Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
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BACKGROUND: The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer's disease (AD), with only the apolipoprotein E (APOE) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain. TREM2 is expressed on microglia, the resident immune cells of the brain and has been linked to phagocytotic clearance of amyloid β (Aβ) plaques. Soluble TREM2 (sTREM2) has previously been measured in cerebrospinal fluid (CSF) by ELISA but in our hands commercial kits have proved unreliable, suggesting that other methods may be required. We developed a mass spectrometry method using selected reaction monitoring for the presence of a TREM2 peptide, which can be used to quantify levels of sTREM2 in CSF. FINDINGS: We examined CSF samples from memory clinics in Sweden and the UK. For all samples the following were available: clinical diagnosis, age, sex, and measurements of the CSF AD biomarkers Aβ42, T-tau and P-tau181. AD patients (n = 37) all met biomarker (IWG2) criteria for AD. Control individuals (n = 22) were cognitively normal without evidence for AD in CSF. We found significantly higher sTREM2 concentration in AD compared to control CSF. There were significant correlations between CSF sTREM2 and T-tau as well as P-tau181. CSF sTREM2 increase in AD was replicated in a second, independent cohort consisting of 24 AD patients and 16 healthy volunteers. CONCLUSION: CSF concentrations of sTREM2 are higher in AD than in controls, and correlate with markers of neurodegeneration. CSF sTREM2 may be used to quantify glial activation in AD.
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This could be representative of changes in TREM2 expression or shedding, both of which are altered during ageing and disease, thereby reducing TREM2-mediated signalling and subsequent conversion of microglia to DAM.
“This could be representative of changes in TREM2 expression or shedding, both of which are altered during ageing and disease [55], thereby reducing TREM2-mediated signalling and subsequent conversion of microglia to DAM [56].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [55]
The Results (page unavailable) show higher CSF soluble TREM2 in Alzheimer’s disease, and the Discussion (page unavailable) cites increased Trem2 expression in mouse models of the disease. The paper does not establish that ageing independently alters TREM2 expression or shedding, or that its measured soluble-TREM2 change reflects altered shedding. The later claim about signalling and conversion to DAM is attached to [56], not this source. (LLM, conf=0.83)
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- Authors
- Heslegrave, A., Heywood, W., Paterson, R., Magdalinou, N., Svensson, J., Johansson, P., Öhrfelt, A., Blennow, K., Hardy, J., Schott, J., Mills, K., & Zetterberg, H.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Skaraborg Hospital (SE)
- Corresponding author
- Heslegrave, Amanda
- ORCID
- Venue
- Molecular Neurodegeneration
- Published
- 2016-01-12
- Volume
- 11
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1750-1326 (ISSN-L)
- PMC
- PMC4709982
- OpenAlex
- W2234866329
- Cited by
- 303
- References
- 40
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 43 · 2023: 24 · 2022: 31 · 2021: 39 · 2020: 34 · 2019: 22 · 2018: 39 · 2017: 24 · 2016: 9
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Neurodegeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Wolfson Foundation
- Alzheimer’s Research UK
- Svenska Forskningsrådet Formas
- Biomedical Research Council (GOSH)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- soluble TREM2, Alzheimer's disease, cerebrospinal fluid biomarkers, microglia, neuroinflammation, tau phosphorylation, phosphorylated tau 181, total tau, amyloid-beta, glial activation, multiple reaction monitoring, mass spectrometry quantification
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Receptors, Immunologic, Risk Factors, Biomarkers, Amyloid beta-Peptides, tau Proteins, Apolipoprotein E4, Plaque, Amyloid
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