Reduced plaque formation by the chloromethyl analogue of victamine C

Turesky, Samuel; Gilmore, Neville D.; Glickman, Irving

doi:10.1902/jop.1970.41.1.41

Cited by 1,450Oral microbiology and periodontitis researchDental Health and Care UtilizationPeriodontal Regeneration and Treatments

Reduced plaque formation by the chloromethyl analogue of victamine C

Turesky, Samuel, Gilmore, Neville D., Glickman, Irving·1970·Journal of Periodontology

DOI 10.1902/jop.1970.41.1.41

Open this paper in CoChat — free account

Abstract

T H E C H L O R O M E T H Y L A N A L O G U E of Victamine C,* a cationic surface-active agent, reduces the formation of dental calculus in humans. 1 2 This chemical prevents crystallization of calcium phosphate in calculus smears in vitro, 3 but the mechanism whereby it inhibits calculus formation in vivo is not known. The following study was conducted to determine whether the chloromethyl analogue of Victamine C reduces the formation of dental plaque considered a precursor of calculus. 4 6

Integrity signals

Registry

Crossref · 10.1902/jop.1970.41.1.41

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In six studies using the modified Quigley and Hein Index, the SnF2 dentifrice produced a mean plaque reduction of 15.3% (range 3.9%-25.8%) compared to a negative control.
“Six studies [42, 43, 44, 45, 46]; used the modified Quigley and Hein Index [25, 27] and reported a mean reduction in plaque of 15.3% (range 3.9%–25.8%) for the SnF2 dentifrice compared to a negative control.”
From Effects of stabilized stannous fluoride dentifrice on dental calculus, dental plaque, gingivitis, halitosis and stain: A systematic review (2019) · cites this paper as [27]

Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · see citing works
Incidence of clinical manifestations of periodontal disease in light of oral hygiene and calculus formation
Lovdal, A., Arno, A., & Waerhaug, J. (1958) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1958.0021 · Cited by 225 · see citing works

