krugers, H. J., Morley‐Fletcher, S., Moshe Szyf, A., & Brunton, P. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12175 · Cited by 347 · see citing works
Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes
Ho, S., Johnson, A. D., Tarapore, P., Janakiram, V., Zhang, X., & Leung, Y. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.289 · Cited by 316 · see citing works
Prenatal psychobiological predictors of anxiety risk in preadolescent children
Davis, E. P., & Sandman, C. A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.016 · Cited by 254 · see citing works
Genome-Wide Methylation Changes in the Brains of Suicide Completers
Labonté, B., Suderman, M., Maussion, G., Lopez, J. P., Navarro-Sánchez, L., Yerko, V., Mechawar, N., Szyf, M., Meaney, M. J., & Turecki, G. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050627 · Cited by 212 · see citing works
Epigenetic life: biological plasticity, abnormality, and new configurations of race and reproduction
Mansfield, B., & Guthman, J. (2015) · cultural geographies · doi:10.1177/1474474014555659 · Cited by 212 · see citing works
Richetto, J., & Meyer, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.008 · Cited by 183 · see citing works
Home Visiting and the Biology of Toxic Stress: Opportunities to Address Early Childhood Adversity
Garner, A. S. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1021d · Cited by 163 · see citing works
Type 2 Diabetes Genetics: Beyond GWAS
Sanghera, D. K., & Blackett, P. R. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000198 · Cited by 158 · see citing works
Kubota, T., Miyake, K., & Hirasawa, T. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-1 · Cited by 157 · see citing works
Crudo, A., Petropoulos, S., Moisiadis, V. G., Iqbal, M., Kostaki, A., Machnes, Z., Szyf, M., & Matthews, S. G. (2012) · Endocrinology · doi:10.1210/en.2011-2160 · Cited by 156 · see citing works
Race and the new epigenetic biopolitics of environmental health
Mansfield, B. (2012) · BioSocieties · doi:10.1057/biosoc.2012.22 · Cited by 155 · see citing works
Adverse Childhood Experiences and Disability in U.S. Adults
Rose, S. M. S., Xie, D., & Stineman, M. G. (2014) · PM&R · doi:10.1016/j.pmrj.2014.01.013 · Cited by 129 · see citing works
Lawn, R. B., Anderson, E. L., Suderman, M. J., Simpkin, A. J., Gaunt, T. R., Teschendorff, A. E., Widschwendter, M., Hardy, R., Kuh, D. J., Relton, C. L., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy036 · Cited by 129 · see citing works
Ballard, E. D., Van Eck, K., Musci, R. J., Hart, S. R., Storr, C. L., Breslau, N., & Wilcox, H. C. (2015) · Psychological Medicine · doi:10.1017/s0033291715001300 · Cited by 119 · see citing works
The early‐life social environment and DNA methylation
Moshe Szyf, A. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2012.01843.x · Cited by 119 · see citing works
Childhood maltreatment and methylation of FK506 binding protein 5 gene (<i>FKBP5</i>)
Tyrka, A. R., Ridout, K. K., Parade, S. H., Paquette, A., Marsit, C. J., & Seifer, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000991 · Cited by 118 · see citing works
The genetics of insomnia – Evidence for epigenetic mechanisms?
