A proteomics approach to investigate the process of Z n hyperaccumulation in N occaea caerulescens ( J & C . P resl) F . K . M eyer
Open accessAbstract
Summary: Zinc ( Z n) is an essential trace element in all living organisms, but is toxic in excess. Several plant species are able to accumulate Z n at extraordinarily high concentrations in the leaf epidermis without showing any toxicity symptoms. However, the molecular mechanisms of this phenomenon are still poorly understood. A state‐of‐the‐art quantitative 2 D liquid chromatography/tandem mass spectrometry (2 D ‐ LC ‐ MS / MS ) proteomics approach was used to investigate the abundance of proteins involved in Z n hyperaccumulation in leaf epidermal and mesophyll tissues of N occaea caerulescens . Furthermore, the Z n speciation in planta was analyzed by a size‐exclusion chromatography/inductively coupled plasma mass spectrometer ( SEC ‐ ICP ‐ MS ) method, in order to identify the Z n‐binding ligands and mechanisms responsible for Z n hyperaccumulation. Epidermal cells have an increased capability to cope with the oxidative stress that results from excess Z n, as indicated by a higher abundance of glutathione S ‐transferase proteins. A Z n importer of the ZIP family was more abundant in the epidermal tissue than in the mesophyll tissue, but the vacuolar Z n transporter MTP 1 was equally distributed. Almost all of the Z n located in the mesophyll was stored as Z n–nicotianamine complexes. In contrast, a much lower proportion of the Z n was found as Z n–nicotianamine complexes in the epidermis. However, these cells have higher concentrations of malate and citrate, and these organic acids are probably responsible for complexation of most epidermal Z n. Here we provide evidence for a cell type‐specific adaptation to excess Z n conditions and an increased ability to transport Z n into the epidermal vacuoles.
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The hyperaccumulation of metal ions is directly related to a higher number of ZIP transporters in the plasma membrane of leaf epidermal cells and transpiration termination in these cells.
“The hyperaccumulation of metal ions is directly related to a higher number of ZIP transporters in the plasma membrane of leaf epidermal cells and transpiration termination in these cells (Küpper et al., 2009; Schneider et al., 2013).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Schneider et al., 2013
In “Transport of Zn in the epidermal tissue” (p. 5), the paper reports an epidermal plasma-membrane protein resembling a ZIP transporter that was not detected in the mesophyll, and suggests it likely helps leaf cells take up Zn. It does not establish a direct causal relationship between ZIP abundance and metal hyperaccumulation, or say that transpiration terminates in epidermal cells; the Introduction (p. 2) instead describes root-to-shoot transport along the transpiration stream. (LLM, conf=0.86)
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Ali, A., Bhat, B. A., Rather, G. A., Malla, B. A., & Ganie, S. A. (2020) · Plant Micronutrients · doi:10.1007/978-3-030-49856-6_11 · Cited by 15 · see citing works
- Authors
- Schneider, T., Persson, D. P., Husted, S., Schellenberg, M., Gehrig, P., Lee, Y., Martinoia, E., Schjoerring, J. K., & Meyer, S.
- Affiliations
- University of Zurich (CH)
- University of Copenhagen (DK)
- Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 DK‐1871 Frederiksberg C Copenhagen Denmark
- ETH Zurich (CH)
- Pohang University of Science and Technology (KR)
- Corresponding author
- Schneider, Thomas
- Schjoerring, Jan K.
- ORCID
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2012-10-26
- Volume
- 73
- Issue
- 1
- Pages
- 131-142
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2115231532
- Semantic Scholar
- 5932842b1fede619dcaad62d31de50bfc057ff72
- Cited by
- 71
- References
- 90
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 2 · 2016: 12 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 1
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Plant Journal (publishedVersion)
- PubMed (publishedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- COST Fellowship (C08.0138)
- Danish Ministry of Science, Innovation and Higher Education (DSF-10-093498-NUTRIEFFICIENT, FTP-10-100087, FTP-10-082111-Sapere Aude)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Physical Sciences › Chemistry › Analytical Chemistry › Heavy Metals in Plants
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Keywords
- zinc hyperaccumulation, Noccaea caerulescens, leaf epidermis, mesophyll, zinc speciation, glutathione S-transferase, vacuolar sequestration, oxidative stress, plant metal tolerance
- MeSH terms
- Gas Chromatography-Mass Spectrometry, Plant Proteins, Zinc, Plant Leaves, Plant Epidermis, Brassicaceae, Proteomics, Mesophyll Cells
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