Efficacy of adjunctive anti‐plaque chemical agents in managing gingivitis: a systematic review and meta‐analysis
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Aim: The aim of this systematic review was to evaluate the efficacy of anti‐plaque chemical formulations for managing gingivitis, in 6‐month, home‐use, randomised clinical trials (RCTs). Material and Methods: A protocol was designed, including inclusion and exclusion criteria to identify RCT s assessing gingival and/or bleeding indices. Electronic and hand‐searches identified relevant papers, which were screened and evaluated for inclusion. Full‐papers were retrieved and relevant information was extracted (also plaque indices), including quality and risk of bias. Mean treatment effects were calculated to obtain weighted mean differences (WMD) and 95% confidence intervals. Results: After the process of screening and selection, 87 articles with 133 comparisons, were included in the review. The additional effects of the tested products were statistically significant in terms of Löe & Silness gingival index (46 comparisons, WMD −0.217), modified gingival index (n = 23, −0.415), gingivitis severity index (n = 26, −14.939%) or bleeding index (n = 23, −7.626%), with significant heterogeneity. For plaque, additional effects were found for Turesky (66 studies, WMD −0.475), Silness & Löe (n = 26, −0.109), and plaque severity (n = 12, −23.4%) indices, with significant heterogeneity. Conclusion: Within the limitations of the present study, formulations with specific agents for chemical plaque control provide statistically significant improvements in terms of gingival, bleeding and plaque indices.
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Only dentifrices containing additional anti-inflammatory agents such as triclosan or stannous fluoride have been found to provide additional effects on plaque removal and gingival health, but not a standard fluoride dentifrice.
“Only dentifrices containing additional anti-inflammatory agents such as triclosan or stannous fluoride have been found to provide additional effects on plaque removal and gingival health, but not a standard fluoride dentifrice.4,11,12,57”
From Contemporary practices for mechanical oral hygiene to prevent periodontal disease. (2020) · cites this paper as [12]
The Gingival indices and Plaque indices sections report additional benefits for triclosan/copolymer dentifrices, and the plaque results also show a benefit for stannous-fluoride dentifrices. But the review reports benefits for other dentifrice ingredients too, so it does not support “only”; its Type of interventions section lists just one comparison involving sodium fluoride and does not establish the broad claim that a standard fluoride dentifrice provides no additional effect. (LLM, conf=0.86)
Experimental — accuracy not yet measuredChemical adjuncts in dentifrices and mouthrinses provide additional benefits in prevention of gingivitis.
“However, chemical adjuncts in dentifrices and mouthrinses have been demonstrated to provide additional benefits in the prevention of gingivitis.11,12”
From Contemporary practices for mechanical oral hygiene to prevent periodontal disease. (2020) · cites this paper as [12]
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Self-citation
- Authors
- Serrano, J., Escribano, M., Roldán, S., Martín, C., & Herrera, D.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Herrera, David
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2015-03-31
- Volume
- 42
- Issue
- S16
- Pages
- S106-38
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W4211141481
- Cited by
- 182
- References
- 137
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 18 · 2023: 25 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 17 · 2018: 11 · 2017: 12 · 2016: 11 · 2015: 8 · 2012: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal Of Clinical Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- gingivitis, antiplaque agents, adjunctive therapy, plaque control, gingival index, bleeding index, plaque index, gingivitis severity
- MeSH terms
- Anti-Infective Agents, Local, Dental Plaque, Dental Plaque Index, Gingivitis, Humans, Periodontal Index, Randomized Controlled Trials as Topic, Treatment Outcome
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