Assessment of unanticipated unintended effects of genetically modified plants on non-target organisms: a controversy worthy of pursuit?

Role of Glucosinolates in Insect-Plant Relationships and Multitrophic Interactions

Hopkins, R. J., van Dam, N. M., & van Loon, J. J. A. (2008) · Annual Review of Entomology · doi:10.1146/annurev.ento.54.110807.090623 · Cited by 1,026 · see citing works

Assessment of risk of insect-resistant transgenic crops to nontarget arthropods

Romeis, J., Bartsch, D. K., Bigler, F., Candolfi, M. P., Gielkens, M. M. C., Hartley, S. E., Hellmich, R. L., Huesing, J. E., JEPSON, P. C., Layton, R. J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1381 · Cited by 501 · see citing works

Plant Interactions with Multiple Insect Herbivores: From Community to Genes

Stam, J. M., Kroes, A., Li, Y., Gols, R., van Loon, J. J. A., Poelman, E. H., & Dicke, M. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050213-035937 · Cited by 482 · see citing works

Herbivore‐induced plant volatiles: targets, perception and unanswered questions

Heil, M. (2014) · New Phytologist · doi:10.1111/nph.12977 · Cited by 353 · see citing works

Deployment of new biotechnologies in plant breeding

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New wind in the sails: improving the agronomic value of crop plants through RNA i‐mediated gene silencing

Koch, A., & Kogel, K. (2014) · Plant Biotechnology Journal · doi:10.1111/pbi.12226 · Cited by 237 · see citing works

Towards social acceptance of plant breeding by genome editing

Araki, M., & Ishii, T. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2015.01.010 · Cited by 234 · see citing works

Recommendations for the design of laboratory studies on non-target arthropods for risk assessment of genetically engineered plants

Romeis, J., Hellmich, R. L., Candolfi, M. P., Carstens, K., de Schrijver, A., Gatehouse, A. M. R., Herman, R. A., Huesing, J. E., McLean, M. A., Raybould, A. F., et al. (2010) · Transgenic Research · doi:10.1007/s11248-010-9446-x · Cited by 232 · see citing works

The food and environmental safety of Bt crops

Koch, M. S., Ward, J., Levine, S. L., Baum, J. A., Vicini, J. L., & Hammond, B. G. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00283 · Cited by 228 · see citing works

Evaluation of Genetically Engineered Crops Using Transcriptomic, Proteomic, and Metabolomic Profiling Techniques

Ricroch, A., Bergé, J. B., & Kuntz, M. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.173609 · Cited by 217 · see citing works

Problem formulation in the environmental risk assessment for genetically modified plants

Wolt, J. D., Keese, P. K., Raybould, A. F., Fitzpatrick, J. W., Burachik, M., Gray, A. J., Olin, S. S., Schiemann, J., Sears, M. K., & Wu, F. (2009) · Transgenic Research · doi:10.1007/s11248-009-9321-9 · Cited by 192 · see citing works

Genetically Engineered Plants and Foods: A Scientist's Analysis of the Issues (Part II)

Lemaux, P. G. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.043008.092013 · Cited by 190 · see citing works

Interplay between insects and plants: dynamic and complex interactions that have coevolved over millions of years but act in milliseconds

Bruce, T. J. A. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru391 · Cited by 189 · see citing works

Science-Based Risk Assessment for Nontarget Effects of Transgenic Crops

Andow, D. A., & Hilbeck, A. (2004) · BioScience · doi:10.1641/0006-3568(2004)054[0637:srafne]2.0.co;2 · Cited by 186 · see citing works

A tiered system for assessing the risk of genetically modified plants to non-target organisms

Garcia-Alonso, M., Jacobs, E., Raybould, A., Nickson, T. E., Sowig, P., Willekens, H., Van Der Kouwe, P., Layton, R., Amijee, F., Fuentes, A. M., et al. (2006) · Environmental Biosafety Research · doi:10.1051/ebr:2006018 · Cited by 161 · see citing works

