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Cited by 58Facial Rejuvenation and Surgery TechniquesDermatologic Treatments and ResearchSkin Protection and Aging

Polynucleotides in aesthetic medicine: a review of current practices and perceived effectiveness

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Lee, Kar Wai Alvin, Chan, Kwin Wah Lisa, Lee, Angela, Lee, Cheuk Hung, Wan, Jovian, Wong, Sky, Yi, Kyu-Ho·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25158224PMC PMC11311621
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Abstract

Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration. This review aims to provide an overview of the current practices and perceived effectiveness of polynucleotides in aesthetic medicine. A comprehensive search of the literature was conducted using keywords related to polynucleotides, cosmetic application, and aesthetic application. Studies were selected based on their relevance to aesthetic medicine and the inclusion of human subjects. The review found that polynucleotides have been used to improve skin texture, reduce wrinkle depth, and enhance facial appearance. The studies reported varying degrees of efficacy and safety, with some studies demonstrating significant improvements in skin elasticity and hydration. However, others reported limited or no benefits. The review also highlighted the need for further research to establish the optimal use and efficacy of polynucleotides in aesthetic medicine. While the existing literature suggests that polynucleotides may have potential benefits in aesthetic medicine, more research is needed to fully understand their mechanisms of action and optimal use. Clinicians should be aware of the current limitations and potential risks associated with the use of polynucleotides in aesthetic medicine.

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  • Recent reviews suggest that PN-based therapies function primarily as biostimulatory agents that improve tissue quality through progressive dermal remodeling rather than immediate structural correction.

    “Recent reviews similarly suggest that PN-based therapies function primarily as biostimulatory agents that improve tissue quality through progressive dermal remodeling rather than immediate structural correction [16,17].”

    From Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials (2026) · cites this paper as [17]

    Section 2 describes PN as stimulating collagen production and improving skin texture and elasticity, supporting the biostimulatory, tissue-quality part of the claim. Section 3 also reports PN use as a filler for wrinkle correction, while the Conclusions say its mechanism of action has not been objectively demonstrated. The review does not establish that PN works primarily through progressive dermal remodeling rather than immediate structural correction. Page numbers were not provided in our copy. (LLM, conf=0.84)

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  1. [1]Caskey C.T. Leder P. The RNA code: Nature’s Rosetta Stone Proc. Natl. Acad. Sci. USA 2014 111 5758 5759 10.1073/pnas.1404819111 24756939 PMC4000803 · DOI