Palagini, L., Biber, K. P. H., & Riemann, D. W. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.05.002 · Cited by 113 · see citing works
Checknita, D., Maussion, G., Labonté, B., Comai, S., Tremblay, R. E., Vitaro, F., Turecki, N., Bertazzo, A., Gobbi, G., Côté, G., et al. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.144964 · Cited by 108 · see citing works
Environmental epigenetics in zebrafish
Cavalieri, V., & Spinelli, G. (2017) · Epigenetics & Chromatin · doi:10.1186/s13072-017-0154-0 · Cited by 102 · see citing works
Cowley, A. W., Nadeau, J. H., Baccarelli, A., Berecek, K. H., Fornage, M., Gibbons, G. H., Harrison, D. G., Liang, M., Nathanielsz, P. W., O’Connor, D. T., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.190116 · Cited by 100 · see citing works
Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection
Bekdash, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032346 · Cited by 96 · see citing works
Provençal, N., Booij, L., & Tremblay, R. E. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.111401 · Cited by 93 · see citing works
Folded Futurity: Epigenetic Plasticity, Temporality, and New Thresholds of Fetal Life
Mansfield, B. (2017) · Science as Culture · doi:10.1080/09505431.2017.1294575 · Cited by 90 · see citing works
Rijlaarsdam, J., van IJzendoorn, M. H., Verhulst, F. C., Jaddoe, V. W. V., Felix, J. F., Tiemeier, H. W., & Bakermans‐Kranenburg, M. J. (2016) · Autism Research · doi:10.1002/aur.1681 · Cited by 89 · see citing works
Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link
Saini, G., Ogden, A., McCullough, L. E., Torres, M. A., Rida, P. C. G., & Aneja, R. (2019) · Cancer Causes & Control · doi:10.1007/s10552-019-01180-4 · Cited by 88 · see citing works
Cattaneo, A., Cattane, N., Malpighi, C., Czamara, D., Suarez, A., Mariani, N., Kajantie, E., Luoni, A., Eriksson, J. G., Lahti, J., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-017-0002-4 · Cited by 86 · see citing works
Provençal, N., Suderman, M. J., Guillemin, C., Vitaro, F., Côté, S. M., Hallett, M., Tremblay, R. E., & Szyf, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089839 · Cited by 85 · see citing works
Self-citationExposure to childhood abuse is associated with human sperm DNA methylation
Roberts, A. L., Gladish, N., Gatev, E., Jones, M. J., Chen, Y., MacIsaac, J. L., Tworoger, S. S., Austin, S. B., Tanrikut, C., Chavarro, J. E., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0252-1 · Cited by 84 · see citing works
DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
Guillemin, C., Provençal, N., Suderman, M. J., Côté, S. M., Vitaro, F., Hallett, M. T., Tremblay, R. E., & Moshe Szyf, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086822 · Cited by 84 · see citing works
Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review
Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 82 · see citing works
Hackett, C., Feeny, D., & Tompa, E. (2016) · Journal of Epidemiology and Community Health · doi:10.1136/jech-2016-207380 · Cited by 80 · see citing works
Burwell, R. G., Dangerfield, P., Moulton, A., & Grivas, T. B. (2011) · Scoliosis · doi:10.1186/1748-7161-6-26 · Cited by 77 · see citing works
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
Schneider, E., Hajj, N. E., Müller, F., Navarro, B., & Haaf, T. (2015) · Cytogenetic and Genome Research · doi:10.1159/000435778 · Cited by 73 · see citing works
Early-life origin of adult insomnia: does prenatal–early-life stress play a role?
Palagini, L., Drake, C. L., Gehrman, P., Meerlo, P., & Riemann, D. W. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.10.013 · Cited by 72 · see citing works
miRNAs as Mediators of Drug Resistance
Haenisch, S., & Cascorbi, I. (2012) · Epigenomics · doi:10.2217/epi.12.39 · Cited by 67 · see citing works
Provençal, N., Suderman, M. J., Caramaschi, D., Wang, D., Hallett, M. T., Vitaro, F., Tremblay, R. E., & Szyf, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071691 · Cited by 65 · see citing works
Sophie Petropoulos, A., Matthews, S. G., & Moshe Szyf, A. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.115899 · Cited by 65 · see citing works
Gemmel, M., Bögi, E., Ragan, C. M., Hazlett, M. F., Dubovický, M., van den Hove, D., Oberlander, T. F., Charlier, T. D., & Pawluski, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.023 · Cited by 65 · see citing works
Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?
