Emerging multidrug-resistant Candida species
Abstract
Purpose of review: To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR)Candida spp. Recent findings: Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been reported in medical centers worldwide. Summary: We checked all papers published along the last 10 years describing epidemiological, diagnostic, and clinical aspects of infections by MDR Candida spp., with emphasis on C. auris and C. glabrata spp.C. auris has been reported in 15 countries and multidrug resistance rates is usually above 30%. Horizontal transmission is a great concern regarding C. auris.C. glabrata ranks the second most reported Candida spp. in deep-seated infections from United States and some European Centers, although multidrug resistance rates above 10% are restricted to some US centers.Candida haemulonii complex isolates with poor susceptibility to azoles and amphotericin B have been isolated in superficial and deep-seated infections, whereas Candida guilliiermondii complex isolates with poor susceptibility to azoles and echinocandins have been recovered from catheter-related bloodstream infections. Other potential MDR Candida species are Candida krusei,Candida lusitaniae,Candida kefyr,Yarrowia(Candida)lypolitica,and Candida rugosa.
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Echinocandins were launched in the early 2000s and became first-line treatment following the emergence of C. glabrata with reduced susceptibility to fluconazole.
“Echinocandins were launched in the early 2000s and became the first-line treatment following the emergence of C. glabrata with reduced susceptibility to fluconazole Colombo et al. [101].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [101]
Mutations frequently occur in FKS2 relative to FKS1.
“Mutations frequently occur in FKS2 relative to FKS1 [101].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [101]
The SENTRY surveillance program between 2006 and 2010 reported 11% echinocandin and fluconazole resistance among C. glabrata (MDR).
“The SENTRY surveillance program between 2006 and 2010 reported 11% echinocandin and fluconazole resistance among C. glabrata (i.e., MDR) [101].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [101]
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- Authors
- Colombo, A. L., Júnior, J. N. D. A., & Guinea, J.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Central Laboratory Division (LIM03), Laboratory of Medical Mycology (LIM53), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Medicine Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
- Corresponding author
- Colombo, Arnaldo L.
- ORCID
- Colombo, Arnaldo L.
- Venue
- Current Opinion in Infectious Diseases
- Published
- 2017-12
- Volume
- 30
- Issue
- 6
- Pages
- 528-538
- ISSN
- 0951-7375 (ISSN-L)
- 1473-6527
- OpenAlex
- W2765742851
- Semantic Scholar
- e4e3cc325bd6f2e43de0c05a4f19c50193ddf27c
- Cited by
- 177
- References
- 136
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 18 · 2023: 30 · 2022: 23 · 2021: 27 · 2020: 20 · 2019: 31 · 2018: 3 · 2017: 2
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- Candida auris, Candida glabrata, Candida krusei, Candida lusitaniae, Candida kefyr, Candida rugosa, invasive candidiasis, candidemia, azole resistance, echinocandin resistance, amphotericin B resistance, horizontal transmission, early detection, clinical management, catheter-related bloodstream infection
- MeSH terms
- Antifungal Agents, Candida, Candidiasis, Humans, Communicable Diseases, Emerging, Drug Resistance, Multiple, Fungal
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