Cited by 140Psychosomatic Disorders and Their TreatmentsPosttraumatic Stress Disorder ResearchChild Abuse and Trauma

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Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders

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Weniger, G., Lange, C., Sachsse, U., Irle, E.·2008·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2008.01246.x

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Abstract

Objective: Trauma‐exposed individuals with post‐traumatic stress disorder (PTSD) display reduced amygdala and hippocampal size and impaired cognition. However, studies on trauma‐exposed individuals with dissociative amnesia (DA) or dissociative identity disorder (DID) are lacking. Method: Twenty‐three young women who had experienced severe childhood sexual/physical abuse, diagnosed with DA/DID or PTSD, and 25 healthy control subjects were subjected to 3D structural magnetic resonance imaging of amygdala and hippocampus and a clinical and neuropsychological investigation. Results: Compared with controls, trauma‐exposed subjects with PTSD ( n = 10) displayed significantly reduced amygdala and hippocampal size and significantly impaired cognition. By contrast, trauma‐exposed subjects with DA or DID ( n = 13) displayed normal amygdala and hippocampal size and normal cognition. Conclusion: We report for the first time volumetric results in subjects with DA/DID without PTSD as comorbid diagnosis. Our results indicate preserved amygdala and hippocampal size and preserved cognition in subjects with these disorders.

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Authors: Weniger, G., Lange, C., Sachsse, U., & Irle, E.
Affiliations: University of Zurich (CH)
University of Göttingen (DE)
Corresponding author: Irle, E.
ORCID: Weniger, G.
Lange, C.
Sachsse, U.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2008-09-10
Volume: 118
Issue: 4
Pages: 281-290
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/j.1600-0447.2008.01246.x
OpenAlex: W2046297778
Cited by: 140
References: 46
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 8 · 2012: 15
FWCI: 5.37
Type: journal article
Language: en
Open access: green
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: amygdala volume, hippocampal volume, dissociative amnesia, dissociative identity disorder, child sexual abuse, child physical abuse, post-traumatic stress disorder, dissociative disorders, cognitive impairment, brain structure, trauma exposure
MeSH terms: Adult, Amygdala, Cognition, Cognition Disorders, Dissociative Disorders, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Neuropsychological Tests, Organ Size, Stress Disorders, Post-Traumatic, Imaging, Three-Dimensional, Adult Survivors of Child Abuse

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Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders

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