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Cited by 80Biochemical Analysis and Sensing TechniquesOlfactory and Sensory Function StudiesMultisensory perception and integration

The Neurophysiology of Taste and Olfaction in Primates, and Umami Flavora

ROLLS, EDMUND T., CRITCHLEY, HUGO D., BROWNING, ANDREW, HERNADI, ISTVAN·1998·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1998.tb10602.x
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Abstract

ABSTRACT: To investigate the neural encoding of glutamate (umami) taste in the primate, recordings were made from taste responsive neurons in the cortical taste areas in macaques. Most of the neurons were in the orbitofrontal cortex (secondary) taste area. First, it was shown that there is a representation of the taste of glutamate which is separate from the representation of the other prototypical tastants sweet (glucose), salt (NaCl), bitter (quinine) and sour (HCl). Second, it was shown that single neurons that had their best responses to sodium glutamate also had good responses to glutamic acid. Third, it was shown that the responses of these neurons to the nucleotide umami tastant inosine 5′‐monophosphate were more correlated with their responses to monosodium glutamate than to any prototypical tastant. Fourth, concentration response curves showed that concentrations of monosodium glutamate as low as 0.001 M were just above threshold for some of these neurons. Fifth, some neurons in the orbitofrontal region, which responded to monosodium glutamate and other food tastes, decreased their responses after feeding with monosodium glutamate to behavioral satiety, revealing a mechanism of satiety. In some cases this reduction was sensory‐specific. Sixth, it was shown in psychophysical experiments in humans that the flavor of umami is strongest with a combination of corresponding taste and olfactory stimuli (e.g., monosodium glutamate and garlic odor). The hypothesis is proposed that part of the way in which glutamate works as a flavor enhancer is by acting in combination with corresponding food odors. The appropriate associations between the odor and the glutamate taste may be learned at least in part by olfactory to taste association learning in the primate orbitofrontal cortex.

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  • In the orbitofrontal cortex and amygdala of monkeys, individual neurons responsive to the taste of specific nutrients such as glucose, amino acids, and fat were modulated by hunger in a sensory-specific manner.

    “In the orbitofrontal cortex and amygdala of monkeys, individual neurons responsive to the taste of specific nutrients such as glucose, amino acids, and fat were modulated by hunger in a sensory-specific manner”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [137]

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Authors
ROLLS, E. T., CRITCHLEY, H. D., BROWNING, A., & HERNADI, I.
Affiliations
University of Oxford (GB)
Corresponding author
ROLLS, EDMUND T.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1998-11
Volume
855
Issue
1
Pages
426-437
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1998.tb10602.x
OpenAlex
W2038652182
Cited by
80
References
30
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
0.55
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2655 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
umami taste, glutamate, monosodium glutamate, inosine 5'-monophosphate, orbitofrontal cortex, taste-odor interaction, flavor enhancement, satiety, taste threshold, macaque
MeSH terms
Animals, Frontal Lobe, Neurons, Primates, Smell, Taste, Glutamic Acid

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