Unintended compositional changes in genetically modified (GM) crops: 20 years of research

Herman, R. A., & Price, W. D. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400135r · Cited by 156 · see citing works

Genetic basis and detection of unintended effects in genetically modified crop plants

Ladics, G. S., Bartholomaeus, A., Bregitzer, P., Doerrer, N. G., Gray, A. J., Holzhauser, T., Jordan, M. C., Keese, P. K., Kok, E. J., Macdonald, P., et al. (2015) · Transgenic Research · doi:10.1007/s11248-015-9867-7 · Cited by 153 · see citing works

Problem formulation and hypothesis testing for environmental risk assessments of genetically modified crops

Raybould, A. F. (2006) · Environmental Biosafety Research · doi:10.1051/ebr:2007004 · Cited by 143 · see citing works

RNAi-Based Insecticidal Crops: Potential Effects on Nontarget Species

Lundgren, J. G., & Duan, J. J. (2013) · BioScience · doi:10.1525/bio.2013.63.8.8 · Cited by 143 · see citing works

A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments

Schnell, J., Steele, M., Bean, J., Neuspiel, M., Girard, C., Dormann, N., Pearson, C., Savoie, A., Bourbonnière, L., & Macdonald, P. (2014) · Transgenic Research · doi:10.1007/s11248-014-9843-7 · Cited by 142 · see citing works

Evaluating environmental risks of genetically modified crops: ecological harm criteria for regulatory decision-making

Sanvido, O., Romeis, J., Gathmann, A., Gielkens, M. M. C., Raybould, A. F., & Bigler, F. (2011) · Environmental Science & Policy · doi:10.1016/j.envsci.2011.08.006 · Cited by 136 · see citing works

Exploiting natural variation to identify insect‐resistance genes

Broekgaarden, C., Snoeren, T. A. L., Dicke, M., et al. (2011) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00635.x · Cited by 135 · see citing works

No effects of Bacillus thuringiensis maize on nontarget organisms in the field in southern Europe: a meta-analysis of 26 arthropod taxa

Comas, C., Lumbierres, B., Pons, X., & Albajes, R. (2014) · Transgenic Research · doi:10.1007/s11248-013-9737-0 · Cited by 129 · see citing works

Extrapolating non-target risk of <i>Bt</i> crops from laboratory to field

Duan, J. J., Lundgren, J. G., Naranjo, S., & Marvier, M. (2010) · Biology Letters · doi:10.1098/rsbl.2009.0612 · Cited by 127 · see citing works

Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: A scientific review

Petrick, J. S., Brower‐Toland, B. D., Jackson, A. L., & Kier, L. D. (2013) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2013.03.008 · Cited by 126 · see citing works

More Faust than Frankenstein: the European debate about the precautionary principle and risk regulation for genetically modified crops

Tait, J. (2001) · Journal of Risk Research · doi:10.1080/13669870010027640 · Cited by 117 · see citing works

Ecological versus ecotoxicological methods for assessing the environmental risks of transgenic crops

Raybould, A. F. (2007) · Plant Science · doi:10.1016/j.plantsci.2007.09.003 · Cited by 116 · see citing works

Genetically engineered maize plants reveal distinct costs and benefits of constitutive volatile emissions in the field

Robert, C. A. M., Erb, M., Hiltpold, I., Hibbard, B. E., Gaillard, M. D. P., Bilat, J., Degenhardt, J., Cambet‐Petit‐Jean, X., Turlings, T. C. J., & Zwahlen, C. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12053 · Cited by 114 · see citing works

Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops

Parrott, W. A., Chassy, B. M., Ligon, J., Meyer, L. S., Petrick, J. S., Zhou, J., Herman, R. A., Delaney, B., & Levine, M. J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.04.017 · Cited by 102 · see citing works

Biotechnological uses of RNAi in plants: risk assessment considerations

Casacuberta, J., Devos, Y., du Jardin, P., et al. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.12.003 · Cited by 101 · see citing works

