The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
Open accessAbstract
Summary: Chronic dietary restriction (DR) is considered among the most robust life‐extending interventions, but several reports indicate that DR does not always extend and may even shorten lifespan in some genotypes. An unbiased genetic screen of the lifespan response to DR has been lacking. Here, we measured the effect of one commonly used level of DR (40% reduction in food intake) on mean lifespan of virgin males and females in 41 recombinant inbred strains of mice. Mean strain‐specific lifespan varied two to threefold under ad libitum (AL) feeding and 6‐ to 10‐fold under DR, in males and females respectively. Notably, DR shortened lifespan in more strains than those in which it lengthened life. Food intake and female fertility varied markedly among strains under AL feeding, but neither predicted DR survival: therefore, strains in which DR shortened lifespan did not have low food intake or poor reproductive potential. Finally, strain‐specific lifespans under DR and AL feeding were not correlated, indicating that the genetic determinants of lifespan under these two conditions differ. These results demonstrate that the lifespan response to a single level of DR exhibits wide variation amenable to genetic analysis. They also show that DR can shorten lifespan in inbred mice. Although strains with shortened lifespan under 40% DR may not respond negatively under less stringent DR, the results raise the possibility that life extension by DR may not be universal.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Even among highly genetically similar strains of yeast or mice, dietary restriction is equally likely to shorten lifespan as to extend lifespan.76,77,78”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [78]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264
The retardation of aging and disease by dietary restriction
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5101 · Cited by 1,477
Longevity, senescence and the genome
(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90026-8 · Cited by 1,403
Overview of caloric restriction and ageing
Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 879
Nutrient Requirements of Laboratory Animals,
National Research Council (1995) · National Academies Press eBooks · doi:10.17226/4758 · Cited by 735
Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program
Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 675
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.
Cm, M., Crowell, M. F., & MAYNARD, L. A. (1989) · PubMed · Cited by 670
Yu, B. P., Masoro, E. J., Murata, I., Bertrand, H. A., & Lynd, F. T. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.2.130 · Cited by 580
Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 422
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396
Longevity, senescence, and the genome
Goldstein, S. (1992) · Choice Reviews Online · doi:10.5860/choice.29-3294 · Cited by 328
Holloszy, J. O., & Fontana, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.009 · Cited by 304
Influence of diet on survival of mice.
Fernandes, G., Yunis, E. J., & Good, R. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1279 · Cited by 264
Genotype and age influence the effect of caloric intake on mortality in mice
Forster, M. J., Morris, P., & Sohal, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0533fje · Cited by 236
Does caloric restriction extend life in wild mice?
Harper, J. M., Leathers, C. W., & Austad, S. N. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00236.x · Cited by 213
Influences of Aging and Dietary Restriction on Serum Thymosin l Levels in Mice
Weindruch, R., Naylor, P. H., Goldstein, A. L., & Walford, R. L. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.2.b40 · Cited by 207
Subfield History: Caloric Restriction, Slowing Aging, and Extending Life
Masoro, E. J. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.8.re2 · Cited by 149
Genetic differences in effects of food restriction on aging in mice
Harrison, D. E., & Archer, J. R. (1987) · The Journal of Nutrition · doi:10.1093/jn/117.2.376 · Cited by 133 · cited 2×
“Others even report that DR shortens lifespan in some strains (Barrows & Roeder, 1965; Fernandes et al., 1976; Harrison & Archer, 1987; Forster et al., 2003), but these studies have not been conclusive given that other studies have shown lifespan extension in those strains, under different…”
BackgroundResultEffect of caloric restriction on life span of the housefly, Musca domestica
Cooper, T. M., Mockett, R. J., Sohal, B. H., Sohal, R. S., & Orr, W. C. (2004) · The FASEB Journal · doi:10.1096/fj.03-1464fje · Cited by 117
Life history response of Mediterranean fruit flies to dietary restriction
Carey, J. R., Liedo, P., Harshman, L. G., Zhang, Y., Müller, H., Partridge, L., & Wang, J. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00019.x · Cited by 114
Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone‐Link, P., Rikke, B. A., Belknap, J. K., & Johnson, T. E. (2004) · Mammalian Genome · doi:10.1007/s00335-004-2380-6 · Cited by 100
Self-citationHousing Density Does Not Influence the Longevity Effect of Calorie Restriction
Ikeno, Y., Hubbard, G. B., Lee, S., Richardson, A., Strong, R., Diaz, V., & Nelson, J. F. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1510 · Cited by 83
Self-citationThe diet restriction paradigm: a brief review of the effects of every-other-day feeding
Anson, R. M., Jones, B., & de Cabo, R. (2005) · AGE · doi:10.1007/s11357-005-3286-2 · Cited by 78
The Effect of Reduced Dietary Intake on Enzymatic Activities and Life Span of Rats
Barrows, C. H., & Roeder, L. M. (1965) · Journal of Gerontology · doi:10.1093/geronj/20.1.69 · Cited by 61
Plasma Glucose and the Action of Calorie Restriction on Aging
McCarter, R., Mejia, W., Ikeno, Y., Monnier, V. M., Kewitt, K., Gibbs, M. A., McMahan, C. A., & Strong, R. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.10.1059 · Cited by 41
Bennett, B., Carosone‐Link, P., Zahniser, N. R., & Johnson, T. E. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103572 · Cited by 33
Self-citation
Cited by
Sorted by citations
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605
From discoveries in ageing research to therapeutics for healthy ageing
Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145
Metadata
- Authors
- Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- University of Colorado Boulder (US)
- Corresponding author
- Nelson, James F.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2010-01-11
- Volume
- 9
- Issue
- 1
- Pages
- 92-95
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC3476836
- OpenAlex
- W2104438296
- Cited by
- 501
- References
- 26
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 25 · 2023: 24 · 2022: 32 · 2021: 34 · 2020: 39 · 2019: 33 · 2018: 30 · 2017: 31 · 2016: 41 · 2015: 39 · 2014: 30 · 2013: 31 · 2012: 21
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG024354)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- dietary restriction, lifespan, genetic variation, recombinant inbred mouse strains, lifespan extension, lifespan reduction, dietary intake, female fertility, sex differences in lifespan, genetic determinants of aging
- MeSH terms
- Animals, Female, Life Expectancy, Longevity, Male, Mice, Inbred Strains, Sex Characteristics, Genetic Variation, Caloric Restriction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