Shalev, I., & Belsky, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.03.002 · Cited by 64 · see citing works
Resilience: Safety in the Aftermath of Traumatic Stressor Experiences
Matheson, K., Asokumar, A., & Anisman, H. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.596919 · Cited by 63 · see citing works
The role of social relationships in bipolar disorder: A review
Greenberg, S. C., Rosenblum, K. L., McInnis, M. G., & Muzik, M. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.05.047 · Cited by 63 · see citing works
Paternain, L., Batlle, M., de la Garza, A. L., Milagro, F. I., Martínez, J. A., & Campión, J. (2012) · Neuroendocrinology · doi:10.1159/000341684 · Cited by 61 · see citing works
The role of DNA methylation in syndromic and non-syndromic congenital heart disease
Cao, J., Wu, Q., Huang, Y., Wang, L., Su, Z., & Ye, H. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01077-7 · Cited by 60 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59 · see citing works
DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo
Machnes, Z. M., Huang, T. C., Chang, P. K. ‐., Gill, R., Reist, N., Dezsi, G., Öztürk, E., Charron, F. M., O'Brien, T. J., Jones, N. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076299 · Cited by 59 · see citing works
Volgin, A. D., Yakovlev, O. A., Demin, K. A., de Abreu, M. S., Alekseeva, P. A., Friend, A. J., Lakstygal, A. M., Amstislavskaya, T. G., Bao, W., Song, C., et al. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24337 · Cited by 59 · see citing works
Lock, M. M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61149-6 · Cited by 58 · see citing works
The Epigenetic Lorax: Gene–Environment Interactions in Human Health
Latham, K. E., Sapienza, C., & Engel, N. (2012) · Epigenomics · doi:10.2217/epi.12.31 · Cited by 57 · see citing works
Kraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.016 · Cited by 57 · see citing works
Belsky, J., & Shalev, I. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000900 · Cited by 56 · see citing works
Testing Mediation Effects in High-Dimensional Epigenetic Studies
Gao, Y., Yang, H., Fang, R., Zhang, Y., Goode, E. L., & Cui, Y. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01195 · Cited by 52 · see citing works
Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis
Neves, I., Dinis‐Oliveira, R. J., & Magalhães, T. (2019) · Forensic Sciences Research · doi:10.1080/20961790.2019.1641954 · Cited by 51 · see citing works
Na, K.-S., Won, E., Kang, J., Kim, A., Choi, S., Tae, W.-S., Kim, Y.-K., Lee, M.-S., Joe, S.-H., & Ham, B.-J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.030 · Cited by 50 · see citing works
Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease
Lyu, G., Zhang, C., Ling, T., Liu, R., Zong, L., Guan, Y., Huang, X., Sun, L., Zhang, L., Li, C., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4814-7 · Cited by 47 · see citing works
Exploring the Complexity of Intellectual Disability in Fetal Alcohol Spectrum Disorders
Chokroborty-Hoque, A., Alberry, B., & Singh, S. M. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00090 · Cited by 46 · see citing works
Epigenetics in the Neoliberal “Regime of Truth”
Dupras, C., & Ravitsky, V. (2015) · The Hastings Center Report · doi:10.1002/hast.522 · Cited by 42 · see citing works
Epigenetics, Media Coverage, and Parent Responsibilities in the Post-Genomic Era
Lappé, M. D. (2016) · Current Genetic Medicine Reports · doi:10.1007/s40142-016-0092-3 · Cited by 41 · see citing works
Moncayo, R., & Moncayo, H. (2014) · BBA Clinical · doi:10.1016/j.bbacli.2014.11.002 · Cited by 40 · see citing works
Alcohol-Induced Epigenetic Changes in Cancer
Dumitrescu, R. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8751-1_9 · Cited by 39 · see citing works
New Frontiers for Organismal Biology
Kültz, D., Clayton, D. F., Robinson, G. E., Albertson, R. C., Carey, H. V., Cummings, M. E., Dewar, K., Edwards, S. V., Hofmann, H. A., Gross, L. J., et al. (2013) · BioScience · doi:10.1525/bio.2013.63.6.8 · Cited by 39 · see citing works
Gentner, M. B., & Leppert, M. L. O. (2019) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14149 · Cited by 37 · see citing works
Guan, D., Ding, R., Hu, X., Yang, X., Xu, S., Gu, W., & Zhang, M. (2019) · BMC Genomics · doi:10.1186/s12864-019-5688-z · Cited by 37 · see citing works