Flagged first, then by citations

Sorted by citations

Powered versus manual toothbrushing for oral health
Yaacob, M., Worthington, H. V., Deacon, S. A., Deery, C., Walmsley, A. D., Robinson, P. G., & Glenny, A.-M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002281.pub3 · Cited by 374 · see citing works
A meta-analysis of six-month studies of antiplaque and antigingivitis agents
Gunsolley, J. C. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0110 · Cited by 357 · see citing works
A systematic review of the effectiveness of self‐performed mechanical plaque removal in adults with gingivitis using a manual toothbrush
Van Der Weijden, G. A., & Hioe, K. P. K. (2005) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00795.x · Cited by 304 · see citing works
Periodontal health status and bacteraemia from daily oral activities: systematic review/meta‐analysis
Tomás, I., Diz, P., Tobías, A., Scully, C., & Donos, N. (2012) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01784.x · Cited by 291 · see citing works
The efficacy of manual toothbrushes following a brushing exercise: a systematic review
Slot, D., Wiggelinkhuizen, L., Rosema, N., & Van der Weijden, G. (2012) · International Journal of Dental Hygiene · doi:10.1111/j.1601-5037.2012.00557.x · Cited by 182 · see citing works
Efficacy of adjunctive anti‐plaque chemical agents in managing gingivitis: a systematic review and meta‐analysis
Serrano, J., Escribano, M., Roldán, S., Martín, C., & Herrera, D. (2015) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12331 · Cited by 182 · see citing works
The efficacy of powered toothbrushes following a brushing exercise: a systematic review
Rosema, N., Slot, D., van Palenstein Helderman, W., Wiggelinkhuizen, L., & Van der Weijden, G. (2016) · International Journal of Dental Hygiene · doi:10.1111/idh.12115 · Cited by 147 · see citing works
Quantification of dental plaque in the research environment
Pretty, I. A., Edgar, W. M., Smith, P. W., & Higham, S. M. (2005) · Journal of Dentistry · doi:10.1016/j.jdent.2004.10.017 · Cited by 140 · see citing works
Early microbial succession in redeveloping dental biofilms in periodontal health and disease
Teles, F. R., Teles, R. P., Uzel, N. G., Song, X. Q., Torresyap, G., Socransky, S. S., & Haffajee, A. D. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01409.x · Cited by 139 · see citing works
A review of the effects of stannous fluoride on gingivitis
Paraskevas, S., & Van Der Weijden, G. A. (2006) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00860.x · Cited by 94 · see citing works
Nutritional intervention in patients with periodontal disease: Clinical, immunological and microbiological variables during 12 months
Jenzsch, A., Eick, S., Rassoul, F., Purschwitz, R., & Jentsch, H. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508047776 · Cited by 91 · see citing works
Impact of single-session motivational interviewing on clinical outcomes following periodontal maintenance therapy
Brand, V., Bray, K., MacNeill, S., Catley, D., & Williams, K. (2013) · International Journal of Dental Hygiene · doi:10.1111/idh.12012 · Cited by 83 · see citing works
Does dentifrice use help to remove plaque? A systematic review
Valkenburg, C., Slot, D. E., Bakker, E. W. P., & Van der Weijden, F. A. (2016) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12615 · Cited by 69 · see citing works
CLINICAL EVALUATION OF RESTORED MAXILLARY INCISORS: VENEERS VS. PFM CROWNS
PIPPIN, D. J., MIXSON, J. M., & SOLDAN-ELS, A. P. (1995) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1995.0081 · Cited by 69 · see citing works
The Additional Effect of a Dentifrice on the Instant Efficacy of Toothbrushing: A Crossover Study
Paraskevas, S., Rosema, N. A. F., Versteeg, P., Timmerman, M. F., van der Velden, U., & van der Weijden, G. A. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060339 · Cited by 67 · see citing works
Oral Health in Young Adults with Long-Term, Controlled Asthma
Stensson, M., Wendt, L.-K., Koch, G., Oldaeus, G., Ramberg, P., & Birkhed, D. (2011) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2010.547516 · Cited by 62 · see citing works
Anti‐gingivitis efficacy of a stabilized 0.454% stannous fluoride/sodium hexametaphosphate dentifrice: A controlled 6‐month clinical trial
Mankodi, S., Bartizek, R. D., Leslie Winston, J., Biesbrock, A. R., McClanahan, S. F., & He, T. (2005) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00639.x · Cited by 61 · see citing works
