Beneficial actions of microbiota‐derived tryptophan metabolites
Abstract
Tryptophan is an important dietary amino acid and it is the precursor for 5‐hydroxytryptamine synthesis in the nervous system and by enterochromaffin cells in the gut mucosa. Tryptophan is also metabolized by enzymes in the gut mucosa and also by enzymes produced by the gut microbiome. Diet and the microbiome can contribute to metabolic disease in part by causing intestinal inflammation and increased permeability. In this issue of Neurogastroenterology and Motility, Jennis et al. test the hypothesis that indole tryptophan metabolites produced by gut bacteria might be responsible for the anti‐inflammatory and beneficial metabolic effects of the gut microbiome and Roux‐en‐Y gastric bypass surgery for weight loss by obese patients. The authors identified indole‐3‐propionic acid as the beneficial metabolite. A review of the literature also revealed the beneficial effects of tryptophan metabolites on diabetes and metabolic disease and on inflammatory bowel disease. Taken together, these data highlight another health benefit of the intestinal microbiome, which produces beneficial products from dietary amino acids especially tryptophan.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many microbial metabolites from dietary components, bodily secretions, or xenobiotics have been shown to influence brain structure and function in preclinical studies.
“Many of these metabolites have been shown to influence brain structure and function in preclinical studies [20, 21].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [20]
Many indoles positively influence both systemic and intestinal homeostasis.
“While many indoles are known to positively influence both systemic and intestinal homeostasis [20]”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [20]
Cites
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614 · see citing works
Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482 · see citing works
Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066 · see citing works
Jenkins, T., Nguyen, J., Polglaze, K., & Bertrand, P. (2016) · Nutrients · doi:10.3390/nu8010056 · Cited by 904 · see citing works
Endogenous kynurenines as targets for drug discovery and development
Stone, T. W., & Darlington, L. G. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd870 · Cited by 768 · see citing works
Kynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works
Smith, K. B., & Smith, M. S. (2016) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2015.10.001 · Cited by 591 · see citing works
Evans, C. C., LePard, K. J., Kwak, J. W., Stancukas, M. C., Laskowski, S., Dougherty, J., Moulton, L., Glawe, A., Wang, Y., Leone, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092193 · Cited by 587 · see citing works
Verdam, F. J., Fuentes, S., de Jonge, C., Zoetendal, E. G., Erbil, R., Greve, J. W., Buurman, W. A., de Vos, W. M., & Rensen, S. S. (2013) · Obesity · doi:10.1002/oby.20466 · Cited by 587 · see citing works
Diabetes, obesity and gut microbiota
Everard, A., & Cani, P. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.007 · Cited by 546 · see citing works
Ussar, S., Griffin, N. W., Bézy, O., Fujisaka, S., Vienberg, S. G., Softic, S., Deng, L., Bry, L., Gordon, J. I., & Kahn, C. R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.007 · Cited by 529 · see citing works
Lecomte, V., Kaakoush, N. O., Maloney, C., Raipuria, M., Huinao, K. D., Mitchell, H. M., & Morris, M. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126931 · Cited by 418 · see citing works
Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function
Keszthelyi, D., Troost, F. J., & Masclee, A. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01370.x · Cited by 369 · see citing works
Biochemistry of tryptophan in health and disease
Bender, D. A. (1983) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(83)90005-5 · Cited by 355 · see citing works
Hersoug, L., Møller, P., & Loft, S. H. (2015) · Obesity Reviews · doi:10.1111/obr.12370 · Cited by 294 · see citing works
