Effect of micronutrient malnutrition on periodontal disease and periodontal therapy
Abstract
Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilm is a "necessary cause" of periodontitis, it is insufficient on its own to cause the disease, and a destructive immune-inflammatory response is a key to the translation of risk to destructive events. Other exposures or "component causes" include individual genetic predisposition, lifestyle (including smoking and nutrition), and environmental factors. Dietary nutrients are essential for life as they provide crucial energy sources in the form of macronutrients, as well as important cofactors in the form of micronutrients, which regulate the functionality of enzymes during the regulation of anabolic and catabolic processes in human cells. Moreover, micronutrients can regulate gene transcription factors, such as the proinflammatory nuclear factor kappa B and the anti-inflammatory nuclear factor (erythroid-derived 2)-like 2. This review focuses on the role of vitamins (vitamin A, carotenoids, the vitamin B complex, vitamins C, D, and E, and coenzyme Q10) and minerals (calcium, magnesium, iron, zinc, potassium, copper, manganese, and selenium) in human physiology and the impact of their deficiencies upon periodontal health and disease.
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Daily intake of heat-inactivated L. plantarum L-137 (HK L-137) can reduce periodontal pocket depth in patients receiving supportive periodontal therapy.
“The results of the study indicate that daily intake of HK L-137 can reduce periodontal pocket depth in patients receiving supportive periodontal therapy [139,140].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [139]
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Periodontal Disease: The Good, The Bad, and The Unknown
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- Authors
- Dommisch, H., Kuzmanova, D., Jönsson, D., Grant, M., & Chapple, I.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Malmö University (SE)
- University of Birmingham (GB)
- Corresponding author
- Chapple, Iain
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2018-09-09
- Volume
- 78
- Issue
- 1
- Pages
- 129-153
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W2891658811
- Cited by
- 154
- References
- 223
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 23 · 2023: 33 · 2022: 18 · 2021: 21 · 2020: 10 · 2019: 12 · 2018: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Periodontology 2000 (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Malmö University Publications (Malmö University) (submittedVersion)
- Funders
- Swedish Dental Public Service, Skåne
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- micronutrient deficiency, periodontitis, periodontal treatment, vitamins, minerals, NF-κB, Nrf2, inflammation, oral microbiota, dietary nutrients, periodontal health
- MeSH terms
- Diet, Humans, Minerals, Periodontal Diseases, Vitamins, Micronutrients, Malnutrition, Nutrigenomics, Phytochemicals
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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