CoChat
Sign Up
Cited by 331

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

Thirumangalakudi, Lakshmi, Prakasam, Annamalai, Zhang, Ran, Bimonte‐Nelson, Heather, Sambamurti, Kumar, Kindy, Mark S., Bhat, Narayan R.·2008·Journal of Neurochemistry
DOI 10.1111/j.1471-4159.2008.05415.xPMC PMC3897170
Open this paper in CoChat — free account

Abstract

Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer’s disease‐like dementia but the underlying mechanisms remain unknown. In this study, we evaluated the cognitive performance in rodent models of hypercholesterolemia in relation to neuroinflammatory changes and amyloid precursor protein (APP) processing, the two key parameters of Alzheimer’s disease pathogenesis. Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)‐deficient mice were fed a high fat/cholesterol diet for an 8‐week period and tested for memory in a radial arm maze. It was found that the C57BL/6 mice receiving a high fat diet were deficient in handling an increasing working memory load compared with counterparts receiving a control diet while the hypercholesterolemic LDLR−/− mice showed impaired working memory regardless of diet. Immunohistochemical analysis revealed the presence of activated microglia and astrocytes in the hippocampi from high fat‐fed C57BL/6 mice and LDLR−/− mice. Consistent with a neuroinflammatory response, the hyperlipidemic mice showed increased expression of cytokines/mediators including tumor necrosis factor‐α, interleukin‐1β and ‐6, nitric oxide synthase 2, and cycloxygenase 2. There was also an induced expression of the key APP processing enzyme i.e. β‐site APP cleaving enzyme 1 in both high fat/cholesterol‐fed C57BL/6 and LDLR−/− mice accompanied by an increased generation of C‐terminal fragments of APP. Although ELISA for beta‐amyloid failed to record significant changes in the non‐transgenic mice, a threefold increase in beta‐amyloid 40 accumulation was apparent in a strain of transgenic mice expressing wild‐type human APP on high fat/cholesterol diet. The findings link hypercholesterolemia with cognitive dysfunction potentially mediated by increased neuroinflammation and APP processing in a non‐transgenic mouse model.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1471-4159.2008.05415.x

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 52

  1. 10.1016/S0031-9384(99)00201-2 · DOI
  2. 10.1016/S0031-9384(00)00259-6 · DOI
  3. 10.1111/j.1365-2796.2006.01725.x · DOI
  4. 10.1016/S0022-2275(20)32188-X · DOI · Paper page
  5. 10.1111/j.1600-0404.2006.00684.x · DOI
  6. 10.1074/jbc.271.8.4436 · DOI · Paper page
  7. 10.1194/jlr.M600214-JLR200 · DOI
  8. 10.1016/S0140-6736(04)15900-X · DOI · Paper page
  9. 10.1074/jbc.M413895200 · DOI
  10. 10.2165/00002512-200320060-00001 · DOI
  11. 10.1083/jcb.200207113 · DOI · Paper page
  12. 10.1111/j.1471-4159.2007.04614.x · DOI · Paper page
  13. 10.1523/JNEUROSCI.4371-06.2007 · DOI
  14. 10.1097/00001756-199906030-00014 · DOI
  15. 10.1016/j.expneurol.2006.03.019 · DOI · Paper page
  16. 10.1111/j.1471-4159.2006.04079.x · DOI · Paper page
  17. 10.3233/JAD-2006-9105 · DOI
  18. 10.3233/JAD-1999-14-501 · DOI
  19. 10.1016/j.jneuroim.2006.11.017 · DOI · Paper page
  20. 10.1016/S0166-4328(02)00275-9 · DOI
  21. 10.1016/j.neuron.2004.08.043 · DOI · Paper page
  22. 10.1016/S0006-8993(97)01417-0 · DOI
  23. 10.1016/S0006-8993(00)02113-2 · DOI
  24. 10.1172/JCI116663 · DOI · Paper page
  25. 10.1037/0735-7044.98.6.946 · DOI
  26. 10.1002/humu.20012 · DOI
  27. Levin‐Allerhand J. A., 2002, Increased amyloid‐levels in APPSWE transgenic mice treated chronically with a physiological high‐fat high‐cholesterol diet, J. Nutr. Health Aging, 6, 315
  28. 10.1016/S0002-9440(10)63572-9 · DOI · Paper page
  29. 10.1073/pnas.0205689101 · DOI
  30. 10.1146/annurev.pharmtox.45.120403.095748 · DOI · Paper page
  31. 10.1016/j.neuron.2007.08.008 · DOI · Paper page
  32. Lutjohann D., 2003, 24S‐hydroxycholesterol: a marker of brain cholesterol metabolism, Pharmacopsychiatry, 36, S102
  33. 10.1016/j.nbd.2004.01.015 · DOI · Paper page
  34. 10.1096/fj.00-0891fje · DOI
  35. 10.1074/jbc.M005968200 · DOI
  36. 10.1038/nn0403-345 · DOI · Paper page
  37. 10.1006/nbdi.2000.0304 · DOI · Paper page
  38. 10.1146/annurev.med.47.1.387 · DOI · Paper page
  39. 10.2174/1389450043345335 · DOI
  40. 10.1073/pnas.0503839103 · DOI · Paper page
  41. 10.1073/pnas.95.11.6460 · DOI
  42. 10.1006/exnr.1994.1044 · DOI · Paper page
  43. 10.1111/j.1749-6632.2000.tb06384.x · DOI
  44. 10.1038/nm1102-1211 · DOI
  45. 10.1007/s001090050097 · DOI
  46. 10.1111/j.1471-4159.2004.02895.x · DOI · Paper page
  47. 10.1016/j.neurobiolaging.2005.09.003 · DOI
  48. 10.1001/archneur.57.10.1439 · DOI
  49. 10.1111/j.1600-0404.2006.00687.x · DOI
  50. 10.1186/1742-2094-4-20 · DOI
  51. 10.1096/fj.07-8175com · DOI
  52. 10.1016/j.tins.2005.02.001 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Thirumangalakudi, L., Prakasam, A., Zhang, R., Bimonte‐Nelson, H., Sambamurti, K., Kindy, M. S., & Bhat, N. R.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2008-04-12
Volume
106
Issue
1
Pages
475-485
ISSN
  • 0022-3042
  • 1471-4159
DOI
10.1111/j.1471-4159.2008.05415.x
PMC
PMC3897170
Cited by
331
References
7
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review