  2. [2]Lengyel P. Speyer J.F. Ochoa S. Synthetic polynucleotides and the amino acid code Proc. Natl. Acad. Sci. USA 1961 47 1936 1942 10.1073/pnas.47.12.1936 14463983 PMC223245 · DOI
  3. [3]Perrone D. Marchesi E. Preti L. Navacchia M.L. Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications Molecules 2021 26 3100 10.3390/molecules26113100 34067312 PMC8196910 · DOI
  4. [4]Budker V.G. Godovikov A.A. Naumova L.P. Slepneva I.A. Interaction of polynucleotides with natural and model membranes Nucleic Acids Res. 1980 8 2499 2515 10.1093/nar/8.11.2499 6160462 PMC324097 · DOI
  5. [5]Selsing E. Wells R.D. Polynucleotide block polymers consisting of a DNA.RNA hybrid joined to a DNA.DNA duplex. Synthesis and characterization of dGn.rCidCk duplexes J. Biol. Chem. 1979 254 5410 5416 10.1016/S0021-9258(18)50611-6 447659 · DOI
  6. [7]Samadi A. Ayatollahi A. Nassiri-Kashani M. Zamani S. Firooz A. Efficacy and tolerability assessment of a polynucleotide-based gel for improvement of pattern hair loss Arch. Dermatol. Res. 2024 316 331 10.1007/s00403-024-03088-9 38842633 · DOI
  7. [8]Araco A. Araco F. Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne Scars Aesthet. Surg. J. 2021 41 NP866 NP874 10.1093/asj/sjab125 33755110 · DOI
  8. [9]Ahn T.H. Cho S.B. Adjuvant Therapy for Revision Rhinoplasty of Contracted Nose Using Polydeoxyribonucleotide and Invasive Bipolar Radiofrequency Plast. Reconstr. Surg. Glob. Open 2018 6 e1645 10.1097/GOX.0000000000001645 29464170 PMC5811300 · DOI
  9. [10]Belletti S. Uggeri J. Gatti R. Govoni P. Guizzardi S. Polydeoxyribonucleotide promotes cyclobutane pyrimidine dimer repair in UVB-exposed dermal fibroblasts Photodermatol. Photoimmunol. Photomed. 2007 23 242 249 10.1111/j.1600-0781.2007.00320.x 17986061 · DOI · Paper page
  10. [11]Galeano M. Bitto A. Altavilla D. Minutoli L. Polito F. Calo M. Lo Cascio P. Stagno d’Alcontres F. Squadrito F. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse Wound Repair. Regen. 2008 16 208 217 10.1111/j.1524-475X.2008.00361.x 18318806 · DOI
  11. [12]Guizzardi S. Galli C. Govoni P. Boratto R. Cattarini G. Martini D. Belletti S. Scandroglio R. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair Life Sci. 2003 73 1973 1983 10.1016/S0024-3205(03)00547-2 12899922 · DOI · Paper page
  12. [13]Kim D.S. Lee J.K. Kim J.H. Lee J. Kim D.S. An S. Park S.B. Kim T.H. Rim J.S. Lee S. Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs Sci. Adv. 2021 7 eabj1083 10.1126/sciadv.abj1083 34878837 PMC8654289 · DOI
  13. [14]Kim Y.J. Kim M.J. Kweon D.K. Lim S.T. Lee S.J. Polydeoxyribonucleotide Activates Mitochondrial Biogenesis but Reduces MMP-1 Activity and Melanin Biosynthesis in Cultured Skin Cells Appl. Biochem. Biotechnol. 2020 191 540 554 10.1007/s12010-019-03171-2 31811642 · DOI · Paper page
  14. [15]Lim H.K. Kwon Y.J. Hong S.J. Choi H.G. Chung S.M. Yang B.E. Lee J.H. Byun S.H. Bone regeneration in ceramic scaffolds with variable concentrations of PDRN and rhBMP-2 Sci. Rep. 2021 11 11470 10.1038/s41598-021-91147-w 34075179 PMC8169763 · DOI
  15. [16]Muratore O. Cattarini G. Gianoglio S. Tonoli E.L. Sacca S.C. Ghiglione D. Venzano D. Ciurlo C. Lantieri P.B. Schito G.C. A human placental polydeoxyribonucleotide (PDRN) may promote the growth of human corneal fibroblasts and iris pigment epithelial cells in primary culture New Microbiol. 2003 26 13 26 12578307
