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Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0©

Open access
Yadlapati, Rena, Kahrilas, Peter J., Fox, Mark R., Bredenoord, Albert J., Prakash Gyawali, C., Roman, Sabine, Babaei, Arash, Mittal, Ravinder K., Rommel, Nathalie, Savarino, Edoardo, Sifrim, Daniel, Smout, André, Vaezi, Michael F., Zerbib, Frank, Akiyama, Junichi, Bhatia, Shobna, Bor, Serhat, Carlson, Dustin A., Chen, Joan W., Cisternas, Daniel, Cock, Charles, Coss‐Adame, Enrique, de Bortoli, Nicola, Defilippi, Claudia, Fass, Ronnie, Ghoshal, Uday C., Gonlachanvit, Sutep, Hani, Albis, Hebbard, Geoffrey S., Wook Jung, Kee, Katz, Philip, Katzka, David A., Khan, Abraham, Kohn, Geoffrey Paul, Lazarescu, Adriana, Lengliner, Johannes, Mittal, Sumeet K., Omari, Taher, Park, Moo In, Penagini, Roberto, Pohl, Daniel, Richter, Joel E., Serra, Jordi, Sweis, Rami, Tack, Jan, Tatum, Roger P., Tutuian, Radu, Vela, Marcelo F., Wong, Reuben K., Wu, Justin C., Xiao, Yinglian, Pandolfino, John E.·2021·Neurogastroenterology & Motility

Abstract

Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high‐resolution manometry (HRM). Fifty‐two diverse international experts separated into seven working subgroups utilized formal validated methodologies over two‐years to develop CCv4.0. Key updates in CCv.4.0 consist of a more rigorous and expansive HRM protocol that incorporates supine and upright test positions as well as provocative testing, a refined definition of esophagogastric junction (EGJ) outflow obstruction (EGJOO), more stringent diagnostic criteria for ineffective esophageal motility and description of baseline EGJ metrics. Further, the CCv4.0 sought to define motility disorder diagnoses as conclusive and inconclusive based on associated symptoms, and findings on provocative testing as well as supportive testing with barium esophagram with tablet and/or functional lumen imaging probe. These changes attempt to minimize ambiguity in prior iterations of Chicago Classification and provide more standardized and rigorous criteria for patterns of disorders of peristalsis and obstruction at the EGJ.

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Metadata

Authors
Yadlapati, R., Kahrilas, P. J., Fox, M. R., Bredenoord, A. J., Prakash Gyawali, C., Roman, S., Babaei, A., Mittal, R. K., Rommel, N., Savarino, E., Sifrim, D., Smout, A., Vaezi, M. F., Zerbib, F., Akiyama, J., Bhatia, S., Bor, S., Carlson, D. A., Chen, J. W., Cisternas, D., Cock, C., Coss‐Adame, E., de Bortoli, N., Defilippi, C., Fass, R., Ghoshal, U. C., Gonlachanvit, S., Hani, A., Hebbard, G. S., Wook Jung, K., Katz, P., Katzka, D. A., Khan, A., Kohn, G. P., Lazarescu, A., Lengliner, J., Mittal, S. K., Omari, T., Park, M. I., Penagini, R., Pohl, D., Richter, J. E., Serra, J., Sweis, R., Tack, J., Tatum, R. P., Tutuian, R., Vela, M. F., Wong, R. K., Wu, J. C., Xiao, Y., & Pandolfino, J. E.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2020-12-29
Volume
33
Issue
1
Pages
e14058-e14058
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
OpenAlex
W3117727838
Cited by
1,080
References
22
FWCI
79.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0©. https://app.cochat.ai/papers/10.1111/nmo.14058
The paper
Yadlapati, R., Kahrilas, P. J., Fox, M. R., Bredenoord, A. J., Prakash Gyawali, C., Roman, S., Babaei, A., Mittal, R. K., Rommel, N., Savarino, E., Sifrim, D., Smout, A., Vaezi, M. F., Zerbib, F., Akiyama, J., Bhatia, S., Bor, S., Carlson, D. A., Chen, J. W., . . . Pandolfino, J. E. (2021). Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0©. Neurogastroenterology & Motility. https://doi.org/10.1111/nmo.14058

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.