Transcriptional regulation of metal transport genes and mineral nutrition during acclimatization to cadmium and zinc in the Cd/Zn hyperaccumulator, Thlaspi caerulescens (Ganges population)

Küpper, Hendrik; Kochian, Leon V.

doi:10.1111/j.1469-8137.2009.03051.x

Cited by 191Plant Micronutrient Interactions and EffectsHeavy metals in environmentHeavy Metals in Plants

Transcriptional regulation of metal transport genes and mineral nutrition during acclimatization to cadmium and zinc in the Cd/Zn hyperaccumulator, Thlaspi caerulescens (Ganges population)

Küpper, Hendrik, Kochian, Leon V.·2010·New Phytologist

DOI 10.1111/j.1469-8137.2009.03051.x

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Abstract

We investigated changes in mineral nutrient uptake and cellular expression levels for metal transporter genes in the cadmium (Cd)/zinc (Zn) hyperaccumulator, Thlaspi caerulescens during whole plant and leaf ontogenesis under different long-term treatments with Zn and Cd. Quantitative mRNA in situ hybridization (QISH) revealed that transporter gene expression changes not only dependent on metal nutrition/toxicity, but even more so during plant and leaf development. The main mRNA abundances found were: ZNT1, mature leaves of young plants; ZNT5, young leaves of young plants; MTP1 (= ZTP1 = ZAT), young leaves of both young and mature plants. Surprisingly different cellular expression patterns were found for ZNT1 and ZNT5, both belonging to the ZIP family of transition metal transporters: ZNT1, photosynthetic mesophyll and bundle sheath cells; ZNT5, nonphotosynthetic epidermal metal storage cells and bundle sheath cells. Thus, ZNT1 may function in micronutrient nutrition while ZNT5 may be involved in metal storage associated with hyperaccumulation. Cadmium inhibited the uptake of Zn, iron (Fe) and manganese (Mn), probably by competing for transporters or by interfering with the regulation of transporter gene expression. Cadmium-induced changes in cellular expression for ZNT1, ZNT5 and MTP1 could also be part of plant acclimatization to Cd toxicity. Defence against Cd toxicity involved enhanced uptake of magnesium (Mg), calcium (Ca) and sulphur (S).

