Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

WHITE, LON; PETROVITCH, HELEN; HARDMAN, JOHN; NELSON, JAMES; DAVIS, DARON G.; ROSS, G. WEBSTER; MASAKI, KAMAL; LAUNER, LENORE; MARKESBERY, WILLIAM R.

doi:10.1111/j.1749-6632.2002.tb04794.x

Cited by 357Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsCerebrovascular and genetic disorders

Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

WHITE, LON, PETROVITCH, HELEN, HARDMAN, JOHN, NELSON, JAMES, DAVIS, DARON G., ROSS, G. WEBSTER, MASAKI, KAMAL, LAUNER, LENORE +1 more·2002·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2002.tb04794.x

Open this paper in CoChat — free account

Abstract

A bstract: Clinicopathologic data from 285 autopsies were analyzed. The decedents were long‐standing participants in the Honolulu‐Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging. We assessed the prevalence at death of four primary neuropathologic processes using specific microscopic lesions as indicators. An algorithm was developed to assign each decedent to one of six subsets, corresponding to pathologic dominance by microvascular lesions (14% of decedents), Alzheimer lesions (12%), hippocampal sclerosis (5%), cortical Lewy bodies (5%), codominance by two or more primary processes (9%), or without a dominant pathologic process recognized (55%). Definite or probable dementia had been identified in 118 of the decedents. The proportions of men in each subset identified as demented were (in the same order) 57%, 53%, 79%, 57%, 76%, and 25%. In this autopsied panel of older Japanese‐American men, the importance of microvascular lesions as a likely explanation for dementia was nearly equal to that of Alzheimer lesions. The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.2002.tb04794.x

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increased CMIs are most strongly and independently associated with increased risk of dementia among forms of VBI.
“However, among these forms of VBI, increased CMIs are most strongly and independently associated with increased risk of dementia.18, 19”
From Ecology of the Aging Human Brain (2011) · cites this paper as [18]
75% to 90% of patients older than 90 years have some degree of CVD pathologic diagnosis.
“75% to 90% of patients older than 90 years have some degree of CVD pathologic diagnosis (189, 205-207).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [205]

Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works
Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590 · see citing works
Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
The Cognitive Abilities Screening Instrument (CASI): A Practical Test for Cross-Cultural Epidemiological Studies of Dementia
Teng, E. L., Hasegawa, K., Homma, A., Imai, Y., Larson, E. B., Graves, A. B., Sugimoto, K., Yamaguchi, T., Sasaki, H., Chiu, D., et al. (1994) · International Psychogeriatrics · doi:10.1017/s1041610294001602 · Cited by 910 · see citing works
Self-citation
Prevalence of Dementia in Older Japanese-American Men in Hawaii: The Honolulu-Asia Aging Study
White, L. (1996) · JAMA · doi:10.1001/jama.1996.03540120033030 · Cited by 437 · see citing works
Self-citation
Neuropathologic Substrates of Ischemic Vascular Dementia
Vinters, H. V., Ellis, W. G., Zarow, C., Zaias, B. W., Jagust, W. J., Mack, W. J., & Chui, H. C. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.11.931 · Cited by 304 · see citing works
The Relative Frequency of "Dementia of Unknown Etiology" Increases With Age and Is Nearly 50% in Nonagenarians
Crystal, H. A., Dickson, D., Davies, P., Masur, D., Grober, E., & Lipton, R. B. (2000) · Archives of Neurology · doi:10.1001/archneur.57.5.713 · Cited by 152 · see citing works
Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based study
Petrovitch, H., White, L. R., Ross, G. W., Steinhorn, S. C., Li, C. Y., Masaki, K., Davis, D. G., Nelson, J., Hardman, J. M., Curb, J. D., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.226 · Cited by 136 · see citing works
Self-citation
Neuropathological Findings in the Very Old: Results from the First 101 Brains of a Population‐based Longitudinal Study of Dementing Disorders
Xuereb, J. H., Brayne, C., Dufouil, C., Gertz, H.-J., Wischik, C. M., Harrington, C. R., Mukaetova‐Ladinska, E. B., McGee, M. A., O'SULLIVAN, A., O’Connor, D., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06404.x · Cited by 113 · see citing works
Neuropathology of Alzheimer's disease and other dementias
Dickson, D. W. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70066-5 · Cited by 110 · see citing works
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Silverman, J. M., Raiford, K., Edland, S. D., Fillenbaum, G. G., Morris, J. C., Clark, C. M., Kukull, W. A., & Heyman, A. (1994) · Neurology · doi:10.1212/wnl.44.7.1253 · Cited by 77 · see citing works
Which Vascular Lesions Are of Importance in Vascular Dementia?
Esiri, M. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06373.x · Cited by 75 · see citing works
Vascular Dementia: The Role of Changes in the Vessels
Ogata, J. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912003-00009 · Cited by 18 · see citing works

Flagged first, then by citations

1 of the 14 references couldn’t be matched to a known paper.