Banack, H. R., & Kaufman, J. S. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.02.003 · Cited by 233 · see citing works
Jennis, M., Cavanaugh, C., Leo, G. C., Mabus, J. R., Lenhard, J. M., & Hornby, P. J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13178 · Cited by 172 · see citing works
Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00965.x · Cited by 164 · see citing works
Albuquerque, E. X., & Schwarcz, R. M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.12.014 · Cited by 150 · see citing works
Serotonin and colonic motility
Kendig, D. M., & Grider, J. R. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12617 · Cited by 113 · see citing works
Varga, G., Érces, D., Fazekas, B., löp, M. F. ⁄., Kovács, T., Kaszaki, J., löp, F. F. ⁄., vécsei, L., & Boros, M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01390.x · Cited by 75 · see citing works
Heterogeneity of enterochromaffin cells within the gastrointestinal tract
Diwakarla, S., Fothergill, L. J., Fakhry, J., Callaghan, B. P., & Furness, J. B. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13101 · Cited by 72 · see citing works
Beyond phylotyping: understanding the impact of gut microbiota on host biology
Reigstad, C. S., & Kashyap, P. C. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12134 · Cited by 66 · see citing works
Érces, D., Varga, G., Fazekas, B., Kovács, T., Tőkés, T., Tiszlavicz, L., Fülöp, F., Vécsei, L., Boros, M., & Kaszaki, J. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.044 · Cited by 45 · see citing works
Kennedy, P. J., Allen, A. P., O’Neill, A., Quigley, E. M. M., Cryan, J. F., Dinan, T. G., & Clarke, G. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3767-z · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180 · see citing works
Gut microbiota-derived metabolites as central regulators in metabolic disorders
Agus, A., Clément, K., & Sokol, H. (2021) · Gut · doi:10.1136/gutjnl-2020-323071 · Cited by 1,347 · see citing works
The microbiota-gut-brain axis: from motility to mood
Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.066 · Cited by 999 · see citing works
Tryptophan Metabolism as a Pharmacological Target
Modoux, M., Rolhion, N., Mani, S., & Sokol, H. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.11.006 · Cited by 285 · see citing works
Konopelski, P., & Mogilnicka, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031222 · Cited by 218 · see citing works
A novel approach to Lactiplantibacillus plantarum: From probiotic properties to the omics insights
Echegaray, N., Yılmaz, B., Sharma, H., Kumar, M., Pateiro, M., Özoğul, F., & Lorenzo, J. M. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127289 · Cited by 215 · see citing works
Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders
Horn, J., Mayer, D. E., Chen, S., & Mayer, E. A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01922-0 · Cited by 193 · see citing works
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer
Yan, J. J., Chen, D., Ye, Z., Zhu, X., Li, X., Jiao, H., Duan, M., Zhang, C., Cheng, J., Xu, L., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02164-y · Cited by 184 · see citing works
Zhang, J., Zhu, S., Ma, N., Johnston, L. J., Wu, C., & Ma, X. (2020) · Medicinal Research Reviews · doi:10.1002/med.21752 · Cited by 181 · see citing works
Microbiota-Related Metabolites and the Risk of Type 2 Diabetes
Vangipurapu, J., Silva, L. F., Kuulasmaa, T., Smith, U., & Laakso, M. (2020) · Diabetes Care · doi:10.2337/dc19-2533 · Cited by 148 · see citing works
Zhou, Y., Chen, Y., He, H., Peng, M., Zeng, M., & Sun, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109690 · Cited by 141 · see citing works
The Microbial Pecking Order: Utilization of Intestinal Microbiota for Poultry Health
Maki, J. J., Klima, C. L., Sylte, M. J., & Looft, T. P. (2019) · Microorganisms · doi:10.3390/microorganisms7100376 · Cited by 128 · see citing works
Li, X., Zhang, Z., Zabed, H. M., Yun, J., Zhang, G., & Qi, X. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000461 · Cited by 124 · see citing works
