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Cited by 109Cardiac Imaging and DiagnosticsECG Monitoring and AnalysisAcute Myocardial Infarction Research

Magnetocardiography Predicts Coronary Artery Disease in Patients with Acute Chest Pain

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Park, Jai‐Wun, Hill, Peter M., Chung, Namsik, Hugenholtz, Paul G., Jung, Friedrich·2005·Annals of Noninvasive Electrocardiology
DOI 10.1111/j.1542-474x.2005.00634.xPMC PMC6932599
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Abstract

Background: The value of magnetocardiography (MCG) for the detection of cardiac electrical disturbances associated with myocardial ischemia was studied. Methods: Sensitivity and predictivity of admission MCG for the presence of coronary artery disease (CAD) were prospectively evaluated in 264 consecutive patients presenting with acute chest pain and without ST‐segment elevation. MCG findings were compared with 12‐lead ECG, echocardiography (ECHO), and troponin‐I in a head‐to‐head design. Coronary angiography was used for CAD diagnosis. Results: The visual assessment of magnetocardiograms by the experienced reader (R1) was superior to that by the unexperienced reader (R2) and superior to the automated computer analysis. Specificity and positive predictive value of MCG by R1 were comparable with those of ECG and troponin‐I (>90%), while ECHO specificity and ECHO positive predictive value were lower (76.2% and 87.9%, respectively). Sensitivity and negative predictive value of MCG were twice as high as those in the ECG, troponin‐I, and ECHO tests. Conclusion: For the prediction of CAD in patients presenting with acute chest pain and without ST‐segment elevation, an admission MCG test was superior to an admission ECG, ECHO, and troponin‐I. The results of the study, however, are applicable only to a highly selected population comprising patients in whom immediate coronary angiography can be performed based on their clinical course in the hospital.

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  • MCG can detect repolarization abnormalities (potential heart infarction) at rest even in patients with non-specific 12-lead ECG and normal troponine enzyme test.

    “As another, the ability to detect repolarization abnormalities (potential heart infarction) at rest, even in patients with non-specific 12-lead ECG and normal troponine enzyme test [28].”

    From Biomagnetism using SQUIDs: status and perspectives (2006) · cites this paper as [28]

    The Data Analysis section describes MCG findings during the T-wave repolarization interval as criteria for ischemia. The Discussion reports that admission MCG predicted coronary artery disease despite false-negative ECG and troponin-I findings, including in patients whose ECG was nondiagnostic. The study assessed ischemia and coronary artery disease, however, not MCG detection of a potential myocardial infarction; its Methods say patients with an unambiguously ECG-diagnosed acute infarction were excluded. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 6

  1. [3]3. Bertrand ME, Simoons ML, Fox KAA, et al. Manage- ment of acute coronary syndromes: Acute coronary syn- dromes without persistent ST-segment elevation. Eur Heart J 2000;21:1-32.
  2. [4]4. Sternickel K, Tralshawala N, Bakharev A, et al. Unshielded measurements of cardiac electric activity using magneto- cardiography. Int J Bioelectromagnetism 2002;4:189-195.
  3. [5]5. Scanlon PJ, Faxon DP, Audet AM, et al. ACC/AHA guidelines for coronary angiography. J Am Coll Cardiol 1999;33:1756-1824.
  4. [8]8. Physical status: The use and interpretation of anthropom- etry. Report of a WHO expert committee. WHO Tech Rep Ser 1995;854:1-452.
  5. [15]15. Park J-W, Reichert U, Gerk U, et al. Early diagnosis of ischemic heart disease in a left bundle branch block pa- tient with acute chest pain using magnetocardiography. In: Kimchi A (ed.): Heart Disease. Pathogenesis, Diagno- sis and Treatment. Bologna, Medimond, 2003, pp. 131- 135.
  6. [16]16. Mizuno K, Satomura K, Miyamoto A, et al. Angioscopic eval- uation of coronary artery thrombi in acute coronary syn- dromes. N Engl J Med 1992;326:287-291.

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Authors
Park, J., Hill, P. M., Chung, N., Hugenholtz, P. G., & Jung, F.
Affiliations
  • Johns Hopkins University (US)
  • Yonsei University (KR)
  • Saarland University (DE)
ORCID
Venue
Annals of Noninvasive Electrocardiology
Publisher
Wiley
Published
2005-07
Volume
10
Issue
3
Pages
312-323
ISSN
  • 1082-720X (ISSN-L)
  • 1542-474X
DOI
10.1111/j.1542-474x.2005.00634.x
PMC
PMC6932599
OpenAlex
W2068244737
Cited by
109
References
20
Citations by year
2026: 10 · 2025: 12 · 2024: 7 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
7.65
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 18 d)
Locations
  • Annals of Noninvasive Electrocardiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords
magnetocardiography, coronary artery disease, acute chest pain, non-ST-segment elevation, myocardial ischemia, diagnostic accuracy, sensitivity and specificity, positive predictive value, 12-lead ECG, echocardiography, troponin I
MeSH terms
Acute Disease, Aged, Chest Pain, Coronary Disease, Echocardiography, Electrocardiography, Female, Humans, Magnetics, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Coronary Angiography

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