Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958

Distinct Sets of Genetic Alterations in Melanoma

Curtin, J. A., Fridlyand, J., Kageshita, T., Patel, H. N., Busam, K. J., Kutzner, H., Cho, K.-H., Aiba, S., Bröcker, E.-B., LeBoit, P. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050092 · Cited by 2,747

Defining the Epithelial Stem Cell Niche in Skin

Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031

Efficient tumour formation by single human melanoma cells

Quintana, E., Shackleton, M. J., Sabel, M. S., Fullen, D. R., Johnson, T. M., & Morrison, S. J. (2008) · Nature · doi:10.1038/nature07567 · Cited by 1,836

Somatic Activation of KIT in Distinct Subtypes of Melanoma

Curtin, J. A., BUSAM, K. J., Pinkel, D., & Bastian, B. C. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.2984 · Cited by 1,612

Isolation of multipotent adult stem cells from the dermis of mammalian skin

Toma, J. G., Akhavan, M., Fernandes, K. J. L., Barnabé‐Heider, F., Sadikot, A. F., Kaplan, D. R., & Miller, F. D. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-778 · Cited by 1,593

Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light

Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501

Identification of cells initiating human melanomas

Schatton, T., Murphy, G. F., Frank, N. Y., Yamaura, K., Waaga-Gasser, A. M., Gasser, M., Zhan, Q., Jordan, S., Duncan, L. M., Weishaupt, C., et al. (2008) · Nature · doi:10.1038/nature06489 · Cited by 1,449

Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche

Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428

Intrinsic tumour suppression

Lowe, S. W., Cepero, E., & Evan, G. I. (2004) · Nature · doi:10.1038/nature03098 · Cited by 1,374

Melanoma biology and new targeted therapy

Gray-Schopfer, V., Wellbrock, C., & Marais, R. (2007) · Nature · doi:10.1038/nature05661 · Cited by 1,371

p63 identifies keratinocyte stem cells

Pellegrini, G., Dellambra, E., Golisano, O., Martinelli, E., Fantozzi, I., Bondanza, S., Ponzin, D., McKeon, F., & Luca, M. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061032098 · Cited by 1,359

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317

A tumorigenic subpopulation with stem cell properties in melanomas

Fang, D., Nguyen, T. K., Leishear, K., Finko, R., Kulp, A. N., Hotz, S., Van Belle, P. A., Xu, X., Elder, D. E., & Herlyn, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1343 · Cited by 1,280

STEM CELL NICHE: Structure and Function

Li, L., & Xie, T. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131525 · Cited by 1,268

Tissue repair and stem cell renewal in carcinogenesis

Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,210

Telomeres and Aging

Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998

Notch1 functions as a tumor suppressor in mouse skin

Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C., Clevers, H. C., Dotto, G. P., & Radtke, F. (2003) · Nature Genetics · doi:10.1038/ng1099 · Cited by 969

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

Weeraratna, A. T., Jiang, Y., Hostetter, G. H., Rosenblatt, K. P., Duray, P. H., Bittner, M. L., & Trent, J. M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00045-4 · Cited by 960

Decreased Collagen Production in Chronologically Aged Skin

Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E. G., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051302 · Cited by 910

Dominant role of the niche in melanocyte stem-cell fate determination

Nishimura, E. K., Jordan, S. A., Oshima, H., Yoshida, H., Osawa, M., Moriyama, M., Jackson, I. J., Barrandon, Y., Miyachi, Y., & Nishikawa, S. (2002) · Nature · doi:10.1038/416854a · Cited by 906

Epidermal Stem Cells of the Skin

Blanpain, C., & Fuchs, E. V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 882

Management of Cutaneous Melanoma

Tsao, H., Atkins, M. B., & Sober, A. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041245 · Cited by 869

Basal cell carcinomas: attack of the hedgehog

Epstein, E. H. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2503 · Cited by 843

Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche

Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750

How stem cells age and why this makes us grow old

Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 743

Resveratrol: A review of preclinical studies for human cancer prevention

Athar, M., Back, J. H., Tang, X., KIM, K., Kopelovich, L., Bickers, D. R., & Kim, A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.12.025 · Cited by 733

A dermal niche for multipotent adult skin-derived precursor cells

Fernandes, K. J. L., McKenzie, I. A., Mill, P., Smith, K. M., Akhavan, M., Barnabé‐Heider, F., Biernaskie, J. A., Junek, A., Kobayashi, N., Toma, J. G., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1181 · Cited by 733

Telomerase and cancer therapeutics

Harley, C. B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2275 · Cited by 728

Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation‐induced matrix degradation – a review

Pillai, S., Oresajo, C., & Hayward, J. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.00241.x · Cited by 706

Role of integrins in regulating epidermal adhesion, growth and differentiation

Watt, F. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf399 · Cited by 647

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

Dahmane, N., Lee, J. D., Robins, P., Heller, P., & Altaba, A. R. I. (1997) · Nature · doi:10.1038/39918 · Cited by 639

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

Dhomen, N. S., Reis-Filho, J. S., Dias, S. D. R., Hayward, R., Savage, K., Delmas, V., Larue, L., Pritchard, C. A., & Marais, R. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.022 · Cited by 626

Characterization and isolation of stem cell-enriched human hair follicle bulge cells

Ohyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26043 · Cited by 623

Limb and Skin Abnormalities in Mice Lacking IKKα

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 606

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., METZGER, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W., et al. (2008) · Nature · doi:10.1038/nature06835 · Cited by 597

ABCB5-Mediated Doxorubicin Transport and Chemoresistance in Human Malignant Melanoma

Frank, N. Y., Margaryan, A., Huang, Y. S., Schatton, T., Waaga-Gasser, A. M., Gasser, M., Sayegh, M. H., Sadée, W., & Frank, M. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3327 · Cited by 579

Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34

Morris, R. J., Bortner, C. D., Cotsarelis, G., Reece, J. M., Trempus, C. S., Faircloth, R. S., & Tennant, R. W. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12088.x · Cited by 567

Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential

Monzani, E., Facchetti, F., Galmozzi, E., Corsini, E., Benetti, A., Cavazzin, C., Gritti, A., Piccinini, A., Porro, D., Santinami, M., et al. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.01.017 · Cited by 556

UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer

de Gruijl, F. R., van Kranen, H. J., & Mullenders, L. H. F. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00199-3 · Cited by 549

Looking Older: Fibroblast Collapse and Therapeutic Implications

Fisher, G. J., Varani, J., & Voorhees, J. J. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.5.666 · Cited by 540

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

Stecca, B. A., Mas, C., Clement, V., Zbinden, M., Correa‐Rocha, R., Piguet, V., Beermann, F., & Altaba, A. R. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700776104 · Cited by 535

Endothelial progenitor cells for postnatal vasculogenesis

Asahara, T., & Kawamoto, A. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00330.2003 · Cited by 530

Malignant melanoma: genetics and therapeutics in the genomic eraPreprint

Chin, L., Garraway, L. A., & Fisher, D. E. (2006) · Genes & Development · doi:10.1101/gad.1437206 · Cited by 524

DNA repair is limiting for haematopoietic stem cells during ageing

Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

Scaffidi, P., & Misteli, T. (2008) · Nature Cell Biology · doi:10.1038/ncb1708 · Cited by 518

Vascular wall resident progenitor cells: a source for postnatal vasculogenesis

Zengin, E., Chalajour, F., Gehling, U. M., Ito, W. D., Treede, H., Lauke, H., Weil, J., Reichenspurner, H. C., Kilic, N., & Ergün, S. (2006) · Development · doi:10.1242/dev.02315 · Cited by 477

Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

Rendl, M., Lewis, L. E., & Fuchs, E. V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030331 · Cited by 476