Sorted by citations

Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187 · see citing works
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992 · see citing works
National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722 · see citing works
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., et al. (2019) · Brain · doi:10.1093/brain/awz099 · Cited by 1,547 · see citing works
Silent brain infarcts: a systematic review
Vermeer, S. E., Longstreth, W. T., & Koudstaal, P. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70170-9 · Cited by 1,221 · see citing works
The age-dependent relation of blood pressure to cognitive function and dementia
Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138 · see citing works
Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
de la Torre, J. C. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00683-0 · Cited by 834 · see citing works
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations
Gouw, A. A., Seewann, A., van der Flier, W. M., Barkhof, F., Rozemuller, A. M., Scheltens, P., & Geurts, J. J. G. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.204685 · Cited by 766 · see citing works
Neuropathology of Cognitively Normal Elderly
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression
Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605 · see citing works
Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
Arvanitakis, Z., Capuano, A. W., Leurgans, S. E., Bennett, D. A., & Schneider, J. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30029-1 · Cited by 581 · see citing works
Glucose transporters in brain in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558 · see citing works
Diabetic Microvascular Disease: An Endocrine Society Scientific Statement
Barrett, E. J., Liu, Z., Khamaisi, M., King, G. L., Klein, R., Klein, R., Hughes, T. M., Craft, S., Freedman, B. I., Bowden, D. W., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01922 · Cited by 519 · see citing works
Cognitive reserve and the neurobiology of cognitive aging
Whalley, L. J., Deary, I. J., Appleton, C. L., & Starr, J. M. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.001 · Cited by 460 · see citing works
Axonal damage: a key predictor of outcome in human CNS diseases
Medana, I. M., & Esiri, M. M. (2003) · Brain · doi:10.1093/brain/awg061 · Cited by 465 · see citing works
Cerebral microinfarcts: the invisible lesions
Smith, E. E., Schneider, J. A., Wardlaw, J. M., & Greenberg, S. M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70307-6 · Cited by 456 · see citing works
Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease
Kalaria, R. N. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1571-z · Cited by 441 · see citing works
Pathological correlates of dementia in a longitudinal, population‐based sample of aging
Sonnen, J. A., Larson, E. B., Crane, P. K., Haneuse, S., Li, G., Schellenberg, G. D., Craft, S., Leverenz, J. B., & Montine, T. J. (2007) · Annals of Neurology · doi:10.1002/ana.21208 · Cited by 432 · see citing works
Microinfarct Pathology, Dementia, and Cognitive Systems
Arvanitakis, Z., Leurgans, S. E., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2011) · Stroke · doi:10.1161/strokeaha.110.595082 · Cited by 404 · see citing works
(Pre)diabetes, brain aging, and cognition
Roriz‐Filho, J. S., Roriz, T. M. D. S., Rosset, I., Camozzato, A. L., dos Santos, A. C., Chaves, M. L. F., Moriguti, J. C., & Roriz‐Cruz, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.003 · Cited by 390 · see citing works
Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies
Nelson, P. T., Head, E., Schmitt, F. A., Davis, P. R., Neltner, J. H., Jicha, G. A., Abner, E. L., Smith, C. D., Van Eldik, L. J., Kryscio, R. J., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0826-y · Cited by 365 · see citing works
Prevalence of mixed pathologies in the aging brain
Rahimi, J., & Kovács, G. G. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0082-1 · Cited by 365 · see citing works
Stroke and the Risk of Alzheimer Disease
Honig, L. S., Tang, M., Albert, S. M., Costa, R., Luchsinger, J. A., Manly, J. J., Stern, Y., & Mayeux, R. P. (2003) · Archives of Neurology · doi:10.1001/archneur.60.12.1707 · Cited by 344 · see citing works
The pathology and pathophysiology of vascular dementia
Kalaria, R. N. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.030 · Cited by 344 · see citing works
Cardiovascular disease and Alzheimer's disease: common links
Stampfer, M. J. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01687.x · Cited by 325 · see citing works
Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment
Skrobot, O. A., Attems, J., Esiri, M. M., Hortobágyi, T., Ironside, J. W., Kalaria, R. N., King, A., Lammie, G. A., Mann, D. M. A., Neal, J., et al. (2016) · Brain · doi:10.1093/brain/aww214 · Cited by 323 · see citing works
Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study
Kawas, C. H., Kim, R. C., Sonnen, J. A., Bullain, S. S., Trieu, T., & Corrada, M. M. (2015) · Neurology · doi:10.1212/wnl.0000000000001831 · Cited by 303 · see citing works
Neuropathologic Outcome of Mild Cognitive Impairment Following Progression to Clinical Dementia
Jicha, G. A., Parisi, J. E., Dickson, D. W., Johnson, K., Cha, R., Ivnik, R. J., Tangalos, E. G., Boeve, B. F., Knopman, D. S., Braak, H., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.674 · Cited by 399 · see citing works
Clinicopathologic Correlations in a Large Alzheimer Disease Center Autopsy Cohort: Neuritic Plaques and Neurofibrillary Tangles "Do Count" When Staging Disease Severity
Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31815c5efb · Cited by 292 · see citing works
Self-citation
Vascular basis for brain degeneration: faltering controls and risk factors for dementia
Kalaria, R. N. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00352.x · Cited by 291 · see citing works
Atherosclerosis and AD: Analysis of data from the US National Alzheimer’s Coordinating Center
Honig, L. S., Kukull, W., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000150886.50187.30 · Cited by 284 · see citing works
Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease
Reed, B. R., Mungas, D. M., Kramer, J. H., Ellis, W., Vinters, H. V., Zarow, C., Jagust, W. J., & Chui, H. C. (2007) · Brain · doi:10.1093/brain/awl385 · Cited by 282 · see citing works
Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons
Schneider, J. A., Boyle, P. A., Arvanitakis, Z., Bienias, J. L., & Bennett, D. A. (2007) · Annals of Neurology · doi:10.1002/ana.21142 · Cited by 264 · see citing works
Cerebral Microinfarcts: A Systematic Review of Neuropathological Studies
Brundel, M., de Bresser, J., van Dillen, J. J., Kappelle, L. J., & Biessels, G. J. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.200 · Cited by 258 · see citing works
Clinical presentations and epidemiology of vascular dementia
Smith, E. E. (2017) · Clinical Science · doi:10.1042/cs20160607 · Cited by 250 · see citing works
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
Okamoto, Y., Yamamoto, T., Kalaria, R. N., Senzaki, H., Maki, T., Hase, Y., Kitamura, A., Washida, K., Yamada, M., Ito, H., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0925-9 · Cited by 249 · see citing works
Cognitive impact of subcortical vascular and Alzheimer’s disease pathology
Chui, H. C., Zarow, C., Mack, W. J., Ellis, W. G., Zheng, L., Jagust, W. J., Mungas, D., Reed, B. R., Kramer, J. H., DeCarli, C. C., et al. (2006) · Annals of Neurology · doi:10.1002/ana.21009 · Cited by 247 · see citing works
Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons
Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Davis, D. G., Poduska, J. W., Patel, E., Mendiondo, M. S., et al. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00244.x · Cited by 239 · see citing works
Self-citation
Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
Li, G., Larson, E. B., Sonnen, J. A., Shofer, J. B., Petrie, E. C., Schantz, A. M., Peskind, E. R., Raskind, M. A., Breitner, J. C. S., & Montine, T. J. (2007) · Neurology · doi:10.1212/01.wnl.0000277657.95487.1c · Cited by 237 · see citing works
Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of aging cohort
Dolan, H., Crain, B. J., Troncoso, J. C., Resnick, S. M., Zonderman, A. B., & O’Brien, R. (2010) · Annals of Neurology · doi:10.1002/ana.22055 · Cited by 232 · see citing works
AD lesions and infarcts in demented and non‐demented Japanese‐American men
Petrovitch, H., Ross, G. W., Steinhorn, S. C., Abbott, R. D., Markesbery, W., Davis, D., Nelson, J., Hardman, J., Masaki, K., Vogt, M. R., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20318 · Cited by 230 · see citing works
Self-citation
Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?
Kelleher, R. J., & Soiza, R. L. (2013) · Europe PMC (PubMed Central) · Cited by 225 · see citing works
Cerebrovascular Disease and Mechanisms of Cognitive Impairment
Kalaria, R. N. (2012) · Stroke · doi:10.1161/strokeaha.112.655803 · Cited by 225 · see citing works
Different Patterns of Cerebral Injury in Dementia With or Without Diabetes