Comparative assessment of plaque removal and motivation between a manual toothbrush and an interactive power toothbrush in adolescents with fixed orthodontic appliances: A single-center, examiner-blind randomized controlled trial
Erbe, C., Klees, V., Braunbeck, F., Ferrari-Peron, P., Ccahuana-Vasquez, R. A., Timm, H., Grender, J., Cunningham, P., Adam, R., & Wehrbein, H. (2019) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2018.12.013 · Cited by 49 · see citing works
Oral Health Benefits of a Daily Dental Chew in Dogs
Quest, B. W. (2013) · Journal of Veterinary Dentistry · doi:10.1177/089875641303000203 · Cited by 47 · see citing works
Oral health practices and prevalence of dental plaque and gingivitis among Indian adults
Sreenivasan, P. K., Prasad, K. V. V., & Javali, S. B. (2016) · Clinical and Experimental Dental Research · doi:10.1002/cre2.15 · Cited by 43 · see citing works
Effects of stabilized stannous fluoride dentifrice on dental calculus, dental plaque, gingivitis, halitosis and stain: A systematic review
Johannsen, A., Emilson, C.-G., Johannsen, G., Konradsson, K., Lingström, P., & Ramberg, P. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02850 · Cited by 47 · see citing works
“Six studies [42, 43, 44, 45, 46]; used the modified Quigley and Hein Index [25, 27] and reported a mean reduction in plaque of 15.”
BackgroundMethodInfluential
Comparative evaluation of honey, chlorhexidine gluconate (0.2%) and combination of xylitol and chlorhexidine mouthwash (0.2%) on the clinical level of dental plaque: A 30 days randomized control trial
Jain, A., Bhaskar, D., Gupta, D., Agali, C., Gupta, V., Gupta, R., Yadav, P., Lavate, A., & Chaturvedi, M. (2015) · Perspectives in Clinical Research · doi:10.4103/2229-3485.148819 · Cited by 42 · see citing works
Three‐year randomized study of manual and power toothbrush effects on pre‐existing gingival recession
Dörfer, C. E., Staehle, H. J., & Wolff, D. (2016) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12518 · Cited by 38 · see citing works
Antimicrobial effects of a stannous fluoride toothpaste in distinct oral microenvironments
Haraszthy, V. I., Raylae, C. C., & Sreenivasan, P. K. (2019) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2019.01.007 · Cited by 34 · see citing works
Efficacy of a rubber bristles interdental cleaner compared to an interdental brush on dental plaque, gingival bleeding and gingival abrasion: A randomized clinical trial
Hennequin‐Hoenderdos, N., van der Sluijs, E., van der Weijden, G., & Slot, D. (2018) · International Journal of Dental Hygiene · doi:10.1111/idh.12316 · Cited by 34 · see citing works
The effect of removable partial denture framework design on gingival inflammation: A clinical model
McHenry, K. R., Johansson, O. E., & Christersson, L. A. (1992) · The Journal of Prosthetic Dentistry · doi:10.1016/0022-3913(92)90205-o · Cited by 33 · see citing works
Toothbrush efficacy for plaque removal
Nightingale, K., Chinta, S., Agarwal, P., Nemelivsky, M., Frisina, A., Cao, Z., Norman, R., Fisch, G., & Corby, P. (2014) · International Journal of Dental Hygiene · doi:10.1111/idh.12081 · Cited by 32 · see citing works
Evaluation of a stabilized stannous fluoride dentifrice on dental plaque and gingivitis in a randomized controlled trial with 6-month follow-up
Hu, D., Li, X., Liu, H., Mateo, L. R., Sabharwal, A., Xu, G., Szewczyk, G., Ryan, M., & Zhang, Y.-P. (2019) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2019.01.005 · Cited by 24 · see citing works
Effectiveness of a motivational–behavioural skills protocol for oral hygiene among patients with hyposalivation
López‐Jornet, P., Fabio, C., Consuelo, R. A., & Paz, A. M. (2014) · Gerodontology · doi:10.1111/ger.12037 · Cited by 21 · see citing works
Effect of a novel ceramic filling material on plaque formation and marginal gingiva
Konradsson, K., & van Dijken, J. W. V. (2002) · Acta Odontologica Scandinavica · doi:10.1080/000163502762667414 · Cited by 17 · see citing works
Multimodality imaging of the effects of a novel dentifrice on oral biofilm: IMAGING EFFECTS OF A NOVEL DENTIFRICE ON BIOFILM
Ajdaharian, J., Dadkhah, M., Sabokpey, S., Biren-Fetz, J., Chung, N. E., Wink, C., & Wilder-Smith, P. (2014) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22265 · Cited by 15 · see citing works
GoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial
