Java project on periodontal diseases: The relationship between vitamin C and the severity of periodontitis
Open accessAbstract
OBJECTIVE: To study the relationship between vitamin C and the severity of periodontitis. MATERIAL AND METHODS: The study population consisted of subjects from the Malabar/Purbasari tea estate on West Java, Indonesia. In 2002, clinical measurements were performed in 128 subjects, including evaluation of plaque, bleeding on probing, pocket depth and attachment loss. In 2005, 123 out of 128 subjects could be retrieved who were present at the examination of 2002. Blood samples were taken to measure plasma vitamin C levels. Information about the subject's dietary habit was obtained by means of a personal interview guided by a questionnaire. RESULTS: Plasma levels of vitamin C ranged from 0.02 to 34.45 mg/l with a mean of 7.90 mg/l (+/-5.35). The correlation coefficient between plasma vitamin C level and periodontal attachment loss was -0.199 (p<0.05); stepwise linear regression revealed that vitamin C levels explained 3.9% of the variance in periodontal attachment loss. Subjects with vitamin C deficiency (14.7% of the study population) had more attachment loss compared with those with depletion or normal plasma vitamin C values. CONCLUSION: The negative association between plasma vitamin C levels and periodontal attachment loss suggests that vitamin C deficiency may contribute to the severity of periodontal breakdown.
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Several cross-sectional studies indicate low serum vitamin C values and lower vitamin C intake in subjects with periodontitis compared with controls.
“Several cross-sectional studies have indicated low serum vitamin C values and lower vitamin C intake in subjects with periodontitis compared with controls [39,104].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [39]
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- Authors
- Amaliya, Timmerman, M. F., Abbas, F., Loos, B. G., Van der Weijden, G. A., Van Winkelhoff, A. J., Winkel, E. G., & Van der Velden, U.
- Affiliations
- Padjadjaran University (ID)
- Academic Center for Dentistry Amsterdam (NL)
- University Medical Center Groningen (NL)
- Venue
- Journal Of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2007-03-16
- Volume
- 34
- Issue
- 4
- Pages
- 299-304
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2132663528
- Cited by
- 115
- References
- 44
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 8
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal Of Clinical Periodontology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- VU Research Portal (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Universitas Padjadjaran
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, periodontitis, periodontal attachment loss, plasma vitamin C levels, scurvy, periodontal disease severity, tea plantation workers, dietary habits
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Ascorbic Acid Deficiency, Diet Surveys, Female, Humans, Indonesia, Male, Periodontal Index, Periodontitis, Linear Models, Periodontal Attachment Loss
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