Sonnen, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.579 · Cited by 223 · see citing works
The enigma of vascular cognitive disorder and vascular dementia
Jellinger, K. A. (2007) · Acta Neuropathologica · doi:10.1007/s00401-006-0185-2 · Cited by 221 · see citing works
Effect of infarcts on dementia in the Baltimore longitudinal study of aging
Troncoso, J. C., Zonderman, A. B., Resnick, S. M., Crain, B., Pletnikova, O., & O'Brien, R. J. (2008) · Annals of Neurology · doi:10.1002/ana.21413 · Cited by 219 · see citing works
Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia.
Román, G. C., & Kalaria, R. N. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.004 · Cited by 213 · see citing works
Cognitive impairment and cardiovascular diseases in the elderly. A heart–brain continuum hypothesis
Abete, P., Della‐Morte, D., Gargiulo, G., Basile, C., Langellotto, A., Galizia, G., Testa, G., Canonico, V., Bonaduce, D., & Cacciatore, F. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.003 · Cited by 208 · see citing works
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
Nelson, P. T., Smith, C. D., Abner, E. L., Wilfred, B. R., Wang, W., Neltner, J. H., Baker, M., Fardo, D. W., Kryscio, R. J., Scheff, S. W., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1154-1 · Cited by 201 · see citing works
<i>In Vivo</i> Detection of Cerebral Cortical Microinfarcts with High-Resolution 7T MRI
van Veluw, S. J., Zwanenburg, J. J., Engelen-Lee, J., Spliet, W. G., Hendrikse, J., Luijten, P. R., & Biessels, G. J. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.196 · Cited by 193 · see citing works
Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge City over-75s cohort (CC75C) study
Brayne, C., the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration, Richardson, K., Matthews, F. E., Fleming, J., Hunter, S., Xuereb, J. H., Paykel, E., Mukaetova-Ladinska, E. B., Huppert, F. A., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1182 · Cited by 191 · see citing works
Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample
Brenowitz, W. D., Hubbard, R. A., Keene, C. D., Hawes, S. E., Longstreth, W. T., Woltjer, R. L., & Kukull, W. A. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.09.015 · Cited by 188 · see citing works
Brain hypoperfusion: a critical factor in vascular dementia
Román, G. C. (2004) · Neurological Research · doi:10.1179/016164104225017686 · Cited by 186 · see citing works
Vascular risk factors and longitudinal changes on brain MRI
Knopman, D. S., Penman, A. D., Catellier, D., Coker, L. H., Shibata, D. K., Sharrett, A. R., & Mosley, T. H. (2011) · Neurology · doi:10.1212/wnl.0b013e31821d753f · Cited by 191 · see citing works
Determinants of vascular dementia in the Cardiovascular Health Cognition Study
Kuller, L. H., Lopez, O. L., Jagust, W. J., Becker, J. T., DeKosky, S. T., Lyketsos, C., Kawas, C., Breitner, J. C. S., Fitzpatrick, A., & Dulberg, C. (2005) · Neurology · doi:10.1212/01.wnl.0000160115.55756.de · Cited by 179 · see citing works
Profile of Cognitive Impairment in Parkinson's Disease
Watson, G. S., & Leverenz, J. B. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00373.x · Cited by 186 · see citing works
Association between Stroke and Alzheimer's Disease: Systematic Review and Meta-Analysis
Zhou, J., Yu, J., Wang, H.-F., Meng, X., Tan, C., Wang, J., Wang, C., & Tan, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140666 · Cited by 184 · see citing works
Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline
Chornenkyy, Y., Wang, W., Wei, A. L., & Nelson, P. T. (2018) · Brain Pathology · doi:10.1111/bpa.12655 · Cited by 184 · see citing works
Cerebral Small Vessel Disease
Litak, J., Mazurek, M., Kulesza, B., Szmygin, P., Litak, J., Kamieniak, P., & Grochowski, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249729 · Cited by 187 · see citing works
LATE-NC staging in routine neuropathologic diagnosis: an update
Nelson, P. T., Lee, E. B., Cykowski, M. D., Alafuzoff, I. I., Arfanakis, K., Attems, J., Brayne, C., Corrada, M. M., Dugger, B. N., Flanagan, M. E., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02524-2 · Cited by 175 · see citing works
Ecology of the Aging Human Brain
Sonnen, J. A. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.157 · Cited by 174 · see citing works
Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies
White, L. R., Edland, S. D., Hemmy, L. S., Montine, K. S., Zarow, C., Sonnen, J. A., Uyehara‐Lock, J. H., Gelber, R. P., Ross, G. W., Petrovitch, H., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002480 · Cited by 171 · see citing works
