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Cited by 29Adenosine and Purinergic SignalingStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis

Kongsui, Ratchaniporn, Beynon, Sarah B., Johnson, Sarah J., Mayhew, Jack, Kuter, Patrick, Nilsson, Michael, Walker, Frederick Rohan·2014·Brain Behavior and Immunity
DOI 10.1016/j.bbi.2014.05.017
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Abstract

A number of studies have identified that mutations in the P2X7 receptor occur with a significantly higher incidence in individuals with major depression. Consistent with these findings, a number of preclinical studies have identified that mice in which the P2X7 receptor has been deleted exhibit a higher level of resilience-like behaviour to acutely aversive situations. At present, however, no studies have examined changes in P2X7 receptor expression in otherwise healthy animals exposed to persistently stressful situations. This is significant as several lines of evidence have demonstrated that it is exposure to persistently aversive, rather than acutely aversive, situations that is associated with the emergence of mood disturbance. Accordingly, the objective of the current study was to examine whether chronic exposure to restraint stress was associated with alterations in the expression of P2X7 within the hippocampal formation. The study involved three principal groups: acute stress (1 session), chronic stress (21 sessions, 1 per day) and a chronic stress with recovery group (21 sessions, 1 per day followed by 7days of no stress) and appropriate control groups. The results of the analysis indicate that all forms of stress, regardless of the duration, provoked a reduction in P2X7 receptor expression. Comparative analysis on normalised data indicated that the magnitude of the P2X7 reduction was significantly greater in the chronic stress relative to the acute stress group. We additionally found that there was a gradual rebound in P2X7 expression, in two of nine regions examined, in animals that were allowed to recover for 7days following the final stress session. Collectively, these findings provide the first evidence that exposure to chronic restraint stress produces a pronounced and relatively persistent suppression of the P2X7 receptor within the hippocampus.

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  • Restraint stress reduced the expression of P2X7R in rats submitted to acute stress, chronic stress, and chronic stress with recovery protocols.

    “Moreover, restraint stress was observed to reduce the expression of P2X7R in rats submitted to three different protocols: (i) acute stress (1 session of restraint stress), (ii) chronic stress (21 sessions of restraint stress, 1 per day) and (iii) chronic stress with recovery (21 sessions of restraint stress, 1 per day followed by 7 days of no stress) [83].”

    From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [83]

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Authors
Kongsui, R., Beynon, S. B., Johnson, S. J., Mayhew, J., Kuter, P., Nilsson, M., & Walker, F. R.
Affiliations
  • Hunter Medical Research Institute (AU)
  • University of Newcastle Australia (AU)
Corresponding author
Walker, Frederick Rohan
ORCID
Venue
Brain Behavior and Immunity
Publisher
Elsevier BV
Published
2014-11
Volume
42
Pages
69-80
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2014.05.017
OpenAlex
W2016100307
Cited by
29
References
69
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Funders
Australian National Health and Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
P2X7 receptor, chronic restraint stress, hippocampus, major depressive disorder, stress resilience, acute stress, stress recovery, receptor expression, mood disturbance
MeSH terms
Animals, Major Depressive Disorder, Disease Models, Animal, Hippocampus, Male, Restraint, Physical, Stress, Physiological, Stress, Psychological, Down-Regulation, Rats, Sprague-Dawley, Rats, Receptors, Purinergic P2X7

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