EFSA’s scientific activities and achievements on the risk assessment of genetically modified organisms (GMOs) during its first decade of existence: looking back and ahead

Devos, Y., Aguilera, J., Diveki, Z., Gomes, A., Liu, Y., Paoletti, C., du Jardin, P., Herman, L., Perry, J. N., & Waigmann, E. (2014) · Transgenic Research · doi:10.1007/s11248-013-9741-4 · Cited by 95 · see citing works

Planning Environmental Risk Assessment for Genetically Modified Crops: Problem Formulation for Stress-Tolerant Crops

Nickson, T. E. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.118422 · Cited by 86 · see citing works

Transgenic or not? No simple answer!

Podevin, N., Devos, Y., Davies, H. V., & Nielsen, K. M. (2012) · EMBO Reports · doi:10.1038/embor.2012.168 · Cited by 79 · see citing works

When bad science makes good headlines: Bt maize and regulatory bans

Romeis, J., McLean, M. A., & Shelton, A. M. (2013) · Nature Biotechnology · doi:10.1038/nbt.2578 · Cited by 74 · see citing works

Non‐target organism risk assessment of MIR604 maize expressing mCry3A for control of corn rootworm

Raybould, A. F., Stacey, D. L., Vlachos, D., Graser, G., Li, X., & Joseph, R. S. I. (2007) · Journal of Applied Entomology · doi:10.1111/j.1439-0418.2007.01200.x · Cited by 73 · see citing works

Plant‐mediated Interactions Among Insects within a Community Ecological Perspective

Poelman, E. H., & Dicke, M. (2014) · Wiley eBooks · doi:10.1002/9781118829783.ch9 · Cited by 60 · see citing works

Development of an Agricultural Biotechnology Crop Product: Testing from Discovery to Commercialization

Privalle, L., Chen, J., Clapper, G. M., et al. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302706e · Cited by 59 · see citing works

Commentary: Statistical aspects of environmental risk assessment of GM plants for effects on non-target organisms

PERRY, J. N., ter Braak, C. J. F., Dixon, P. M., Duan, J. J., Hails, R. S., Hüsken, A., Lavielle, M., Marvier, M., Scardi, M., Schmidt, K., et al. (2009) · Environmental Biosafety Research · doi:10.1051/ebr/2009009 · Cited by 58 · see citing works

Going mobile: Non‐cell‐autonomous small RNAs shape the genetic landscape of plants

Pyott, D. E., & Molnár, A. (2015) · Plant Biotechnology Journal · doi:10.1111/pbi.12353 · Cited by 55 · see citing works

Potential use of an arthropod database to support the non-target risk assessment and monitoring of transgenic plants

Romeis, J., Meissle, M., Álvarez‐Alfageme, F., Bigler, F., Bohan, D. A., Devos, Y., Malone, L. A., Pons, X., & Rauschen, S. (2014) · Transgenic Research · doi:10.1007/s11248-014-9791-2 · Cited by 53 · see citing works

Biotechnology in agriculture: Agronomic and environmental considerations and reflections based on 15 years of GM crops

Mannion, A. M., & Morse, S. (2012) · Progress in Physical Geography Earth and Environment · doi:10.1177/0309133312457109 · Cited by 49 · see citing works

Principles for regulatory testing and interpretation of semi-field and field studies with non-target arthropods

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The bucket and the searchlight: formulating and testing risk hypotheses about the weediness and invasiveness potential of transgenic crops

Raybould, A. F. (2010) · Environmental Biosafety Research · doi:10.1051/ebr/2011101 · Cited by 44 · see citing works

RNAi‐based GM plants: food for thought for risk assessors

Ramon, M., Devos, Y., Lanzoni, A., Liu, Y., Gomes, A., Gennaro, A., & Waigmann, E. (2014) · Plant Biotechnology Journal · doi:10.1111/pbi.12305 · Cited by 42 · see citing works

Towards a more open debate about values in decision-making on agricultural biotechnology

Devos, Y., Sanvido, O., Tait, J., & Raybould, A. F. (2013) · Transgenic Research · doi:10.1007/s11248-013-9754-z · Cited by 41 · see citing works

Reducing uncertainty in regulatory decision-making for transgenic crops: More ecological research or clearer environmental risk assessment?

