Cited by 128Cellular transport and secretionNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

SNAP‐25 in Neuropsychiatric Disorders

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Corradini, Irene, Verderio, Claudia, Sala, Mariaelvina, Wilson, Michael C., Matteoli, Michela·2009·Annals of the New York Academy of Sciences

Abstract

SNAP‐25 (synaptosomal‐associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP‐25 also modulates different voltage‐gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP‐25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

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Crossref · 10.1111/j.1749-6632.2008.03995.x

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  • Rbfox1−/− splicing changes affect transcripts encoding ion channels, neurotransmitter receptors, structural proteins and Ca2+ signalling molecules.

    “However, these splicing changes affect transcripts encoding ion channels, neurotransmitter receptors, structural proteins and Ca2+ signalling molecules”

    From The neurogenetics of alternative splicing (2016) · cites this paper as [137]

  • Many of the transcripts affected by Rbfox1−/− splicing changes are associated with seizure disorders in humans or mice.

    “many of which are associated with seizure disorders in humans or mice, such as the GABAA receptor subunit Gabrg2, Grin1, the voltage-gated sodium channel Scn8a (which encodes NaV1.6), and synaptosomal-associated protein 25 (Snap25)133–137”

    From The neurogenetics of alternative splicing (2016) · cites this paper as [137]

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Authors
Corradini, I., Verderio, C., Sala, M., Wilson, M. C., & Matteoli, M.
Affiliations
  • University of Milan (IT)
  • University of New Mexico Health Sciences Center (US)
Corresponding author
Matteoli, Michela
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2009-01
Volume
1152
Issue
1
Pages
93-99
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2071613912
Cited by
128
References
63
Citations by year
2026: 7 · 2025: 8 · 2024: 3 · 2023: 18 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 11 · 2012: 8
FWCI
4.45
Type
journal article
Language
en
Open access
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH 4-8989, R01MH048989)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
SNAP-25, SNARE complex, regulated exocytosis, neurotransmitter release, voltage-gated calcium channels, neuropsychiatric disorders, neurological disorders, genetic variants, mouse model, syntaxin, synaptobrevin
MeSH terms
Animals, Attention Deficit Disorder with Hyperactivity, Epilepsy, Humans, Nervous System Diseases, Schizophrenia, Synaptosomal-Associated Protein 25

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