Ikeda-Ohtsubo, W., Brugman, S., Warden, C. H., Rebel, J. M. J., Folkerts, G., & Pieterse, C. M. J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00090 · Cited by 115 · see citing works
Camilleri, M., Lyle, B. J., Madsen, K. L., Sonnenburg, J. L., Verbeke, K., & Wu, G. D. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2019 · Cited by 111 · see citing works
Greathouse, K. L., & Wyatt, M. (2021) · Nutrients · doi:10.3390/nu13041189 · Cited by 111 · see citing works
Zhang, Q., Cheng, L., Wang, J., Hao, M., & Che, H. (2021) · Nutrients · doi:10.3390/nu13103315 · Cited by 110 · see citing works
Ghiboub, M., Verburgt, C. M., Sovran, B., Benninga, M. A., de Jonge, W. J., & Limbergen, J. V. (2020) · Nutrients · doi:10.3390/nu12092846 · Cited by 94 · see citing works
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Gupta, S. K., Vyavahare, S. S., Blanes, I. L. D., Berger, F. G., Isales, C. M., & Fulzele, S. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112319 · Cited by 85 · see citing works
Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis
Farzi, A., Hassan, A. M., Zenz, G., & Holzer, P. D. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.11.003 · Cited by 77 · see citing works
Liaqat, H., Parveen, A., & Kim, S. Y. (2022) · Nutrients · doi:10.3390/nu14163270 · Cited by 71 · see citing works
Rhoades, N. S., Barr, T., Hendrickson, S. M., Prongay, K., Haertel, A. J., Gill, L., Garzel, L. M., Whiteson, K., Slifka, M. K., & Messaoudi, I. (2019) · Genome biology · doi:10.1186/s13059-019-1789-x · Cited by 66 · see citing works
A Crucial Role for Diet in the Relationship Between Gut Microbiota and Cardiometabolic Disease
Attaye, I., Pinto‐Sietsma, S., Herrema, H., & Nieuwdorp, M. (2019) · Annual Review of Medicine · doi:10.1146/annurev-med-062218-023720 · Cited by 64 · see citing works
Johnson, T. A., Sylte, M. J., & Looft, T. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-44338-5 · Cited by 60 · see citing works
Ge, P., Qu, S., Ni, S., Yao, Z., Qi, Y., Zhao, X., Guo, R., Yang, N., Zhang, Q., & Zhu, H. (2022) · Phytotherapy Research · doi:10.1002/ptr.7616 · Cited by 59 · see citing works
Ai, X., Wu, C., Yin, T., Zhur, O., Liu, C., Yan, X., Yi, C., Liu, D., Xiao, L., Li, W., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.682290 · Cited by 56 · see citing works
Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host
Wang, Y., Huang, B., Wei, X., Guan, Y., Li, L., Zheng, Y., & Sun, W. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2644681 · Cited by 55 · see citing works
Zhao, Y., Wu, C., Zhu, Y. G., Zhou, C., Xiong, Z., Eweys, A. S., Zhou, H., Dong, Y., & Xiao, X. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109808 · Cited by 52 · see citing works
Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders
Fila, M., Chojnacki, J., Pawlowska, E., Szczepanska, J., Chojnacki, C., & Blasiak, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810134 · Cited by 50 · see citing works
Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial Metabolites
Wang, D., Liu, J. Y., Zhou, L., Zhang, Q., Li, M., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.905171 · Cited by 46 · see citing works
Wang, Q., Chen, C., Zuo, S., Cao, K., & Li, H. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04262-9 · Cited by 41 · see citing works
Zhou, Y., Zhao, R., Lyu, Y., Shi, H., Ye, W., Tan, Y., Li, R., & Xu, Y. (2021) · Nutrients · doi:10.3390/nu13103644 · Cited by 40 · see citing works
Murakami, Y., Imamura, Y., Kasahara, Y., Yoshida, C., Momono, Y., Fang, K., Sakai, D., Konishi, Y., & Nishiyama, T. (2023) · Cells · doi:10.3390/cells12071087 · Cited by 36 · see citing works
Song, H., Xue, H., Zhang, Z., Wang, J., Li, A., Zhang, J., Luo, P., Zhan, M., Zhou, X., Chen, L., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c04665 · Cited by 40 · see citing works
Shan, S., Qiao, Q., Yin, R., Zhang, L., Shi, J., Zhao, W., Zhou, J., & Li, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05764 · Cited by 36 · see citing works
Maternal microbiota and gestational diabetes: impact on infant health
Singh, P., Elhag, D. A., Ibrahim, I., Abdullahi, H., & Khodor, S. A. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04230-3 · Cited by 38 · see citing works
