Ethnic differences in cardiovascular-somatosensory interactions and in the central processing of noxious stimuli
Abstract
Ethnic differences in central sensitization of pain processing and stress-relevant endogenous pain regulatory mechanisms were examined. Forty-four African Americans (AAs; 50% women) and 44 non-Hispanic Whites (nHWs; 50% women) matched for socioeconomic status, were tested for pain responses to the temporal summation of heat pulses and ischemic and cold pain. Resting and stress blood pressure (BP) and norepinephrine (NE) were assessed. AAs had heightened pain responses to all 3 pain tasks relative to nHWs. In nHWs, higher BP and NE were related to reduced pain. In AAs, there was no relationship between BP and pain, but higher NE was related to increased pain. This study provides evidence for ethnic differences in centrally mediated pain and extends prior research demonstrating ethnic differences in endogenous pain regulatory mechanisms. These results have implications for understanding biobehavioral factors contributing to ethnic disparities in clinical pain.
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Central sensitization precedes brain-dependent alterations in pain processing and may be less likely to be influenced by other physiological systems (e.g., cortisol).
“Central sensitization precedes brain-dependent alterations in pain processing, and may be less likely to be influenced by other physiological systems (e.g., cortisol).(82)”
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Ethnic Differences in Pain and Pain Management
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Demographic predictors of pain sensitivity: results from the OPPERA study
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Exploring pain processing differences in Native Americans
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Andersen, E., Geiger, P., Schiller, C., Bluth, K., Watkins, L., Zhang, Y., Xia, K., Tauseef, H., Leserman, J., Girdler, S., et al. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000889 · Cited by 19 · see citing works
Self-citation
- Authors
- Mechlin, B., Heymen, S., Edwards, C. L., & Girdler, S. S.
- Affiliations
- Washington and Lee University (US)
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Mechlin, Beth
- ORCID
- Girdler, Susan S.
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2010-10-29
- Volume
- 48
- Issue
- 6
- Pages
- 762-773
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- OpenAlex
- W2114331295
- Cited by
- 37
- References
- 124
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2017: 2 · 2016: 4 · 2014: 4 · 2013: 3 · 2012: 6
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f31da023009-01a1)
- National Institute on Drug Abuse (R01DA013705, 2 RO1DA013705, F31DA023009-01A1)
- National Center for Research Resources (RR00046, M01RR000046, UL1RR025747)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- ethnic differences, African Americans, pain processing, central sensitization, stress, norepinephrine, blood pressure, ischemic pain, cold pain
- MeSH terms
- Adult, Black or African American, Blood Pressure, Cardiovascular Physiological Phenomena, Cold Temperature, Data Interpretation, Statistical, Electroencephalography, Ethnicity, Evoked Potentials, Somatosensory, Female, Hot Temperature, Humans, Hydrocortisone, Ischemia, Male, Norepinephrine, Sensation, Social Class, Social Environment, Stress, Psychological, Tourniquets, White People, Pain Perception
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