Basal cell carcinoma: biology, morphology and clinical implications

CROWSON, A. N. (2006) · Modern Pathology · doi:10.1038/modpathol.3800512 · Cited by 467

Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies

Mimeault, M., Hauke, R. J., & Batra, S. K. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100301 · Cited by 451

Skin stem cells: rising to the surface

Fuchs, E. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708185 · Cited by 450

Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior

Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448

Sirtuins — novel therapeutic targets to treat age-associated diseases

Lavu, S., Boss, O., Elliott, P. J., & Lambert, P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2665 · Cited by 427

Sox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell Compartment

Vidal, V., Chaboissier, M., Lützkendorf, S., Cotsarelis, G., Mill, P., Hui, C., Ortonne, N., Ortonne, J. P., & Schedl, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.064 · Cited by 427

Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.06.048 · Cited by 426

Conditional telomerase induction causes proliferation of hair follicle stem cells

Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425

Calorie restriction mimetics: an emerging research field

Ingram, D. K., Zhu, M., Mamczarz, J., Zou, S., Lane, M. A., Roth, G. S., & de Cabo, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00202.x · Cited by 424

Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis

Levy, V., Lindon, C., Harfe, B. D., & Morgan, B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.003 · Cited by 419

Major Response to Imatinib Mesylate in KIT-Mutated Melanoma

Hodi, F. S., Friedlander, P. A., Corless, C. L., Heinrich, M. C., Rae, S. M., Kruse, A., Jagannathan, J. P., den Abbeele, A. D. V., Velázquez, E. F., Demetri, G. D., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.0707 · Cited by 418

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

Aszterbaum, M., Epstein, J. H., Oro, A. E., Douglas, V. C., LeBoit, P. E., Scott, M. P., & Epstein, E. H. (1999) · Nature Medicine · doi:10.1038/15242 · Cited by 417

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

Gray-Schopfer, V. C., Cheong, S. C., Chong, H., Chow, J., Moss, T., Abdel-Malek, Z. A., Marais, R., Wynford-Thomas, D., & Bennett, D. C. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603283 · Cited by 394

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

Cooper, M. K., Wassif, C. A., Krakowiak, P. A., Taipale, J., Gong, R., Kelley, R. I., Porter, F. D., & Beachy, P. A. (2003) · Nature Genetics · doi:10.1038/ng1134 · Cited by 390

Pluripotent neural crest stem cells in the adult hair follicle

Sieber‐Blum, M., Grim, M., Hu, Y. F., & Szeder, V. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20129 · Cited by 388

Epidermal stem cells arise from the hair follicle after wounding

Levy, V., Lindon, C., Zheng, Y., Harfe, B. D., & Morgan, B. A. (2007) · The FASEB Journal · doi:10.1096/fj.06-6926com · Cited by 386

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationPreprint

Nguyen, B.-C., Lefort, K., Mandinova, A., Antonini, D., Devgan, V., Gatta, G. D., Koster, M. I., Zhang, Z., Wang, J., di Vignano, A. T., et al. (2006) · Genes & Development · doi:10.1101/gad.1406006 · Cited by 384

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

Nilsson, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050467397 · Cited by 378

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

Wong, K.-K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W., & DePinho, R. A. (2003) · Nature · doi:10.1038/nature01385 · Cited by 375

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., et al. (2005) · Genomics · doi:10.1016/j.ygeno.2004.11.003 · Cited by 367

Ultraviolet radiation and skin cancer: molecular mechanisms

Hussein, M. R. (2005) · Journal of Cutaneous Pathology · doi:10.1111/j.0303-6987.2005.00281.x · Cited by 356

Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)

Ingraham, C. R., Kinoshita, A., Kondo, S., Yang, B., Sajan, S. A., Trout, K. J., Malik, M., Dunnwald, M., Goudy, S. L., Lovett, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1903 · Cited by 356