  16. [18]Squadrito F. Bitto A. Irrera N. Pizzino G. Pallio G. Minutoli L. Altavilla D. Pharmacological Activity and Clinical Use of PDRN Front. Pharmacol. 2017 8 224 10.3389/fphar.2017.00224 28491036 PMC5405115 · DOI · Paper page
  17. [19]Veronesi F. Dallari D. Sabbioni G. Carubbi C. Martini L. Fini M. Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A(2A) Receptor Involvement J. Cell Physiol. 2017 232 2299 2307 10.1002/jcp.25663 27791262 · DOI
  18. [20]Araco A. Araco F. Raichi M. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study J. Cosmet. Dermatol. 2023 22 146 155 10.1111/jocd.15064 35531796 PMC10084116 · DOI · Paper page
  19. [21]De Caridi G. Massara M. Acri I. Zavettieri S. Grande R. Butrico L. de Franciscis S. Serra R. Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: A clinical study Int. Wound J. 2016 13 754 758 10.1111/iwj.12368 25224018 PMC7949893 · DOI
  20. [22]Oh S. Seo S.B. Kim G. Batsukh S. Son K.H. Byun K. Poly-D,L-Lactic Acid Stimulates Angiogenesis and Collagen Synthesis in Aged Animal Skin Int. J. Mol. Sci. 2023 24 7986 10.3390/ijms24097986 37175693 PMC10178436 · DOI
  21. [23]Park K.Y. Seok J. Rho N.K. Kim B.J. Kim M.N. Long-chain polynucleotide filler for skin rejuvenation: Efficacy and complications in five patients Dermatol. Ther. 2016 29 37 40 10.1111/dth.12299 26814448 · DOI · Paper page
  22. [24]Rho N.-K. Chung S.T. Treatment of a Full-thickness Laceration Scar on the Forehead Using a 1,064-nm Fractional Picosecond Laser and Polynucleotide Gel Injection Med. Lasers 2018 7 88 90 10.25289/ML.2018.7.2.88 · DOI
  23. [25]Yi K.-H. Lee B. Kim M.J. Lee S.-H. Hidajat I.J. Lim T.S. Kim H.M. Kim J.-H. Observation on cadavers and through ultrasonography using a 2 mm needle length for intradermal injections Ski. Res. Technol. 2023 29 e13529 10.1111/srt.13529 38009043 PMC10661215 · DOI
  24. [26]Yi K.H. Winayanuwattikun W. Kim S.Y. Wan J. Vachatimanont V. Putri A.I. Hidajat I.J. Yogya Y. Pamela R. Skin boosters: Definitions and varied classifications Skin. Res. Technol. 2024 30 e13627 10.1111/srt.13627 38481069 PMC10938033 · DOI · Paper page
  25. [27]Morganti P. Morganti G. Gagliardini A. Lohani A. From Cosmetics to Innovative Cosmeceuticals—Non-Woven Tissues as New Biodegradable Carriers Cosmetics 2021 8 65 10.3390/cosmetics8030065 · DOI
  26. [28]Yi K.-H. Park M.-S. Ree Y.-S. Kim H.M. A Review on “Skin Boosters”: Hyaluronic Acid, Poly-L-lactic Acid and Pol-D-lactic Acid, Polydeoxyribonucleotide, Polynucleotides, Growth Factor, and Exosome Korean Assoc. Laser Dermatol. Trichology 2023 4 6 10.46738/Aesthetics.2023.4.1.6 · DOI
  27. [29]Lis A. Kawałkiewicz W. Kubisz L. A comparison of the efficacy of reducing the signs of ageing in the neck skin after polynucleotides injections in regimens with different dosing intervals—A case study J. Face Aesthet. 2023 6 28 45 10.20883/jofa.68 · DOI
  28. [30]Brandi C. Cuomo R. Nisi G. Grimaldi L. D’Aniello C. Face Rejuvenation: A new combinated protocol for biorevitalization Acta Biomed. 2018 89 400 405 30333466 PMC6502127
  29. [31]Minoretti P. Emanuele E. Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners Cureus 2024 16 e52548 10.7759/cureus.52548 38371024 PMC10874500 · DOI