Raybould, A. F. (2010) · GM Crops · doi:10.4161/gmcr.1.1.9776 · Cited by 38 · see citing works

Assessing the ecological risks from the persistence and spread of feral populations of insect-resistant transgenic maize

Raybould, A. F., Higgins, L. S., Horak, M. J., Layton, R. J., Storer, N. P., de la Fuente, J. M., & Herman, R. A. (2011) · Transgenic Research · doi:10.1007/s11248-011-9560-4 · Cited by 37 · see citing works

Volatile organic compounds released by R umex confertus following H ypera rumicis herbivory and weevil responses to volatiles

Piesik, D., Wenda-Piesik, A., Krasińska, A., et al. (2015) · Journal of Applied Entomology · doi:10.1111/jen.12238 · Cited by 32 · see citing works

Plant interactions with other organisms: molecules, ecology and evolution

Austin, A. T., & Ballaré, C. L. (2014) · New Phytologist · doi:10.1111/nph.13062 · Cited by 32 · see citing works

Environmental risk assessments for transgenic crops producing output trait enzymes

Raybould, A. F., Tuttle, A., Shore, S. K., & Stone, T. B. (2009) · Transgenic Research · doi:10.1007/s11248-009-9343-3 · Cited by 32 · see citing works

Development of Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) on pollen from Bt-transgenic and conventional maize

Meissle, M., Zünd, J., Waldburger, M., & Romeis, J. (2014) · Scientific Reports · doi:10.1038/srep05900 · Cited by 31 · see citing works

Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maize

Rauschen, S., Schaarschmidt, F., & Gathmann, A. (2009) · Transgenic Research · doi:10.1007/s11248-009-9351-3 · Cited by 28 · see citing works

Compositional differences between near‐isogenic GM and conventional maize hybrids are associated with backcrossing practices in conventional breeding

Venkatesh, T. V., Cook, K. A., Liu, B., Perez, T. M., Willse, A., Tichich, R., Feng, P., & Harrigan, G. G. (2014) · Plant Biotechnology Journal · doi:10.1111/pbi.12248 · Cited by 26 · see citing works

Environmental risk assessment of GE plants under low-exposure conditions

Roberts, A., Devos, Y., Raybould, A. F., Bigelow, P. J., & Gray, A. J. (2013) · Transgenic Research · doi:10.1007/s11248-013-9762-z · Cited by 22 · see citing works

Spatial and numerical relationships of arthropod communities associated with key pests of maize

Lundgren, J. G., McDonald, T. M., Rand, T. A., & Fausti, S. W. (2015) · Journal of Applied Entomology · doi:10.1111/jen.12215 · Cited by 21 · see citing works

A critical evaluation of whether recombination in virus‐resistant transgenic plants will lead to the emergence of novel viral diseases

Tepfer, M. M., Jacquemond, M., & García‐Arenal, F. (2015) · New Phytologist · doi:10.1111/nph.13358 · Cited by 18 · see citing works

Statistical power analysis of a 2‐year field study and design of experiments to evaluate non‐target effects of genetically modified Bacillius thuringiensis corn

Duan, J. J., Jiang, C., Head, G., et al. (2006) · Ecological Entomology · doi:10.1111/j.1365-2311.2006.00811.x · Cited by 17 · see citing works

Can science justify regulatory decisions about the cultivation of transgenic crops?

Raybould, A. F. (2012) · Transgenic Research · doi:10.1007/s11248-012-9613-3 · Cited by 16 · see citing works

Application of Laws, Policies, and Guidance from the United States and Canada to the Regulation of Food and Feed Derived from Genetically Modified Crops: Interpretation of Composition Data

Price, W. D., & Underhill, L. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf401178d · Cited by 16 · see citing works

Ex-Ante Determination of the Capacity of Field Tests to Detect Effects of Genetically Modified Corn on Nontarget Arthropods

Comas, J., Lumbierres, B., Pons, X., & Albajes, R. (2013) · Journal of Economic Entomology · doi:10.1603/ec12508 · Cited by 16 · see citing works

Current challenges in environmental risk assessment: the assessment of unintended effects of GM crops on non-target organisms.

