Cited by 133Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Dopaminergic transmission rapidly and persistently enhances excitability of D1 receptor-expressing striatal projection neurons

Open access
Lahiri, Asha K., Bevan, Mark D.·2020·Neuron

Abstract

Substantia nigra dopamine neurons have been implicated in the initiation and invigoration of movement, presumably through their modulation of striatal projection neuron (SPN) activity. However, the impact of native dopaminergic transmission on SPN excitability has not been directly demonstrated. Using perforated patch-clamp recording, we found that optogenetic stimulation of nigrostriatal dopamine axons rapidly and persistently elevated the excitability of D1 receptor-expressing SPNs (D1-SPNs). The evoked firing of D1-SPNs increased within hundreds of milliseconds of stimulation and remained elevated for ≥ 10 min. Consistent with the negative modulation of depolarization- and Ca 2+-activated K+ currents, dopaminergic transmission accelerated subthreshold depolarization in response to current injection, reduced the latency to fire, and transiently diminished action potential afterhyperpolarization. Persistent modulation was protein kinase A dependent and associated with a reduction in action potential threshold. Together, these data demonstrate that dopaminergic transmission potently increases D1-SPN excitability with a time course that could support subsecond and sustained behavioral control.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2020.01.028

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • DA release affects postsynaptic cells much more slowly, with about a 500-ms delay, than GABA or glutamate synaptic currents, which last 2-4 ms.

    “DA release affects the postsynaptic cell considerably more slowly ($500-ms delay) than the synaptic currents generated by either cotransmitted GABA or glutamate (2-4 ms).115,123”
  • Dopamine, GABA, and glutamate released by DANs may elicit prolonged waves of postsynaptic effects, from millisecond excitability changes to tens-of-seconds biochemical signaling and excitability.

    “the dopamine, GABA, and glutamate released by DANs may elicit prolonged waves of postsynaptic effects, cascading from the millisecond changes in excitability triggered by ionotropic receptors, to the tens of seconds on biochemical signaling and excitability 109,115,122,123 (Figure 3A).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lahiri, A. K., & Bevan, M. D.
Affiliations
Northwestern University (US)
Corresponding author
Bevan, Mark D.
Venue
Neuron
Publisher
Elsevier BV
Published
2020-04
Volume
106
Issue
2
Pages
277-290.e6
ISSN
0896-6273 (ISSN-L)
OpenAlex
W3007736386
Cited by
133
References
93
Citations by year
2026: 9 · 2025: 27 · 2024: 18 · 2023: 26 · 2022: 20 · 2021: 17 · 2020: 15 · 2019: 1
FWCI
8.93
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • OSF Preprints (OSF Preprints) (submittedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke
  • National Cancer Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
dopamine signaling, dopamine D1 receptor, striatal projection neurons, substantia nigra dopamine neurons, nigrostriatal pathway, neuronal excitability, protein kinase A, action potential threshold, afterhyperpolarization, potassium currents, optogenetic stimulation, basal ganglia
MeSH terms
Animals, Dopamine, Female, Male, Synaptic Transmission, Neurons, Neostriatum, Receptors, Dopamine D1, Neurotransmitter Agents, Patch-Clamp Techniques, Mice, Electrophysiological Phenomena, Optogenetics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review