  30. [32]Yip L. Anti-aging trends in Australia J. Eur. Acad. Dermatol. Venereol. 2024 38 (Suppl. 4) 45 52 10.1111/jdv.19647 38881437 · DOI
  31. [34]Cheng L.-Y. Sun X.-M. Tang M.-Y. Jin R. Cui W. Zhang Y.-G. An update review on recent skin fillers Plast. Aesthetic Res. 2016 3 92 10.20517/2347-9264.2015.124 · DOI · Paper page
  32. [35]Samizadeh S. Polynucleotides: The crucial biomolecules bridging therapeutics and aesthetics J. Aesthet. Nurs. 2023 12 391 399 10.12968/joan.2023.12.9.391 · DOI · Paper page
  33. [36]Lee Y.J. Kim H.T. Lee Y.J. Paik S.H. Moon Y.S. Lee W.J. Chang S.E. Lee M.W. Choi J.H. Jung J.M. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: A randomized, double-blind, split-face trial J. Dermatolog. Treat. 2022 33 254 260 10.1080/09546634.2020.1748857 32248707 · DOI
  34. [37]Cavallini M. Bartoletti E. Maioli L. Massirone A. Pia Palmieri I. Papagni M. Priori M. Trocchi G. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine J. Cosmet. Dermatol. 2021 20 922 928 10.1111/jocd.13679 32799391 PMC7984045 · DOI · Paper page
  35. [38]Pak C.S. Lee J. Lee H. Jeong J. Kim E.H. Jeong J. Choi H. Kim B. Oh S. Kim I. A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow’s feet: A new concept of regenerative filler J. Korean Med. Sci. 2014 29 (Suppl. 3) S201 S209 25473210 PMC4248006
  36. [39]Jeong G.J. Ahn G.R. Park S.J. Hong J.Y. Kim B.J. A randomized, patient/evaluator-blinded, split-face study to compare the efficacy and safety of polycaprolactone and polynucleotide fillers in the correction of crow’s feet: The latest biostimulatory dermal filler for crow’s feet J. Cosmet. Dermatol. 2020 19 1593 1599 10.1111/jocd.13199 31680395 · DOI
  37. [40]Webb W. Rahman E. Rao P. Abu-Farsakh H. Yu N. Garcia P. Ioannidis S. Sayed K. Tam E. Philipp-Dormston W. Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: A systematic review Eur. J. Plast. Surg. 2024 47 66 10.1007/s00238-024-02209-x · DOI
  38. [41]Kim J.H. Kim E.S. Kim S.W. Hong S.P. Kim J. Effects of Polynucleotide Dermal Filler in the Correction of Crow’s Feet Using an Antera Three-Dimensional Camera Aesthetic Plast. Surg. 2022 46 1902 1909 10.1007/s00266-022-02832-8 35357558 · DOI · Paper page
  39. [42]Oh H. Lee S. Na J. Kim J.H. Comparative Evaluation of Safety and Efficacy of a Novel Hyaluronic Acid-polynucleotide/Poly-L-lactic Acid Composite Dermal Filler Aesthetic Plast. Surg. 2021 45 1792 1801 10.1007/s00266-021-02295-3 33876290 · DOI
  40. [43]Lim T.S. Liew S. Tee X.J. Chong I. Lo F.J. Ho M.J. Ong K. Cavallini M. Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation Clin. Cosmet. Investig. Dermatol. 2024 17 417 431 10.2147/CCID.S437942 38371328 PMC10874187 · DOI · Paper page
  41. [44]Lee D. Kim M.J. Park H.J. Rah G.C. Choi H. Anh S.T. Ji G.H. Kim M.S. Kim G. Shin D.W. Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians Skin. Res. Technol. 2023 29 e13466 10.1111/srt.13466 37753681 PMC10485387 · DOI
  42. [46]Kim J.H. Jeong J.J. Lee Y.I. Lee W.J. Lee C. Chung W.Y. Nam K.H. Lee J.H. Preventive effect of polynucleotide on post-thyroidectomy scars: A randomized, double-blinded, controlled trial Lasers Surg. Med. 2018 50 755 762 10.1002/lsm.22812 29574803 · DOI · Paper page
