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Cited by 51Health disparities and outcomesStress Responses and CortisolAttachment and Relationship Dynamics

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Social Support Mediates Loneliness and Human Herpesvirus Type 6 (HHV‐6) Antibody Titers

Open access
Dixon, Denise, Cruess, Stacy, Kilbourn, Kristin, Klimas, Nancy, Fletcher, Mary Ann, Ironson, Gail, Baum, Andrew, Schneiderman, Neil, Antoni, Michael H.·2001·Journal of Applied Social Psychology
DOI 10.1111/j.1559-1816.2001.tb02665.xPMC PMC2855978
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Abstract

The current study investigated the impact of a severe environmental stressor and the role that declining social integration played in mediating its effect on loneliness and immune status. Increased loneliness and decreased social support in the months following the stressor (storm) were significantly associated with increased HHV‐6 antibody liters, reflecting poorer control over the virus. Poorer social integration mediated the relationship between loneliness and HHV‐6, even after controlling for nonspecific polyclonal B‐cell activation, disease status (CD3+CD4+ cell counts), living arrangements, acute social losses (bereavement), and potential disruptions in social‐support resources. These findings suggest that specific elements of social support may explain the oft‐noted negative effects of loneliness on the immune system, and generalized to a medically vulnerable population.

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  • Loneliness is associated with impaired cellular immunity, as reflected in lower natural killer (NK) cell activity and higher antibody titers to the Epstein Barr Virus and human herpes viruses.

    “Loneliness has been associated with impaired cellular immunity as reflected in lower natural killer (NK) cell activity and higher antibody titers to the Epstein Barr Virus and human herpes viruses [70, 80–82].”

    From Loneliness matters: a theoretical and empirical review of consequences and mechanisms (2010) · cites this paper as [80]

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Research works printed but not linked: 79

