The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
Abstract
Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse models with face validity to the core symptoms offer an experimental approach to test hypotheses about the causes of autism and translational tools to evaluate potential treatments. We discovered that the inbred mouse strain BTBR T+tf/J (BTBR) incorporates multiple behavioral phenotypes relevant to all three diagnostic symptoms of autism. BTBR displayed selectively reduced social approach, low reciprocal social interactions and impaired juvenile play, as compared with C57BL/6J (B6) controls. Impaired social transmission of food preference in BTBR suggests communication deficits. Repetitive behaviors appeared as high levels of self‐grooming by juvenile and adult BTBR mice. Comprehensive analyses of procedural abilities confirmed that social recognition and olfactory abilities were normal in BTBR, with no evidence for high anxiety‐like traits or motor impairments, supporting an interpretation of highly specific social deficits. Database comparisons between BTBR and B6 on 124 putative autism candidate genes showed several interesting single nucleotide polymorphisms (SNPs) in the BTBR genetic background, including a nonsynonymous coding region polymorphism in Kmo . The Kmo gene encodes kynurenine 3‐hydroxylase, an enzyme‐regulating metabolism of kynurenic acid, a glutamate antagonist with neuroprotective actions. Sequencing confirmed this coding SNP in Kmo , supporting further investigation into the contribution of this polymorphism to autism‐like behavioral phenotypes. Robust and selective social deficits, repetitive self‐grooming, genetic stability and commercial availability of the BTBR inbred strain encourage its use as a research tool to search for background genes relevant to the etiology of autism, and to explore therapeutics to treat the core symptoms.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Repetitive behaviours are also often seen in autistic patients and in some mouse models of ASDs34–36.”
From Shank3 mutant mice display autistic-like behaviours and striatal dysfunction (2011) · cites this paper as [34]
In the citing paper
“In contrast to C57Bl6J mice, BTBR mice show no social preference in the test (Fig. 1c, d).20,21”
From Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment (2016) · cites this paper as [20]
In the citing paper
“BTBR T+tf/J (BTBR) is a commercially available inbred strain of mouse that displays behavioral phenotypes relevant to all three diagnostic symptoms of autism (60–62, 64, 66, 68–70, 72, 74–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [64]
In the citing paper
“Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders (59–70).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [64]
In the citing paper
“BTBR engages in low levels of reciprocal social interactions as juveniles and adults, minimal social approach by both males and females, and low levels of ultrasonic vocalizations in response to social olfactory cues and during reciprocal social interactions compared to other standard inbred strains such as C57BL/6J (B6) and FVB (60–62, 64, 66, 68–70, 74, 76–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [64]
In the citing paper
“Unlike mouse models based on identified genetic mutations, the background genes responsible for autism-relevant behavioral traits in these inbred strains of mice remain under investigation (64, 83–85).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [64]
In the citing paper
“The BTBR T+ Itpr3tf/J (BTBR) inbred mouse line exhibits the core ASD symptoms, including abnormal social behavior (McFarlane et al., 2008; Scattoni et al., 2008).”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as McFarlane et al., 2008
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
(1943) · The Nervous child · Cited by 8,870
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522 · cited 4×
“Although previous experiments found similar social approach by subjects when the strangers were of the same or different strains, and of the same or different sex (Moy et al. 2004; Nadler et al. 2004), the present experiments used strangers of the same strain and sex for internal consistency.”
BackgroundResultInfluentialSelf-citationMuhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Autism From 2 to 9 Years of Age
Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.694 · Cited by 973 · cited 5×
“…presence of three defining symptoms: (1) aberrant reciprocal social interactions, (2) qualitative impairments in communication and (3) restricted repetitive and stereotyped patterns of behavior, interests and activities (DSM-IV 2000; Lord et al. 2001, 2006; Losh & Piven 2007; Volkmar et al. 2004).”