  43. [47]Palmieri I. Raichi M. Biorevitalization of postmenopausal labia majora, the polynucleotide/hyaluronic acid option Obstet. Gynecol. Rep. 2019 3 1 5 10.15761/OGR.1000135 · DOI
  44. [48]Angelucci M. Frascani F. Franceschelli A. Lusi A. Garo M.L. Efficacy of intradermal hyaluronic acid plus polynucleotides in vulvovaginal atrophy: A pilot study Climacteric 2022 25 490 496 10.1080/13697137.2022.2052840 35389304 · DOI
  45. [49]Park K.Y. Kwon H.J. Youn C.S. Seo S.J. Kim M.N. Treatments of Infra-Orbital Dark Circles by Various Etiologies Ann. Dermatol. 2018 30 522 528 10.5021/ad.2018.30.5.522 33911473 PMC7992473 · DOI
  46. [50]Yogya Y. Wanitphakdeedecha R. Wongdama S. Nanchaipruek Y. Yan C. Rakchart S. Efficacy and Safety of Using Noninsulated Microneedle Radiofrequency Alone versus in Combination with Polynucleotides for Treatment of Periorbital Wrinkles Dermatol. Ther. 2022 12 1133 1145 10.1007/s13555-022-00729-7 35501660 PMC9110589 · DOI · Paper page
  47. [51]Gulfan M.C.B. Wanitphakdeedecha R. Wongdama S. Jantanapornchai N. Yan C. Rakchart S. Efficacy and Safety of Using Noninsulated Microneedle Radiofrequency Alone Versus in Combination with Polynucleotides for the Treatment of Melasma: A Pilot Study Dermatol. Ther. 2022 12 1325 1336 10.1007/s13555-022-00728-8 35538360 PMC9209614 · DOI
  48. [52]Slominski A.T. Slominski R.M. Raman C. Chen J.Y. Athar M. Elmets C. Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides Am. J. Physiol. Cell Physiol. 2022 323 C1757 C1776 10.1152/ajpcell.00147.2022 36317800 PMC9744652 · DOI
  49. [53]Slominski A. Wortsman J. Neuroendocrinology of the skin Endocr. Rev. 2000 21 457 487 10.1210/er.21.5.457 11041445 · DOI
  50. [54]Bosch R. Philips N. Suárez-Pérez J.A. Juarranz A. Devmurari A. Chalensouk-Khaosaat J. González S. Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals Antioxidants 2015 4 248 268 10.3390/antiox4020248 26783703 PMC4665475 · DOI · Paper page
  51. [55]Slominski A.T. Zmijewski M.A. Plonka P.M. Szaflarski J.P. Paus R. How UV Light Touches the Brain and Endocrine System Through Skin, and Why Endocrinology 2018 159 1992 2007 10.1210/en.2017-03230 29546369 PMC5905393 · DOI · Paper page
  52. [56]Slominski R.M. Chen J.Y. Raman C. Slominski A.T. Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system Proc. Natl. Acad. Sci. USA 2024 121 e2308374121 10.1073/pnas.2308374121 38489380 PMC10998607 · DOI
  53. [57]Slominski A.T. Kim T.K. Janjetovic Z. Slominski R.M. Li W. Jetten A.M. Indra A.K. Mason R.S. Tuckey R.C. Biological Effects of CYP11A1-Derived Vitamin D and Lumisterol Metabolites in the Skin J. Investig. Dermatol. 2024 10.1016/j.jid.2024.04.022 PMC11416330 39001720 · DOI
  54. [58]de Luca Brunori I. Battini L. Filippeschi M. Romani L. Tarani A. Urbano M. Topical therapy with placental polydeoxyribonucleotide in cervical ectopy and ectropion Ann. Ostet. Ginecol. Med. Perinat. 1989 110 35 41 2757327
  55. [59]Perino A. Genova G. Vita C. Costa P. Biondo A. Palmeri M.A. Filippazzo G. The pharmacologic therapy of post-cauterization and post-laser vaporization with polydeoxyribonucleotide Ann. Ostet. Ginecol. Med. Perinat. 1990 111 372 378 2102064
