The diagnostic uses of saliva
Abstract
It is becoming increasingly apparent to investigators and clinicians in a variety of disciplines that saliva has many diagnostic uses and is especially valuable in the young, the old and infirm and in large scale screening and epidemiologic studies. The highly sensitive test procedures that are now commonplace makes it practical to quantitate, despite very low concentrations, a large number of hormones and drugs in saliva. Indeed, all steroids of diagnostic significance in routine clinical endocrinology can now be readily measured in saliva. Drug monitoring can include abusive as well as therapeutic agents. The concordance between anti HIV antibodies in saliva and serum has stimulated application to various other antiviral antibodies as well as to viral antigens per se. Saliva has found use as a diagnostic aid in an increasing number of clinical situations and in systemic diseases that can affect salivary gland function and composition such as Sjögren's syndrome, cystic fibrosis and diseases of the adrenal cortex. The list keeps growing.
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Saliva is a complex oral fluid, produced mainly by the parotid gland and composed of numerous constituents, such as metabolites, enzymes, hormones, proteins, microorganisms and ions.
“Saliva is a complex oral fluid, which is produced mainly by the parotid gland and is composed of numerous constituents, such as metabolites, enzymes, hormones, proteins, microorganisms and ions125,135-140.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [139]
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Wearable biosensors for healthcare monitoring
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- Authors
- Mandel, I. D.
- Affiliations
- Columbia University (US)
- Corresponding author
- Mandel, Irwin D.
- Venue
- Journal of Oral Pathology & Medicine
- Publisher
- Wiley
- Published
- 1990-03
- Volume
- 19
- Issue
- 3
- Pages
- 119-125
- ISSN
- 0300-9777 (ISSN-L)
- 0904-2512
- 1600-0714
- OpenAlex
- W2096271678
- Cited by
- 305
- References
- 91
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 20 · 2014: 12 · 2013: 16 · 2012: 18
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Oral Pathology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Keywords
- saliva diagnostics, salivary hormones, steroid hormone measurement, drug monitoring, drug abuse, HIV antibodies, antiviral antibodies, viral antigens, Sjögren's syndrome, cystic fibrosis, adrenal cortex diseases, salivary gland dysfunction
- MeSH terms
- Diagnosis, Oral, Disease, Pharmaceutical Preparations, Humans, Saliva
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