BackgroundInfluentialPten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931
(2000) · Cited by 919
Self-citation
Research works printed but not linked: 1
- Bolivar V.J., 2003, Assessing autism‐like behaviors in inbred strains of mice, Soc Neurosci Abstr, 318, 13
Cited by
Sorted by citations
Items 201–300 of 817
Mouse Models of Autism: Testing Hypotheses About Molecular Mechanisms
Roullet, F., & Crawley, J. N. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_113 · Cited by 67
Self-citationWilkes, B. J., & Lewis, M. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.022 · Cited by 64
Monogenic mouse models of social dysfunction: Implications for autism
Oddi, D., Crusio, W. E., D'Amato, F. R., & Pietropaolo, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.002 · Cited by 66
Dwivedi, S., Medishetti, R., Rani, R., Sevilimedu, A., Kulkarni, P., & Yogeeswari, P. (2018) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2018.11.006 · Cited by 66
Action detection using a neural network elucidates the genetics of mouse grooming behavior
Geuther, B. Q., Peer, A., He, H., Sabnis, G. S., Philip, V. M., & Kumar, V. (2021) · eLife · doi:10.7554/elife.63207 · Cited by 66
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior
Depino, A. M., Lucchina, L., & Pitossi, F. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.05.007 · Cited by 63
Cross-fostering: Elucidating the effects of gene×environment interactions on phenotypic development
McCarty, R. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.025 · Cited by 65
Jones, K. L., Pride, M. C., Edmiston, E., Yang, M., Silverman, J. L., Crawley, J. N., & de Water, J. V. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0126-1 · Cited by 70
Self-citationChao, O. Y.-H., Pathak, S. S., Zhang, H., Dunaway, N., Li, J., Mattern, C., Nikolaus, S., Huston, J. P., & Yang, Y. (2020) · Molecular Brain · doi:10.1186/s13041-020-00649-7 · Cited by 62
Water T-maze: A useful assay for determination of repetitive behaviors in mice
Guariglia, S. R., & Chadman, K. K. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.08.019 · Cited by 62
Psychopharmacologic Interventions for Repetitive Behaviors in Autism Spectrum Disorders
Soorya, L. V., Kiarashi, J., & Hollander, E. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2008.06.003 · Cited by 70
D’Agostino, G., Cristiano, C., Lyons, D. J., Citraro, R., Russo, E., Avagliano, C., Russo, R., Raso, G. M., Meli, R., Sarro, G. D., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.005 · Cited by 63
Seese, R. R., Maske, A. R., LYNCH, G. S., & Gall, C. M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.13 · Cited by 62
Tsilioni, I., Dodman, N. H., Petra, A. I., Taliou, A., Francis, K., Moon-Fanelli, A. A., Shuster, L., & Theoharides, T. C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.106 · Cited by 63
Jones-Davis, D. M., Yang, M., Rider, E., Osbun, N. C., da Gente, G. J., Li, J., Katz, A. M., Weber, M. D., Sen, S., Crawley, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061829 · Cited by 61
Self-citationRoussin, L., Prince, N., Perez‐Pardo, P., Kraneveld, A. D., Rabot, S., & Naudon, L. (2020) · Microorganisms · doi:10.3390/microorganisms8091369 · Cited by 64
Sociability and brain development in BALB/cJ and C57BL/6J mice
Fairless, A. H., Dow, H. C., Kreibich, A. S., Torre, M., Kuruvilla, M., Gordon, E., Morton, E. A., Tan, J., Berrettini, W. H., Li, H., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.001 · Cited by 64
Netser, S., Haskal, S., Magalnik, H., & Wagner, S. (2017) · Molecular Autism · doi:10.1186/s13229-017-0169-1 · Cited by 65
Blanchard, D. C., Summers, C. H., & Blanchard, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.008 · Cited by 60
Chévere-Torres, I., Maki, J. M., Santini, E., & Klann, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.018 · Cited by 59
Light phase testing of social behaviors: not a problem