Garcia‐Alonso, M. (2010) · Cited by 15 · see citing works

The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms

Semenov, A. V., van Elsas, J. D., Glandorf, B., Schilthuizen, M., & de Boer, W. F. (2013) · Ecology and Evolution · doi:10.1002/ece3.640 · Cited by 14 · see citing works

A statistical simulation model for field testing of non‐target organisms in environmental risk assessment of genetically modified plants

Goedhart, P. W., van der Voet, H., Baldacchino, F., & Arpaia, S. (2014) · Ecology and Evolution · doi:10.1002/ece3.1019 · Cited by 11 · see citing works

Safety assessment of genetically modified plants with deliberately altered composition

Halford, N. G., Hudson, E. M., Gimson, A. P., et al. (2014) · Plant Biotechnology Journal · doi:10.1111/pbi.12194 · Cited by 8 · see citing works

Optimising the capacity of field trials to detect the effect of genetically modified maize on non-target organisms through longitudinal sampling

Comas, J., Lumbierres, B., Comas, C., Pons, X., & Albajes, R. (2014) · Annals of Applied Biology · doi:10.1111/aab.12164 · Cited by 7 · see citing works

Invoking ideology in the promotion of ecological risk assessment for GM crops

Herman, R. A., & Raybould, A. F. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.01.007 · Cited by 6 · see citing works

Outcome of the public consultation on the draft Scientific Opinion of the Scientific Panel on Genetically Modified Organisms (GMO) on the assessment of potential impacts of genetically modified plants on non‐target organisms

Authority, E. F. S. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1878 · Cited by 5 · see citing works

The power of statistical tests using field trial count data of nontarget organisms in environmental risk assessment of genetically modified plants

van der Voet, H., & Goedhart, P. W. (2014) · Agricultural and Forest Entomology · doi:10.1111/afe.12092 · Cited by 4 · see citing works

EFSA GMO Panel guidance on the evaluation of potential adverse effects of GM plants on non-target organisms

Devos, Y., Bartsch, D. K., Gathmann, A., et al. (2011) · NERC Open Research Archive (Natural Environment Research Council) · Cited by 1 · see citing works

Leafhoppers as indicators for risk assessment of GM biofortified crops

Ardanuy, A., & Albajes, R. (2013) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 1 · see citing works

Genetically engineered crops help support conservation biological control

Romeis, J., Naranjo, S. E., Meissle, M., & Shelton, A. M. (2019) · Biological Control · doi:10.1016/j.biocontrol.2018.10.001 · Cited by 231 · see citing works

Assessing environmental impacts of genetically modified plants on non-target organisms: the relevance of in planta studies

Arpaia, S., Birch, A. N. E., Kiss, J., van Loon, J. J. A., Messéan, A., Nuti, M., Perry, J. N., Sweet, J. B., & Tebbe, C. C. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.01.039 · Cited by 62 · see citing works

Composting rapidly degrades DNA from genetically modified plants

Rasmussen, L. D., Møller, J., & Magid, J. (2004) · Organic Eprints (International Centre for Research in Organic Food Systems, and Research Institute of Organic Agriculture)

PCR for the detection of the anti-herbicide genes in genetically modified organisms

Xu, W., Kun-Lun, H., Ai-Ke, D., et al. (2006) · Chinese Journal of Agricultural Biotechnology · doi:10.1079/cjb200591

Evaluation of genetically modified oilseed and oil

Yang, F. (2004) · Zhongguo youzhi

Current status and detection of genetically modified organism

Pan, T. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.2739 · Cited by 18 · see citing works

Genetically Modified Crops

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