Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome

Giltay, Erik J.; Tishova, Yuliya A.; Mskhalaya, George J.; Gooren, Louis J.G.; Saad, Farid; Kalinchenko, Svetlana Y.

doi:10.1111/j.1743-6109.2010.01859.x

Cited by 141Hormonal and reproductive studiesSexual function and dysfunction studiesAdrenal Hormones and Disorders

Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome

Giltay, Erik J., Tishova, Yuliya A., Mskhalaya, George J., Gooren, Louis J.G., Saad, Farid, Kalinchenko, Svetlana Y.·2010·The Journal of Sexual Medicine

DOI 10.1111/j.1743-6109.2010.01859.x

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Abstract

Introduction: Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction. Aim: To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS. Main Outcome Measures: The Beck Depression Inventory (BDI-IA), Aging Males’ Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale at baseline, 18 and 30 weeks were analysed using multilevel analysis. Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering from both the MetS and hypogonadism were included. They were treated for 30 weeks with either parenteral testosterone undecanoate (TU; 1,000 mg IM TU, at baseline, and after 6 and 18 weeks; Nebido®) or placebo injections, 105 (92.9%) men receiving TU and 65 (91.5%) receiving placebo completed the 30-week trial. Results: The 184 men were aged mean 52.1 years old (standard deviation [SD] 9.6; range 35–69), with a mean body mass index of 35.5 kg/m2 (SD 6.7; range 25.1–54.8), and a mean total testosterone level of 8.0 nmol/L (SD 4.0). There were significant improvements in BDI-IA (mean difference vs. placebo after 30 weeks: −2.5 points; 95% confidence interval [CI]: −0.9; −4.1; P = 0.003), AMS (−7.4 points; 95% CI: −4.3; −10.5; P <0.001), and IIEF-5 (+3.1 points; 95% CI: +1.8; +4.4; P <0.001). The effects on the BDI-IA, AMS, and IIEF-5 were strongest in men with baseline total testosterone levels <7.7 mmol/L (i.e., median value). Conclusions: TU administration may improve depressive symptoms, aging male symptoms and sexual dysfunction in hypogonadal men with the MetS. The beneficial effects of testosterone were most evident in men with the lowest baseline total testosterone levels.

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Effects of testosterone on depressive mood become detectable after 3-6 weeks, with a maximum after 18-30 weeks.
“Effects on depressive mood become detectable after 3–6 weeks with a maximum after 18–30 weeks.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [79]
Effects of testosterone on depressive symptoms are more pronounced in men with the lowest baseline testosterone levels.
“It is remarkable that effects were more pronounced in men with the lowest baseline testosterone levels (79).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [79]
Positive effects of testosterone on depressive symptoms start as early as after 3-6 weeks, but most likely take 18-30 weeks to find a patient with significant improvement.
“It is very likely that the positive effects of testosterone on depressive symptoms start as early as after 3–6 weeks, but will most likely take 18–30 weeks to find the patient with a significant improvement.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [79]

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P01-37 - Effects of Testosterone Supplementation on Depressive Symptoms in Hypogonadal men with the Metabolic Syndrome: The Moscow Study
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Effects of Testosterone Supplementation on Depressive, Ageing Male, and Sexual Symptoms in Hypogonadal Men: a Randomized, Placebo-controlled, Double-blind Trial
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Self-citation
Patients with testosterone deficit syndrome and depression.
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Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome: the Moscow Study
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Self-citation
The effect of testosterone supplementation on depression symptoms in hypogonadal men from the Testim Registry in the US (TRiUS)
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Authors: Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y.
Affiliations: Leiden University Medical Center (NL)
Peoples' Friendship University of Russia (RU)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Gulf Medical University (AE)
Corresponding author: Giltay, Erik J.
ORCID: Giltay, Erik J.
Gooren, Louis J.G.
Saad, Farid
Venue: The Journal of Sexual Medicine
Publisher: Oxford University Press (OUP)
Published: 2010-07-01
Volume: 7
Issue: 7
Pages: 2572-2582
ISSN: 1743-6095 (ISSN-L)
1743-6109
DOI: 10.1111/j.1743-6109.2010.01859.x
OpenAlex: W1706522822
Cited by: 140
References: 67
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2022: 10 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 9
FWCI: 8.47
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Journal of Sexual Medicine (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: testosterone undecanoate, testosterone supplementation, hypogonadism, metabolic syndrome, depressive symptoms, sexual dysfunction, erectile function, aging male symptoms, androgen deficiency, men's health, low energy, lack of motivation, low self-esteem, low self-confidence
MeSH terms: Adult, Age Factors, Aged, Aging, Androgens, Antidepressive Agents, Depression, Double-Blind Method, Humans, Hypogonadism, Infusions, Intravenous, Infusions, Parenteral, Male, Middle Aged, Psychometrics, Psychotropic Drugs, Surveys and Questionnaires, Regression Analysis, Statistics as Topic, Testosterone, Multivariate Analysis, Confidence Intervals, Statistics, Nonparametric, Metabolic Syndrome

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Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome

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