Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night: Circadian breast cancer control by melatonin
Open accessAbstract
This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular, dietary, and metabolic signaling mechanisms involved in human breast cancer growth and the consequences of circadian disruption by exposure to light at night (LAN). The antiproliferative effects of the circadian melatonin signal are mediated through a major mechanism involving the activation of MT(1) melatonin receptors expressed in human breast cancer cell lines and xenografts. In estrogen receptor (ERα+) human breast cancer cells, melatonin suppresses both ERα mRNA expression and estrogen-induced transcriptional activity of the ERα via MT(1) -induced activation of G(αi2) signaling and reduction of 3',5'-cyclic adenosine monophosphate (cAMP) levels. Melatonin also regulates the transactivation of additional members of the steroid hormone/nuclear receptor super-family, enzymes involved in estrogen metabolism, expression/activation of telomerase, and the expression of core clock and clock-related genes. The anti-invasive/anti-metastatic actions of melatonin involve the blockade of p38 phosphorylation and the expression of matrix metalloproteinases. Melatonin also inhibits the growth of human breast cancer xenografts via another critical pathway involving MT(1) -mediated suppression of cAMP leading to blockade of linoleic acid uptake and its metabolism to the mitogenic signaling molecule 13-hydroxyoctadecadienoic acid (13-HODE). Down-regulation of 13-HODE reduces the activation of growth factor pathways supporting cell proliferation and survival. Experimental evidence in rats and humans indicating that LAN-induced circadian disruption of the nocturnal melatonin signal activates human breast cancer growth, metabolism, and signaling provides the strongest mechanistic support, thus far, for population and ecological studies demonstrating elevated breast cancer risk in night shift workers and other individuals increasingly exposed to LAN.
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Insomnia is associated with deleterious consequences, including heightened fatigue and pain sensitivity, and reduced quality of life and immune functioning.
“Insomnia has been associated with deleterious consequences, including heightened fatigue and pain sensitivity, and reduced quality of life and immune functioning. 7,8”
From Digital Cognitive-Behavioral Therapy for Insomnia in Cancer Survivors: Protocol for a Pragmatic Clinical Trial (2024) · cites this paper as [8]
The Introduction and Summary and Conclusions discuss circadian disruption, melatonin, and breast cancer growth or risk, not the consequences of insomnia described in the claim. Searches for insomnia, fatigue, pain sensitivity, quality of life, and immune functioning found no passage in our copy addressing those associations. No page numbers were provided for the indexed passages. (LLM, conf=0.76)
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Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,256 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142 · see citing works
Carcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082 · see citing works
The basic physiology and pathophysiology of melatonin
Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951 · see citing works
Night Shift Work, Light at Night, and Risk of Breast Cancer
Davis, S., Mirick, D. K., & Stevens, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1557 · Cited by 930 · see citing works
Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors
Guillaumond, F., Dardente, H., Giguère, V., & Cermakian, N. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277232 · Cited by 762 · see citing works
Melatonin: The chemical expression of darkness
Reiter, R. J. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90087-9 · Cited by 634 · see citing works
Increased breast cancer risk among women who work predominantly at night
Hansen, J. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00013 · Cited by 503 · see citing works
ELECTRIC POWER USE AND BREAST CANCER: A HYPOTHESIS
Stevens, R. G. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114569 · Cited by 502 · see citing works
Melatonin, sleep disturbance and cancer risk
Blask, D. E. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.007 · Cited by 452 · see citing works
Self-citationHill, S. M., & Blask, D. E. (1988) · PubMed · Cited by 442 · see citing works
Self-citationBlask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 431 · see citing works
Self-citationEffects of Chronic Jet Lag on Tumor Progression in Mice
Filipski, E., Delaunay, F., King, V. M., Wu, M., Claustrat, B., Gréchez‐Cassiau, A., Guettier, C., Hastings, M. H., & Lévi, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0674 · Cited by 416 · see citing works
The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer
Liu, T., Liu, P. Y., & Marshall, G. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3365 · Cited by 384 · see citing works