Garyga, V., Pochelu, F., Thivichon-Prince, B., Aouini, W., Santamaria, J., Lambert, F., Maucort-Boulch, D., Gueyffier, F., Gritsch, K., & Grosgogeat, B. (2019) · Trials · doi:10.1186/s13063-019-3738-0 · Cited by 14 · see citing works
Effect of a Multidirectional Power Toothbrush and a Manual Toothbrush in Individuals Susceptible to Gingival Recession: A 12‐Month Randomized Controlled Clinical Study
Sälzer, S., Graetz, C., Plaumann, A., Heinevetter, N., Grender, J., Klukowska, M., Schneider, C. A., Springer, C., Van der Weijden, F. A., & Dörfer, C. E. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.150472 · Cited by 13 · see citing works
Evaluating efficacy of a novel dentifrice in reducing probing depths in Stage I and II periodontitis maintenance patients: A randomized, double-blind, positive controlled clinical trial
Kaur, M., Geurs, N. C., Cobb, C. M., Otomo‐Corgel, J., Takesh, T., Lee, J. H., Lam, T. M., Lin, K., Nguyen, A., Nguyen, B. L., et al. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0721 · Cited by 11 · see citing works
Plaque Removal and Gingival Health after Use of a Novel Dental Gel: A Clinical Study
Nayudu, A., & Lam, T. (2016) · Dentistry · doi:10.4172/2161-1122.1000396 · Cited by 10 · see citing works
Aragonite toothpaste for management of dental calculus: A double‐blinded randomized controlled clinical trial
Al‐Hashedi, A. A., Dubreuil, N., Schwinghamer, T., Dorzhiyeva, S., Anweigi, L., Emami, E., & Tamimi, F. (2022) · Clinical and Experimental Dental Research · doi:10.1002/cre2.559 · Cited by 9 · see citing works
Plaque index and gingival index during rapid maxillary expansion of patients with unilateral cleft lip and palate
Rocha, M. O., Oliveira, D. D., Costa, F. O., Pires, L. R., Diniz, A. R., & Soares, R. V. (2017) · Dental Press Journal of Orthodontics · doi:10.1590/2177-6709.22.6.043-048.oar · Cited by 9 · see citing works
Presenting patients with information on their oral health risk: the PREFER three-arm RCT and ethnography
Harris, R., Vernazza, C., Laverty, L., Lowers, V., Burnside, G., Brown, S., Higham, S., & Ternent, L. (2020) · Health Services and Delivery Research · doi:10.3310/hsdr08030 · Cited by 7 · see citing works
Dental Calculus Formation Rate: The Role of Salivary Proteome and Metaproteome
Cai, W., Dubreuil, N., Abu Nada, L., Zhou, W. B. S., Basiri, T., Hadad, A., Charde, P., Ducret, M., & Tamimi, F. (2025) · Journal of Clinical Periodontology · doi:10.1111/jcpe.14142 · Cited by 9 · see citing works
“The plaque accumulation on the labial and lingual surfaces of the teeth, evaluated using the Quigley-Hain Plaque Index (QHI) (Turesky et al. 1970).”
Effect of compliance during periodontal maintenance therapy on c‐reactive protein levels: a 6‐year follow‐up
Costa, F. O., Esteves Lima, R. P., Cortelli, S. C., Costa, A. M., Cortelli, J. R., & Cota, L. O. M. (2021) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13407 · Cited by 5 · see citing works
A randomized double-blind clinical trial evaluating comparative plaque and gingival health associated with commercially available stannous fluoride-containing dentifrices as compared to a sodium fluoride control dentifrice
Geisinger, M. L., Geurs, N. C., Novy, B., Otomo‐Corgel, J., Cobb, C. M., Jacobsen, P. L., Takesh, T., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0675 · Cited by 3 · see citing works

Authors: Turesky, S., Gilmore, N. D., & Glickman, I.
Affiliations: Tufts University (US)
Venue: Journal of Periodontology
Publisher: Wiley
Published: 1970-01
Volume: 41
Issue: 1
Pages: 41-43
ISSN: 0022-3492 (ISSN-L)
1943-3670
DOI: 10.1902/jop.1970.41.1.41
OpenAlex: W2066616037
Cited by: 1,450
References: 2
Citations by year: 2026: 67 · 2025: 50 · 2024: 63 · 2023: 57 · 2022: 68 · 2021: 73 · 2020: 53 · 2019: 79 · 2018: 46 · 2017: 61 · 2016: 41 · 2015: 62 · 2014: 56 · 2013: 47 · 2012: 58
FWCI: 10.91
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Periodontology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords: dental plaque, dental calculus, plaque inhibition, calcium phosphate crystallization, cationic surfactants
MeSH terms: Adult, Analysis of Variance, Ascorbic Acid, Dental Plaque, Humans, Male, Mouthwashes, Surface-Active Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reduced plaque formation by the chloromethyl analogue of victamine C

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Record

About these checks