Cited by 99Gut microbiota and healthTryptophan and brain disordersAnimal Nutrition and Physiology

Beneficial actions of microbiota‐derived tryptophan metabolites

Galligan, J. J.·2018·Neurogastroenterology & Motility

Abstract

Tryptophan is an important dietary amino acid and it is the precursor for 5‐hydroxytryptamine synthesis in the nervous system and by enterochromaffin cells in the gut mucosa. Tryptophan is also metabolized by enzymes in the gut mucosa and also by enzymes produced by the gut microbiome. Diet and the microbiome can contribute to metabolic disease in part by causing intestinal inflammation and increased permeability. In this issue of Neurogastroenterology and Motility, Jennis et al. test the hypothesis that indole tryptophan metabolites produced by gut bacteria might be responsible for the anti‐inflammatory and beneficial metabolic effects of the gut microbiome and Roux‐en‐Y gastric bypass surgery for weight loss by obese patients. The authors identified indole‐3‐propionic acid as the beneficial metabolite. A review of the literature also revealed the beneficial effects of tryptophan metabolites on diabetes and metabolic disease and on inflammatory bowel disease. Taken together, these data highlight another health benefit of the intestinal microbiome, which produces beneficial products from dietary amino acids especially tryptophan.

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Crossref · 10.1111/nmo.13283

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Authors
Galligan, J. J.
Affiliations
Michigan State University (US)
Corresponding author
Galligan, J. J.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2018-01-17
Volume
30
Issue
2
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
OpenAlex
W2788825121
Cited by
99
References
26
Citations by year
2026: 10 · 2025: 7 · 2024: 5 · 2023: 25 · 2022: 16 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 3
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (DK103759, DK094932)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
tryptophan metabolites, gut microbiota, indole-3-propionic acid, Roux-en-Y gastric bypass, obesity, metabolic disorders, intestinal inflammation, intestinal permeability, diabetes mellitus, inflammatory bowel disease, serotonin, enterochromaffin cells
MeSH terms
Gastrointestinal Microbiome, Diabetes Mellitus, Type 2, Humans, Obesity, Tryptophan

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