Yeo, S., Enoch, M., Gorodetsky, E. K., Akhtar, L. A., Schuebel, K. E., Roy, A., & Goldman, D. A. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12342 · Cited by 36 · see citing works
Hartung, T., Zhang, L., Kanwar, R., Khrebtukova, I., Reinhardt, M., Wang, C., Therneau, T. M., Banck, M. S., Schroth, G. P., & Beutler, A. S. (2012) · Epigenetics · doi:10.4161/epi.19565 · Cited by 35 · see citing works
Pallier, P. N., Ferrara, M., Romagnolo, F., Ferretti, M. T., Soreq, H., & Cerase, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102353 · Cited by 35 · see citing works
Roberts, A. L., Liew, Z., Lyall, K., Ascherio, A., & Weisskopf, M. G. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy098 · Cited by 33 · see citing works
Impact of early adverse experience on complexity of adult-generated neurons
Leslie, A. T., Akers, K. G., Krakowski, A. D., Stone, S. S. D., Sakaguchi, M., Arruda-Carvalho, M., & Frankland, P. W. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.38 · Cited by 30 · see citing works
Rose, E. J., Picci, G., & Fishbein, D. H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00399 · Cited by 30 · see citing works
Inflammatory and Epigenetic Pathways for Perinatal Depression
Garfield, L., Mathews, H. L., & Janusek, L. W. (2015) · Biological Research For Nursing · doi:10.1177/1099800415614892 · Cited by 29 · see citing works
Epigenetic Mechanisms of Rapid-Acting Antidepressants
Inserra, A., Campanale, A., Rezai, T., Romualdi, P., & Rubino, T. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03055-y · Cited by 27 · see citing works
Reduction of anterior cingulate in adults with urban violence- related PTSD
Baldaçara, L., Zugman, A., de Araújo, C. M., Cogo‐Moreira, H., Lacerda, A. L. T., Schoedl, A. F., Pupo, M. C., Mello, M. F., Andreoli, S. B., Mari, J. D. J., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.036 · Cited by 27 · see citing works
Abnormal PITX1 gene methylation in adolescent idiopathic scoliosis: a pilot study
Shi, B., Xu, L., Mao, S., Xu, L., Liu, Z., Sun, X., Zhu, Z., & Qiu, Y. (2018) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-018-2054-2 · Cited by 27 · see citing works
DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons
Anderson, J. A., Lin, D., Lea, A. J., Johnston, R. A., Voyles, T., Akinyi, M. Y., Archie, E. A., Alberts, S. C., & Tung, J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309469121 · Cited by 26 · see citing works
Chiarella, J., Tremblay, R. E., Moshe Szyf, A., Provençal, N., & Booij, L. (2015) · Twin Research and Human Genetics · doi:10.1017/thg.2015.84 · Cited by 24 · see citing works
Diet changes alter paternally inherited epigenetic pattern in male Wild guinea pigs
Weyrich, A., Jeschek, M., Schrapers, K. T., Lenz, D., Chung, T. H., Rübensam, K., Yasar, S., Schneemann, M., Ortmann, S., Jewgenow, K., et al. (2018) · Current Zoology · doi:10.1093/eep/dvy011 · Cited by 23 · see citing works
Géranton, S. M. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0283 · Cited by 23 · see citing works
Dynamics and stability: epigenetic conversions in position effect variegation
Yankulov, K. (2013) · Biochemistry and Cell Biology · doi:10.1139/bcb-2012-0048 · Cited by 22 · see citing works
Leadership Evolution for Planetary Health: A Genomics Perspective
Ryan, J., Jones, S., Hayes, P., & Craig, J. M. (2019) · Challenges · doi:10.3390/challe10010004 · Cited by 21 · see citing works
Epigenetic Regulation during Fetal Femur Development: DNA Methylation Matters
de Andrés, M. C., Kingham, E., Imagawa, K., Gonzalez, A., Roach, H. I., Wilson, D. I., & Oreffo, R. O. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054957 · Cited by 20 · see citing works
Quantitative Evaluation of MMP-9 and TIMP-1 Promoter Methylation in Chronic Periodontitis
Li, X., Lu, J., Teng, W., Zhao, C., & Ye, X. (2018) · DNA and Cell Biology · doi:10.1089/dna.2017.3948 · Cited by 20 · see citing works
Genetics and pathogenesis of scoliosis
Petrosyan, E., Fares, J., Ahuja, C. S., Lesniak, M. S., Koski, T. R., Dahdaleh, N. S., & Tecle, N. E. E. (2024) · North American Spine Society Journal (NASSJ) · doi:10.1016/j.xnsj.2024.100556 · Cited by 19 · see citing works
Personalized medicine in Alzheimer's disease and depression
Souslova, T., Marple, T. C., Spiekerman, A. M., & Mohammad, A. A. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.06.012 · Cited by 19 · see citing works
