Plant polyphenols and human skin: Friends or foes
Abstract
In response to abiotic and biotic stressors, numerous polyphenols (PPs) are synthesized from phenylalanine by higher plants, amid many other plants that are poisonous for insects, birds, animals, and humans. PPs are also widely recognized by botanical dermatology as major plant constituents inducing allergic reactions, contact dermatitis, phytodermatoses, and photophytodermatoses. Notwithstanding these clinical observations, thousands of cosmetic/dermatological preparations based on PP-containing plant extracts or pure PPs emerge yearly with the claims of photoprotection, chemoprevention of skin tumors, anti-aging, wound healing, etc. However, because of their peculiar physical, chemical, and biological properties, PPs could be a double-edged sword for human skin, exerting both protective and damaging actions. Here, we distinguish direct and indirect anti- and pro-oxidant properties of PPs, their interactions with major xenobiotic metabolic systems and sensors/receptors of environmental hazards, anti- and proinflammatory potential, and photoprotection versus photosensitization.
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Most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells; clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on polyphenol cytotoxicity.
“This article lists some experimental cases of food-derived polyphenol extracts to alleviate skin aging (Table 2), but most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells. Nonetheless, the clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on the cytotoxicity of poly”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [113]
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Diet and Skin Aging—From the Perspective of Food Nutrition
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- Authors
- Korkina, L., De Luca, C., & Pastore, S.
- Affiliations
- Istituto Dermopatico dell'Immacolata (IT)
- Corresponding author
- Korkina, Liudmila
- ORCID
- Korkina, Liudmila
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2012-07
- Volume
- 1259
- Issue
- 1
- Pages
- 77-86
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2171419743
- Cited by
- 47
- References
- 86
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 3
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- plant polyphenols, human skin, allergic contact dermatitis, photodermatosis, cosmetic preparations, photoprotection, photosensitization, antioxidant activity, pro-oxidant activity, xenobiotic metabolism, inflammation, skin cancer chemoprevention, wound healing, anti-aging
- MeSH terms
- Animals, Antioxidants, Humans, Models, Biological, Plant Extracts, Radiation-Protective Agents, Skin, Skin Physiological Phenomena, Oxidants, Chemoprevention, Polyphenols
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