The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The role of dopamine in reward and pleasure behaviour – review of data from preclinical research
Abstract
Objective: The purpose of this article is to review some of the basic aspects of the dopaminergic system and its role in reward and pleasure behaviour. We also discuss the association between dopamine and unpleasant symptoms that are commonly found in neuropsychiatric disorders and may also be side‐effects of neuroleptic drugs. Method: A computer‐based search of the literature, augmented by extensive bibliography‐guided article reviews, were used to find basic information on the dopamine and the reward systems, and symptoms such as dysphoria, anhedonia and depression. Results: Central dopaminergic neurotransmission is complex, having multiple actions at each level of the mesocorticolimbic reward pathway. The role of dopamine in the reward process was classically associated with the ability to experience pleasure; recent data suggest a more motivational role. Dysfunction of the dopamine transmission in the reward circuit is associated with symptoms such as anhedonia, apathy and dysphoria found in several neuropsychiatric disorders, including Parkinson's disease, depression, drug addiction, and neuroleptic‐induced dysphoria. Conclusion: Viewing the dysfunctions of the reward pathways within a broader spectrum and exploring its complex relations with the dopaminergic transmission may help understand the pathophysiology of these neuropsychiatric disorders and lead to a rational development of novel treatments.
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Cites
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Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies
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Nature's clocks and human mood: the circadian system modulates reward motivation
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Wichers, M. C., Barge-Schaapveld, D. Q. C. M., Nicolson, N. A., Peeters, F., de Vries, M., Mengelers, R., & van Os, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.66 · Cited by 139
Mapping inflammation onto mood: inflammatory mediators of anhedonia
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.017 · Cited by 125
Pharmacological interventions for apathy in Alzheimer's disease
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Anhedonia and amotivation in psychiatric outpatients with fully remitted stimulant use disorder
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Genetically determined dopamine availability predicts disposition for depression
Felten, A., Montag, C., Markett, S., Walter, N. T., & Reuter, M. (2011) · Brain and Behavior · doi:10.1002/brb3.20 · Cited by 54
“Moreover, DA neurotransmission is implicated in the regulation of reward and cognitive processes (Bressan and Crippa 2005; Yacubian and Buchel 2009).”
BackgroundTargeting the dopamine system in the treatment of attention-deficit/hyperactivity disorder
Staller, J. A., & Faraone, S. V. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.4.351 · Cited by 44
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Pharmacotherapy of Depressed Children and Adolescents: Current Issues and Potential Directions
Vasa, R. A., Carlino, A. R., & Pine, D. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.010 · Cited by 29
Marszalek-Grabska, M., Gibula-Bruzda, E., Jenda, M., Gawel, K., & Kotlinska, J. H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.026 · Cited by 22
Pérez de la Mora, M., Borroto-Escuela, D. O., Crespo-Ramírez, M., Rejón-Orantes, J. D. C., Palacios-Lagunas, D. A., Martínez-Mata, M. K., Sánchez-Luna, D., Tesoro-Cruz, E., & Fuxe, K. (2022) · Cells · doi:10.3390/cells11111826 · Cited by 21
Moses, T. E. H., & Javanbakht, A. (2023) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001636 · Cited by 4
Metadata
- Authors
- Bressan, R. A., & Crippa, J. A.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2005-05-05
- Volume
- 111
- Issue
- s427
- Pages
- 14-21
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2073571522
- Cited by
- 254
- References
- 5
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