  56. [60]Muratore O. Pesce Schito A. Cattarini G. Tonoli E.L. Gianoglio S. Schiappacasse S. Felli L. Picchetta F. Schito G.C. Evaluation of the trophic effect of human placental polydeoxyribonucleotide on human knee skin fibroblasts in primary culture Cell. Mol. Life Sci. 1997 53 279 285 10.1007/PL00000605 9104493 PMC11147285 · DOI
  57. [61]Thellung S. Florio T. Maragliano A. Cattarini G. Schettini G. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: Involvement of A2 purinergic receptor subtypes Life Sci. 1999 64 1661 1674 10.1016/S0024-3205(99)00104-6 10328526 · DOI · Paper page
  58. [62]Valdatta L. Thione A. Mortarino C. Buoro M. Tuinder S. Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: A pilot study Curr. Med. Res. Opin. 2004 20 403 408 10.1185/030079904125003116 15025849 · DOI · Paper page
  59. [63]Altavilla D. Bitto A. Polito F. Marini H. Minutoli L. Di Stefano V. Irrera N. Cattarini G. Squadrito F. Polydeoxyribonucleotide (PDRN): A safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers Cardiovasc. Hematol. Agents Med. Chem. 2009 7 313 321 10.2174/187152509789541909 19860658 · DOI · Paper page
  60. [64]Kim M.J. Park H.J. Oh S.M. Yi K.H. Polynucleotide injection treatment for iatrogenic fat atrophy in two patients: Potential for safe volumization in aesthetic medicine Skin. Res. Technol. 2023 29 e13439 10.1111/srt.13439 37632185 PMC10423761 · DOI · Paper page
  61. [65]Kim T.H. Heo S.Y. Oh G.W. Heo S.J. Jung W.K. Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering Mar. Drugs 2021 19 296 10.3390/md19060296 34067499 PMC8224764 · DOI · Paper page
  62. [66]Noh T.K. Chung B.Y. Kim S.Y. Lee M.H. Kim M.J. Youn C.S. Lee M.W. Chang S.E. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster Int. J. Mol. Sci. 2016 17 1448 10.3390/ijms17091448 27598132 PMC5037727 · DOI · Paper page
  63. [67]Lee S.H. Yoo S.H. Lee H.J. Han D. Lee J. Jeon S.H. Cho E.A. Park H.J. Anti-Allodynic Effects of Polydeoxyribonucleotide in an Animal Model of Neuropathic Pain and Complex Regional Pain Syndrome J. Korean Med. Sci. 2020 35 e225 10.3346/jkms.2020.35.e225 32627441 PMC7338212 · DOI
  64. [68]Mannino F. Pallio G. Bitto A. Altavilla D. Minutoli L. Squadrito V. Arcoraci V. Giorgi D.A. Pirrotta I. Squadrito F. Targeting Adenosine Receptor by Polydeoxyribonucleotide: An Effective Therapeutic Strategy to Induce White-to-Brown Adipose Differentiation and to Curb Obesity Pharmaceuticals 2021 14 728 10.3390/ph14080728 34451825 PMC8402160 · DOI
  65. [70]McMillen P. Holley S.A. Integration of cell-cell and cell-ECM adhesion in vertebrate morphogenesis Curr. Opin. Cell Biol. 2015 36 48 53 10.1016/j.ceb.2015.07.002 26189063 PMC4639458 · DOI
  66. [71]Gibson M.C. Patel A.B. Nagpal R. Perrimon N. The emergence of geometric order in proliferating metazoan epithelia Nature 2006 442 1038 1041 10.1038/nature05014 16900102 · DOI
  67. [72]Standring S. Ellis H. Healy J. Johnson D. Williams A. Collins P. Wigley C. Gray’s Anatomy, 39th Edition: The Anatomical Basis of Clinical Practice Am. J. Neuroradiol. 2005 26 2703 2704
  68. [73]Hayashi K. Yanagisawa T. Kishida R. Ishikawa K. Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System ACS Nano 2022 16 11755 11768 10.1021/acsnano.2c03776 35833725 PMC9413413 · DOI
  69. [74]Zadpoor A.A. Bone tissue regeneration: The role of scaffold geometry Biomater. Sci. 2015 3 231 245 10.1039/C4BM00291A 26218114 · DOI
