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Cited by 94Cancer survivorship and careFrailty in Older AdultsNursing care and research

Quality of Life of Caregivers of Older Patients with Advanced Cancer

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Kehoe, Lee A., Xu, Huiwen, Duberstein, Paul, Loh, Kah Poh, Culakova, Eva, Canin, Beverly, Hurria, Arti, Dale, William +12 more·2019·Journal of the American Geriatrics Society
DOI 10.1111/jgs.15862PMC PMC7818364
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Abstract

OBJECTIVES: To evaluate the relationships between aging-related domains captured by geriatric assessment (GA) for older patients with advanced cancer and caregivers' emotional health and quality of life (QOL). DESIGN: In this cross sectional study of baseline data from a nationwide investigation of older patients and their caregivers, patients completed a GA that included validated tests to evaluate eight domains of health (eg, function, cognition). SETTING: Thirty-one community oncology practices throughout the United States. PARTICIPANTS: Enrolled patients were aged 70 and older, had one or more GA domain impaired, and had an incurable solid tumor malignancy or lymphoma. Each could choose one caregiver to enroll. MEASUREMENTS: Caregivers completed the Generalized Anxiety Disorder-7, Distress Thermometer, Patient Health Questionnaire-2 (depression), and Short Form Health Survey-12 (SF-12 for QOL). Separate multivariate linear or logistic regression models were used to examine the association of the number and type of patient GA impairments with caregiver outcomes, controlling for patient and caregiver covariates. RESULTS: A total of 541 patients were enrolled, 414 with a caregiver. Almost half (43.5%) of the caregivers screened positive for distress, 24.4% for anxiety, and 18.9% for depression. Higher numbers of patient GA domain impairments were associated with caregiver depression (adjusted odds ratio [aOR] = 1.29; P < .001], caregiver physical health on SF-12 (regression coefficient [β] = -1.24; P < .001), and overall caregiver QOL (β = -1.14; P < .01). Impaired patient function was associated with lower caregiver QOL (β = -4.11; P < .001). Impaired patient nutrition was associated with caregiver depression (aOR = 2.08; P < .01). Lower caregiver age, caregiver comorbidity, and patient distress were also associated with worse caregiver outcomes. CONCLUSION: Patient GA impairments were associated with poorer emotional health and lower QOL of caregivers. J Am Geriatr Soc 67:969-977, 2019.

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  • Eight studies described that care work implies a greater risk for caregivers of suffering physical morbidity with considerable wear, which increases as care burden continues over time.

    “In relation to physical problems, eight studies [25,34,37,40,41,42,43,44] described that care work implies a greater risk for caregivers of suffering physical morbidity with considerable wear, which in fact increases as the care burden continues over time.”

    From Quality of Life in Caregivers of Cancer Patients: A Literature Review (2023) · cites this paper as [42]

    The Introduction (page not available) says caregiving stress can adversely affect physical health and that care burden increases as cancer progresses. The Discussion (page not available) reports an association between patient impairments and poorer caregiver physical health. The paper does not establish that caregiving causes physical morbidity or that caregivers’ physical deterioration increases over time. (LLM, conf=0.85)

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  1. [9]Given BA. Caregiver Burden In: Holland JC, Weisel TW, Nelson CJ, Roth AJ, Alici Y, eds. Geriatric Psycho-Oncology: A Quick Reference on the Psychological Dimensions of Cancer Symptom Management. New York, NY: Oxford University Press; 2015.

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Authors
Kehoe, L. A., Xu, H., Duberstein, P., Loh, K. P., Culakova, E., Canin, B., Hurria, A., Dale, W., Wells, M., Gilmore, N., Kleckner, A. S., Lund, J., Kamen, C., Flannery, M., Hoerger, M., Hopkins, J. O., Liu, J. J., Geer, J., Epstein, R., & Mohile, S. G.
Affiliations
  • University of Rochester Medicine (US)
  • Rutgers, The State University of New Jersey (US)
  • City Of Hope National Medical Center (US)
  • University of North Carolina at Chapel Hill (US)
  • Tulane University (US)
  • Novant Health (US)
  • Heartland Cancer Research (US)
  • Metro‐Minnesota NCORP St. Louis Park Minnesota
  • URCC NCORP Research Base University of Rochester Medical Center Rochester New York
Corresponding author
Mohile, Supriya G.
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2019-03-29
Volume
67
Issue
5
Pages
969-977
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/jgs.15862
PMC
PMC7818364
OpenAlex
W2928441960
Cited by
94
References
51
Citations by year
2026: 6 · 2025: 11 · 2024: 17 · 2023: 9 · 2022: 14 · 2021: 15 · 2020: 11 · 2019: 11
FWCI
5.33
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Foundation for the National Institutes of Health (K24 AG056589, R01 CA177592, UG1 CA189961)
  • Patient-Centered Outcomes Research Institute (4634)
  • University of Rochester
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Health Professions › Pharmacy › Nursing care and research
Keywords
caregiver quality of life, geriatric assessment, caregiver depression, caregiver anxiety, caregiver distress, caregiver age, patient distress
MeSH terms
Adult, Aged, Aged, 80 and over, Anxiety, Cognition, Cross-Sectional Studies, Depression, Emotions, Female, Humans, Male, Mental Health, Middle Aged, Neoplasms, Quality of Life, Surveys and Questionnaires, United States, Geriatric Assessment, Incidence, Caregivers

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