Low episodic memory performance as a premorbid marker of depression: evidence from a 3‐year follow‐up
Abstract
Objective: To examine low episodic memory scores as a potential risk factor for depression. Method: A population‐based sample of non‐depressed individuals (20–64 years) were re‐examined 3 years after an initial screening (n = 708). At baseline, information on episodic memory scores, demographic and socioeconomic factors, alcohol use and anxiety diagnoses was collected. The data for depression diagnoses were collected at both baseline and follow‐up. Results: Logistic regressions, conducted on three separate study groups that were defined according to three assessments of episodic memory (i.e. free + cued recall, free recall, cued recall) among individuals who scored in the 25 lowest or highest percentiles in the memory tests, revealed that low episodic memory performance defined as the sum of free and cued recalls of organizable words constitutes a risk of depression diagnosis 3 years later. Conclusion: Low episodic memory performance predated depressive diagnosis and might be considered as a premorbid marker of depression.
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Preliminary evidence suggests that cognitive impairment may pre-date the onset of clinically significant depressive symptoms.
“Furthermore, preliminary evidence suggests that cognitive impairment may even pre-date the onset of clinically significant depressive symptoms.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [41]
Poor performance in tests of episodic memory may predict the onset of depressive symptoms.
“Different population-based studies have suggested that poor performance in tests of episodic memory may predict the onset of depressive symptoms [26, 41].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [41]
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- Authors
- Airaksinen, E., Wahlin, Å., Forsell, Y., & Larsson, M.
- Affiliations
- Karolinska Institutet (SE)
- Stockholm University (SE)
- Corresponding author
- Airaksinen, E.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2007-04-05
- Volume
- 115
- Issue
- 6
- Pages
- 458-465
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2167880618
- Cited by
- 74
- References
- 31
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 2 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Identity, Memory, and Therapy
- Keywords
- episodic memory, depression, risk factors, free recall, cued recall, word recall, longitudinal follow-up, alcohol consumption, anxiety
- MeSH terms
- Adult, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Memory Disorders, Middle Aged, Population Surveillance, Mental Recall, Severity of Illness Index, Biomarkers, Diagnostic and Statistical Manual of Mental Disorders
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