Self-citation
Diabetic Retinopathy and Cognitive Decline in Older People With Type 2 Diabetes
Ding, J., Strachan, M. W. J., Reynolds, R. M., Frier, B. M., Deary, I. J., Gerald, F. F. R., Lee, A. J., McKnight, J., Halpin, P., Swa, K., et al. (2010) · Diabetes · doi:10.2337/db10-0752 · Cited by 162 · see citing works
Recent Clinical-Pathologic Research on the Causes of Dementia in Late Life: Update From the Honolulu-Asia Aging Study
White, L., Small, B. J., Petrovitch, H., Ross, G. W., Masaki, K., Abbott, R. D., Hardman, J., Davis, D., Nelson, J., & Markesbery, W. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705281872 · Cited by 155 · see citing works
Self-citation
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
APOE , vascular pathology, and the AD brain
Yip, A. G., McKee, A. C., Green, R. C., WELLS, J. S., Young, H., Cupples, L. A., & Farrer, L. A. (2005) · Neurology · doi:10.1212/01.wnl.0000168863.49053.4d · Cited by 155 · see citing works
Cerebral Microinfarcts Associated with Severe Cerebral β‐Amyloid Angiopathy
Soontornniyomkij, V., Lynch, M. D., Mermash, S., Pomakian, J., Badkoobehi, H., Clare, R., & Vinters, H. V. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00322.x · Cited by 153 · see citing works
The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment
P. Gelber, R., J. Launer, L., & R. White, L. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322618 · Cited by 149 · see citing works
Self-citation
Mixed dementia: A review of the evidence
Custodio, N., Montesinos, R., Lira, D., Herrera-Pérez, E., Bardales, Y., & Valeriano-Lorenzo, L. (2017) · Dementia & Neuropsychologia · doi:10.1590/1980-57642016dn11-040005 · Cited by 148 · see citing works
Functional and morphological changes of the retinal vessels in Alzheimer’s disease and mild cognitive impairment
Querques, G., Borrelli, E., Sacconi, R., Vitis, L. A. D., Leocani, L., Santangelo, R., Magnani, G., Comı, G., & Bandello, F. M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37271-6 · Cited by 149 · see citing works
Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review
Chui, H. C., Zheng, L., Reed, B., Vinters, H. V., & Mack, W. J. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt98 · Cited by 141 · see citing works
Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)
O'Brien, R. J., Resnick, S. M., Zonderman, A. B., Ferrucci, L., Crain, B. J., Pletnikova, O., Rudow, G., Iacono, D., Riudavets, M. A., Driscoll, I., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1179 · Cited by 137 · see citing works
Challenges of multimorbidity of the aging brain: a critical update
Jellinger, K. A., & Attems, J. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-014-1288-x · Cited by 154 · see citing works
Vascular disease and dementias: Paradigm shifts to drive research in new directions
Kling, M. A., Trojanowski, J. Q., Wolk, D. A., Lee, V. M. ‐., & Arnold, S. E. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.007 · Cited by 132 · see citing works
Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis
Cheng, H.-L., Lin, C.-J., Soong, B.-W., Wang, P.-N., Chang, F.-C., Wu, Y.-T., Chou, K.-H., Lin, C.-P., Tu, P.-C., & Lee, I.-H. (2012) · Stroke · doi:10.1161/strokeaha.111.645614 · Cited by 128 · see citing works
Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
Prohovnik, I., Perl, D. P., Davis, K. L., Libow, L. S., Lesser, G. T., & Haroutunian, V. H. (2006) · Neurology · doi:10.1212/01.wnl.0000191298.68045.50 · Cited by 129 · see citing works
Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing
Neltner, J. H., Abner, E. L., Baker, S., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Hammack, E., Kukull, W. A., Brenowitz, W. D., et al. (2013) · Brain · doi:10.1093/brain/awt318 · Cited by 130 · see citing works
Cognitive impairment risk: White matter hyperintensity progression matters
Silbert, L. C., Howieson, D. B., Dodge, H., & Kaye, J. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181ad53fd · Cited by 123 · see citing works
Trajectory of white matter hyperintensity burden preceding mild cognitive impairment
Silbert, L. C., Dodge, H. H., Perkins, L. N., Sherbakov, L. O., Lahna, D. L., Erten‐Lyons, D., Woltjer, R. L., Shinto, L. H., & Kaye, J. A. (2012) · Neurology · doi:10.1212/wnl.0b013e3182661f2b · Cited by 125 · see citing works
Update on Vascular Dementia
Khan, A., Kalaria, R. N., Corbett, A., & Ballard, C. G. (2016) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988716654987 · Cited by 125 · see citing works
Vascular Risk Factors: Imaging and Neuropathologic Correlates