Yang, M. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.029.2008 · Cited by 62
Self-citationHirsch, M. M., Deckmann, I., Fontes‐Dutra, M., Bauer‐Negrini, G., Nunes, G. D., Nunes, W. S., Rabelo, B. F., Riesgo, R. D. S., Margis, R., Bambini-Júnior, V., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.02.061 · Cited by 64
Felice, A. D., Scattoni, M. L., Ricceri, L., & Calamandrei, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121663 · Cited by 61
Needham, B. D., Tang, W., & Wu, W. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22581 · Cited by 60
Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex
Amodeo, D. A., Lai, C.-Y., Hassan, O., Mukamel, E. A., Behrens, M. M., & Powell, S. B. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.025 · Cited by 61
Bakheet, S. A., Alzahrani, M. Z., Nadeem, A., Ansari, M. A., Zoheir, K. M. A., Attia, S. M., AL-Ayadhi, L. Y., & Ahmad, S. F. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.09.004 · Cited by 57
Precocious myelination in a mouse model of autism
Khanbabaei, M., Hughes, E., Ellegood, J., Qiu, L. R., Yip, R., Dobry, J., Murari, K., Lerch, J. P., Rho, J. M., & Cheng, N. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0590-7 · Cited by 59
Pearson, B. L., Bettis, J. K., Meyza, K. Z., Yamamoto, L. Y., Blanchard, D. C., & Blanchard, R. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.040 · Cited by 57
Ike, K. G. O., de Boer, S. F., Buwalda, B., & Kas, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.030 · Cited by 64
Fenlon, L. R., Liu, S., Gobius, I., Kurniawan, N. D., Murphy, S. J., Moldrich, R. X., & Richards, L. J. (2015) · Neural Development · doi:10.1186/s13064-015-0033-y · Cited by 59
Immune-mediated animal models of Tourette syndrome
Hornig, M., & Lipkin, W. I. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.007 · Cited by 56
Robson, M. J., Quinlan, M. A., Margolis, K. G., Gajewski-Kurdziel, P. A., Veenstra-VanderWeele, J. M., Gershon, M. D., Watterson, D. M., & Blakely, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809137115 · Cited by 58
Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.05.003 · Cited by 57
Lin, C.-W., & Hsueh, Y. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.002 · Cited by 55
DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures
Raveau, M., Shimohata, A., Amano, K., Miyamoto, H., & Yamakawa, K. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.003 · Cited by 53
Ahmad, S. F., Ansari, M. A., Nadeem, A., Alzahrani, M. Z., Bakheet, S. A., & Attia, S. M. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8483-0 · Cited by 56
Mercier, F., Kwon, Y. C., & Douet, V. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.007 · Cited by 55
5HT2A receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice
Amodeo, D. A., Rivera, E., Cook, E. H., Sweeney, J. A., & Ragozzino, M. E. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12343 · Cited by 56
BTBR T+tf/J mice: Autism-relevant behaviors and reduced fractone-associated heparan sulfate
Blanchard, D. C., Defensor, E. B., Meyza, K. Z., Pobbe, R. L. H., Pearson, B. L., Bolivar, V. J., & Blanchard, R. J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.008 · Cited by 56
Self-citationNakamura, T., Arima‐Yoshida, F., Sakaue, F., Nasu‐Nishimura, Y., Takeda, Y., Matsuura, K., Akshoomoff, N. A., Mattson, S. N., Grossfeld, P., Manabe, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms10861 · Cited by 58
Lee, J. H., Espinera, A. R., Chen, D., Choi, K., Caslin, A. Y., Won, S., Pecoraro, V., Xu, G., Wei, L., & Yu, S. P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0575-x · Cited by 55
Oxytocin in animal models of autism spectrum disorder
Peñagarikano, O. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22449 · Cited by 56
Fingher, N., Dinstein, I., Ben‐Shachar, M., Haar, S., Dale, A. M., Eyler, L. T., Pierce, K., & Courchesne, E. (2017) · Cortex · doi:10.1016/j.cortex.2016.12.024 · Cited by 56