Jackson, M. I., Waldy, C., & Jewell, D. E. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241037 · Cited by 35 · see citing works
Liu, D., Wang, J., Zeng, H., Zhou, F., Wen, B., Zhang, X.-N., Luo, Y. L., Wu, W., Huang, J., & Liu, Z. (2021) · Food & Function · doi:10.1039/d1fo02181h · Cited by 35 · see citing works
Gangaiah, D., Ryan, V., van Hoesel, D., Mane, S. P., McKinley, E. T., Lakshmanan, N., Reddy, N. D., Dolk, E., & Kumar, A. (2022) · MicrobiologyOpen · doi:10.1002/mbo3.1270 · Cited by 33 · see citing works
Ross, F. C., Mayer, D. E., Gupta, A., Gill, C. I. R., Rio, D. D., Cryan, J. F., Lavelle, A., Ross, R. P., Stanton, C., & Mayer, E. A. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.018 · Cited by 35 · see citing works
Beneficial Effect of Increased Tryptophan Intake on Its Metabolism and Mental State of the Elderly
Chojnacki, C. J., Gąsiorowska, A., Popławski, T., Konrad, P., Chojnacki, M., Fila, M., & Błasiak, J. (2023) · Nutrients · doi:10.3390/nu15040847 · Cited by 32 · see citing works
Ji, Y. S., Yang, Y., Sun, S., Dai, Z., Ren, F., & Wu, Z. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac039 · Cited by 31 · see citing works
Short-Chain Fatty Acids and Their Metabolic Interactions in Heart Failure
Chulenbayeva, L., Issilbayeva, A., Sailybayeva, A., Bekbossynova, M. S., Kozhakhmetov, S., & Kushugulova, A. R. (2025) · Biomedicines · doi:10.3390/biomedicines13020343 · Cited by 34 · see citing works
Cheng, M., Zhang, Y., Yan, J., Huang, Y., Wang, M., Zhai, Z., Liu, G., Liu, C., Li, J., Zhang, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116481 · Cited by 29 · see citing works
Zou, B., Sun, Y., Xu, Z., Chen, Y., Li, L., Lin, L., Zhang, S., Liao, Q., & Xie, Z. (2020) · Biomedical Chromatography · doi:10.1002/bmc.4985 · Cited by 29 · see citing works
Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice
Hatamnejad, M. R., Baradaran Ghavami, S., Shirvani, M., Asghari Ahmadabad, M., Shahrokh, S., Farmani, M., Sherkat, G., Asadzadeh Aghdaei, H., & Zali, M. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.980189 · Cited by 28 · see citing works
Discrete interplay of gut microbiota L-tryptophan metabolites in host biology and disease
Ranhotra, H. S. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04867-0 · Cited by 27 · see citing works
Han, J., Zhang, S., Xu, Y., Pang, Y., Zhang, X., Hu, Y., Chen, H., Chen, W., Zhang, J., & He, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01380 · Cited by 28 · see citing works
Cai, H., Wen, Z., Xu, X., Wang, J., Li, X., Meng, K., & Yang, P. (2022) · Foods · doi:10.3390/foods11020184 · Cited by 28 · see citing works
Hu, L., Wang, Y., Sun, H., Xiong, Y., Zhong, L., Wu, Z., & Ming, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112665 · Cited by 27 · see citing works
Baranwal, G., Goodlett, B. L., Arenaz, C. M., Creed, H. A., Navaneethabalakrishnan, S., Rutkowski, J. M., Alaniz, R. C., & Mitchell, B. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119192 · Cited by 27 · see citing works
Jia, Y., Liu, Y., Wu, Y., Feng, C., Zhang, H., Ren, F., & Liu, H. (2024) · Food & Function · doi:10.1039/d4fo00585f · Cited by 27 · see citing works
Tryptophan metabolism and the intestinal microbiota: Implications for inflammatory bowel disease.
Hua, X., Chen, Y.-C., Ding, S.-J., & Fang, J. (2025) · Microbiology Research · doi:10.1016/j.micres.2025.128280 · Cited by 29 · see citing works
Lacerda, J. D. H. L. F., Lagos, A. C., Carolino, E., Silva-Herdade, A. S., Silva, M., & Guerreiro, C. S. (2021) · Nutrients · doi:10.3390/nu13020642 · Cited by 24 · see citing works
Liu, W., Guo, P., Dai, T., Shi, X., Shen, G., & Feng, J. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00879 · Cited by 22 · see citing works
Anderson, G. M. (2021) · Journal of Chromatography B · doi:10.1016/j.jchromb.2021.123008 · Cited by 22 · see citing works
Zhang, J., Zhang, R., Chen, Y., Guo, X., Ren, Y., Wang, M., Li, X., Huang, Z., Zhu, W., & Yu, K. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02381 · Cited by 21 · see citing works