  70. [75]Rumpler M. Woesz A. Dunlop J.W. van Dongen J.T. Fratzl P. The effect of geometry on three-dimensional tissue growth J. R. Soc. Interface 2008 5 1173 1180 10.1098/rsif.2008.0064 18348957 PMC2495039 · DOI
  71. [76]Evans M.J. Guha S.C. Cox R.A. Moller P.C. Attenuated fibroblast sheath around the basement membrane zone in the trachea Am. J. Respir. Cell Mol. Biol. 1993 8 188 192 10.1165/ajrcmb/8.2.188 8427709 · DOI
  72. [77]Dembo M. Bell G.I. The Thermodynamics of Cell Adhesion Current Topics in Membranes and Transport Bronner F. Klausner R.D. Kempf C. Renswoude J.V. Academic Press Cambridge, MA, USA 1987 71 89
  73. [78]Fisher G.J. Varani J. Voorhees J.J. Looking older: Fibroblast collapse and therapeutic implications Arch. Dermatol. 2008 144 666 672 10.1001/archderm.144.5.666 18490597 PMC2887041 · DOI · Paper page
  74. [79]Varani J. Dame M.K. Rittie L. Fligiel S.E. Kang S. Fisher G.J. Voorhees J.J. Decreased collagen production in chronologically aged skin: Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation Am. J. Pathol. 2006 168 1861 1868 10.2353/ajpath.2006.051302 16723701 PMC1606623 · DOI · Paper page
  75. [80]Fisher G.J. Shao Y. He T. Qin Z. Perry D. Voorhees J.J. Quan T. Reduction of fibroblast size/mechanical force down-regulates TGF-beta type II receptor: Implications for human skin aging Aging Cell 2016 15 67 76 10.1111/acel.12410 26780887 PMC4717276 · DOI
  76. [81]Naga N. Jinno M. Wang Y. Nakano T. The first space-filling polyhedrons of polymer cubic cells originated from Weaire-Phelan structure created by polymerization induced phase separation Sci. Rep. 2022 12 19141 10.1038/s41598-022-22058-7 36351975 PMC9646714 · DOI
  77. [82]Douglas S.M. Dietz H. Liedl T. Hogberg B. Graf F. Shih W.M. Self-assembly of DNA into nanoscale three-dimensional shapes Nature 2009 459 414 418 10.1038/nature08016 19458720 PMC2688462 · DOI
  78. [83]Abd Elrahman M. Chung S.Y. Sikora P. Rucinska T. Stephan D. Influence of Nanosilica on Mechanical Properties, Sorptivity, and Microstructure of Lightweight Concrete Materials 2019 12 3078 10.3390/ma12193078 31546591 PMC6804061 · DOI
  79. [84]Gasperini A.E. Sanchez S. Doiron A.L. Lyles M. German G.K. Non-ionising UV light increases the optical density of hygroscopic self assembled DNA crystal films Sci. Rep. 2017 7 6631 10.1038/s41598-017-06884-8 28747733 PMC5529544 · DOI
  80. [85]Engler A.J. Sen S. Sweeney H.L. Discher D.E. Matrix elasticity directs stem cell lineage specification Cell 2006 126 677 689 10.1016/j.cell.2006.06.044 16923388 · DOI · Paper page
  81. [86]Watt F.M. Huck W.T. Role of the extracellular matrix in regulating stem cell fate Nat. Rev. Mol. Cell Biol. 2013 14 467 473 10.1038/nrm3620 23839578 · DOI · Paper page
  82. [87]Lu H. Oh H.H. Kawazoe N. Yamagishi K. Chen G. PLLA-collagen and PLLA-gelatin hybrid scaffolds with funnel-like porous structure for skin tissue engineering Sci. Technol. Adv. Mater. 2012 13 064210 10.1088/1468-6996/13/6/064210 27877537 PMC5099770 · DOI
  83. [88]Holzwarth J.M. Ma P.X. Biomimetic nanofibrous scaffolds for bone tissue engineering Biomaterials 2011 32 9622 9629 10.1016/j.biomaterials.2011.09.009 21944829 PMC3195926 · DOI