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Bae, M. H., Roh, J. D., Kim, Y.-J., Kim, S. S., Han, H. M., Yang, E., Kang, H., Lee, S., Kim, J. Y., Kang, R., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012632 · Cited by 54
Communication, interventions, and scientific advances in autism: A commentary
Llaneza, D. C., DeLuke, S. V., Batista, M., Crawley, J. N., Christodulu, K. V., & Frye, C. A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.003 · Cited by 62
Self-citationComparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review
Alamoudi, M. U. A., Hosie, S., Shindler, A. E., Wood, J. L., Franks, A. E., & Hill‐Yardin, E. L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.905841 · Cited by 59
Kazdoba, T. M., Hagerman, R. J., Żółkowska, D., Rogawski, M. A., & Crawley, J. N. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4115-7 · Cited by 51
Self-citationMuehlmann, A. M., Edington, G., Mihalik, A., Buchwald, Z., Koppuzha, D., Korah, M. M., & Lewis, M. H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.041 · Cited by 52
Resistance to change and vulnerability to stress: autistic‐like features of GAP43‐deficient mice
Zaccaria, K. J., Lagace, D. C., Eisch, A. J., & McCasland, J. S. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00638.x · Cited by 53
Does microglial dysfunction play a role in autism and Rett syndrome?
Maezawa, I., Calafiore, M., Wulff, H., & Jin, L. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x1200004x · Cited by 53
Behavioral impact of maternal allergic-asthma in two genetically distinct mouse strains
Schwartzer, J. J., Careaga, M., Coburn, M., Rose, D. R., Hughes, H. K., & Ashwood, P. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.007 · Cited by 53
Nadeem, A., Ahmad, S. F., El‐Sherbeeny, A. M., Al-Harbi, N. O., Bakheet, S. A., & Attia, S. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.015 · Cited by 54
Armstrong, E. C., Caruso, A., Servadio, M., Andreae, L. C., Trezza, V., Scattoni, M. L., & Fernandes, C. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12630 · Cited by 57
Ahn, Y., Sabouny, R., Villa, B. R., Yee, N. C., Mychasiuk, R., Uddin, G. M., Rho, J. M., & Shutt, T. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093266 · Cited by 55
Serotonin neuron abnormalities in the BTBR mouse model of autism
Guo, Y., & Commons, K. G. (2017) · Autism Research · doi:10.1002/aur.1665 · Cited by 51
Kalueff, A. V., Stewart, A., Song, C., & Gottesman, I. I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.03.007 · Cited by 50
NMDA receptor activation regulates sociability by its effect on mTOR signaling activity
Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.009 · Cited by 53
Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
Frye, C. A., & Llaneza, D. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.005 · Cited by 52
Studying Autism in Rodent Models: Reconciling Endophenotypes with Comorbidities
Argyropoulos, A., Gilby, K. L., & Hill‐Yardin, E. L. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00417 · Cited by 51
Baroncelli, L., Molinaro, A., Cacciante, F., Alessandri, M., Napoli, D., Putignano, E., Tola, J., Leuzzi, V., Cioni, G., & Pizzorusso, T. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw252 · Cited by 51
Chao, O. Y.-H., Yunger, R., & Yang, Y. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.014 · Cited by 52
Modeling autism in non‐human primates: Opportunities and challenges
Zhao, H., Jiang, Y., & Zhang, Y. (2018) · Autism Research · doi:10.1002/aur.1945 · Cited by 53
Temporal microstructure of dyadic social behavior during relationship formation in mice
Lee, W., Fu, J., Bouwman, N., Farago, P., & Curley, J. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220596 · Cited by 50
Camacho, J., Jones, K., Miller, E., Ariza, J., Noctor, S., Van de Water, J., & Martínez-Cerdeño, V. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.045 · Cited by 49
