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Cited by 56

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Insights into the Phosphoregulation of β‐Secretase Sorting Signal by the VHS Domain of GGA1

Shiba, Tomoo, Kametaka, Satoshi, Kawasaki, Masato, Shibata, Masahiro, Waguri, Satoshi, Uchiyama, Yasuo, Wakatsuki, Soichi·2004·Traffic
DOI 10.1111/j.1600-0854.2004.00188.x
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Abstract

BACE (β‐site amyloid precursor protein cleaving enzyme, β‐secretase) is a type‐I membrane protein which functions as an aspartic protease in the production of β‐amyloid peptide, a causative agent of Alzheimer's disease. Its cytoplasmic tail has a characteristic acidic‐cluster dileucine motif recognized by the VHS domain of adaptor proteins, GGAs (Golgi‐localizing, γ‐adaptin ear homology domain, ARF‐interacting). Here we show that BACE is colocalized with GGAs in the trans‐Golgi network and peripheral structures, and phosphorylation of a serine residue in the cytoplasmic tail enhances interaction with the VHS domain of GGA1 by about threefold. The X‐ray crystal structure of the complex between the GGA1‐VHS domain and the BACE C‐terminal peptide illustrates a similar recognition mechanism as mannose 6‐phosphate receptors except that a glutamine residue closes in to fill the gap created by the shorter BACE peptide. The serine and lysine of the BACE peptide point their side chains towards the solvent. However, phosphorylation of the serine affects the lysine side chain and the peptide backbone, resulting in one additional hydrogen bond and a stronger electrostatic interaction with the VHS domain, hence the reversible increase in affinity.

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Crossref · 10.1111/j.1600-0854.2004.00188.x

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2 of 2 references verified0 citation errors · 0 not checkable

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  • BACE1 interacts with GGA proteins that are involved in the subcellular trafficking of BACE1.

    “BACE1 interacts with Golgi-localized, ␥-ear-containing, ADP ribosylation factor-binding (GGA) proteins that are involved in the subcellular trafficking of BACE1.”

    From GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide (2006) · cites this paper as Shiba et al., 2004

Citations

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Research works printed but not linked: 40

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Metadata

Authors
Shiba, T., Kametaka, S., Kawasaki, M., Shibata, M., Waguri, S., Uchiyama, Y., & Wakatsuki, S.
Venue
Traffic
Publisher
Wiley
Published
2004-04-13
Volume
5
Issue
6
Pages
437-448
ISSN
  • 1398-9219
  • 1600-0854
DOI
10.1111/j.1600-0854.2004.00188.x
Cited by
56
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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