Cited by 37Pain Mechanisms and TreatmentsPain Management and Placebo EffectPain Management and Treatment

Ethnic differences in cardiovascular-somatosensory interactions and in the central processing of noxious stimuli

Mechlin, Beth, Heymen, Steven, Edwards, Christopher L., Girdler, Susan S.·2011·Psychophysiology

Abstract

Ethnic differences in central sensitization of pain processing and stress-relevant endogenous pain regulatory mechanisms were examined. Forty-four African Americans (AAs; 50% women) and 44 non-Hispanic Whites (nHWs; 50% women) matched for socioeconomic status, were tested for pain responses to the temporal summation of heat pulses and ischemic and cold pain. Resting and stress blood pressure (BP) and norepinephrine (NE) were assessed. AAs had heightened pain responses to all 3 pain tasks relative to nHWs. In nHWs, higher BP and NE were related to reduced pain. In AAs, there was no relationship between BP and pain, but higher NE was related to increased pain. This study provides evidence for ethnic differences in centrally mediated pain and extends prior research demonstrating ethnic differences in endogenous pain regulatory mechanisms. These results have implications for understanding biobehavioral factors contributing to ethnic disparities in clinical pain.

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Crossref · 10.1111/j.1469-8986.2010.01140.x

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Authors
Mechlin, B., Heymen, S., Edwards, C. L., & Girdler, S. S.
Affiliations
  • Washington and Lee University (US)
  • Duke University (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Mechlin, Beth
Venue
Psychophysiology
Publisher
Wiley
Published
2010-10-29
Volume
48
Issue
6
Pages
762-773
ISSN
  • 0048-5772 (ISSN-L)
  • 1469-8986
OpenAlex
W2114331295
Cited by
37
References
124
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2017: 2 · 2016: 4 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Locations
  • Psychophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f31da023009-01a1)
  • National Institute on Drug Abuse (R01DA013705, 2 RO1DA013705, F31DA023009-01A1)
  • National Center for Research Resources (RR00046, M01RR000046, UL1RR025747)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
ethnic differences, African Americans, pain processing, central sensitization, stress, norepinephrine, blood pressure, ischemic pain, cold pain
MeSH terms
Adult, Black or African American, Blood Pressure, Cardiovascular Physiological Phenomena, Cold Temperature, Data Interpretation, Statistical, Electroencephalography, Ethnicity, Evoked Potentials, Somatosensory, Female, Hot Temperature, Humans, Hydrocortisone, Ischemia, Male, Norepinephrine, Sensation, Social Class, Social Environment, Stress, Psychological, Tourniquets, White People, Pain Perception

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