  1. 10.1016/S0966-842X(00)88964-7 · DOI
  2. Ablashi D., 1997, Longitudinal follow‐up of two AIDS patients for active human herpesvirus‐6 (HHV‐6) infection, In Vivo, 11, 383
  3. 10.1037/0003-066X.39.3.252 · DOI
  4. Antoni M. H., 1991, Coping responses to HIV‐1 serostatus notification predict short‐term affective distress and one‐year immunologic status in HIV‐1 seronegative and seropositive gay men, Psychosomatic Medicine, 53, 227
  5. 10.1016/B0080-4270(73)00231-5 · DOI
  6. 10.1037/0022-006X.58.1.38 · DOI
  7. 10.1037/0022-3514.59.2.344 · DOI
  8. 10.1037/0278-6133.16.3.248 · DOI
  9. 10.1097/00006842-199601000-00004 · DOI
  10. Blasquez M., 1995, Human herpesvirus‐6 and the course of human immunodeficiency virus infection, Journal of Acquired Immune Deficiency Syndrome and Human Retrovirology, 9, 389
  11. 10.1093/oxfordjournals.aje.a113575 · DOI
  12. 10.1017/S0033291700033468 · DOI
  13. 10.1017/S0033291796004278 · DOI
  14. 10.1037/0278-6133.7.3.269 · DOI · Paper page
  15. 10.1111/j.1559-1816.1983.tb02325.x · DOI · Paper page
  16. Cohen S., 1985, Social support and health
  17. 10.1037/0033-2909.98.2.310 · DOI · Paper page
  18. 10.1207/S15327558IJBM0702_5 · DOI
  19. Cutrona C. E., 1987, Advances in personal relationships, 37
  20. 10.1002/jts.2490090316 · DOI
  21. Dixon D., 1999, Acute and sustained effects of anxiety on immune status and social support in HIV+ gay men following Hurricane Andrew, NeuroImmuno Modulation, 6, 214
  22. 10.1002/(SICI)1096-9071(199604)48:4<344::AID-JMV8>3.0.CO;2-7 · DOI
  23. Esterling B., 1994, Emotional disclosure through writing or speaking modulates latent Epstein‐Barr virus reactivation, Journal of Consulting and Clinical Psychology, 62, 130, 10.1037/0022-006X.62.1.130 · DOI
  24. 10.1016/0022-3956(75)90026-6 · DOI · Paper page
  25. Fritsche H. A., 1975, The determination of serum immunoglob‐ulins by automated nephelometric analysis, American Journal of Medical Technology, 41, 136
  26. 10.1016/0889-1591(87)90013-4 · DOI
  27. 10.1007/BF02883323 · DOI
  28. 10.1111/j.1749-6632.1998.tb09603.x · DOI
  29. 10.1007/BF00870312 · DOI · Paper page
  30. 10.1016/0889-1591(87)90002-X · DOI
  31. 10.1159/000022021 · DOI
  32. 10.1136/jnnp.23.1.56 · DOI · Paper page
  33. 10.1002/1520-6629(199010)18:4<374::AID-JCOP2290180410>3.0.CO;2-C · DOI
  34. Hays R. B., 1992, Social support, AlDS‐related symptoms, and depression among gay men, Journal of Consulting and Clinical Psychology, 60, 463, 10.1037/0022-006X.60.3.463 · DOI
  35. 10.1016/S1078-5884(98)80152-4 · DOI
  36. 10.1016/0165-5728(96)00055-0 · DOI
  37. 10.1207/s15327558ijbm0101_6 · DOI
  38. 10.1097/00006842-199005000-00001 · DOI
  39. 10.1097/00006842-199703000-00003 · DOI
  40. 10.1086/514272 · DOI
  41. 10.1097/00006842-199107000-00001 · DOI · Paper page
  42. 10.1097/00006842-198701000-00002 · DOI
  43. 10.1097/00006842-198401000-00003 · DOI · Paper page
  44. 10.1097/00006842-198805000-00001 · DOI
  45. 10.1097/00006842-198401000-00004 · DOI · Paper page
  46. 10.1002/1097-4679(198803)44:2<203::AID-JCLP2270440218>3.0.CO;2-5 · DOI
  47. 10.1016/S0140-6736(94)91524-5 · DOI
  48. 10.1097/00042560-199604010-00007 · DOI
  49. 10.1002/depr.3050020403 · DOI
  50. 10.1097/00006842-199905000-00021 · DOI
  51. 10.1176/ajp.149.11.1514 · DOI
  52. 10.1111/j.1600-0447.1987.tb02919.x · DOI
  53. 10.1097/00005053-199306000-00009 · DOI
  54. Luppi M., 1996, The new lymphotropic herpesviruses (HHV‐6, HHV‐7, HHV‐8) and hepatitis C virus (HCV) in human lymphoproliferative diseases: An overview, Haematologica, 81, 265
  55. Luddo P., 1991, Human herpesvirus‐6 may be a cofactor in AIDS, American Family Physician, 44, 936
  56. 10.1038/349533a0 · DOI
  57. 10.1016/0167-5699(95)80090-5 · DOI
  58. 10.1084/jem.181.4.1303 · DOI
  59. 10.1097/00006842-199803000-00017 · DOI
  60. 10.1097/00005768-199712000-00014 · DOI
  61. 10.1037/0022-006X.56.6.856 · DOI
  62. 10.1111/j.1467-7717.1995.tb00342.x · DOI
  63. 10.1037/0278-6133.7.3.231 · DOI
  64. 10.1007/BF02884959 · DOI
  65. 10.1007/BF02883331 · DOI · Paper page
  66. 10.1080/08870448908400367 · DOI
  67. Penninx B. W. J. H., 1998, Effects of social support and personal coping resources on depressive symptoms: Different for various chronic diseases, Health Psychology, 17, 551, 10.1037/0278-6133.17.6.551 · DOI
  68. 10.1037/0033-2909.109.3.384 · DOI
  69. 10.1037/0022-3514.39.3.472 · DOI · Paper page
  70. 10.1016/S0165-1781(98)00133-4 · DOI
  71. 10.1001/archpsyc.1989.01810010083011 · DOI
  72. Schnurr P. P., 1996, Trauma, PTSD, and physical health, The National Center for Post-Traumatic Stress Disorder Research Quarterly, 7, 1
  73. 10.1097/00006842-199703000-00002 · DOI
  74. 10.1016/S0031-9384(98)00127-9 · DOI
  75. 10.1016/S0165-5728(98)00242-2 · DOI
  76. 10.2307/2137303 · DOI
  77. Weiss R. S., 1974, Doing unto others, 7
  78. 10.1002/cncr.1984.53.s10.2339 · DOI
  79. 10.1002/cpp.5640020404 · DOI

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Metadata

Authors
Dixon, D., Cruess, S., Kilbourn, K., Klimas, N., Fletcher, M. A., Ironson, G., Baum, A., Schneiderman, N., & Antoni, M. H.
Affiliations
  • University of Miami (US)
  • University of Pittsburgh Medical Center (US)
Corresponding author
Antoni, Michael H.
ORCID
Venue
Journal of Applied Social Psychology
Publisher
Wiley
Published
2001-06
Volume
31
Issue
6
Pages
1111-1132
ISSN
  • 0021-9029 (ISSN-L)
  • 1559-1816
DOI
10.1111/j.1559-1816.2001.tb02665.x
PMC
PMC2855978
OpenAlex
W2087694689
Cited by
51
References
3
Citations by year
2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 3
FWCI
1.45
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1886 d)
Locations
  • Journal of Applied Social Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • NSUWorks (Nova Southeastern University) (submittedVersion)
Funders
  • National Institutes of Health (5t32mh018917-24)
  • National Institute of Mental Health (T32-MH018917)
Topics
  • Social Sciences › Health › Health disparities and outcomes
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
Keywords
loneliness, social support, social integration, human herpesvirus 6, immune function, environmental stress, storms, bereavement, immunosuppression

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