Blask, D. E., Sauer, L. A., & Dauchy, R. T. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394407 · Cited by 381 · see citing works
Self-citationStevens, R. G., Blask, D. E., Brainard, G. C., Hansen, J., Lockley, S. W., Provencio, I., Rea, M. S., & Reinlib, L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10200 · Cited by 357 · see citing works
Self-citationLight-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345 · see citing works
Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins
Brydon, L., Roka, F., Petit, L., de Coppet, P., Tissot, M., Barrett, P., Morgan, P. J., Nanoff, C., Strosberg, A. D., & Jockers, R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0390 · Cited by 281 · see citing works
Stevens, R. G., & Rea, M. S. (2001) · Cancer Causes & Control · doi:10.1023/a:1011237000609 · Cited by 245 · see citing works
Putting Cancer to Sleep at Night: The Neuroendocrine/Circadian Melatonin Signal
Blask, D. E., Dauchy, R. T., & Sauer, L. A. (2005) · Endocrine · doi:10.1385/endo:27:2:179 · Cited by 238 · see citing works
Self-citationA sense of time: how molecular clocks organize metabolism
Kohsaka, A., & Bass, J. T. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.005 · Cited by 233 · see citing works
Melatonin–estrogen interactions in breast cancer
Sánchez‐Barceló, E. J., Cos, S., Mediavilla, D., Martínez‐Campa, C., González, A., & Alonso‐González, C. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00207.x · Cited by 229 · see citing works
Telomere dysfunction and the initiation of genome instability
Feldser, D. M., Hackett, J. A., & Greider, C. W. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1142 · Cited by 223 · see citing works
Tan, M., Yao, J., & Yu, D. (1997) · PubMed · Cited by 222 · see citing works
Blask, D. E., Sauer, L. A., Dauchy, R. T., Holowachuk, E. W., Ruhoff, M. S., & Kopff, H. S. (1999) · PubMed · Cited by 198 · see citing works
Self-citationKim, M., Lee, E.-J., Kim, H.-R. C., & Moon, A. (2003) · PubMed · Cited by 190 · see citing works
Urinary Melatonin Levels and Breast Cancer Risk
Schernhammer, E. S., & Hankinson, S. E. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji190 · Cited by 183 · see citing works
Estrogen-signaling pathway: A link between breast cancer and melatonin oncostatic actions
Cos, S., González, A., Martínez‐Campa, C., Mediavilla, M. D., Alonso‐González, C., & Sánchez‐Barceló, E. J. (2006) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2006.03.002 · Cited by 174 · see citing works
Molecular Mechanisms of Melatonin Anticancer Effects
Hill, S. M., Frasch, T., Xiang, S., Yuan, L., Duplessis, T., & Mao, L. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409353332 · Cited by 168 · see citing works
Self-citationMao, L., Yuan, L., Slakey, L. M., Jones, F. E., Burow, M. E., & Hill, S. M. (2010) · Breast Cancer Research · doi:10.1186/bcr2794 · Cited by 160 · see citing works
Self-citationNighttime light level co-distributes with breast cancer incidence worldwide
Kloog, I., Stevens, R. G., Haim, A., & Portnov, B. A. (2010) · Cancer Causes & Control · doi:10.1007/s10552-010-9624-4 · Cited by 159 · see citing works
Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells.
Molis, T. M., Spriggs, L. L., & Hill, S. M. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.12.7708056 · Cited by 159 · see citing works
Self-citationCos, S., Blask, D. E., Lemus-Wilson, A. M., & Hill, A. B. (1991) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1991.tb00007.x · Cited by 155 · see citing works
Self-citationWitt‐Enderby, P. A., Radio, N. M., Doctor, J. S., & Davis, V. L. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00369.x · Cited by 150 · see citing works
Yuan, L., Collins, A., Dai, J., Dubocovich, M. L., & Hill, S. M. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00029-1 · Cited by 142 · see citing works
Self-citationMelatonin inhibits telomerase activity in the MCF‐7 tumor cell line both in vivo and in vitro
Leon-Blanco, M. M., Guerrero, J. M., Reiter, R. J., Calvo, J. R., & Pozo, D. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00077.x · Cited by 141 · see citing works
Metabolic homeostasis in mice with disruptedClockgene expression in peripheral tissues
Kennaway, D. J., Owens, J. A., Voultsios, A., Boden, M. J., & Varcoe, T. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00018.2007 · Cited by 140 · see citing works
Melatonin, an Endogenous-specific Inhibitor of Estrogen Receptor α via Calmodulin
del Río, B., Garcia-Pedrero, J. M., Martínez‐Campa, C., Zuazua, P., Lazo, P. S., & Ramos, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403140200 · Cited by 139 · see citing works
Cailotto, C., Lei, J., van der Vliet, J., Heijningen, C. L. V., van Eden, C. G., Kalsbeek, A., Pévet, P., & Buijs, R. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005650 · Cited by 133 · see citing works
Heselmeyer‐Haddad, K., Janz, V., Castle, P. E., Chaudhri, N., White, N. M. A., Wilber, K., Morrison, L. E., Auer, G., Burroughs, F. H., Sherman, M. E., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63498-0 · Cited by 123 · see citing works
The days and nights of cancer cells.
