The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Recycling to the Plasma Membrane is Delayed in EHD1 Knockout Mice
Abstract
EHD1 is a member of the EHD family that contains four mammalian homologs. Among the invertebrate orthologs are a single Drosophila and Caenorhabditis elegans proteins and two plant members. They all contain three modules, a N‐terminal domain that contains nucleotide‐binding motifs, a central coiled–coil domain involved in oligomerization and a C‐terminal region that harbors the EH domain. Studies in C. elegans and EHD1 depletion by RNA interference in human cells have demonstrated that it regulates recycling of membrane proteins. We addressed the physiological role of EHD1 through its inactivation in the mouse. Ehd1 knockout mice were indistinguishable from normal mice, had a normal life span and showed no histological abnormalities. Analysis of transferrin uptake in Ehd1–/– embryonic fibroblasts demonstrated delayed recycling to the plasma membrane with accumulation of transferrin in the endocytic recycling compartment. Our results corroborate the established role of EHD1 in the exit of membrane proteins from recycling endosomes in vivo in a mouse model.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
EHD1 catalyzes fission and releases endosome-derived vesicles for recycling to the plasma membrane.
“Recent studies suggest that a dynamin-homolog, Eps15 homology domain protein 1, catalyzes fission and releases endosome-derived vesicles for recycling to the plasma membrane.”
From Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)–mediated fission machinery (2020) · cites this paper as [19]
EHD1 interacts with Rab11-FIP2 and regulates transport of Rab11-FIP2- and Rab11-containing vesicles.
“we have also demonstrated an interaction between EHD1 and the Rab11 effector protein, Rab11-FIP2, suggesting that EHD1 regulates the transport of Rab11-FIP2- and Rab11-containing vesicles [21].”
From EHD1 regulates cholesterol homeostasis and lipid droplet storage (2007) · cites this paper as [21]
Another Ehd1-null mouse model on a 129Sv/Ev background had no overt developmental or other phenotypes.
“which was in contrast to another Ehd1-null mouse model on a 129Sv/Ev background29, in which no overt developmental or other phenotypes were observed.”
From Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development (2016) · cites this paper as [29]
EHD1 deletion on a 129Sv/Ev background reported by another group was without any phenotype.
“EHD1 deletion on a 129Sv/Ev background reported by another group was without any phenotype29”
From Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development (2016) · cites this paper as [29]
Citations
Cites
Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730
Galperin, E., Benjamin, S., Rapaport, D., Rotem‐Yehudar, R., Tolchinsky, S., & Horowitz, M. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30807.x · Cited by 83
Self-citation
Flagged first, then by citations
Research works printed but not linked: 39
- 10.1152/physrev.1997.77.3.759 · DOI
- 10.1038/nrm1571 · DOI
- Wong WT, 1994, The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31‐p32, Oncogene, 9, 1591
- 10.1016/S0014-5793(01)03241-0 · DOI
- 10.1006/excr.1999.4694 · DOI · Paper page
- 10.1385/CBB:41:2:295 · DOI
- 10.1038/80924 · DOI
- 10.1126/stke.2132003re17 · DOI
- 10.1006/geno.1999.5800 · DOI · Paper page
- 10.1006/geno.1999.6087 · DOI
- 10.1038/35078549 · DOI
- 10.1091/mbc.E04-01-0026 · DOI
- 10.1074/jbc.M412751200 · DOI
- 10.1093/emboj/21.11.2557 · DOI · Paper page
- 10.1083/jcb.200201063 · DOI · Paper page
- 10.1021/bi049970f · DOI
- 10.1074/jbc.M106128200 · DOI
- 10.1242/jcs.02595 · DOI · Paper page
- 10.1038/35078543 · DOI · Paper page
- 10.1074/jbc.M009913200 · DOI · Paper page
- 10.1152/ajpcell.00140.2003 · DOI
- 10.1074/jbc.M401918200 · DOI · Paper page
- 10.1091/mbc.e03-10-0733 · DOI
- 10.1083/jcb.151.3.601 · DOI
- 10.1101/gad.987402 · DOI
- 10.1016/S0006-291X(02)00282-6 · DOI
- 10.1080/09687680410001716871 · DOI · Paper page
- BraunA PinyolIAR DahlhausR KochD FonarevP GrantBD KesselsMM QualmannB.EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.Mol Biol Cell2005;16:3642–3658. · DOI · Paper page
- 10.1073/pnas.251532398 · DOI
- 10.1074/jbc.273.51.34171 · DOI
- 10.1083/jcb.153.5.1111 · DOI
- 10.1091/mbc.10.2.501 · DOI
- 10.1083/jcb.148.5.1047 · DOI
- 10.1074/jbc.M307702200 · DOI · Paper page
- 10.1128/MCB.25.7.2853-2860.2005 · DOI
- 10.1016/S0925-4773(99)00242-7 · DOI
- Wurst W, 1993, Gene Targeting: A Practical Approach., 33
- 10.1007/BF01560723 · DOI
- Gurney EG, 1980, Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens, J Virol, 34, 752, 10.1128/jvi.34.3.752-763.1980 · DOI
Cited by
Sorted by citations
Posey, A. D., Swanson, K. E., Alvarez, M. G., Krishnan, S., Earley, J. U., Band, H., Pytel, P., McNally, E. M., & Demonbreun, A. R. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.01.004 · Cited by 52
EHD1 regulates cholesterol homeostasis and lipid droplet storage
Naslavsky, N., Rahajeng, J., Rapaport, D., Horowitz, M., & Caplan, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.022 · Cited by 53
Self-citationYap, C. C. C., Lasiecka, Z. M., Caplan, S., & Winckler, B. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5428-09.2010 · Cited by 44
Self-citationBhattacharyya, S., Rainey, M. A., Arya, P., Mohapatra, B. C., Mushtaq, I., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., et al. (2016) · Scientific Reports · doi:10.1038/srep20727 · Cited by 36
Dhawan, K., Naslavsky, N., & Caplan, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011368 · Cited by 36
Self-citation
Metadata
- Authors
- Rapaport, D., Auerbach, W., Naslavsky, N., Pasmanik‐Chor, M., Galperin, E., Fein, A., Caplan, S., Joyner, A. L., & Horowitz, M.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2005-11-16
- Volume
- 7
- Issue
- 1
- Pages
- 52-60
- ISSN
- 1398-9219
- 1600-0854
- Cited by
- 67
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
