Cited by 178Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesOcular Infections and Treatments

Emerging multidrug-resistant Candida species

Colombo, Arnaldo L., Júnior, João N. de Almeida, Guinea, Jesus·2017·Current Opinion in Infectious Diseases

Abstract

Purpose of review: To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR)Candida spp. Recent findings: Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been reported in medical centers worldwide. Summary: We checked all papers published along the last 10 years describing epidemiological, diagnostic, and clinical aspects of infections by MDR Candida spp., with emphasis on C. auris and C. glabrata spp.C. auris has been reported in 15 countries and multidrug resistance rates is usually above 30%. Horizontal transmission is a great concern regarding C. auris.C. glabrata ranks the second most reported Candida spp. in deep-seated infections from United States and some European Centers, although multidrug resistance rates above 10% are restricted to some US centers.Candida haemulonii complex isolates with poor susceptibility to azoles and amphotericin B have been isolated in superficial and deep-seated infections, whereas Candida guilliiermondii complex isolates with poor susceptibility to azoles and echinocandins have been recovered from catheter-related bloodstream infections. Other potential MDR Candida species are Candida krusei,Candida lusitaniae,Candida kefyr,Yarrowia(Candida)lypolitica,and Candida rugosa.

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Crossref · 10.1097/qco.0000000000000411

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Authors
Colombo, A. L., Júnior, J. N. D. A., & Guinea, J.
Affiliations
  • Universidade Federal de São Paulo (BR)
  • Central Laboratory Division (LIM03), Laboratory of Medical Mycology (LIM53), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
  • Medicine Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
Corresponding author
Colombo, Arnaldo L.
Venue
Current Opinion in Infectious Diseases
Published
2017-12
Volume
30
Issue
6
Pages
528-538
ISSN
  • 0951-7375 (ISSN-L)
  • 1473-6527
OpenAlex
W2765742851
Cited by
177
References
136
Citations by year
2026: 11 · 2025: 12 · 2024: 18 · 2023: 30 · 2022: 23 · 2021: 27 · 2020: 20 · 2019: 31 · 2018: 3 · 2017: 2
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
Candida auris, Candida glabrata, Candida krusei, Candida lusitaniae, Candida kefyr, Candida rugosa, invasive candidiasis, candidemia, azole resistance, echinocandin resistance, amphotericin B resistance, horizontal transmission, early detection, clinical management, catheter-related bloodstream infection
MeSH terms
Antifungal Agents, Candida, Candidiasis, Humans, Communicable Diseases, Emerging, Drug Resistance, Multiple, Fungal

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