Lupus anticoagulant testing – sometimes mixing is required: potential for false negatives without mixing studies
Abstract
aDepartment of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, Westmead Hospital bRCPAQAP Haematology, St Leonards, New South Wales cPathology, Royal Hobart Hospital, Hobart, Tasmania, Australia Correspondence to Dr Emmanuel J. Favaloro, Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, NSW 2145, Australia Tel: +612 9845 6618; fax: +612 9689 2331; e-mail: [email protected] Received 23 January, 2013 Revised 24 February, 2013 Accepted 1 March, 2013
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Omitting the mixing step may produce false-positive and false-negative LA results.
“More recent studies illustrate that omitting the mixing step may give false-positive and false-negative results.35,58,60”
Cites
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Update of the guidelines for lupus anticoagulant detection
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Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740 · see citing works
Favaloro, E., Bonar, R., & Marsden, K. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1311993 · Cited by 49 · see citing works
Self-citationLaboratory investigation of lupus anticoagulants: mixing studies are sometimes required
FAVALORO, E. J., BONAR, R., ZEBELJAN, D., KERSHAW, G., & MARSDEN, K. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04090.x · Cited by 48 · see citing works
Self-citationMoore, G. W., & Savidge, G. F. (2006) · Thrombosis Research · doi:10.1016/j.thromres.2005.09.010 · Cited by 46 · see citing works
Laboratory Identification of Lupus Anticoagulants
Kershaw, G. W., Suresh, S., Orellana, D., & Nguy, Y.-M. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1311991 · Cited by 43 · see citing works
Normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulant
Thom, J., Ivey, L., & Eikelboom, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2003.0543h.x · Cited by 39 · see citing works
Roubey, R. (2010) · Lupus · doi:10.1177/0961203310361356 · Cited by 39 · see citing works
To Mix or Not to Mix in Lupus Anticoagulant Testing? That is the Question
Tripodi, A. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1304717 · Cited by 38 · see citing works
Intensity and Duration of Anticoagulation Therapy in Antiphospholipid Syndrome
Les, Í., Ruiz‐Irastorza, G., & Khamashta, M. A. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1304720 · Cited by 38 · see citing works
Favaloro, E. J., & Wong, R. C. W. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.064 · Cited by 36 · see citing works
Self-citationComparison of six dilute Russell viper venom time lupus anticoagulant screen/confirm assay kits
Fritsma, G., & McGlasson, D. (2013) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1334865 · Cited by 33 · see citing works
More on: laboratory investigation of lupus anticoagulants: mixing studies are sometimes required
Tripodi, A., & Pengo, V. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04440.x · Cited by 25 · see citing works
Clinical significance of the mixing test in laboratory diagnoses of lupus anticoagulant
Hong, S. K., Hwang, S. M., Kim, J.-E., & Kim, H. K. (2012) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e328358e899 · Cited by 22 · see citing works
Trials and tribulations in lupus anticoagulant testing
Favaloro, E. J. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0578 · Cited by 13 · see citing works
Self-citationBonar, R. A., Favaloro, E. J., Zebeljan, D., Rosenfeld, D., Kershaw, G., Mohammed, S., MARSDEN, K. A., & Hertzberg, M. (2011) · Pathology · doi:10.1097/pat.0b013e32834d7b83 · Cited by 12 · see citing works
Self-citationAboud, M., RODDIE, C., Wård, C., & Coyle, L. A. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.078683 · Cited by 11 · see citing works
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Devreese, K. M. J., de Groot, P. G., de Laat, B., Erkan, D., Favaloro, E. J., Mackie, I., Martinuzzo, M., Ortel, T. L., Pengo, V., Rand, J. H., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15047 · Cited by 439 · see citing works
Self-citationMixing studies for lupus anticoagulant: mostly yes, sometimes no
Favaloro, E. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-1240 · Cited by 20 · see citing works
Self-citationMixing studies for lupus anticoagulant: mostly no, sometimes yes
Moore, G. W. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-1248 · Cited by 19 · see citing works
Kumano, O., Ieko, M., Naito, S., Yoshida, M., Takahashi, N., Suzuki, T., & Aoki, T. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.05.030 · Cited by 15 · see citing works
Viewpoint: Lupus anticoagulant detection and interpretation in antiphospholipid syndrome
Efthymiou, M., Bertolaccini, M. L., & Cohen, H. (2024) · Rheumatology · doi:10.1093/rheumatology/kead623 · Cited by 5 · see citing works
- Authors
- Favaloro, E. J., Bonar, R., & Marsden, K.
- Affiliations
- Westmead Hospital (AU)
- Royal Hobart Hospital (AU)
- Corresponding author
- Favaloro, Emmanuel J.
- Venue
- Blood Coagulation & Fibrinolysis
- Published
- 2013-09
- Volume
- 24
- Issue
- 6
- Pages
- 673-676
- ISSN
- 0957-5235 (ISSN-L)
- OpenAlex
- W2329104075
- Cited by
- 14
- References
- 19
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 5 · 2020: 1 · 2019: 2 · 2014: 2 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood Coagulation & Fibrinolysis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- lupus anticoagulant, sample mixing, coagulation tests, antiphospholipid syndrome
- MeSH terms
- Female, Humans, Male, Thrombosis, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome
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