A review of longitudinal studies of cognitive functions in schizophrenia patients

Rund, B. R.

doi:10.1093/oxfordjournals.schbul.a033337

Cited by 451Schizophrenia research and treatmentMental Health and PsychiatryDementia and Cognitive Impairment Research

A review of longitudinal studies of cognitive functions in schizophrenia patients

Rund, B. R.·1998·Schizophrenia Bulletin

DOI 10.1093/oxfordjournals.schbul.a033337

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Abstract

Even though the idea that schizophrenia is a neurobehavioral syndrome has become a mainstream position, there is no consensus on the precise nature of the cognitive and neuropsychological impairment. Research on cognitive dysfunctions in schizophrenia has been directed toward discriminating stable dysfunctions (traits) from symptom-linked (state) deficits. A longitudinal study design is the only one that can provide answers to the question of the stability of psychological functions. This article reviews 15 studies with a followup of at least a year. The main conclusion drawn from these studies is that after the onset of schizophrenia, cognitive deficits are relatively stable over long periods. No support for a decline in cognitive functions is found. Thus, schizophrenia does not appear to be a degenerative process, but rather a static encephalopathy. Whether or not the cognitive deficits found in schizophrenia can be remediated is still an open question that needs to be examined.

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Cognitive impairments are generally stable over relatively short periods of time in the longitudinal course of schizophrenia.
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Authors: Rund, B. R.
Affiliations: University of Oslo (NO)
Corresponding author: Rund, B. R.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 1998-01-01
Volume: 24
Issue: 3
Pages: 425-435
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/oxfordjournals.schbul.a033337
OpenAlex: W2146082988
Cited by: 451
References: 70
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 8 · 2019: 32 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 20 · 2012: 24
FWCI: 11.25
Type: journal article
Language: en
Open access: closed
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: schizophrenia, cognitive impairment
MeSH terms: Cognition Disorders, Humans, Longitudinal Studies, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Disease Progression

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A review of longitudinal studies of cognitive functions in schizophrenia patients

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