The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
Open accessAbstract
Autism spectrum disorders (ASD) form a common group of neurodevelopmental disorders appearing to be under polygenic control, but also strongly influenced by multiple environmental factors. The brain mechanisms responsible for ASD are not understood and animal models paralleling related emotional and cognitive impairments may prove helpful in unraveling them. BTBR T+ tf/J (BTBR) mice display behaviors consistent with the three diagnostic categories for ASD. They show impaired social interaction and communication as well as increased repetitive behaviors. This review covers much of the data available to date on BTBR behavior, neuroanatomy and physiology in search for candidate biomarkers, which could both serve as diagnostic tools and help to design effective treatments for the behavioral symptoms of ASD.
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BTBR mice display impaired social interactions.
“In agreement with previous reports (Meyza et al., 2013), BTBR mice demonstrated impaired social interactions (a–c) and enhanced engagement in repetitive behaviors (e–f), as well as increased anxiety levels (h–k).”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Meyza et al., 2013
BTBR mice display enhanced engagement in repetitive behaviors.
“In agreement with previous reports (Meyza et al., 2013), BTBR mice demonstrated impaired social interactions (a–c) and enhanced engagement in repetitive behaviors (e–f), as well as increased anxiety levels (h–k).”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Meyza et al., 2013
BTBR mice display increased anxiety levels.
“In agreement with previous reports (Meyza et al., 2013), BTBR mice demonstrated impaired social interactions (a–c) and enhanced engagement in repetitive behaviors (e–f), as well as increased anxiety levels (h–k).”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Meyza et al., 2013
The BTBR mouse model exhibits core behavioral features of ASD, including deficits in social interactions and engagement in repetitive behaviors.
“the BTBR T+ Itpr3tf/J (BTBR) mouse model, which exhibits core behavioral features of ASD including deficits in social interactions and engagement in repetitive behaviors [65]”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [65]
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- Authors
- Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- New York State Department of Health (US)
- Corresponding author
- Defensor, Erwin B.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 251
- Pages
- 25-34
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC3529977
- OpenAlex
- W2013997760
- Cited by
- 147
- References
- 122
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 17 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 10 · 2013: 11
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH081845)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, animal models of autism, biomarkers, social interaction deficits, repetitive behavior, corpus callosum, synaptogenesis, neurogenesis, glutamatergic neurotransmission, sociability, neuroanatomy
- MeSH terms
- Animals, Animal Communication, Behavior, Animal, Child, Child Development Disorders, Pervasive, Disease Models, Animal, Humans, Mice, Inbred Strains, Phenotype, Social Behavior, Biomarkers, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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