Cited by 325Alzheimer's disease research and treatmentsPI3K/AKT/mTOR signaling in cancerDementia and Cognitive Impairment Research

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Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

Li, Xu, Alafuzoff, Irina, Soininen, Hilkka, Winblad, Bengt, Pei, Jin‐Jing·2005·The FEBS Journal

DOI 10.1111/j.1742-4658.2005.04833.x

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Abstract

The pathogenesis of formation of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains is unknown. One of the possibilities might be that translation of tau mRNA is aberrantly regulated in AD brains. In the current study, levels of various translation control elements including total and phosphorylated (p) forms of mammalian target of rapamycin (mTOR), eukaryotic initiation factor 4E binding protein 1 (4E-BP1), eukaryotic elongation factor 2 (eEF2), and eEF2 kinase were investigated in relationship with tau in homogenates of the medial temporal cortex from 20 AD and 10 control brains. We found that levels of p-mTOR (Ser2481), and p-4E-BP1 (Thr70 and Ser65) dramatically increase in AD, and are positively significantly correlated with total tau and p-tau. Levels of p-eEF2K were significantly increased, and total eEF2 significantly decreased in AD, when compared to controls. The changes of p-mTOR (2481), p-4E-BP1, and p-eEF2 were immunohistochemically confirmed to be in neurons of AD brains. This suggested that there are obvious abnormalities of elements related with translation control in AD brain and their aberrant changes may up-regulate the translation of tau mRNA, contributing to hyperphosphorylated tau accumulation in NFT-bearing neurons.

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Authors: Li, X., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J.
Affiliations: Karolinska Institutet (SE)
Kuopio University Hospital (FI)
Corresponding author: Pei, Jin‐Jing
ORCID: Li, Xu
Alafuzoff, Irina
Soininen, Hilkka
Winblad, Bengt
Venue: The FEBS Journal
Publisher: Wiley
Published: 2005-08
Volume: 272
Issue: 16
Pages: 4211-4220
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/j.1742-4658.2005.04833.x
OpenAlex: W1873073107
Cited by: 324
References: 27
Citations by year: 2026: 6 · 2025: 12 · 2024: 13 · 2023: 15 · 2022: 28 · 2021: 23 · 2020: 24 · 2019: 22 · 2018: 14 · 2017: 19 · 2016: 21 · 2015: 18 · 2014: 22 · 2013: 16 · 2012: 11
FWCI: 5.59
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations: FEBS Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Gun och Bertil Stohnes Stiftelse
Alzheimerfonden
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, tau protein, mTOR, 4E-BP1, elongation factor 2, eEF2 kinase, translational regulation, neurofibrillary tangles, tau hyperphosphorylation, medial temporal cortex, protein phosphorylation
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Autoantibodies, Brain, Carrier Proteins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunohistochemistry, Male, Middle Aged, Phosphoproteins, Phosphorylation, Protein Kinases, Case-Control Studies, Calcium-Calmodulin-Dependent Protein Kinases, Cell Cycle Proteins, Peptide Elongation Factor 2, Adaptor Proteins, Signal Transducing, Elongation Factor 2 Kinase, TOR Serine-Threonine Kinases

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Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

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