The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders
Open accessAbstract
Objective: Trauma‐exposed individuals with post‐traumatic stress disorder (PTSD) display reduced amygdala and hippocampal size and impaired cognition. However, studies on trauma‐exposed individuals with dissociative amnesia (DA) or dissociative identity disorder (DID) are lacking. Method: Twenty‐three young women who had experienced severe childhood sexual/physical abuse, diagnosed with DA/DID or PTSD, and 25 healthy control subjects were subjected to 3D structural magnetic resonance imaging of amygdala and hippocampus and a clinical and neuropsychological investigation. Results: Compared with controls, trauma‐exposed subjects with PTSD ( n = 10) displayed significantly reduced amygdala and hippocampal size and significantly impaired cognition. By contrast, trauma‐exposed subjects with DA or DID ( n = 13) displayed normal amygdala and hippocampal size and normal cognition. Conclusion: We report for the first time volumetric results in subjects with DA/DID without PTSD as comorbid diagnosis. Our results indicate preserved amygdala and hippocampal size and preserved cognition in subjects with these disorders.
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“In DID, reduced volumes in the amygdala and hippocampus [94, 95] and parahippocampus [95] were found, although discrepant findings of normal amygdala and hippocampal volumes compared to healthy controls were also reported [96].”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [96]
Citations
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Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
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Metadata
- Authors
- Weniger, G., Lange, C., Sachsse, U., & Irle, E.
- Affiliations
- University of Zurich (CH)
- University of Göttingen (DE)
- Corresponding author
- Irle, E.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2008-09-10
- Volume
- 118
- Issue
- 4
- Pages
- 281-290
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2046297778
- Cited by
- 140
- References
- 46
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 8 · 2012: 15
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- amygdala volume, hippocampal volume, dissociative amnesia, dissociative identity disorder, child sexual abuse, child physical abuse, post-traumatic stress disorder, dissociative disorders, cognitive impairment, brain structure, trauma exposure
- MeSH terms
- Adult, Amygdala, Cognition, Cognition Disorders, Dissociative Disorders, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Neuropsychological Tests, Organ Size, Stress Disorders, Post-Traumatic, Imaging, Three-Dimensional, Adult Survivors of Child Abuse
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