Cited by 47Skin Protection and AgingContact Dermatitis and AllergiesPhytochemicals and Antioxidant Activities

Plant polyphenols and human skin: Friends or foes

Korkina, Liudmila, De Luca, Chiara, Pastore, Saveria·2012·Annals of the New York Academy of Sciences

Abstract

In response to abiotic and biotic stressors, numerous polyphenols (PPs) are synthesized from phenylalanine by higher plants, amid many other plants that are poisonous for insects, birds, animals, and humans. PPs are also widely recognized by botanical dermatology as major plant constituents inducing allergic reactions, contact dermatitis, phytodermatoses, and photophytodermatoses. Notwithstanding these clinical observations, thousands of cosmetic/dermatological preparations based on PP-containing plant extracts or pure PPs emerge yearly with the claims of photoprotection, chemoprevention of skin tumors, anti-aging, wound healing, etc. However, because of their peculiar physical, chemical, and biological properties, PPs could be a double-edged sword for human skin, exerting both protective and damaging actions. Here, we distinguish direct and indirect anti- and pro-oxidant properties of PPs, their interactions with major xenobiotic metabolic systems and sensors/receptors of environmental hazards, anti- and proinflammatory potential, and photoprotection versus photosensitization.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.2012.06510.x

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells; clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on polyphenol cytotoxicity.

    “This article lists some experimental cases of food-derived polyphenol extracts to alleviate skin aging (Table 2), but most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells. Nonetheless, the clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on the cytotoxicity of poly”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [113]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Korkina, L., De Luca, C., & Pastore, S.
Affiliations
Istituto Dermopatico dell'Immacolata (IT)
Corresponding author
Korkina, Liudmila
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2012-07
Volume
1259
Issue
1
Pages
77-86
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2171419743
Cited by
47
References
86
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 3
FWCI
5.59
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
plant polyphenols, human skin, allergic contact dermatitis, photodermatosis, cosmetic preparations, photoprotection, photosensitization, antioxidant activity, pro-oxidant activity, xenobiotic metabolism, inflammation, skin cancer chemoprevention, wound healing, anti-aging
MeSH terms
Animals, Antioxidants, Humans, Models, Biological, Plant Extracts, Radiation-Protective Agents, Skin, Skin Physiological Phenomena, Oxidants, Chemoprevention, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review