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In mature leaves, NcZNT5 was overexpressed in guard cells rather than epidermal cells.
“In contrast, an opposite expression pattern was observed in mature leaves, wherein, NcZNT5 was overexpressed in guard cells rather than epidermal cells (Küpper and Kochian, 2010).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Küpper and Kochian, 2010
The QISH results (p. 10) say ZNT5 expression in mature leaves of young plants was generally very weak and measurable only in mesophyll and bundle sheath cells—not guard cells. The discussion (p. 13) says high ZNT5 expression in leaves occurred only in young leaves of young plants, where it was high in epidermal metal-storage cells. (LLM, conf=0.91)
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Experimental — accuracy not yet measured
Several hyperaccumulator species have accumulated Cd, including A. halleri, B. juncea, Lactuca orientalis, N. caerulescens, Tragopogon collinus, and S. hohenackeriana.
“Several hyperaccumulator species have accumulated Cd, including A. halleri, B. juncea, Lactuca orientalis Boiss., N. caerulescens, Tragopogon collinus DC., and S. hohenackeriana (Cosio et al., 2005; Küpper and Kochian, 2010; Moameri et al., 2017).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Küpper and Kochian, 2010
The Introduction (p. 2) identifies Thlaspi caerulescens as a Cd/Zn hyperaccumulator and reports Cd accumulation in its Ganges ecotype. Our copy does not establish the claim’s name N. caerulescens or support Cd hyperaccumulation by the other listed species; their appearances in reference titles do not establish that point. (LLM, conf=0.84)
Experimental — accuracy not yet measured
NcZNT1 was differentially expressed in shoot apical meristem and mesophyll, bundle sheath, and stomatal guard cells.
“In addition, it is reported that NcZNT1 was differentially expressed in shoot apical meristem and mesophyll, bundle sheath, and stomatal guard cells.”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Küpper and Kochian, 2010
The QISH results (p. 8) report differing ZNT1 expression in mesophyll, bundle sheath and guard cells, including changes with leaf age. They do not report expression in the shoot apical meristem, so that part of the attributed claim is unsupported. (LLM, conf=0.85)
Experimental — accuracy not yet measured
The expression of transporter genes very often varies concerning metal ion supply, tissue, organ, and populations of hyperaccumulators.
“It is pertinent to mention that the expression of transporter genes very often varies concerning metal ion supply, tissue, organ, and populations of hyperaccumulators (Krämer et al., 2007; Verbruggen et al., 2009b; Küpper and Kochian, 2010; Visioli et al., 2014).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Küpper and Kochian, 2010
The Summary (p. 1) reports that transporter-gene expression varies with Zn/Cd treatment, plant and leaf development, and cell type in the Ganges population of Thlaspi caerulescens. The study examines expression in leaves, so it does not establish variation between organs or between hyperaccumulator populations. (LLM, conf=0.85)
Experimental — accuracy not yet measured
NcZNT5 overexpression was observed in epidermal cells instead of in guard and subsidiary cells in young leaves of N. caerulescens.
“The NcZNT5 overexpression was observed in epidermal cells instead of in guard and subsidiary cells in young leaves of N. caerulescens (Küpper and Kochian, 2010).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Küpper and Kochian, 2010
The QISH results (p. 9) report much higher ZNT5 mRNA in epidermal metal-storage cells than in other epidermal cells, consistent with the contrast to guard and subsidiary cells. But the paper limits this pattern to young leaves of young plants and also identifies bundle sheath cells as a main expression site; the citing sentence omits those qualifications. (LLM, conf=0.85)
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Cobbett C, Goldsbrough P. 2002. Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis. Annual Review of Plant Biology 53: 159–182.

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The molecular physiology of heavy metal transport in the Zn/Cd\n hyperaccumulator Thlaspi caerulescens
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The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens
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Investigating The Molecular Basis Of Zn And Cd Transport And Homeostasis In The Metal Hyperaccumulating Plant Species, Thlaspi Caerulescens
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Identification and functional analysis of two ZIP metal transporters of the hyperaccumulator Thlaspi caerulescens
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Authors: Küpper, H., & Kochian, L. V.
Affiliations: United States Department of Agriculture (US)
Corresponding author: Küpper, Hendrik
ORCID: Küpper, Hendrik
Kochian, Leon V.
Venue: New Phytologist
Publisher: Wiley
Published: 2009-10-19
Volume: 185
Issue: 1
Pages: 114-129
ISSN: 0028-646X (ISSN-L)
1469-8137
DOI: 10.1111/j.1469-8137.2009.03051.x
OpenAlex: W2135630839
Cited by: 191
References: 81
Citations by year: 2026: 6 · 2025: 15 · 2024: 11 · 2023: 11 · 2022: 7 · 2021: 11 · 2020: 25 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 15 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 14
FWCI: 12.52
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: New Phytologist (publishedVersion)
PubMed (publishedVersion)
KOPS (University of Konstanz) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Physical Sciences › Chemistry › Analytical Chemistry › Heavy Metals in Plants
Keywords: Thlaspi caerulescens, cadmium hyperaccumulation, zinc hyperaccumulation, metal transporters, ZnT1, mineral nutrition, cadmium toxicity, plant acclimation, leaf ontogenesis, micronutrient uptake
MeSH terms: Acclimatization, Biological Transport, Cadmium, Minerals, Plant Proteins, RNA, Messenger, Zinc, Gene Expression, Genes, Plant, Gene Expression Regulation, Plant, Plant Leaves, Metals, Heavy, Cation Transport Proteins, Thlaspi

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Transcriptional regulation of metal transport genes and mineral nutrition during acclimatization to cadmium and zinc in the Cd/Zn hyperaccumulator, Thlaspi caerulescens (Ganges population)

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