Metabotropic Glutamate Receptors in Central Nervous System Diseases
Golubeva, A. V., Moloney, R. D., O’Connor, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Current Drug Targets · doi:10.2174/1389450116666150316224011 · Cited by 51
The X-Linked Intellectual Disability Protein IL1RAPL1 Regulates Dendrite Complexity
Montani, C., Ramos-Brossier, M., Ponzoni, L., Gritti, L., Cwetsch, A. W., Braida, D., Saillour, Y., Terragni, B., Mantegazza, M., Sala, M., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3775-16.2017 · Cited by 48
Lo, L. H.-Y., Dong, R., Lyu, Q., & Lai, K. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107744 · Cited by 51
Cope, E. C., Zych, A. D., Katchur, N. J., Waters, R. C., Laham, B. J., Diethorn, E. J., Park, C. Y., Meara, W. R., & Gould, E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01174-2 · Cited by 49
Arakawa, H. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113432 · Cited by 49
Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice
Fairless, A. H., Katz, J. M., Safi, N., Dow, H. C., Kreibich, A. S., Berrettini, W. H., Abel, T. G., & Brodkin, E. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.051 · Cited by 47
Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism
Wang, Y., Billon, C., Walker, J. K., & Burris, T. P. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00159 · Cited by 48
Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism
Queen, N. J., Boardman, A. A., Patel, R. S., Siu, J. J., Mo, X. M., & Cao, L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104476 · Cited by 50
Bambico, F. R., Lacoste, B., Hattan, P. R., & Gobbi, G. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht310 · Cited by 48
Nakai, N., Takumi, T., Nakai, J., & Sato, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00412 · Cited by 49
Mazarati, A. M., Jones, N. C., Galanopoulou, A. S., Harte‐Hargrove, L. C., Kalynchuk, L. E., Lenck‐Santini, P., Medel‐Matus, J., Nehlig, A., de la Prida, L. M., Sarkisova, K. Y., et al. (2018) · Epilepsia Open · doi:10.1002/epi4.12236 · Cited by 50
Wang, L. Y., Cai, Y., & Fan, X. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00290 · Cited by 48
Foldi, C. J., Eyles, D. W., McGrath, J. J., & Burne, T. H. J. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07074.x · Cited by 49
Vitobello, A., Mazel, B., Lelianova, V. G., Zangrandi, A., Petitto, E., Suckling, J., Salpietro, V., Meyer, R., Elbracht, M., Kurth, I., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.06.011 · Cited by 46
Systematic autistic-like behavioral phenotyping of 4 mouse strains using a novel wheel-running assay
Karvat, G., & Kimchi, T. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.028 · Cited by 46
Weiser, M. J., Mucha, B., Denheyer, H., Atkinson, D., Schanz, N., Vassiliou, E. K., & Benno, R. H. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.005 · Cited by 49
Faraji, J., Karimi, M., Lawrence, C., Mohajerani, M. H., & Metz, G. A. S. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0280-x · Cited by 47
Current state of evidence of cannabis utilization for treatment of autism spectrum disorders
Agarwal, R., Burke, S. L., & Maddux, M. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2259-4 · Cited by 46
Mychasiuk, R., & Rho, J. M. (2017) · Autism Research · doi:10.1002/aur.1682 · Cited by 45
Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain
Lai, J., Lerch, J. P., Doering, L. C., Foster, J. A., & Ellegood, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.021 · Cited by 46
Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice
Hisaoka, T., Komori, T., Kitamura, T., & Morikawa, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-19844-7 · Cited by 45
Rajamani, K. T., Doherty-Lyons, S., Bolden, C. A., Willis, D., Hoffman, C. A., Zelikoff, J. T., Chen, L., & Gu, H. H. (2013) · Autism Research · doi:10.1002/aur.1287 · Cited by 46
Microglia: Synaptic modulator in autism spectrum disorder
