Molecular basis of antifungal drug resistance in yeasts

Morio, Florent; Jensen, Rasmus Hare; Le Pape, Patrice; Arendrup, Maiken Cavling

doi:10.1016/j.ijantimicag.2017.05.012

Cited by 114Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

Molecular basis of antifungal drug resistance in yeasts

Morio, Florent, Jensen, Rasmus Hare, Le Pape, Patrice, Arendrup, Maiken Cavling·2017·International Journal of Antimicrobial Agents

DOI 10.1016/j.ijantimicag.2017.05.012

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Abstract

Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.

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Factors that promote the acquisition of resistance and treatment failure include the use of sub-therapeutic concentrations, drug sequestration in the biofilm matrix, and poor control of infections.
“Besides the overall use and exposure to antifungals (often used in prophylactic measures), other factors that promote the acquisition of resistance and a treatment failure include the use of sub-therapeutic concentrations, drug sequestration in the biofilm matrix, and poor control of infections [67,68].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [68]

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Authors: Morio, F., Jensen, R. H., Le Pape, P., & Arendrup, M. C.
Affiliations: Centre Hospitalier Universitaire de Nantes (FR)
Statens Serum Institut (DK)
Corresponding author: Morio, Florent
ORCID: Morio, Florent
Arendrup, Maiken Cavling
Venue: International Journal of Antimicrobial Agents
Publisher: Elsevier BV
Published: 2017-11
Volume: 50
Issue: 5
Pages: 599-606
ISSN: 0924-8579 (ISSN-L)
DOI: 10.1016/j.ijantimicag.2017.05.012
OpenAlex: W2731961272
Semantic Scholar: 265bab70f053b3739b9d8c254210c7a291e53398
Cited by: 114
References: 81
Citations by year: 2026: 3 · 2025: 9 · 2024: 8 · 2023: 16 · 2022: 24 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 9 · 2017: 3
FWCI: 8.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Antimicrobial Agents (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: antifungal resistance, Candida, Candida glabrata, multidrug resistance, molecular mechanisms of resistance, antifungal susceptibility testing, resistance mutations, clinical failure
MeSH terms: Antifungal Agents, Candida, Genes, Fungal, Humans, Microbial Sensitivity Tests, Mutation, Drug Resistance, Fungal

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Molecular basis of antifungal drug resistance in yeasts

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