Laboratory investigation of lupus anticoagulants: mixing studies are sometimes required
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A reduced sensitivity is likely to be expected for weak LAC when these are diluted in the mixture of PP and NPP except in the case of the cofactor effect.
“A reduced sensitivity is likely to be expected for weak LAC, when these are diluted in the mixture of PP and NPP except in the case of the cofactor effect (4, 13).”
From Mixing studies in lupus anticoagulant testing are required at least in some type of samples (2015) · cites this paper as [4]
Cites
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works
Update of the guidelines for lupus anticoagulant detection
PENGO, V., TRIPODI, A., REBER, G., RAND, J. H., ORTEL, T. L., GALLI, M., & DE GROOT, P. G. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03555.x · Cited by 1,197 · see citing works
Brandt, J. T., Triplett, D. A., Alving, B., & Scharrer, I. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649901 · Cited by 993 · see citing works
Normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulant
Thom, J., Ivey, L., & Eikelboom, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2003.0543h.x · Cited by 39 · see citing works
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Devreese, K. M. J., de Groot, P. G., de Laat, B., Erkan, D., Favaloro, E. J., Mackie, I., Martinuzzo, M., Ortel, T. L., Pengo, V., Rand, J. H., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15047 · Cited by 439 · see citing works
Self-citationRecent Guidelines and Recommendations for Laboratory Detection of Lupus Anticoagulants
Moore, G. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1364185 · Cited by 148 · see citing works
“48,49,51,62,63,66 The principle arises from the fact that the traditional testing order of screen-mix-con fi rm is circumvented and the presence of a LA can be immediately apparent without performing the mixing test.”
BackgroundInfluentialAntiphospholipid antibody testing and standardization
Devreese, K. M. J. (2014) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12234 · Cited by 98 · see citing works
Mixing studies in lupus anticoagulant testing are required at least in some type of samples
Devreese, K. M. J., & de Laat, B. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13020 · Cited by 63 · see citing works
Favaloro, E., Bonar, R., & Marsden, K. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1311993 · Cited by 49 · see citing works
Self-citationMoore, G. W., Jones, P. O., Platton, S., Hussain, N., White, D., Thomas, W., Rigano, J., Pouplard, C., Gray, E., & Devreese, K. M. J. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15438 · Cited by 47 · see citing works
Moore, G. W., Culhane, A. P., Daw, C. R., Noronha, C. P., & Kumano, O. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.01.019 · Cited by 42 · see citing works
Current Controversies in Lupus Anticoagulant Detection
Moore, G. (2016) · Antibodies · doi:10.3390/antib5040022 · Cited by 36 · see citing works
Dilute Russell's viper venom time reagents in lupus anticoagulant testing: a well‐considered choice
Depreter, B., & Devreese, K. M. J. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0245 · Cited by 34 · see citing works
Kumano, O., & Moore, G. W. (2018) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12069 · Cited by 26 · see citing works
Mixing studies for lupus anticoagulant: mostly yes, sometimes no
Favaloro, E. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-1240 · Cited by 20 · see citing works
Self-citationKumano, O., Ieko, M., Naito, S., Yoshida, M., Takahashi, N., Suzuki, T., & Aoki, T. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.05.030 · Cited by 15 · see citing works
Favaloro, E. J., Bonar, R., & Marsden, K. (2013) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e328360c71b · Cited by 14 · see citing works
Self-citationMoore, G. W., Foxton, E., Platton, S., Yartey, N., White, D., & MacDonald, S. G. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.08.009 · Cited by 6 · see citing works
Analytical dilemmas in lupus anticoagulant detection
Moore, G. W. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00104 · Cited by 5 · see citing works
Lupus Anticoagulant Testing: Taipan Snake Venom Time with Ecarin Time as Confirmatory Test
Moore, G. W. (2023) · Methods in Molecular Biology · doi:10.1007/978-1-0716-3175-1_16 · Cited by 5 · see citing works
- Authors
- FAVALORO, E. J., BONAR, R., ZEBELJAN, D., KERSHAW, G., & MARSDEN, K.
- Affiliations
- Westmead Hospital (AU)
- Royal College of Pathologists of Australasia (AU)
- Liverpool Hospital (AU)
- Royal Prince Alfred Hospital (AU)
- Corresponding author
- FAVALORO, E.J.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 8
- Issue
- 12
- Pages
- 2828-2831
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W1600794191
- Cited by
- 48
- References
- 4
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 8 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- lupus anticoagulant, mixing studies, antiphospholipid syndrome, dilute Russell viper venom time, activated partial thromboplastin time, external quality assurance, integrated test system, laboratory standardization, false-negative results, assay reproducibility, cut-off values, confirmatory testing, sample processing
- MeSH terms
- Humans, Lupus Erythematosus, Systemic, Quality Assurance, Health Care, Lupus Coagulation Inhibitor, Clinical Laboratory Techniques
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