Hu, C., Li, H., Li, J., Luo, X., & Hao, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.958661 · Cited by 50
Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice
Amodeo, D. A., Yi, J., Sweeney, J. A., & Ragozzino, M. E. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00017 · Cited by 47
Animal models of autism spectrum disorders: Information for neurotoxicologists
Halladay, A. K., Amaral, D. G., Aschner, M., Bolivar, V. J., Bowman, A. B., DiCicco-Bloom, E. M., Hyman, S. L., Keller, F., Lein, P. J., Pessah, I. N., et al. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.07.002 · Cited by 45
Self-citationCao, F., Yin, A., Wen, G. Y., Sheikh, A. M., Tauqeer, Z., Malik, M. N., Nagori, A., Schirripa, M., Schirripa, F. V., Merz, G., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-223 · Cited by 44
RetractedPerinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism
Ranger, P., & Ellenbroek, B. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_404 · Cited by 43
Wöhr, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00073 · Cited by 43
Martin, L. A., Sample, H. A., Gregg, M., & Wood, C. A. (2014) · Brain and Behavior · doi:10.1002/brb3.273 · Cited by 46
The maternal autoimmune environment affects the social behavior of offspring
Zhang, Y., Gao, D., Kluetzman, K., Mendoza, A., Bolivar, V. J., Reilly, A. A., Kasten‐Jolly, J., & Lawrence, D. A. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.02.019 · Cited by 42
Self-citationBové, M., Ike, K. G. O., Eldering, A., Buwalda, B., de Boer, S. F., Morgese, M. G., Schiavone, S., Cuomo, V., Trabace, L., & Kas, M. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.003 · Cited by 43
Amodeo, D. A., Pahua, A. E., Zarate, M., Taylor, J. A., Peterson, S., Posadas, R., Oliver, B. L., & Amodeo, L. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112028 · Cited by 43
Fyke, W., Premoli, M., Echeverry‐Alzate, V., López‐Moreno, J. A., Lemaire, V., Crusio, W. E., Marsicano, G., Wöhr, M., & Pietropaolo, S. (2021) · Autism Research · doi:10.1002/aur.2562 · Cited by 43
de Cossío, L. F., Lacabanne, C., Bordeleau, M., Castino, G., Kyriakakis, P., & Tremblay, M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.025 · Cited by 43
Deconstructing Sociability, An Autism‐Relevant Phenotype, in Mouse Models
Fairless, A. H., Shah, R. Y., Guthrie, A. J., Li, H., & Brodkin, E. S. (2011) · The Anatomical Record · doi:10.1002/ar.21318 · Cited by 42
Jalbrzikowski, M., Lázaro, M. T., Gao, F., Huang, A., Chow, C. C., Geschwind, D. H., Coppola, G., & Bearden, C. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132542 · Cited by 43
Metadata
- Authors
- McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N.
- Affiliations
- Kenyon College (US)
- New York State Department of Health (US)
- National Institute of Mental Health (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Crawley, J. N.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2007-04-27
- Volume
- 7
- Issue
- 2
- Pages
- 152-163
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2071797996
- Cited by
- 812
- References
- 82
- Citations by year
- 2026: 23 · 2025: 36 · 2024: 41 · 2023: 49 · 2022: 52 · 2021: 62 · 2020: 51 · 2019: 44 · 2018: 47 · 2017: 48 · 2016: 63 · 2015: 50 · 2014: 52 · 2013: 42 · 2012: 51
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, BTBR T+tf/J mice, social dysfunction, social approach, reciprocal social interaction, social transmission of food preference, KMO, single nucleotide polymorphisms, autism candidate genes, inbred mouse strains, mouse models of autism
- MeSH terms
- Aging, Animals, Autistic Disorder, Circadian Rhythm, Disease Models, Animal, Food Preferences, Mice, Inbred C57BL, Mice, Inbred Strains, National Institute of Mental Health (U.S.), Phenotype, Play and Playthings, Social Behavior, United States, Videotape Recording, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