Chung, S. H., Yoo, D., Ahn, T., Lee, W., & Hong, J. (2023) · Pharmaceuticals · doi:10.3390/ph16101495 · Cited by 20 · see citing works
Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors
Huang, Z., Xie, L., & Huang, Z. (2023) · Medicine in Microecology · doi:10.1016/j.medmic.2023.100081 · Cited by 19 · see citing works
Liu, D., Wang, S., Liu, Y., Luo, Y., Wen, B., Wu, W., Zeng, H., Huang, J., & Liu, Z. (2023) · Food & Function · doi:10.1039/d3fo01782f · Cited by 18 · see citing works
Liu, J., Liu, J., Zhang, J., Liu, C., Qu, C., & Na, L. (2023) · Food & Function · doi:10.1039/d3fo00503h · Cited by 16 · see citing works
Gutiérrez‐Repiso, C., Moreno‐Indias, I., Martín‐Núñez, G. M., Ho‐Plagaro, A., Rodríguez‐Cañete, A., Gonzalo, M., García‐Fuentes, E., & Tinahones, F. J. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.04.008 · Cited by 14 · see citing works
Wu, Z.-H., Yang, J., Chen, L.-X., Du, C., Zhang, Q., Zhao, S., Wang, X.-Y., Liu, Y., Cai, D.-M., Du, J., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.899829 · Cited by 13 · see citing works
Piazzesi, A., & Putignani, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.958346 · Cited by 12 · see citing works
Xia, P., Hou, T., Jin, H., Meng, Y., Li, J., Zhan, F., Geng, F., & Li, B. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2204147 · Cited by 11 · see citing works
Scardaci, R., Manfredi, M., Barberis, E., Scutera, S., Marengo, E., & Pessione, E. (2021) · Microbiology Research · doi:10.3390/microbiolres12030043 · Cited by 10 · see citing works
Vacca, A., Brosolo, G., Marcante, S., Mora, S. D., Bulfone, L., Porto, A. D., Pagano, C., Catena, C., & Sechi, L. A. (2026) · Nutrients · doi:10.3390/nu18020321 · Cited by 11 · see citing works
Human microbiome and cardiovascular diseases
Alam, J., Puppala, V., Uppulapu, S. K., Das, B., & Banerjee, S. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.07.012 · Cited by 9 · see citing works
Understanding Microbial Mediation of the Brain-Gut Axis
Horn, J. V., Delgadillo, D. R., & Mayer, E. A. (2025) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2024.12.004 · Cited by 7 · see citing works
Haiou, W., Li, J., Huang, W., Ye, Y., & Gao, L. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100356 · Cited by 7 · see citing works
Tryptophan Metabolism and the Microbiome-Gut-Brain Axis
Clarke, G. A., Villalobos-Manríquez, F., & Marin, D. C. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.13 · Cited by 7 · see citing works
Ahlin, S., Cefalo, C., Bondia‐Pons, I., Trôst, K., Capristo, E., Marini, L., Romero, M., Zorzano, A., Gastaldelli, A., Mingrone, G., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.786952 · Cited by 7 · see citing works
Anderson, G. M. (2023) · Metabolites · doi:10.3390/metabo13050602 · Cited by 7 · see citing works
Role of Tryptophan Metabolism in Cancer
Cui, Z., Wang, D., Zhang, Y., Yuan, L., Zhang, Y., & Qi, X. (2025) · Cancer Innovation · doi:10.1002/cai2.70037 · Cited by 6 · see citing works
Ren, Y., Mao, S., Chen, P., Tan, W., Ye, X., & Tian, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138122 · Cited by 5 · see citing works
A Minireview on Gastrointestinal Microbiota and Radiosusceptibility
Mao, A., Sun, C., Katsube, T., & Wang, B. (2020) · Dose-Response · doi:10.1177/1559325820963859 · Cited by 5 · see citing works
Liu, X., Liang, Z., Liu, C., Ma, Y., Qi, L., Zhang, X., Zhu, F., Xiao, M., Pan, J. A., Sun, C., et al. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70471 · Cited by 4 · see citing works
Nutraceuticals in digestive therapy
Головинская, О., & Wang, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821232-5.00030-6 · Cited by 4 · see citing works
Microbiota–metabolite axis in endometriosis: Pathogenic mechanisms and clinical implications
Li, M., Yue, A., Gu, L., Li, F., Ye, N., Xu, S., Gong, Z., Li, D., & Xu, P. (2026) · Journal of Biomedical Research · doi:10.7555/jbr.39.20250566 · Cited by 3 · see citing works
Jia, C., Peters, B. A., Usyk, M., Wang, Z., Hanna, D. B., Sharma, A., Anastos, K., Kaplan, R. C., Burk, R. D., & Qi, Q. (2025) · AIDS · doi:10.1097/qad.0000000000004231 · Cited by 2 · see citing works