Canaple, L., Kakizawa, T., & Laudet, V. (2003) · PubMed · Cited by 110 · see citing works
Urinary 6-Sulfatoxymelatonin Levels and Risk of Breast Cancer in Postmenopausal Women
Schernhammer, E. S., Berrino, F., Krogh, V., Secreto, G., Micheli, A., Venturelli, E., Sieri, S., Sempos, C. T., Cavalleri, A., Schünemann, H. J., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn171 · Cited by 101 · see citing works
Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors
Ram, P. T., Kiefer, T. L., Silverman, M. R., et al. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00095-1 · Cited by 100 · see citing works
Sauer, L. A., Dauchy, R. T., & Blask, D. E. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00634-7 · Cited by 97 · see citing works
Self-citationModulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells
Molis, T. M. (1994) · Molecular Endocrinology · doi:10.1210/me.8.12.1681 · Cited by 96 · see citing works
Cos, S., González, A., Güezmes, A., Mediavilla, M. D., Martínez‐Campa, C., Alonso‐González, C., & Sánchez‐Barceló, E. J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21401 · Cited by 92 · see citing works
Dauchy, R. T., Blask, D. E., Sauer, L. A., Brainard, G. C., & Krause, J. A. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00207-4 · Cited by 85 · see citing works
Self-citationDaily coordination of cancer growth and circadian clock gene expression
You, S., Wood, P. A., Xiong, Y., Kobayashi, M., Du‐Quiton, J., & Hrushesky, W. J. M. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-6603-z · Cited by 85 · see citing works
Dauchy, R. T., Sauer, L. A., Blask, D. E., & Vaughan, G. M. (1997) · PubMed · Cited by 78 · see citing works
Self-citationCollins, A., Yuan, L., Kiefer, T. L., Cheng, Q., Lai, L., & Hill, S. M. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00502-5 · Cited by 78 · see citing works
Self-citationModulation of intracellular calcium and calmodulin by melatonin in MCF‐7 human breast cancer cells
Dai, J., Inscho, E. W., Yuan, L., et al. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.1844.x · Cited by 75 · see citing works
Self-citationCXCR4 is Expressed in Ductal Carcinoma in situ of the Breast and in Atypical Ductal Hyperplasia
Schmid, B. C., Rudas, M., Rezniczek, G. A., Leodolter, S., & Zeillinger, R. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000019962.18922.87 · Cited by 73 · see citing works
Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats
Cos, S., Mediavilla, D., Martínez‐Campa, C., González, A., Alonso‐González, C., & Sánchez‐Barceló, E. J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.025 · Cited by 71 · see citing works
Period-2: a tumor suppressor gene in breast cancer
Xiang, S., Coffelt, S. B., Mao, L., Yuan, L., Cheng, Q., & Hill, S. M. (2008) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-6-4 · Cited by 70 · see citing works
Self-citationGirgert, R., Hanf, V., Emons, G., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00684.x · Cited by 68 · see citing works
Blask, D. E., Dauchy, R. T., Brainard, G. C., & Hanifin, J. P. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352320 · Cited by 65 · see citing works
Self-citationTranscriptional repression of RORα activity in human breast cancer cells by melatonin
Dai, J., Ram, P. T., Yuan, L., Spriggs, L. L., & Hill, S. M. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00449-x · Cited by 62 · see citing works
Self-citationKiefer, T. L., Lai, L., Yuan, L., et al. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00198.x · Cited by 55 · see citing works
Self-citationYasui, W., Tahara, H., Tahara, E., Fujimoto, J., Nakayama, J., Ishikawa, F., Ide, T., & Tahara, E. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb00502.x · Cited by 54 · see citing works
The melatonin hypothesis, breast cancer and use of electric power
BERG, H. D. V. (1997) · Bioelectrochemistry and Bioenergetics · doi:10.1016/s0302-4598(97)00064-0 · Cited by 51 · see citing works
Lai, L., Yuan, L., Cheng, Q., et al. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0220-1 · Cited by 47 · see citing works
Self-citationEffect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D
Reyes, N., Reyes, I., Tiwari, R. K., et al. (2004) · Cancer Letters · doi:10.1016/j.canlet.2003.12.010 · Cited by 47 · see citing works
L�pez-Mart�n, E., Caruncho, H. J., Rodríguez‐Pallares, J., Guerra, M. J., & Labandeira-García, J. L. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990405)406:2 · Cited by 40 · see citing works
Lai, L., Yuan, L., Chen, Q., et al. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00620.x · Cited by 36 · see citing works
Self-citationLeon-Blanco, M. M., Guerrero, J. M., Reiter, R. J., & Pozo, D. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.05.003 · Cited by 36 · see citing works
Tracking the elusive antiestrogenic effect of melatonin: a new methodological approach.