Knopman, D. S., & Roberts, R. O. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091555 · Cited by 122 · see citing works
Circulating Biomarkers of Cognitive Decline and Dementia
Solfrizzi, V., D'Introno, A., Colacicco, A. M., Capurso, C., Todarello, O., Pellicani, V., Capurso, S. A., Pietrarossa, G., Santamato, V., Capurso, A., et al. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.06.015 · Cited by 120 · see citing works
Retinal microvascular abnormalities and cognitive decline
Lesage, S. R., Mosley, T. H., Wong, T. Y., Szklo, M., Knopman, D. S., Catellier, D., Cole, S. R., Klein, R., Coresh, J., Coker, L. H., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b78436 · Cited by 130 · see citing works
Is synaptic loss a unique hallmark of Alzheimer’s disease?
Scheff, S. W., Neltner, J. H., & Nelson, P. T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.028 · Cited by 118 · see citing works
Contribution of vascular pathology to the clinical expression of dementia
Altschul, D., Dickson, D. W., Lipton, R. B., Katz, M. J., Derby, C. A., Lee, S. H., Wang, C., & Verghese, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.011 · Cited by 114 · see citing works
Impaired Cerebral Autoregulation and Vasomotor Reactivity in Sporadic Alzheimer’s Disease
den Abeelen, A. S. S. M.-V., Lagró, J., van Beek, A. H. E. A., & Claassen, J. A. H. R. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131119234845 · Cited by 114 · see citing works
Associations of cortical astrogliosis with cognitive performance and dementia status
Kashon, M. L., Ross, G. W., O'Callaghan, J. P., Miller, D. B., Petrovitch, H., Burchfiel, C. M., Sharp, D. S., Markesbery, W. R., Davis, D. G., Hardman, J. M., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6604 · Cited by 114 · see citing works
Self-citation
Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort
Knopman, D. S., Mosley, T. H., Catellier, D., & Sharrett, A. R. (2005) · Neurology · doi:10.1212/01.wnl.0000176074.09733.a8 · Cited by 113 · see citing works
Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review
ZACCAI, J. H., Ince, P. G., & Brayne, C. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-2 · Cited by 111 · see citing works
Vascular Dementia Prevention: A Risk Factor Analysis
Román, G. C. (2005) · Cerebrovascular Diseases · doi:10.1159/000089361 · Cited by 150 · see citing works
Classification of vascular dementia in the Cardiovascular Health Study Cognition Study
Lopez, O. L., Kuller, L. H., Becker, J. T., Jagust, W. J., DeKosky, S. T., Fitzpatrick, A., Breitner, J., Lyketsos, C., Kawas, C., & Carlson, M. (2005) · Neurology · doi:10.1212/01.wnl.0000159860.19413.c4 · Cited by 109 · see citing works
White matter lesions defined by diffusion tensor imaging in older adults
Back, S. A., Kroenke, C. D., Sherman, L. S., Lawrence, G., Gong, X., Taber, E. N., Sonnen, J. A., Larson, E. B., & Montine, T. J. (2011) · Annals of Neurology · doi:10.1002/ana.22484 · Cited by 109 · see citing works
Hypertension, hypertension-clustering factors and Alzheimer's disease
Skoog, I. G., & Gustafson, D. (2003) · Neurological Research · doi:10.1179/016164103101201986 · Cited by 110 · see citing works
Examination of the Clinicopathologic Continuum of Alzheimer Disease in the Autopsy Cohort of the National Alzheimer Coordinating Center
Serrano‐Pozo, A., Qian, J., Monsell, S. E., Frosch, M. P., Betensky, R. A., & Hyman, B. T. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000016 · Cited by 105 · see citing works
The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia
Nichols, E., Merrick, R., Hay, S. I., Himali, D., Himali, J. J., Hunter, S., Keage, H. A. D., Latimer, C. S., Scott, M. R., Steinmetz, J. D., et al. (2023) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(23)00019-3 · Cited by 108 · see citing works
Self-citation
Adjustment for Selection Bias in Observational Studies with Application to the Analysis of Autopsy Data
Haneuse, S., Schildcrout, J. S., Crane, P. K., Sonnen, J. A., Breitner, J. C. S., & Larson, E. B. (2009) · Neuroepidemiology · doi:10.1159/000197389 · Cited by 106 · see citing works
The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and A lzheimer's disease
Kövari, E., Herrmann, F. R., Hof, P. R., & Bouras, C. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12003 · Cited by 105 · see citing works
Understanding hippocampal sclerosis in the elderly: Epidemiology, characterization, and diagnostic issues
Zarow, C., Sitzer, T. E., & Chui, H. C. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0057-3 · Cited by 104 · see citing works