Zhang, J., Li, M., Guo, Y., Jiang, X., Li, W., Huang, J., Yang, Y., Ou, Z., Cai, Y., Kong, Y., et al. (2026) · Environment International · doi:10.1016/j.envint.2026.110128 · Cited by 2 · see citing works
Li, J., Zhang, J., Ke, J., Ren, Z., & Feng, C. (2026) · PLoS ONE · doi:10.1371/journal.pone.0344478 · Cited by 2 · see citing works
Role of the gut microbiome in the pathophysiology of brain disorders
Mayer, E. A., Horn, J. V., Mayer, E. D., & Chen, S. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00058-7 · Cited by 2 · see citing works
Pomon, B., Madler, A. K., Jiang, X., & Abbaspourrad, A. (2025) · Food and Bioprocess Technology · doi:10.1007/s11947-025-03907-5 · Cited by 1 · see citing works
Xia, K., Jiao, Y.-R., Zhang, L.-Q., Gao, R.-Y., Wang, F.-T., Pan, Y., Cui, S., Lin, Y., Wu, T., Li, L., et al. (2025) · United European Gastroenterology journal · doi:10.1002/ueg2.70069 · Cited by 1 · see citing works
Liu, Y., Huang, Y., Zhang, M., Zhang, Y., Zhu, C., Xia, S., & Liao, J. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128535 · Cited by 1 · see citing works
The therapeutic role of microbial metabolites in human health and diseases
Manoharan, N., Parasuraman, R., Jayamurali, D., & Govindarajulu, S. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90113-0.00002-x · Cited by 1 · see citing works
Okeny, C., KIDUUMA, W., IKIRIIZA, A., Sonia, S. S., Omara, S., & Abaasa, C. N. (2023) · Student s Journal of Health Research Africa · doi:10.51168/sjhrafrica.v4i9.612 · Cited by 1 · see citing works
Nutritional Regulation of the Microbiota - Can One Meal Change a Trillion Lives?
Trikha, S. R. J., Wrigley, S. D., Gentile, C. L., & Weir, T. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22883-7
Bedeutung des Mikrobioms für Adipositas und Glukosestoffwechsel
Ecker, M., & Haller, D. (2021) · Der Diabetologe · doi:10.1007/s11428-021-00735-x
Bedeutung des Mikrobioms für Adipositas und Glukosestoffwechsel
Ecker, M., & Haller, D. (2022) · Gynäkologische Endokrinologie · doi:10.1007/s10304-022-00467-1
Abshire, K. M., & Leggio, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823453-2.00013-8
Role of tryptophan metabolism in inflammatory bowel disease
Li, M., Sun, S., Sun, K., Lv, B., & Fan, Y. (2023) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v31.i21.896 · Cited by 1 · see citing works
Wang, Q., Chen, C., Zuo, S., Cao, K., & Li, H. (2023) · Figshare · doi:10.6084/m9.figshare.23537663
Wang, Q., Chen, C., Zuo, S., Cao, K., & Li, H. (2023) · Figshare · doi:10.6084/m9.figshare.23537666
Wang, Q., Chen, C., Zuo, S., Cao, K., & Li, H. (2023) · Figshare · doi:10.6084/m9.figshare.23537660
Cecal microbiota transportation, social stress, and injurious behaviors in chickens – A review
Cheng, H.-W. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107305
Huang, Q., Liang, Z., Zeng, Y., Yao, C., He, J. S., Cao, Y., & Chen, Y. (2026) · Food Frontiers · doi:10.1002/fft2.70337
Anti-hyperuricemia therapy alleviates diet-induced gut inflammation via AhR-IL-22-signalling
Bouquez, S., Campos, P. L., Ottobre, M., & Vega, M. D. (2026) · Journal of Molecular Medicine · doi:10.1007/s00109-026-02713-6
- Authors
- Galligan, J. J.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Galligan, J. J.
- ORCID
- Galligan, J. J.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2018-01-17
- Volume
- 30
- Issue
- 2
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2788825121
- Cited by
- 99
- References
- 26
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 5 · 2023: 25 · 2022: 16 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 3
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK103759, DK094932)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- tryptophan metabolites, gut microbiota, indole-3-propionic acid, Roux-en-Y gastric bypass, obesity, metabolic disorders, intestinal inflammation, intestinal permeability, diabetes mellitus, inflammatory bowel disease, serotonin, enterochromaffin cells
- MeSH terms
- Gastrointestinal Microbiome, Diabetes Mellitus, Type 2, Humans, Obesity, Tryptophan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review