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Cited by 283

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Testosterone Deficiency in Men: Systematic Review and Standard Operating Procedures for Diagnosis and Treatment

Buvat, Jacques, Maggi, Mario, Guay, André, Torres, Luiz Otavio·2013·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2012.02783.x
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Abstract

Introduction: Testosterone (T) deficiency (TD) may significantly affect sexual function and multiple organ systems. Aim: To provide recommendations and Standard Operating Procedures (SOPs) based on best evidence for diagnosis and treatment of TD in men Methods: Medical literature was reviewed by the Endocrine subcommittee of the ISSM Standards Committee, followed by extensive internal discussion over two years, then public presentation and discussion with other experts Main Outcome Measure: Recommendations and SOPs based on grading of evidence-based medical literature and interactive discussion Results: TD is the association of a low serum T with consistent symptoms or signs. T level tends to decline with age. T modulates sexual motivation and erection. It also plays a broader role in men's health. Recent studies have established associations between low T, male sexual dysfunctions and metabolic risk factors. Though association does not mean causation, low T is associated with reduced longevity, risk of fatal cardiovascular events, obesity, sarcopenia, mobility limitations, osteoporosis, frailty, cognitive impairment, depression, Sleep Apnea Syndrome, and other chronic diseases. The paper proposes a standardized process for diagnosis and treatment of TD, and updates the knowledge on T therapy (Tth) and prostate and cardiovascular safety. There is no compelling evidence that Tth causes prostate cancer or its progression in men without severe TD. Polycythemia is presently the only cardiovascular-related adverse-event significantly associated with Tth. But follow-up of controlled T trials is limited to 3 years Conclusions: Men with sexual dysfunctions, and/or with visceral obesity and metabolic diseases should be screened for TD and treated. Young men with TD should also be treated. Benefits and risks of Tth should be carefully assessed in older men. Prospective, long-term, placebo-controlled, interventional studies are required before screening for TD in more conditions, including cardiovascular diseases, and considering correction of TD as preventive medicine.

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Metadata

Authors
Buvat, J., Maggi, M., Guay, A., & Torres, L. O.
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2013-01-01
Volume
10
Issue
1
Pages
245-284
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2012.02783.x
OpenAlex
W1943633560
Cited by
283
References
44
FWCI
4.61
Type
journal article
Language
en
Open access
closed

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