Girgert, R., Bartsch, C., Sm, H., et al. (2003) · PubMed · Cited by 33 · see citing works
Lapin, V. (1976) · PubMed · Cited by 17 · see citing works
Hrushesky, W. J. M. (2000) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyd134 · Cited by 16 · see citing works
Blask, D. E., Dauchy, R. T., Sauer, L. A., et al. (2005) · Cancer Research · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [42]BLASK DE Reiter Rj The pineal: an oncostatic gland? The Pineal Gland 1984 253 284 Raven Press New York
Cited by
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Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738 · see citing works
Lunn, R. M., Blask, D. E., Coogan, A. N., Figueiro, M. G., Gorman, M. R., Hall, J. E., Hansen, J., Nelson, R. J., Panda, S., Smolensky, M. H., et al. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.056 · Cited by 402 · see citing works
Self-citationJohnson, J. A., Rash, J. A., Campbell, T. S., Savard, J., Gehrman, P. R., Perlis, M., Carlson, L. E., & Garland, S. N. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.07.001 · Cited by 371 · see citing works
Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt054 · Cited by 371 · see citing works
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251 · see citing works
Hansen, J., & Lassen, C. F. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100240 · Cited by 214 · see citing works
Endocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170 · see citing works
Circadian gene variants in cancer
Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147 · see citing works
Artificial light at night: melatonin as a mediator between the environment and epigenome
Haim, A., & Zubidat, A. E. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0121 · Cited by 133 · see citing works
Matthews, E. E., Berger, A. M., Schmiege, S. J., Cook, P. F., McCarthy, M. S., Moore, C. M., & Aloia, M. S. (2014) · Oncology Nursing Forum · doi:10.1188/14.onf.41-03ap · Cited by 103 · see citing works
Dim Light at Night Does Not Disrupt Timing or Quality of Sleep in Mice
Borniger, J. C., Weil, Z. M., Zhang, N., & Nelson, R. J. (2013) · Chronobiology International · doi:10.3109/07420528.2013.803196 · Cited by 58 · see citing works
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Reis, J. C., Antoni, M. H., & Travado, L. (2020) · CNS Spectrums · doi:10.1017/s1092852918001621 · Cited by 44 · see citing works
Clara, M. I., Van Straten, A., Canavarro, M. C., & Allen Gomes, A. (2024) · Acta Medica Portuguesa · doi:10.20344/amp.21094 · Cited by 5 · see citing works
- Authors
- Blask, D. E., Hill, S. M., Dauchy, R. T., Xiang, S., Yuan, L., Duplessis, T., Mao, L., Dauchy, E., & Sauer, L. A.
- Affiliations
- Tulane University (US)
- Corresponding author
- Blask, David E.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2011-05-24
- Volume
- 51
- Issue
- 3
- Pages
- 259-269
- ISSN
- 0742-3098 (ISSN-L)
- PMC
- PMC3162043
- OpenAlex
- W1525288721
- Cited by
- 187
- References
- 72
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 14 · 2017: 15 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 21 · 2012: 29
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01 CA85408, R01CA085408, R01CA054152, R01CA076197)
- National Institute of Environmental Health Sciences (R21ES011659, R21ES11659)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- melatonin, circadian rhythm, breast cancer, light at night, MT1 receptor, estrogen receptor alpha, cAMP signaling, Gαi2, clock genes, telomerase, matrix metalloproteinases, p38 MAPK, 13-hydroxyoctadecadienoic acid, linoleic acid metabolism, night shift work, circadian rhythm disruption, breast cancer risk
- MeSH terms
- Breast Neoplasms, Circadian Rhythm, Diet, Female, Humans, Light, Melatonin, Neoplasm Invasiveness, Neoplasm Metastasis, Transcription, Genetic, Signal Transduction, Gene Expression Regulation, Neoplastic, Receptors, Cytoplasmic and Nuclear, Cell Proliferation
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