The interaction between FOXO and SIRT1: tipping the balance towards survival

Giannakou, M. E., & Partridge, L. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.07.006 · Cited by 354

The longest telomeres: a general signature of adult stem cell compartments

Flores, I., Canela, A., Vera, E., Tejera, A., Cotsarelis, G., & Blasco, M. A. (2008) · Genes & Development · doi:10.1101/gad.451008 · Cited by 352

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

González-Suárez, E., Samper, E., Flores, J. M., & Blasco, M. A. (2000) · Nature Genetics · doi:10.1038/79089 · Cited by 347

Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

Yu, H., Fang, D., Kumar, S., Li, L., Nguyen, T. K., Ács, G., Herlyn, M., & Xu, X. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051170 · Cited by 341

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

Nilsson, M., Undén, A. B., Krause, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3438 · Cited by 338

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

Choi, J., Southworth, L. K., Sarin, K. Y., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M. K., Shah, N., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040010 · Cited by 336

Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.

Bartolazzi, A., Peach, R., Aruffo, A. A., & Stamenkovic, I. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.53 · Cited by 331

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

Richardson, R. J., Dixon, J., Malhotra, S., Hardman, M. J., Knowles, L., Boot-Handford, R., Shore, P., Whitmarsh, A. J., & Dixon, M. J. (2006) · Nature Genetics · doi:10.1038/ng1894 · Cited by 325

Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves

Amoh, Y., Li, L., Campillo, R., Kawahara, K., Katsuoka, K., Penman, S., & Hoffman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508440102 · Cited by 322

A Highly Enriched Niche of Precursor Cells with Neuronal and Glial Potential Within the Hair Follicle Dermal Papilla of Adult Skin

Hunt, D. P. J., Morris, P. N., Sterling, J. C., Anderson, J. A., Joannides, A. J., Jahoda, C. A. B., Compston, A., & Chandran, S. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0281 · Cited by 322

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

Jensen, K. B., & Watt, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601886103 · Cited by 321

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

Bijlsma, M. F., Spek, C. A., Živković, D., van de Water, S., Rezaee, F., & Peppelenbosch, M. P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040232 · Cited by 321

Genetics of melanoma predisposition

Hayward, N. K. (2003) · Oncogene · doi:10.1038/sj.onc.1206445 · Cited by 320

Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin

Wong, C. E., Paratore, C., Dours-Zimmermann, M. T., Rochat, A., Pietri, T., Suter, U., Zimmermann, D. R., Dufour, S., Thiery, J. P., Meijer, D., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606062 · Cited by 318

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinasesPreprint

Lefort, K., Mandinova, A., Ostano, P., Kolev, V. N., Calpini, V., Kolfschoten, I., Devgan, V., Lieb, J., Raffoul, W., Hohl, D., et al. (2007) · Genes & Development · doi:10.1101/gad.1484707 · Cited by 313

The genetics of malignant melanoma: lessons from mouse and man

Chin, L. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1145 · Cited by 312

SP analysis may be used to identify cancer stem cell populations

Hadnagy, A., Gaboury, L. A., Beaulieu, R., & Balicki, D. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.08.030 · Cited by 310

Increased expression of stem cell markers in malignant melanoma

Klein, W. M., Wu, B. P., Zhao, S., Wu, H. G., Klein–Szanto, A. J., & Tahan, S. R. (2006) · Modern Pathology · doi:10.1038/modpathol.3800720 · Cited by 309

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient Background

Ackermann, J., Frutschi, M., Kaloulis, K., McKee, T., Trumpp, A., & Beermann, F. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2970 · Cited by 308

Identification of Mutations in the Human PATCHED Gene in Sporadic Basal Cell Carcinomas and in Patients with the Basal Cell Nevus Syndrome

Aszterbaum, M., Rothman, A., Fisher, M. P., Xie, J., Bonifas, J. M., Zhang, X., Epstein, E. H., Johnson, R. L., & Scott, M. P. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00222.x · Cited by 306

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