Cited by 169Circadian rhythm and melatoninPancreatic function and diabetesDiabetes Treatment and Management

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Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

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Agil, Ahmad, Rosado, Isaac, Ruiz, Rosario, Figueroa, Adriana, Zen, Nourahouda, Fernández‐Vázquez, Gumersindo·2012·Journal of Pineal Research

DOI 10.1111/j.1600-079x.2011.00928.x

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Abstract

Abstract: The aim of this study was to investigate the effects of melatonin on glucose homeostasis in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM). ZDF rats (n = 30) and lean littermates (ZL) (n = 30) were used. At 6 wk of age, both lean and fatty animals were subdivided into three groups, each composed of ten rats: naive (N), vehicle treated (V), and melatonin treated (M) (10 mg/kg/day) for 6 wk. Vehicle and melatonin were added to the drinking water. ZDF rats developed DM (fasting hyperglycemia, 460 ± 39.8 mg/dL; HbA 1 c 8.3 ± 0.5%) with both insulin resistance (HOMA‐IR 9.28 ± 0.9 versus 1.2 ± 0.1 in ZL) and decreased β‐cell function (HOMA1‐%B) by 75%, compared with ZL rats. Melatonin reduced fasting hyperglycemia by 18.6% (P < 0.05) and HbA 1 c by 11% (P < 0.05) in ZDF rats. Also, melatonin lowered insulinemia by 15.9% (P < 0.05) and HOMA‐IR by 31% (P < 0.01) and increased HOMA1‐%B by 14.4% (P < 0.05). In addition, melatonin decreased hyperleptinemia by 34% (P < 0.001) and raised hypoadiponectinemia by 40% (P < 0.001) in ZDF rats. Moreover, melatonin reduced serum free fatty acid levels by 13.5% (P < 0.05). These data demonstrate that oral melatonin administration ameliorates glucose homeostasis in young ZDF rats by improving both insulin action and β‐cell function. These observations have implications on melatonin’s possible use as a new pharmacologic therapy for improving glucose homeostasis and of obesity‐related T2DM, in young subjects.

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Authors: Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G.
Affiliations: Universidad de Granada (ES)
Carlos III Hospital (ES)
Corresponding author: Agil, Ahmad
ORCID: Agil, Ahmad
Venue: Journal of Pineal Research
Publisher: Wiley
Published: 2011-08-25
Volume: 52
Issue: 2
Pages: 203-210
ISSN: 0742-3098 (ISSN-L)
1600-079X
DOI: 10.1111/j.1600-079x.2011.00928.x
OpenAlex: W1793372331
Cited by: 169
References: 71
Citations by year: 2026: 3 · 2025: 6 · 2024: 12 · 2023: 5 · 2022: 6 · 2021: 18 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 12 · 2016: 13 · 2015: 16 · 2014: 21 · 2013: 14 · 2012: 8
FWCI: 6.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Pineal Research (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Universidad de Granada
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: melatonin, glucose homeostasis, Zucker diabetic fatty rats, type 2 diabetes, insulin resistance, beta-cell function, hyperleptinemia, adiponectin, free fatty acids, fasting hyperglycemia, metabolic syndrome, obesity, young adults
MeSH terms: Animals, Antioxidants, Diabetes Mellitus, Type 2, Disease Models, Animal, Fatty Acids, Nonesterified, Glucose, Homeostasis, Hyperglycemia, Insulin, Male, Melatonin, Rats, Zucker, Metabolic Syndrome, Rats

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Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

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