  84. [89]Li X. Wang L. Fan Y. Feng Q. Cui F.Z. Watari F. Nanostructured scaffolds for bone tissue engineering J. Biomed. Mater. Res. A 2013 101 2424 2435 10.1002/jbm.a.34539 23377988 · DOI
  85. [90]Nikolova M.P. Chavali M.S. Recent advances in biomaterials for 3D scaffolds: A review Bioact. Mater. 2019 4 271 292 10.1016/j.bioactmat.2019.10.005 31709311 PMC6829098 · DOI · Paper page
  86. [91]Das P. Manna S. Roy S. Nandi S.K. Basak P. Polymeric biomaterials-based tissue engineering for wound healing: A systemic review Burns Trauma. 2023 11 tkac058 10.1093/burnst/tkac058 36761088 PMC9904183 · DOI
  87. [92]Krishani M. Shin W.Y. Suhaimi H. Sambudi N.S. Development of Scaffolds from Bio-Based Natural Materials for Tissue Regeneration Applications: A Review Gels 2023 9 100 10.3390/gels9020100 36826270 PMC9957409 · DOI
  88. [93]Ingber D.E. Wang N. Stamenovic D. Tensegrity, cellular biophysics, and the mechanics of living systems Rep. Prog. Phys. 2014 77 046603 10.1088/0034-4885/77/4/046603 24695087 PMC4112545 · DOI
  89. [94]Ingber D.E. Tensegrity-based mechanosensing from macro to micro Prog. Biophys. Mol. Biol. 2008 97 163 179 10.1016/j.pbiomolbio.2008.02.005 18406455 PMC2570054 · DOI
  90. [95]Ingber D.E. Cellular mechanotransduction: Putting all the pieces together again FASEB J. 2006 20 811 827 10.1096/fj.05-5424rev 16675838 · DOI · Paper page
  91. [96]Ingber D.E. Tensegrity II. How structural networks influence cellular information processing networks J. Cell Sci. 2003 116 1397 1408 10.1242/jcs.00360 12640025 · DOI
  92. [97]Ingber D.E. Tensegrity I. Cell structure and hierarchical systems biology J. Cell Sci. 2003 116 1157 1173 10.1242/jcs.00359 12615960 · DOI
  93. [98]Chen C.S. Ingber D.E. Tensegrity and mechanoregulation: From skeleton to cytoskeleton Osteoarthr. Cartil. 1999 7 81 94 10.1053/joca.1998.0164 10367017 · DOI
  94. [99]Ingber D.E. Cellular tensegrity: Defining new rules of biological design that govern the cytoskeleton J. Cell Sci. 1993 104 Pt 3 613 627 10.1242/jcs.104.3.613 8314865 · DOI
  95. [100]Rho N.K. Han K.H. Cho M. Kim H.S. A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists J. Cosmet. Dermatol. 2024 23 1243 1252 10.1111/jocd.16125 38093498 · DOI · Paper page

Cited by

Sorted by citations

Authors
Lee, K. W. A., Chan, K. W. L., Lee, A., Lee, C. H., Wan, J., Wong, S., & Yi, K.-H.
Affiliations
  • EverKeen Medical Centre, Hong Kong
  • The Skin Oracle, Hong Kong
  • Asia-Pacific Aesthetic Academy, Hong Kong
  • Leciel Medical Centre, Hong Kong
  • Yonsei University (KR)
Corresponding author
Yi, Kyu-Ho
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-07-27
Volume
25
Issue
15
Pages
8224
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms25158224
PMC
PMC11311621
OpenAlex
W4401123331
Cited by
58
References
3
Citations by year
2026: 33 · 2025: 24 · 2024: 1
FWCI
4.51
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
polynucleotides, aesthetic medicine, cosmetic applications, gene expression regulation, tissue regeneration, skin texture, wrinkle reduction, skin elasticity, skin hydration, treatment efficacy, safety
MeSH terms
Cosmetic Techniques, Esthetics, Humans, Polynucleotides, Skin Aging

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