Cited by 147Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers

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Meyza, Ksenia Z., Defensor, Erwin B., Jensen, Ashley L., Corley, Michael J., Pearson, Brandon L., Pobbe, Roger L.H., Bolivar, Valerie J., Blanchard, D. Caroline +1 more·2013·Behavioural Brain Research

Abstract

Autism spectrum disorders (ASD) form a common group of neurodevelopmental disorders appearing to be under polygenic control, but also strongly influenced by multiple environmental factors. The brain mechanisms responsible for ASD are not understood and animal models paralleling related emotional and cognitive impairments may prove helpful in unraveling them. BTBR T+ tf/J (BTBR) mice display behaviors consistent with the three diagnostic categories for ASD. They show impaired social interaction and communication as well as increased repetitive behaviors. This review covers much of the data available to date on BTBR behavior, neuroanatomy and physiology in search for candidate biomarkers, which could both serve as diagnostic tools and help to design effective treatments for the behavioral symptoms of ASD.

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Authors
Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J.
Affiliations
  • University of Hawaiʻi at Mānoa (US)
  • New York State Department of Health (US)
Corresponding author
Defensor, Erwin B.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2013-08
Volume
251
Pages
25-34
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2013997760
Cited by
147
References
122
Citations by year
2026: 8 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 17 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 10 · 2013: 11
FWCI
0.86
Type
journal article
Language
en
Open access
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH081845)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
autism spectrum disorder, animal models of autism, biomarkers, social interaction deficits, repetitive behavior, corpus callosum, synaptogenesis, neurogenesis, glutamatergic neurotransmission, sociability, neuroanatomy
MeSH terms
Animals, Animal Communication, Behavior, Animal, Child, Child Development Disorders, Pervasive, Disease Models, Animal, Humans, Mice, Inbred Strains, Phenotype, Social Behavior, Biomarkers, Mice

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