Cited by 154Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsDental Health and Care Utilization

Effect of micronutrient malnutrition on periodontal disease and periodontal therapy

Dommisch, Henrik, Kuzmanova, Denica, Jönsson, Daniel, Grant, Melissa, Chapple, Iain·2018·Periodontology 2000

Abstract

Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilm is a "necessary cause" of periodontitis, it is insufficient on its own to cause the disease, and a destructive immune-inflammatory response is a key to the translation of risk to destructive events. Other exposures or "component causes" include individual genetic predisposition, lifestyle (including smoking and nutrition), and environmental factors. Dietary nutrients are essential for life as they provide crucial energy sources in the form of macronutrients, as well as important cofactors in the form of micronutrients, which regulate the functionality of enzymes during the regulation of anabolic and catabolic processes in human cells. Moreover, micronutrients can regulate gene transcription factors, such as the proinflammatory nuclear factor kappa B and the anti-inflammatory nuclear factor (erythroid-derived 2)-like 2. This review focuses on the role of vitamins (vitamin A, carotenoids, the vitamin B complex, vitamins C, D, and E, and coenzyme Q10) and minerals (calcium, magnesium, iron, zinc, potassium, copper, manganese, and selenium) in human physiology and the impact of their deficiencies upon periodontal health and disease.

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Crossref · 10.1111/prd.12233

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Authors
Dommisch, H., Kuzmanova, D., Jönsson, D., Grant, M., & Chapple, I.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • Malmö University (SE)
  • University of Birmingham (GB)
Corresponding author
Chapple, Iain
Venue
Periodontology 2000
Publisher
Wiley
Published
2018-09-09
Volume
78
Issue
1
Pages
129-153
ISSN
  • 0906-6713 (ISSN-L)
  • 1600-0757
OpenAlex
W2891658811
Cited by
154
References
223
Citations by year
2026: 14 · 2025: 21 · 2024: 23 · 2023: 33 · 2022: 18 · 2021: 21 · 2020: 10 · 2019: 12 · 2018: 1
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Locations
  • Periodontology 2000 (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
  • Malmö University Publications (Malmö University) (submittedVersion)
Funders
Swedish Dental Public Service, Skåne
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
Keywords
micronutrient deficiency, periodontitis, periodontal treatment, vitamins, minerals, NF-κB, Nrf2, inflammation, oral microbiota, dietary nutrients, periodontal health
MeSH terms
Diet, Humans, Minerals, Periodontal Diseases, Vitamins, Micronutrients, Malnutrition, Nutrigenomics, Phytochemicals

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