Jeffery, D., Wyse, B. A., Rehman, M. A., Brown, G. W., You, Z., Oshidari, R., Masai, H., & Yankulov, K. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt623 · Cited by 19 · see citing works
Epigenomics and gene regulation in mammalian social systems
Guerrero-Altamirano, T., Fickel, J., Benhaiem, S., & Weyrich, A. (2020) · Current Zoology · doi:10.1093/cz/zoaa005 · Cited by 17 · see citing works
Fang, X., Poulsen, R. R., Zhao, L., Wang, J., Rivkees, S. A., & Wendler, C. C. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13252 · Cited by 17 · see citing works
Yang, Z., Kubant, R., Cho, C. E., Kranenburg, E., Beaudry, J. L., Bottiglieri, T., & Anderson, G. H. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300199 · Cited by 16 · see citing works
Multifactorial determinants of cognition — Thyroid function is not the only one
Moncayo, R., & Ortner, K. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.04.002 · Cited by 15 · see citing works
Leshem, R., & Weisburd, D. L. (2019) · Journal of Contemporary Criminal Justice · doi:10.1177/1043986219828924 · Cited by 14 · see citing works
Mind-Body Interrelationship in DNA Methylation
Szyf, M. (2012) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000336503 · Cited by 14 · see citing works
Liang, A., & Gomaa, N. A. (2023) · The International Journal of Aging and Human Development · doi:10.1177/00914150231208689 · Cited by 13 · see citing works
The Effects of Stress on Early Brain and Behavioral Development
Gunnar, M. R., & Davis, E. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397267-5.00063-7 · Cited by 13 · see citing works
Population Diversity and Pharmacogenomics in Africa
Masimirembwa, C. M., Dandara, C., & Hasler, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386882-4.00043-8 · Cited by 13 · see citing works
Glucocorticoid receptor gene (NR3C1) is hypermethylated in adult males with aggressive behaviour
Liu, L., Li, J., Qing, L., Yan, M., Xiong, G., Lian, X., Hu, L., & Nie, S. (2020) · International Journal of Legal Medicine · doi:10.1007/s00414-020-02328-7 · Cited by 13 · see citing works
Anthropogenic impacts on behavior: the pros and cons of plasticity
Rubenstein, D. I. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781139627078.008 · Cited by 11 · see citing works
Hummel, E. M., Elgizouli, M., Beygo, J., Giuranna, J., Sicorello, M., Leitão, E., Schröder, C., Zeschnigk, M., Müller, S., Öztürk, D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22177-1 · Cited by 11 · see citing works
Physical abuse during childhood predicts IL-2R levels in adult panic disorder patients
Quagliato, L. A., Coelho, D. A., de Matos, U. M. A., & Nardi, A. E. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.022 · Cited by 10 · see citing works
Frías-Lasserre, D., Villagra, C., & Guerrero‐Bosagna, C. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00143 · Cited by 10 · see citing works
Model organisms and their application in environmental epigenetics
Cavalieri, V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819968-8.00003-2 · Cited by 9 · see citing works
Neurobiological Basis of Childhood Trauma and the Risk for Neurological Deficits Later in Life
Assogna, F., Piras, F., & Spalletta, G. (2020) · Springer eBooks · doi:10.1007/978-3-030-49414-8_18 · Cited by 9 · see citing works
- Authors
- Szyf, M.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2011-08
- Volume
- 6
- Issue
- 8
- Pages
- 971-978
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- PMC
- PMC3359487
- OpenAlex
- W2050896885
- Cited by
- 161
- References
- 79
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 9 · 2023: 7 · 2022: 6 · 2021: 30 · 2020: 8 · 2019: 10 · 2018: 16 · 2017: 3 · 2016: 10 · 2015: 12 · 2014: 14 · 2013: 15 · 2012: 14
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epigenetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- DNA methylation, nature versus nurture, genome adaptation, cell differentiation, cell type-specific methylation, social environment, developmental origins of health and disease
- MeSH terms
- Adaptation, Physiological, Behavior, Child, Preschool, Humans, Life Change Events, Social Environment, Signal Transduction, Genome, Human, DNA Methylation, Life
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