Brain Lesions at Autopsy in Older Japanese-American Men as Related to Cognitive Impairment and Dementia in the Final Years of Life: A Summary Report from the Honolulu-Asia Aging Study
White, L. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1178 · Cited by 193 · see citing works
Self-citation
Recent Clinical-Pathologic Research on the Causes of Dementia in Late Life: Update From the Honolulu-Asia Aging Study
White, L., Small, B. J., Petrovitch, H., Ross, G. W., Masaki, K., Abbott, R. D., Hardman, J., Davis, D., Nelson, J., & Markesbery, W. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705281872 · Cited by 155 · see citing works
Self-citation
Clinicopathological analysis of dementia disorders in the elderly – An update
Jellinger, K. A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s308 · Cited by 143 · see citing works
A Neuropathological Study of Dementia in Nursing Homes in Shimane Prefecture, Japan: Evaluation of the Age and Gender Effect
Seno, H., Ishino, H., Inagaki, T., Iijima, M., Kaku, K., Inata, T., & Hirai, M. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.6.m312 · Cited by 6 · see citing works
The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment
P. Gelber, R., J. Launer, L., & R. White, L. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322618 · Cited by 149 · see citing works
Self-citation

Authors: WHITE, L., PETROVITCH, H., HARDMAN, J., NELSON, J., DAVIS, D. G., ROSS, G. W., MASAKI, K., LAUNER, L., & MARKESBERY, W. R.
Affiliations: University of Hawaiʻi at Mānoa (US)
University of Kentucky (US)
United States Department of Veterans Affairs (US)
National Institutes of Health (US)
Corresponding author: WHITE, LON
ORCID: WHITE, LON
PETROVITCH, HELEN
MASAKI, KAMAL
LAUNER, LENORE
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2002-11
Volume: 977
Issue: 1
Pages: 9-23
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2002.tb04794.x
OpenAlex: W2072753569
Cited by: 357
References: 14
Citations by year: 2026: 5 · 2025: 10 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 7 · 2018: 15 · 2017: 19 · 2016: 25 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 35
FWCI: 7.39
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1180 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01ag042149-007)
National Institute on Aging (N01‐AG‐4‐2149)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
Keywords: cerebrovascular pathology, dementia, microvascular lesions, hippocampal sclerosis, cortical Lewy bodies, sex differences in dementia, Honolulu-Asia Aging Study, aging
MeSH terms: Aged, Alzheimer Disease, Asia, Autopsy, Brain, Cerebral Infarction, Cerebrovascular Circulation, Dementia, Female, Hawaii, Humans, Male, Microcirculation, Prospective Studies, Lewy Bodies, Amoxicillin-Potassium Clavulanate Combination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks